AFAP1 (actin filament associated protein 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 60312 |
| Gene name | Actin filament associated protein 1 |
| Gene symbol | AFAP1 |
| Synonyms (NCBI Gene) |
AFAPAFAP-110AFAP110
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| Chromosome | 4 |
| Chromosome location | 4p16.1 |
| Summary | The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling prot |
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miRNA
miRNA information provided by mirtarbase database.
549
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8N556 | |||||||||||||||
| Protein name | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | |||||||||||||||
| Protein function | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SR | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in pr | |||||||||||||||
| Sequence |
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| Sequence length | 730 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||