Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6283
Gene name Gene Name - the full gene name approved by the HGNC.	S100 calcium binding protein A12
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	S100A12
Synonyms (NCBI Gene) Gene synonyms aliases	CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q21.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of ce

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miRTarBase ID	miRNA	Experiments	Reference
MIRT437615	hsa-miR-146a-5p	Microarray, qRT-PCR	22815788
MIRT437621	hsa-miR-146b-5p	Microarray, qRT-PCR	22815788

Show/Hide all(38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001816	Process	Cytokine production	TAS	18443896
GO:0002548	Process	Monocyte chemotaxis	TAS	18443896
GO:0005507	Function	Copper ion binding	TAS	18443896
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005509	Function	Calcium ion binding	TAS	18443896
GO:0005515	Function	Protein binding	IPI	19386136
GO:0005576	Component	Extracellular region	TAS	18443896
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005634	Component	Nucleus	IDA	15033494
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	15033494
GO:0005829	Component	Cytosol	TAS	18443896
GO:0005856	Component	Cytoskeleton	TAS	18443896
GO:0005886	Component	Plasma membrane	TAS	18443896
GO:0006805	Process	Xenobiotic metabolic process	IDA	11522286
GO:0006954	Process	Inflammatory response	IEA
GO:0008270	Function	Zinc ion binding	TAS	11522286, 18443896
GO:0030593	Process	Neutrophil chemotaxis	TAS	18443896
GO:0031640	Process	Killing of cells of other organism	IDA	11522286
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042742	Process	Defense response to bacterium	TAS	18443896
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	15033494
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043406	Process	Positive regulation of MAP kinase activity	TAS	18443896
GO:0045087	Process	Innate immune response	TAS	18443896
GO:0045576	Process	Mast cell activation	TAS	18443896
GO:0048306	Function	Calcium-dependent protein binding	IBA	21873635
GO:0050729	Process	Positive regulation of inflammatory response	TAS	18443896
GO:0050786	Function	RAGE receptor binding	IBA	21873635
GO:0050786	Function	RAGE receptor binding	IDA	19386136
GO:0050786	Function	RAGE receptor binding	IPI	15033494
GO:0050786	Function	RAGE receptor binding	TAS	18443896
GO:0050832	Process	Defense response to fungus	IDA	11522286
GO:0050832	Process	Defense response to fungus	TAS	18443896
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	TAS	18443896
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA	21873635
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	11522286

MIM	HGNC	e!Ensembl
603112	10489	ENSG00000163221

Protein

UniProt ID

P80511

Protein name

Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S1

Protein function

S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and che

PDB

1E8A , 1GQM , 1ODB , 2M9G , 2WC8 , 2WCB , 2WCE , 2WCF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01023	S_100	4 → 46	S-100/ICaBP type calcium binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients su

Sequence

MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQG
LDANQDEQVDFQEFISLVAIALKAAHYHTHKE

Sequence length

Interactions

View interactions

	Reactome
			TAK1 activates NFkB by phosphorylation and activation of IKKs complex Neutrophil degranulation Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation

S100A12 (S100 calcium binding protein A12)