Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	5999
Gene name	Regulator of G protein signaling 4
Gene symbol	RGS4
Synonyms (NCBI Gene)	RGP4SCZD9
Chromosome	1
Chromosome location	1q23.3
Summary	Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alph

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miRTarBase ID	miRNA	Experiments	Reference
MIRT054900	hsa-miR-124-3p	Luciferase reporter assay	23332465
MIRT054900	hsa-miR-124-3p	Luciferase reporter assay	23332465
MIRT549834	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT549833	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT549832	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT683473	hsa-miR-342-3p	HITS-CLIP	23313552
MIRT549834	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT549833	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT549832	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT549834	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT549833	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT549832	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT549834	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT549833	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT549832	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT576239	hsa-miR-342-3p	HITS-CLIP	23313552
MIRT549834	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT549833	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT549832	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT549834	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT549833	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT549832	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT1304408	hsa-miR-1266	CLIP-seq
MIRT1304409	hsa-miR-3148	CLIP-seq
MIRT1304410	hsa-miR-3664-3p	CLIP-seq
MIRT1304411	hsa-miR-377	CLIP-seq
MIRT1304412	hsa-miR-4420	CLIP-seq
MIRT1304413	hsa-miR-4502	CLIP-seq
MIRT1304414	hsa-miR-4518	CLIP-seq
MIRT1304415	hsa-miR-671-5p	CLIP-seq
MIRT1304416	hsa-miR-873	CLIP-seq
MIRT1304417	hsa-miR-18a	CLIP-seq
MIRT1304418	hsa-miR-18b	CLIP-seq
MIRT1304419	hsa-miR-198	CLIP-seq
MIRT1304420	hsa-miR-3691-5p	CLIP-seq
MIRT1304421	hsa-miR-380	CLIP-seq
MIRT1304422	hsa-miR-3907	CLIP-seq
MIRT1304423	hsa-miR-4270	CLIP-seq
MIRT1304424	hsa-miR-4441	CLIP-seq
MIRT1304425	hsa-miR-4468	CLIP-seq
MIRT1304426	hsa-miR-4491	CLIP-seq
MIRT1304427	hsa-miR-4657	CLIP-seq
MIRT1304428	hsa-miR-4685-5p	CLIP-seq
MIRT1304429	hsa-miR-4690-5p	CLIP-seq
MIRT1304430	hsa-miR-4735-3p	CLIP-seq
MIRT1304431	hsa-miR-4752	CLIP-seq
MIRT1304432	hsa-miR-4778-5p	CLIP-seq
MIRT1304433	hsa-miR-630	CLIP-seq
MIRT1304434	hsa-miR-1224-3p	CLIP-seq
MIRT1304435	hsa-miR-1260	CLIP-seq
MIRT1304436	hsa-miR-1260b	CLIP-seq
MIRT1304408	hsa-miR-1266	CLIP-seq
MIRT1304437	hsa-miR-1280	CLIP-seq
MIRT1304409	hsa-miR-3148	CLIP-seq
MIRT1304438	hsa-miR-3620	CLIP-seq
MIRT1304410	hsa-miR-3664-3p	CLIP-seq
MIRT1304439	hsa-miR-371-5p	CLIP-seq
MIRT1304411	hsa-miR-377	CLIP-seq
MIRT1304413	hsa-miR-4502	CLIP-seq
MIRT1304414	hsa-miR-4518	CLIP-seq
MIRT1304416	hsa-miR-873	CLIP-seq
MIRT1304440	hsa-miR-888	CLIP-seq
MIRT1304411	hsa-miR-377	CLIP-seq
MIRT1556989	hsa-miR-374c	CLIP-seq
MIRT1556990	hsa-miR-655	CLIP-seq
MIRT1304411	hsa-miR-377	CLIP-seq
MIRT2314933	hsa-miR-3180-5p	CLIP-seq
MIRT1304420	hsa-miR-3691-5p	CLIP-seq
MIRT1304426	hsa-miR-4491	CLIP-seq
MIRT1304427	hsa-miR-4657	CLIP-seq
MIRT1304431	hsa-miR-4752	CLIP-seq
MIRT2314934	hsa-miR-4757-5p	CLIP-seq
MIRT2314935	hsa-miR-4789-3p	CLIP-seq
MIRT2314936	hsa-miR-4789-5p	CLIP-seq
MIRT2393690	hsa-miR-103a	CLIP-seq
MIRT1304420	hsa-miR-3691-5p	CLIP-seq
MIRT1304411	hsa-miR-377	CLIP-seq
MIRT1304426	hsa-miR-4491	CLIP-seq
MIRT1304427	hsa-miR-4657	CLIP-seq
MIRT1304431	hsa-miR-4752	CLIP-seq
MIRT2393690	hsa-miR-103a	CLIP-seq
MIRT1304411	hsa-miR-377	CLIP-seq
MIRT2393690	hsa-miR-103a	CLIP-seq
MIRT1304411	hsa-miR-377	CLIP-seq
MIRT2393690	hsa-miR-103a	CLIP-seq
MIRT2611258	hsa-miR-103b	CLIP-seq
MIRT2611259	hsa-miR-1202	CLIP-seq
MIRT2611260	hsa-miR-1256	CLIP-seq
MIRT2611261	hsa-miR-1301	CLIP-seq
MIRT2611262	hsa-miR-142-5p	CLIP-seq
MIRT2611263	hsa-miR-297	CLIP-seq
MIRT2611264	hsa-miR-31	CLIP-seq
MIRT2611265	hsa-miR-3117-5p	CLIP-seq
MIRT2611266	hsa-miR-3149	CLIP-seq
MIRT2611267	hsa-miR-3154	CLIP-seq
MIRT2314933	hsa-miR-3180-5p	CLIP-seq
MIRT2611268	hsa-miR-3190	CLIP-seq
MIRT2611269	hsa-miR-329	CLIP-seq
MIRT2611270	hsa-miR-3607-5p	CLIP-seq
MIRT2611271	hsa-miR-3616-5p	CLIP-seq
MIRT2611272	hsa-miR-362-3p	CLIP-seq
MIRT2611273	hsa-miR-3647-5p	CLIP-seq
MIRT1304420	hsa-miR-3691-5p	CLIP-seq
MIRT2611274	hsa-miR-369-3p	CLIP-seq
MIRT2611275	hsa-miR-374a	CLIP-seq
MIRT2611276	hsa-miR-374b	CLIP-seq
MIRT1556989	hsa-miR-374c	CLIP-seq
MIRT2611277	hsa-miR-376c	CLIP-seq
MIRT1304411	hsa-miR-377	CLIP-seq
MIRT2611278	hsa-miR-3915	CLIP-seq
MIRT2611279	hsa-miR-3924	CLIP-seq
MIRT2611280	hsa-miR-3926	CLIP-seq
MIRT2611281	hsa-miR-3928	CLIP-seq
MIRT2611282	hsa-miR-3941	CLIP-seq
MIRT2611283	hsa-miR-3972	CLIP-seq
MIRT2611284	hsa-miR-410	CLIP-seq
MIRT2611285	hsa-miR-4297	CLIP-seq
MIRT2611286	hsa-miR-4299	CLIP-seq
MIRT2611287	hsa-miR-4434	CLIP-seq
MIRT2611288	hsa-miR-4436b-3p	CLIP-seq
MIRT2611289	hsa-miR-4456	CLIP-seq
MIRT2611290	hsa-miR-4477a	CLIP-seq
MIRT1304426	hsa-miR-4491	CLIP-seq
MIRT2611291	hsa-miR-4501	CLIP-seq
MIRT1304413	hsa-miR-4502	CLIP-seq
MIRT2611292	hsa-miR-4504	CLIP-seq
MIRT2611293	hsa-miR-450b-5p	CLIP-seq
MIRT2611294	hsa-miR-4516	CLIP-seq
MIRT2611295	hsa-miR-4531	CLIP-seq
MIRT2611296	hsa-miR-4633-3p	CLIP-seq
MIRT2611297	hsa-miR-4642	CLIP-seq
MIRT1304427	hsa-miR-4657	CLIP-seq
MIRT2611298	hsa-miR-466	CLIP-seq
MIRT2611299	hsa-miR-4666-5p	CLIP-seq
MIRT2611300	hsa-miR-4672	CLIP-seq
MIRT1304428	hsa-miR-4685-5p	CLIP-seq
MIRT2611301	hsa-miR-4690-3p	CLIP-seq
MIRT2611302	hsa-miR-4696	CLIP-seq
MIRT2611303	hsa-miR-4711-3p	CLIP-seq
MIRT2611304	hsa-miR-4714-3p	CLIP-seq
MIRT2611305	hsa-miR-4731-3p	CLIP-seq
MIRT1304431	hsa-miR-4752	CLIP-seq
MIRT2314934	hsa-miR-4757-5p	CLIP-seq
MIRT2611306	hsa-miR-4761-3p	CLIP-seq
MIRT2611307	hsa-miR-4764-5p	CLIP-seq
MIRT2314935	hsa-miR-4789-3p	CLIP-seq
MIRT2314936	hsa-miR-4789-5p	CLIP-seq
MIRT2611308	hsa-miR-4801	CLIP-seq
MIRT2611309	hsa-miR-487a	CLIP-seq
MIRT2611310	hsa-miR-5047	CLIP-seq
MIRT2611311	hsa-miR-507	CLIP-seq
MIRT2611312	hsa-miR-508-5p	CLIP-seq
MIRT2611313	hsa-miR-516b	CLIP-seq
MIRT2611314	hsa-miR-518d-5p	CLIP-seq
MIRT2611315	hsa-miR-519b-5p	CLIP-seq
MIRT2611316	hsa-miR-519c-5p	CLIP-seq
MIRT2611317	hsa-miR-520a-5p	CLIP-seq
MIRT2611318	hsa-miR-520c-5p	CLIP-seq
MIRT2611319	hsa-miR-525-5p	CLIP-seq
MIRT2611320	hsa-miR-526a	CLIP-seq
MIRT2611321	hsa-miR-542-3p	CLIP-seq
MIRT2611322	hsa-miR-548q	CLIP-seq
MIRT2611323	hsa-miR-548s	CLIP-seq
MIRT2611324	hsa-miR-557	CLIP-seq
MIRT2611325	hsa-miR-561	CLIP-seq
MIRT2611326	hsa-miR-573	CLIP-seq
MIRT2611327	hsa-miR-579	CLIP-seq
MIRT2611328	hsa-miR-586	CLIP-seq
MIRT2611329	hsa-miR-603	CLIP-seq
MIRT2611330	hsa-miR-642a	CLIP-seq
MIRT1556990	hsa-miR-655	CLIP-seq
MIRT2611331	hsa-miR-892a	CLIP-seq
MIRT2611332	hsa-miR-924	CLIP-seq
MIRT2393690	hsa-miR-103a	CLIP-seq
MIRT2611258	hsa-miR-103b	CLIP-seq
MIRT2611259	hsa-miR-1202	CLIP-seq
MIRT2611260	hsa-miR-1256	CLIP-seq
MIRT2611261	hsa-miR-1301	CLIP-seq
MIRT2611262	hsa-miR-142-5p	CLIP-seq
MIRT2611263	hsa-miR-297	CLIP-seq
MIRT2611264	hsa-miR-31	CLIP-seq
MIRT2611265	hsa-miR-3117-5p	CLIP-seq
MIRT2611266	hsa-miR-3149	CLIP-seq
MIRT2611267	hsa-miR-3154	CLIP-seq
MIRT2314933	hsa-miR-3180-5p	CLIP-seq
MIRT2611268	hsa-miR-3190	CLIP-seq
MIRT2611269	hsa-miR-329	CLIP-seq
MIRT2611270	hsa-miR-3607-5p	CLIP-seq
MIRT2611271	hsa-miR-3616-5p	CLIP-seq
MIRT2611272	hsa-miR-362-3p	CLIP-seq
MIRT2611273	hsa-miR-3647-5p	CLIP-seq
MIRT1304420	hsa-miR-3691-5p	CLIP-seq
MIRT2611274	hsa-miR-369-3p	CLIP-seq
MIRT2611275	hsa-miR-374a	CLIP-seq
MIRT2611276	hsa-miR-374b	CLIP-seq
MIRT1556989	hsa-miR-374c	CLIP-seq
MIRT2611277	hsa-miR-376c	CLIP-seq
MIRT1304411	hsa-miR-377	CLIP-seq
MIRT2611278	hsa-miR-3915	CLIP-seq
MIRT2611279	hsa-miR-3924	CLIP-seq
MIRT2611280	hsa-miR-3926	CLIP-seq
MIRT2611281	hsa-miR-3928	CLIP-seq
MIRT2611282	hsa-miR-3941	CLIP-seq
MIRT2611283	hsa-miR-3972	CLIP-seq
MIRT2611284	hsa-miR-410	CLIP-seq
MIRT2611286	hsa-miR-4299	CLIP-seq
MIRT2611287	hsa-miR-4434	CLIP-seq
MIRT2611288	hsa-miR-4436b-3p	CLIP-seq
MIRT2611289	hsa-miR-4456	CLIP-seq
MIRT2611290	hsa-miR-4477a	CLIP-seq
MIRT1304426	hsa-miR-4491	CLIP-seq
MIRT2611291	hsa-miR-4501	CLIP-seq
MIRT1304413	hsa-miR-4502	CLIP-seq
MIRT2611292	hsa-miR-4504	CLIP-seq
MIRT2611293	hsa-miR-450b-5p	CLIP-seq
MIRT2611294	hsa-miR-4516	CLIP-seq
MIRT2611295	hsa-miR-4531	CLIP-seq
MIRT2611296	hsa-miR-4633-3p	CLIP-seq
MIRT2611297	hsa-miR-4642	CLIP-seq
MIRT1304427	hsa-miR-4657	CLIP-seq
MIRT2611298	hsa-miR-466	CLIP-seq
MIRT2611299	hsa-miR-4666-5p	CLIP-seq
MIRT2611300	hsa-miR-4672	CLIP-seq
MIRT1304428	hsa-miR-4685-5p	CLIP-seq
MIRT2611302	hsa-miR-4696	CLIP-seq
MIRT2611303	hsa-miR-4711-3p	CLIP-seq
MIRT2611304	hsa-miR-4714-3p	CLIP-seq
MIRT2611305	hsa-miR-4731-3p	CLIP-seq
MIRT1304431	hsa-miR-4752	CLIP-seq
MIRT2314934	hsa-miR-4757-5p	CLIP-seq
MIRT2611306	hsa-miR-4761-3p	CLIP-seq
MIRT2611307	hsa-miR-4764-5p	CLIP-seq
MIRT2314935	hsa-miR-4789-3p	CLIP-seq
MIRT2314936	hsa-miR-4789-5p	CLIP-seq
MIRT2611308	hsa-miR-4801	CLIP-seq
MIRT2611309	hsa-miR-487a	CLIP-seq
MIRT2611310	hsa-miR-5047	CLIP-seq
MIRT2611311	hsa-miR-507	CLIP-seq
MIRT2611312	hsa-miR-508-5p	CLIP-seq
MIRT2611313	hsa-miR-516b	CLIP-seq
MIRT2611314	hsa-miR-518d-5p	CLIP-seq
MIRT2611315	hsa-miR-519b-5p	CLIP-seq
MIRT2611316	hsa-miR-519c-5p	CLIP-seq
MIRT2611317	hsa-miR-520a-5p	CLIP-seq
MIRT2611318	hsa-miR-520c-5p	CLIP-seq
MIRT2611319	hsa-miR-525-5p	CLIP-seq
MIRT2611320	hsa-miR-526a	CLIP-seq
MIRT2611321	hsa-miR-542-3p	CLIP-seq
MIRT2611322	hsa-miR-548q	CLIP-seq
MIRT2611323	hsa-miR-548s	CLIP-seq
MIRT2611324	hsa-miR-557	CLIP-seq
MIRT2611325	hsa-miR-561	CLIP-seq
MIRT2611326	hsa-miR-573	CLIP-seq
MIRT2611327	hsa-miR-579	CLIP-seq
MIRT2611328	hsa-miR-586	CLIP-seq
MIRT2611329	hsa-miR-603	CLIP-seq
MIRT2611330	hsa-miR-642a	CLIP-seq
MIRT1556990	hsa-miR-655	CLIP-seq
MIRT2611332	hsa-miR-924	CLIP-seq
MIRT2611264	hsa-miR-31	CLIP-seq
MIRT1556989	hsa-miR-374c	CLIP-seq
MIRT2611303	hsa-miR-4711-3p	CLIP-seq
MIRT1556990	hsa-miR-655	CLIP-seq

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Transcription factor	Regulation	Reference
NFKB1	Activation	18260825
PROX1	Repression	22942256
RELA	Activation	18260825

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001965	Function	G-protein alpha-subunit binding	IEA
GO:0001975	Process	Response to amphetamine	IEA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS	10747990
GO:0005516	Function	Calmodulin binding	TAS	10747990
GO:0005634	Component	Nucleus	IDA	10791963
GO:0005737	Component	Cytoplasm	IDA	10791963
GO:0005886	Component	Plasma membrane	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	10747990
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0010460	Process	Positive regulation of heart rate	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0042220	Process	Response to cocaine	IEA
GO:0045471	Process	Response to ethanol	IEA
GO:0045744	Process	Negative regulation of G protein-coupled receptor signaling pathway	IEA
GO:0051924	Process	Regulation of calcium ion transport	IEA
GO:0060160	Process	Negative regulation of dopamine receptor signaling pathway	IEA
GO:0061052	Process	Negative regulation of cell growth involved in cardiac muscle cell development	IEA
GO:0110053	Process	Regulation of actin filament organization	IEA
GO:1900924	Process	Negative regulation of glycine import across plasma membrane	IEA
GO:1901379	Process	Regulation of potassium ion transmembrane transport	IEA
GO:1901380	Process	Negative regulation of potassium ion transmembrane transport	IEA
GO:1990791	Process	Dorsal root ganglion development	IEA
GO:2000463	Process	Positive regulation of excitatory postsynaptic potential	IEA

MIM	HGNC	e!Ensembl
602516	10000	ENSG00000117152

P49798

Protein name

Regulator of G-protein signaling 4 (RGP4) (RGS4)

Protein function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00615	RGS	62 → 177	Regulator of G protein signaling domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. {E

Sequence

MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWA
ESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFIS
VQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNP
SSCGAEKQKGAKSSADCASLVPQCA

Sequence length

205

Interactions

View interactions

	Reactome
			G alpha (q) signalling events G alpha (i) signalling events

RGS4 (regulator of G protein signaling 4)