RLN2 (relaxin 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6019
Gene name Gene Name - the full gene name approved by the HGNC.
Relaxin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RLN2
Synonyms (NCBI Gene) Gene synonyms aliases
H2, H2-RLX, RLXH2, bA12D24.1.1, bA12D24.1.2
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9p24.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(35)
miRTarBase ID miRNA Experiments Reference
MIRT609113 hsa-miR-8084 HITS-CLIP 24906430
MIRT609112 hsa-miR-7153-3p HITS-CLIP 24906430
MIRT571257 hsa-miR-1255a HITS-CLIP 24906430
MIRT571256 hsa-miR-1255b-5p HITS-CLIP 24906430
MIRT609111 hsa-miR-4789-5p HITS-CLIP 24906430
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
NR3C1 Unknown 15149733
PGR Unknown 15149733
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005576 Component Extracellular region TAS
GO:0007186 Process G protein-coupled receptor signaling pathway TAS
GO:0007565 Process Female pregnancy TAS 6548702
GO:0010628 Process Positive regulation of gene expression IDA 11459784
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
179740 10027 ENSG00000107014
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P04090
Protein name Prorelaxin H2 [Cleaved into: Relaxin B chain; Relaxin A chain]
Protein function Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
PDB 2MV1 , 6RLX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00049 Insulin 32 → 185 Insulin/IGF/Relaxin family Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary. {ECO:
Sequence
Sequence length 185
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Relaxin signaling pathway 		  G alpha (s) signalling events
Relaxin receptors
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 16434975
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Ulcerative colitis Ulcerative colitis GWAS
Show/Hide Text Mining Associations (28)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Inhibit 19695764
Anemia Sickle Cell Associate 16412024
Aneurysm Stimulate 32024951
Atherosclerosis Associate 32024951
Breast Neoplasms Associate 37747033
Cap Myopathy Stimulate 21789713
Carcinoma Hepatocellular Associate 23661524
Cardiovascular Diseases Associate 28883402
Cerebral Arterial Diseases Associate 32024951
Disease Associate 32024951