Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	6227
Gene name	Ribosomal protein S21
Gene symbol	RPS21
Synonyms (NCBI Gene)	HLDFS21eS21
Chromosome	20
Chromosome location	20q13.33
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT044996	hsa-miR-186-5p	CLASH	23622248
MIRT700008	hsa-miR-4464	HITS-CLIP	23313552
MIRT700007	hsa-miR-4748	HITS-CLIP	23313552
MIRT700006	hsa-miR-329-5p	HITS-CLIP	23313552
MIRT560440	hsa-miR-425-5p	HITS-CLIP	23313552
MIRT350493	hsa-miR-4528	HITS-CLIP	23313552
MIRT700005	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT700004	hsa-miR-3925-3p	HITS-CLIP	23313552
MIRT565957	hsa-miR-6845-3p	HITS-CLIP	23313552
MIRT296646	hsa-miR-4677-3p	HITS-CLIP	23313552
MIRT296647	hsa-miR-4679	HITS-CLIP	23313552
MIRT700003	hsa-miR-5571-3p	HITS-CLIP	23313552
MIRT700002	hsa-miR-7975	HITS-CLIP	23313552
MIRT565956	hsa-miR-6873-3p	HITS-CLIP	23313552
MIRT296648	hsa-miR-8070	HITS-CLIP	23313552
MIRT296645	hsa-miR-3692-3p	HITS-CLIP	23313552
MIRT700001	hsa-miR-384	HITS-CLIP	23313552
MIRT565955	hsa-miR-4768-5p	HITS-CLIP	23313552
MIRT565954	hsa-miR-6833-3p	HITS-CLIP	23313552
MIRT350492	hsa-miR-335-3p	HITS-CLIP	23313552
MIRT560440	hsa-miR-425-5p	PAR-CLIP	20371350
MIRT350493	hsa-miR-4528	PAR-CLIP	20371350
MIRT565957	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT296646	hsa-miR-4677-3p	PAR-CLIP	20371350
MIRT296647	hsa-miR-4679	PAR-CLIP	20371350
MIRT565956	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT296648	hsa-miR-8070	PAR-CLIP	20371350
MIRT296645	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT565955	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT565954	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT350492	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT560440	hsa-miR-425-5p	PAR-CLIP	20371350
MIRT350493	hsa-miR-4528	PAR-CLIP	20371350
MIRT296645	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT350492	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT501314	hsa-miR-193b-3p	PAR-CLIP	24398324
MIRT501313	hsa-miR-193a-3p	PAR-CLIP	24398324
MIRT501312	hsa-miR-548av-3p	PAR-CLIP	24398324
MIRT501311	hsa-miR-548g-3p	PAR-CLIP	24398324
MIRT501310	hsa-miR-3190-5p	PAR-CLIP	24398324
MIRT501309	hsa-miR-4529-5p	PAR-CLIP	24398324
MIRT501308	hsa-miR-3187-3p	PAR-CLIP	24398324
MIRT700008	hsa-miR-4464	HITS-CLIP	23313552
MIRT700007	hsa-miR-4748	HITS-CLIP	23313552
MIRT700006	hsa-miR-329-5p	HITS-CLIP	23313552
MIRT560440	hsa-miR-425-5p	HITS-CLIP	23313552
MIRT350493	hsa-miR-4528	HITS-CLIP	23313552
MIRT700005	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT700004	hsa-miR-3925-3p	HITS-CLIP	23313552
MIRT565957	hsa-miR-6845-3p	HITS-CLIP	23313552
MIRT296646	hsa-miR-4677-3p	HITS-CLIP	23313552
MIRT296647	hsa-miR-4679	HITS-CLIP	23313552
MIRT700003	hsa-miR-5571-3p	HITS-CLIP	23313552
MIRT700002	hsa-miR-7975	HITS-CLIP	23313552
MIRT565956	hsa-miR-6873-3p	HITS-CLIP	23313552
MIRT296648	hsa-miR-8070	HITS-CLIP	23313552
MIRT296645	hsa-miR-3692-3p	HITS-CLIP	23313552
MIRT700001	hsa-miR-384	HITS-CLIP	23313552
MIRT565955	hsa-miR-4768-5p	HITS-CLIP	23313552
MIRT565954	hsa-miR-6833-3p	HITS-CLIP	23313552
MIRT350492	hsa-miR-335-3p	HITS-CLIP	23313552
MIRT560440	hsa-miR-425-5p	PAR-CLIP	20371350
MIRT350493	hsa-miR-4528	PAR-CLIP	20371350
MIRT565957	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT296646	hsa-miR-4677-3p	PAR-CLIP	20371350
MIRT296647	hsa-miR-4679	PAR-CLIP	20371350
MIRT565956	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT296648	hsa-miR-8070	PAR-CLIP	20371350
MIRT296645	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT565955	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT565954	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT350492	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT560440	hsa-miR-425-5p	PAR-CLIP	20371350
MIRT350493	hsa-miR-4528	PAR-CLIP	20371350
MIRT296645	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT350492	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT501314	hsa-miR-193b-3p	PAR-CLIP	24398324
MIRT501313	hsa-miR-193a-3p	PAR-CLIP	24398324
MIRT501312	hsa-miR-548av-3p	PAR-CLIP	24398324
MIRT501311	hsa-miR-548g-3p	PAR-CLIP	24398324
MIRT501310	hsa-miR-3190-5p	PAR-CLIP	24398324
MIRT501309	hsa-miR-4529-5p	PAR-CLIP	24398324
MIRT501308	hsa-miR-3187-3p	PAR-CLIP	24398324
MIRT1317797	hsa-miR-3692	CLIP-seq
MIRT1317798	hsa-miR-425	CLIP-seq
MIRT1317797	hsa-miR-3692	CLIP-seq
MIRT2094437	hsa-miR-766	CLIP-seq
MIRT1317797	hsa-miR-3692	CLIP-seq
MIRT1317798	hsa-miR-425	CLIP-seq
MIRT2094437	hsa-miR-766	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000447	Process	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000461	Process	Endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005515	Function	Protein binding	IPI	10079194, 16169070, 28514442, 32296183, 33961781
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	8332502
GO:0015935	Component	Small ribosomal subunit	HDA	15883184
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022626	Component	Cytosolic ribosome	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699, 25957688
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	8332502, 25901680
GO:0045202	Component	Synapse	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
180477	10409	ENSG00000171858

P63220

Protein name

Small ribosomal subunit protein eS21 (40S ribosomal protein S21)

Protein function

Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6G18 , 6G4S , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH , 6ZVJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01249	Ribosomal_S21e	1 → 80	Ribosomal protein S21e	Family

Sequence

MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTGRFNGQFKTYAICGAIR
RMGESDDSILRLAKADGIVSKNF

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

RPS21 (ribosomal protein S21)