Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6227
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein S21
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPS21
Synonyms (NCBI Gene) Gene synonyms aliases	HLDF, S21, eS21
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q13.33
Summary Summary of gene provided in NCBI Entrez Gene.	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all(90)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044996	hsa-miR-186-5p	CLASH	23622248
MIRT700008	hsa-miR-4464	HITS-CLIP	23313552
MIRT700007	hsa-miR-4748	HITS-CLIP	23313552
MIRT700006	hsa-miR-329-5p	HITS-CLIP	23313552
MIRT560440	hsa-miR-425-5p	HITS-CLIP	23313552
MIRT350493	hsa-miR-4528	HITS-CLIP	23313552
MIRT700005	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT700004	hsa-miR-3925-3p	HITS-CLIP	23313552
MIRT565957	hsa-miR-6845-3p	HITS-CLIP	23313552
MIRT296646	hsa-miR-4677-3p	HITS-CLIP	23313552
MIRT296647	hsa-miR-4679	HITS-CLIP	23313552
MIRT700003	hsa-miR-5571-3p	HITS-CLIP	23313552
MIRT700002	hsa-miR-7975	HITS-CLIP	23313552
MIRT565956	hsa-miR-6873-3p	HITS-CLIP	23313552
MIRT296648	hsa-miR-8070	HITS-CLIP	23313552
MIRT296645	hsa-miR-3692-3p	HITS-CLIP	23313552
MIRT700001	hsa-miR-384	HITS-CLIP	23313552
MIRT565955	hsa-miR-4768-5p	HITS-CLIP	23313552
MIRT565954	hsa-miR-6833-3p	HITS-CLIP	23313552
MIRT350492	hsa-miR-335-3p	HITS-CLIP	23313552
MIRT560440	hsa-miR-425-5p	PAR-CLIP	20371350
MIRT350493	hsa-miR-4528	PAR-CLIP	20371350
MIRT565957	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT296646	hsa-miR-4677-3p	PAR-CLIP	20371350
MIRT296647	hsa-miR-4679	PAR-CLIP	20371350
MIRT565956	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT296648	hsa-miR-8070	PAR-CLIP	20371350
MIRT296645	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT565955	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT565954	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT350492	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT560440	hsa-miR-425-5p	PAR-CLIP	20371350
MIRT350493	hsa-miR-4528	PAR-CLIP	20371350
MIRT296645	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT350492	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT501314	hsa-miR-193b-3p	PAR-CLIP	24398324
MIRT501313	hsa-miR-193a-3p	PAR-CLIP	24398324
MIRT501312	hsa-miR-548av-3p	PAR-CLIP	24398324
MIRT501311	hsa-miR-548g-3p	PAR-CLIP	24398324
MIRT501310	hsa-miR-3190-5p	PAR-CLIP	24398324
MIRT501309	hsa-miR-4529-5p	PAR-CLIP	24398324
MIRT501308	hsa-miR-3187-3p	PAR-CLIP	24398324
MIRT700008	hsa-miR-4464	HITS-CLIP	23313552
MIRT700007	hsa-miR-4748	HITS-CLIP	23313552
MIRT700006	hsa-miR-329-5p	HITS-CLIP	23313552
MIRT560440	hsa-miR-425-5p	HITS-CLIP	23313552
MIRT350493	hsa-miR-4528	HITS-CLIP	23313552
MIRT700005	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT700004	hsa-miR-3925-3p	HITS-CLIP	23313552
MIRT565957	hsa-miR-6845-3p	HITS-CLIP	23313552
MIRT296646	hsa-miR-4677-3p	HITS-CLIP	23313552
MIRT296647	hsa-miR-4679	HITS-CLIP	23313552
MIRT700003	hsa-miR-5571-3p	HITS-CLIP	23313552
MIRT700002	hsa-miR-7975	HITS-CLIP	23313552
MIRT565956	hsa-miR-6873-3p	HITS-CLIP	23313552
MIRT296648	hsa-miR-8070	HITS-CLIP	23313552
MIRT296645	hsa-miR-3692-3p	HITS-CLIP	23313552
MIRT700001	hsa-miR-384	HITS-CLIP	23313552
MIRT565955	hsa-miR-4768-5p	HITS-CLIP	23313552
MIRT565954	hsa-miR-6833-3p	HITS-CLIP	23313552
MIRT350492	hsa-miR-335-3p	HITS-CLIP	23313552
MIRT560440	hsa-miR-425-5p	PAR-CLIP	20371350
MIRT350493	hsa-miR-4528	PAR-CLIP	20371350
MIRT565957	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT296646	hsa-miR-4677-3p	PAR-CLIP	20371350
MIRT296647	hsa-miR-4679	PAR-CLIP	20371350
MIRT565956	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT296648	hsa-miR-8070	PAR-CLIP	20371350
MIRT296645	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT565955	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT565954	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT350492	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT560440	hsa-miR-425-5p	PAR-CLIP	20371350
MIRT350493	hsa-miR-4528	PAR-CLIP	20371350
MIRT296645	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT350492	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT501314	hsa-miR-193b-3p	PAR-CLIP	24398324
MIRT501313	hsa-miR-193a-3p	PAR-CLIP	24398324
MIRT501312	hsa-miR-548av-3p	PAR-CLIP	24398324
MIRT501311	hsa-miR-548g-3p	PAR-CLIP	24398324
MIRT501310	hsa-miR-3190-5p	PAR-CLIP	24398324
MIRT501309	hsa-miR-4529-5p	PAR-CLIP	24398324
MIRT501308	hsa-miR-3187-3p	PAR-CLIP	24398324
MIRT1317797	hsa-miR-3692	CLIP-seq
MIRT1317798	hsa-miR-425	CLIP-seq
MIRT1317797	hsa-miR-3692	CLIP-seq
MIRT2094437	hsa-miR-766	CLIP-seq
MIRT1317797	hsa-miR-3692	CLIP-seq
MIRT1317798	hsa-miR-425	CLIP-seq
MIRT2094437	hsa-miR-766	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0000447	Process	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA	21873635
GO:0000461	Process	Endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA	21873635
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	TAS
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	NAS	8332502
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0015935	Component	Small ribosomal subunit	HDA	15883184
GO:0019083	Process	Viral transcription	TAS
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA	21873635
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699, 25957688
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	8332502
GO:0042788	Component	Polysomal ribosome	IDA	25957688
GO:0047485	Function	Protein N-terminus binding	IPI	10079194

MIM	HGNC	e!Ensembl
180477	10409	ENSG00000171858

Protein

UniProt ID

P63220

Protein name

Small ribosomal subunit protein eS21 (40S ribosomal protein S21)

Protein function

Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6G18 , 6G4S , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH , 6ZVJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01249	Ribosomal_S21e	1 → 80	Ribosomal protein S21e	Family

Sequence

MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTGRFNGQFKTYAICGAIR
RMGESDDSILRLAKADGIVSKNF

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802 View all (244 more)	21364753

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Meningeal Carcinomatosis	Stimulate	34263942
Obesity	Associate	34555498
Pigmentary Disorder Reticulate with Systemic Manifestations	Associate	25159325
Prostatic Neoplasms	Associate	29016636
Sarcoma Kaposi	Associate	40016701

RPS21 (ribosomal protein S21)