RELA (RELA proto-oncogene, NF-kB subunit)

Gene

• Entrez ID: 5970
• Gene name: RELA proto-oncogene, NF-kB subunit
• Gene symbol: RELA
• Synonyms (NCBI Gene): AIF3BL3, CMCU, NFKB3, p65
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcripti

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1565191003	C>T	Pathogenic	Splice donor variant
rs1590931704	T>G	Likely-pathogenic	Splice acceptor variant, intron variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002616	hsa-miR-124-3p	Luciferase reporter assay, Microarray	15685193
MIRT002531	hsa-miR-373-3p	Microarray	15685193
MIRT002531	hsa-miR-373-3p	Microarray;Other	15685193
MIRT002616	hsa-miR-124-3p	Microarray;Other	15685193
MIRT025722	hsa-miR-7-5p	Sequencing	20371350
MIRT025722	hsa-miR-7-5p	Microarray	17612493
MIRT025722	hsa-miR-7-5p	Microarray	19073608
MIRT027888	hsa-miR-96-5p	Sequencing	20371350
MIRT044799	hsa-miR-320a	CLASH	23622248
MIRT044799	hsa-miR-320a	CLASH	23622248
MIRT044156	hsa-miR-30e-5p	CLASH	23622248
MIRT043112	hsa-miR-324-5p	CLASH	23622248
MIRT025722	hsa-miR-7-5p	qRT-PCR, Western blot	25232110
MIRT025722	hsa-miR-7-5p	qRT-PCR, Western blot	25232110
MIRT025722	hsa-miR-7-5p	qRT-PCR, Western blot	25232110
MIRT025722	hsa-miR-7-5p	qRT-PCR, Western blot	25232110
MIRT642962	hsa-miR-3125	HITS-CLIP	23824327
MIRT642961	hsa-miR-3916	HITS-CLIP	23824327
MIRT642960	hsa-miR-6859-5p	HITS-CLIP	23824327
MIRT642959	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT383563	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT642958	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT642956	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT642957	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT642955	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT642954	hsa-miR-1303	HITS-CLIP	23824327
MIRT642962	hsa-miR-3125	HITS-CLIP	23824327
MIRT642961	hsa-miR-3916	HITS-CLIP	23824327
MIRT642960	hsa-miR-6859-5p	HITS-CLIP	23824327
MIRT642959	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT383563	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT642958	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT642956	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT642957	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT642955	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT642954	hsa-miR-1303	HITS-CLIP	23824327
MIRT559980	hsa-miR-4534	PAR-CLIP	20371350
MIRT559979	hsa-miR-8082	PAR-CLIP	20371350
MIRT559978	hsa-miR-3134	PAR-CLIP	20371350
MIRT025722	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT559977	hsa-miR-6077	PAR-CLIP	20371350
MIRT559975	hsa-miR-3161	PAR-CLIP	20371350
MIRT559976	hsa-miR-599	PAR-CLIP	20371350
MIRT559974	hsa-miR-1261	PAR-CLIP	20371350
MIRT559980	hsa-miR-4534	PAR-CLIP	20371350
MIRT559979	hsa-miR-8082	PAR-CLIP	20371350
MIRT559978	hsa-miR-3134	PAR-CLIP	20371350
MIRT025722	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT559977	hsa-miR-6077	PAR-CLIP	20371350
MIRT559975	hsa-miR-3161	PAR-CLIP	20371350
MIRT559976	hsa-miR-599	PAR-CLIP	20371350
MIRT559974	hsa-miR-1261	PAR-CLIP	20371350
MIRT025722	hsa-miR-7-5p	ChIP-seq, Immunofluorescence, Immunohistochemistry, In situ hybridization, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	26261179
MIRT025722	hsa-miR-7-5p	ChIP-seq, Immunofluorescence, Immunohistochemistry, In situ hybridization, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	26261179
MIRT025722	hsa-miR-7-5p	ChIP-seq, Immunofluorescence, Immunohistochemistry, In situ hybridization, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	26261179
MIRT025722	hsa-miR-7-5p	ChIP-seq, Immunofluorescence, Immunohistochemistry, In situ hybridization, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	26261179
MIRT025722	hsa-miR-7-5p	qRT-PCR, Western blot	25814668
MIRT737051	hsa-miR-375	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR	31802830
MIRT737051	hsa-miR-375	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR	31802830
MIRT737051	hsa-miR-375	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR	31802830
MIRT642962	hsa-miR-3125	HITS-CLIP	23824327
MIRT642961	hsa-miR-3916	HITS-CLIP	23824327
MIRT642960	hsa-miR-6859-5p	HITS-CLIP	23824327
MIRT642959	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT383563	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT642958	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT642956	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT642957	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT642955	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT642954	hsa-miR-1303	HITS-CLIP	23824327
MIRT642962	hsa-miR-3125	HITS-CLIP	23824327
MIRT642961	hsa-miR-3916	HITS-CLIP	23824327
MIRT642960	hsa-miR-6859-5p	HITS-CLIP	23824327
MIRT642959	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT383563	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT642958	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT642956	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT642957	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT642955	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT642954	hsa-miR-1303	HITS-CLIP	23824327
MIRT559980	hsa-miR-4534	PAR-CLIP	20371350
MIRT559979	hsa-miR-8082	PAR-CLIP	20371350
MIRT559978	hsa-miR-3134	PAR-CLIP	20371350
MIRT025722	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT559977	hsa-miR-6077	PAR-CLIP	20371350
MIRT559975	hsa-miR-3161	PAR-CLIP	20371350
MIRT559976	hsa-miR-599	PAR-CLIP	20371350
MIRT559974	hsa-miR-1261	PAR-CLIP	20371350
MIRT559980	hsa-miR-4534	PAR-CLIP	20371350
MIRT559979	hsa-miR-8082	PAR-CLIP	20371350
MIRT559978	hsa-miR-3134	PAR-CLIP	20371350
MIRT025722	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT559977	hsa-miR-6077	PAR-CLIP	20371350
MIRT559975	hsa-miR-3161	PAR-CLIP	20371350
MIRT559976	hsa-miR-599	PAR-CLIP	20371350
MIRT559974	hsa-miR-1261	PAR-CLIP	20371350
MIRT025722	hsa-miR-7-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC), Flow cytometry	35510522
MIRT756464	hsa-miR-182-5p	qRT-PCR	38796528
MIRT1300046	hsa-miR-1253	CLIP-seq
MIRT1300047	hsa-miR-1276	CLIP-seq
MIRT1300048	hsa-miR-182	CLIP-seq
MIRT1300049	hsa-miR-302a	CLIP-seq
MIRT1300050	hsa-miR-302b	CLIP-seq
MIRT1300051	hsa-miR-302c	CLIP-seq
MIRT1300052	hsa-miR-302d	CLIP-seq
MIRT1300053	hsa-miR-302e	CLIP-seq
MIRT1300054	hsa-miR-3691-3p	CLIP-seq
MIRT1300055	hsa-miR-372	CLIP-seq
MIRT1300056	hsa-miR-373	CLIP-seq
MIRT1300057	hsa-miR-4419a	CLIP-seq
MIRT1300058	hsa-miR-4453	CLIP-seq
MIRT1300059	hsa-miR-4510	CLIP-seq
MIRT1300060	hsa-miR-451b	CLIP-seq
MIRT1300061	hsa-miR-4538	CLIP-seq
MIRT1300062	hsa-miR-4676-5p	CLIP-seq
MIRT1300063	hsa-miR-520a-3p	CLIP-seq
MIRT1300064	hsa-miR-520b	CLIP-seq
MIRT1300065	hsa-miR-520c-3p	CLIP-seq
MIRT1300066	hsa-miR-520d-3p	CLIP-seq
MIRT1300067	hsa-miR-520e	CLIP-seq
MIRT1300068	hsa-miR-520f	CLIP-seq
MIRT1300069	hsa-miR-575	CLIP-seq
MIRT1300070	hsa-miR-580	CLIP-seq
MIRT1300048	hsa-miR-182	CLIP-seq
MIRT1300071	hsa-miR-320e	CLIP-seq
MIRT1300058	hsa-miR-4453	CLIP-seq
MIRT1300061	hsa-miR-4538	CLIP-seq
MIRT1300062	hsa-miR-4676-5p	CLIP-seq
MIRT1300069	hsa-miR-575	CLIP-seq
MIRT1300072	hsa-miR-7	CLIP-seq
MIRT2089206	hsa-miR-1275	CLIP-seq
MIRT1300047	hsa-miR-1276	CLIP-seq
MIRT1300048	hsa-miR-182	CLIP-seq
MIRT1300054	hsa-miR-3691-3p	CLIP-seq
MIRT2089207	hsa-miR-4311	CLIP-seq
MIRT1300058	hsa-miR-4453	CLIP-seq
MIRT1300060	hsa-miR-451b	CLIP-seq
MIRT1300061	hsa-miR-4538	CLIP-seq
MIRT2089208	hsa-miR-4665-5p	CLIP-seq
MIRT1300062	hsa-miR-4676-5p	CLIP-seq
MIRT1300069	hsa-miR-575	CLIP-seq
MIRT2089209	hsa-miR-596	CLIP-seq
MIRT1300072	hsa-miR-7	CLIP-seq
MIRT2089210	hsa-miR-759	CLIP-seq
MIRT2089206	hsa-miR-1275	CLIP-seq
MIRT2089208	hsa-miR-4665-5p	CLIP-seq
MIRT1300072	hsa-miR-7	CLIP-seq
MIRT2610567	hsa-miR-135a	CLIP-seq
MIRT2610568	hsa-miR-135b	CLIP-seq
MIRT2610569	hsa-miR-186	CLIP-seq
MIRT2610570	hsa-miR-3163	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
APEX1	Activation	17045925
AR	Repression	18386814
ATF2	Activation	21350211
BCL3	Unknown	7896265
EP300	Unknown	21146504
ETV3	Repression	18025162
FHL2	Unknown	18752053
GATA3	Unknown	19686049
HDAC9	Repression	15964798
HOXA9	Repression	18068911
HSF1	Unknown	18689673
NFKBIA	Activation	9500973
NFKBIA	Repression	11278471;18606063;20173029
NFKBIA	Unknown	15713458;17148610
NR1H4	Activation	21364590
NR1I2	Repression	22248096
PARP1	Unknown	16026317
PGR	Repression	8626413
RUNX1	Unknown	19686049
SP1	Activation	20538607;11964305;9151857
SP1	Unknown	8450395
SP3	Activation	20538607
SP4	Activation	20538607
TNFAIP3	Repression	19124729
TNFAIP3	Unknown	24039598
TP53	Unknown	15988033
TRIM22	Unknown	21651891
USF1	Unknown	19686049

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	17350185
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	IC	1406630
GO:0000785	Component	Chromatin	IDA	1406630, 8413223, 38114488
GO:0000785	Component	Chromatin	IDA	21343296, 26268439
GO:0000785	Component	Chromatin	IEA
GO:0000785	Component	Chromatin	IGI	23729669
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	17350185
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	7959007, 24955228, 25411248
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP	18045535
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	1406630, 17350185, 23729669, 23811396, 23878390
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI	21806946
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS	21329555
GO:0000979	Function	RNA polymerase II core promoter sequence-specific DNA binding	IDA	21343296
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	3091258, 21343177, 23878390
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001223	Function	Transcription coactivator binding	IPI	23811396
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	17350185
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	1406630, 17350185, 23811396, 26435691
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IGI	21806946
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	26268439
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	ISS	21329555
GO:0001818	Process	Negative regulation of cytokine production	IEA
GO:0001889	Process	Liver development	IEA
GO:0001942	Process	Hair follicle development	IEA
GO:0002357	Process	Defense response to tumor cell	IDA	28362429
GO:0002931	Process	Response to ischemia	IEA
GO:0003677	Function	DNA binding	IDA	15790681, 18073330, 23091055
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	IMP	18212740
GO:0003682	Function	Chromatin binding	IDA	19058135
GO:0003682	Function	Chromatin binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	8413223, 12048232, 19103749
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IMP	9425125
GO:0005515	Function	Protein binding	IPI	1493333, 7651415, 7739562, 8246997, 9865693, 10353611, 10498867, 11387332, 11526476, 11591705, 11931769, 12842894, 14600157, 14624448, 14685242, 14743216, 15029197, 15125834, 15140884, 15152190, 15355351, 15601829, 15799966, 15917220, 16291753, 16452207, 16683270, 16951195, 17000776
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	1493333
GO:0005634	Component	Nucleus	IDA	3140380, 15790681, 17350185, 18045535, 18212740, 19058135, 21097510, 21343177, 21343296, 21474709, 21830064, 22065573, 25411248
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IGI	25327529
GO:0005634	Component	Nucleus	IMP	9425125
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IDA	12048232
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005667	Component	Transcription regulator complex	TAS	33785602
GO:0005730	Component	Nucleolus	IDA	21343177
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	3140380, 15790681, 21097510, 21343177, 21830064, 25411248, 27736973
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	IGI	23729669
GO:0005829	Component	Cytosol	IDA	21474709, 25327529
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006325	Process	Chromatin organization	IEA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IMP	23178297
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	1406630
GO:0006952	Process	Defense response	IEA
GO:0006954	Process	Inflammatory response	IBA
GO:0006954	Process	Inflammatory response	IDA	10748004
GO:0006954	Process	Inflammatory response	IDA	12924514
GO:0006968	Process	Cellular defense response	NAS	8717528
GO:0007218	Process	Neuropeptide signaling pathway	IGI	21806946
GO:0007249	Process	Canonical NF-kappaB signal transduction	IBA
GO:0007249	Process	Canonical NF-kappaB signal transduction	IDA	1406630, 12048232, 21343177, 23811396, 23878390
GO:0007249	Process	Canonical NF-kappaB signal transduction	IEA
GO:0007249	Process	Canonical NF-kappaB signal transduction	IGI	21343177
GO:0007249	Process	Canonical NF-kappaB signal transduction	IMP	23619365
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	23091055
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009612	Process	Response to mechanical stimulus	IEA
GO:0009617	Process	Response to bacterium	IEA
GO:0009887	Process	Animal organ morphogenesis	IEA
GO:0010224	Process	Response to UV-B	IDA	15616591
GO:0010575	Process	Positive regulation of vascular endothelial growth factor production	IMP	25196641
GO:0010628	Process	Positive regulation of gene expression	IMP	28159925
GO:0014040	Process	Positive regulation of Schwann cell differentiation	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IMP	23619365
GO:0019221	Process	Cytokine-mediated signaling pathway	IDA	15876188
GO:0019899	Function	Enzyme binding	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	10521409, 15465828
GO:0023019	Process	Signal transduction involved in regulation of gene expression	IDA	1406630
GO:0030163	Process	Protein catabolic process	IEA
GO:0031490	Function	Chromatin DNA binding	IDA	25411248
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	12748188
GO:0032495	Process	Response to muramyl dipeptide	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032570	Process	Response to progesterone	IEA
GO:0032731	Process	Positive regulation of interleukin-1 beta production	IDA	27203220
GO:0032735	Process	Positive regulation of interleukin-12 production	IEA
GO:0032755	Process	Positive regulation of interleukin-6 production	IDA	27203220
GO:0032755	Process	Positive regulation of interleukin-6 production	IMP	25196641
GO:0032757	Process	Positive regulation of interleukin-8 production	IDA	27203220
GO:0032757	Process	Positive regulation of interleukin-8 production	IGI	21343296
GO:0032868	Process	Response to insulin	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IDA	21343177, 25411248
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IGI	28159925
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IMP	23878390
GO:0033234	Process	Negative regulation of protein sumoylation	IEA
GO:0033590	Process	Response to cobalamin	IEA
GO:0034097	Process	Response to cytokine	IBA
GO:0034097	Process	Response to cytokine	IEA
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IDA	25355951
GO:0035525	Component	NF-kappaB p50/p65 complex	IBA
GO:0035525	Component	NF-kappaB p50/p65 complex	IDA	18045535
GO:0035525	Component	NF-kappaB p50/p65 complex	IEA
GO:0035525	Component	NF-kappaB p50/p65 complex	NAS	30205516
GO:0035556	Process	Intracellular signal transduction	IDA	27203220
GO:0035729	Process	Cellular response to hepatocyte growth factor stimulus	IEA
GO:0035994	Process	Response to muscle stretch	IEA
GO:0038061	Process	Non-canonical NF-kappaB signal transduction	IBA
GO:0038061	Process	Non-canonical NF-kappaB signal transduction	IDA	8413223, 12048232
GO:0038084	Process	Vascular endothelial growth factor signaling pathway	IMP	23878390
GO:0038124	Process	Toll-like receptor TLR6:TLR2 signaling pathway	IDA	27708357
GO:0038161	Process	Prolactin signaling pathway	IMP	23619365
GO:0042177	Process	Negative regulation of protein catabolic process	IEA
GO:0042277	Function	Peptide binding	IPI	18045535
GO:0042301	Function	Phosphate ion binding	IDA	10521409
GO:0042542	Process	Response to hydrogen peroxide	IEA
GO:0042802	Function	Identical protein binding	IDA	9437432
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	8246997, 10498867
GO:0042803	Function	Protein homodimerization activity	IDA	18045535, 18212740
GO:0042805	Function	Actinin binding	IEA
GO:0042805	Function	Actinin binding	IPI	25411248
GO:0042826	Function	Histone deacetylase binding	IPI	17785205
GO:0043066	Process	Negative regulation of apoptotic process	IDA	10747850, 23091055
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEP	12761501
GO:0043200	Process	Response to amino acid	IEA
GO:0043278	Process	Response to morphine	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045087	Process	Innate immune response	IBA
GO:0045202	Component	Synapse	IEA
GO:0045471	Process	Response to ethanol	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	17350185
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	17350185, 18073330
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	9425125
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	1406630, 8246997, 17350185, 23091055, 23811396, 26435691
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IGI	21343296, 21518763
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	10660609, 21310825, 24955228, 25762865
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS	21329555
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	NAS	30205516
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IEA
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:0050862	Process	Positive regulation of T cell receptor signaling pathway	IMP	18045535
GO:0051059	Function	NF-kappaB binding	IPI	8441377
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IDA	15790681
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IGI	18045535
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IMP	18045535
GO:0051591	Process	Response to cAMP	IEA
GO:0051607	Process	Defense response to virus	NAS	8717528
GO:0070301	Process	Cellular response to hydrogen peroxide	IDA	21830064
GO:0070431	Process	Nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA	12527755
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IGI	25327529
GO:0070555	Process	Response to interleukin-1	IGI	15489227
GO:0071159	Component	NF-kappaB complex	IPI	8246997
GO:0071159	Component	NF-kappaB complex	NAS	30205516
GO:0071159	Component	NF-kappaB complex	TAS	33785602
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IMP	25762865
GO:0071223	Process	Cellular response to lipoteichoic acid	IMP	26649771
GO:0071224	Process	Cellular response to peptidoglycan	IMP	24955228
GO:0071316	Process	Cellular response to nicotine	IMP	22357537
GO:0071347	Process	Cellular response to interleukin-1	IDA	18073330
GO:0071354	Process	Cellular response to interleukin-6	IMP	22357537
GO:0071356	Process	Cellular response to tumor necrosis factor	IDA	18073330, 23091055
GO:0071356	Process	Cellular response to tumor necrosis factor	IEA
GO:0071356	Process	Cellular response to tumor necrosis factor	IMP	18045535
GO:0071532	Function	Ankyrin repeat binding	IEA
GO:0098978	Component	Glutamatergic synapse	IDA	12947408
GO:0098978	Component	Glutamatergic synapse	IMP	12947408
GO:0099527	Process	Postsynapse to nucleus signaling pathway	IDA	12947408
GO:0099527	Process	Postsynapse to nucleus signaling pathway	IMP	12947408
GO:0140296	Function	General transcription initiation factor binding	IPI	10849440
GO:0140297	Function	DNA-binding transcription factor binding	IPI	10660609, 15489227, 28362429
GO:0140374	Process	Antiviral innate immune response	IDA	38114488
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IDA	16968406
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IMP	18212740
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IMP	23178297
GO:1902004	Process	Positive regulation of amyloid-beta formation	IEA
GO:1902004	Process	Positive regulation of amyloid-beta formation	ISS	21329555
GO:1902894	Process	Negative regulation of miRNA transcription	IMP	23878390
GO:1902895	Process	Positive regulation of miRNA transcription	IGI	21806946
GO:1902895	Process	Positive regulation of miRNA transcription	IMP	23619365, 26268439
GO:1904385	Process	Cellular response to angiotensin	IMP	22357537
GO:1904996	Process	Positive regulation of leukocyte adhesion to vascular endothelial cell	IMP	25515214
GO:2000630	Process	Positive regulation of miRNA metabolic process	IMP	22357537
GO:2001237	Process	Negative regulation of extrinsic apoptotic signaling pathway	IEA
GO:2001237	Process	Negative regulation of extrinsic apoptotic signaling pathway	IMP	21310825

Other IDs

• MIM: 164014
• HGNC: 9955
• e!Ensembl: ENSG00000173039

Protein

• UniProt ID: Q04206
• Protein name: Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
• Protein function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammati
• PDB: 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 4KV4, 5U4K, 5URN, 6NV2, 6QHL, 6QHM, 6YOW, 6YOX, 6YOY, 6YP2, 6YP3, 6YP8, 6YPL, 6YPY, 6YQ2, 7BI3, 7BIQ, 7BIW, 7BIY, 7BJB, 7BJF, 7BJL, 7BJW, 7BKH, 7LET, 7LEU, 7LF4, 7NJ9, 7NJB, 7NK3, 7NK5, 7NLA, 7NLE, 7NM1, 7NM3, 7NM9, 7NMH, 7NQP, 7NR7, 7NSV, 7NV4, 7NVI, 7NWS, 7NXS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00554	RHD_DNA_bind	21 → 186	Rel homology DNA-binding domain	Domain
  PF16179	RHD_dimer	195 → 292	Rel homology dimerisation domain	Domain

• Sequence:

  MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
  IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
  VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
  HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
  QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
  KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
  DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
  VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
  GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
  DFSALLSQISS

• Sequence length: 551

Pathways

KEGG:

Antifolate resistance
MAPK signaling pathway
Ras signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
Mitophagy - animal
PI3K-Akt signaling pathway
Apoptosis
Longevity regulating pathway
Cellular senescence
Osteoclast differentiation
Neutrophil extracellular trap formation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
C-type lectin receptor signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Prolactin signaling pathway
Adipocytokine signaling pathway
Relaxin signaling pathway
Insulin resistance
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Alcoholic liver disease
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Cocaine addiction
Epithelial cell signaling in Helicobacter pylori infection
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pertussis
Legionellosis
Yersinia infection
Leishmaniasis
Chagas disease
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Human cytomegalovirus infection
Influenza A
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Coronavirus disease - COVID-19
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Pancreatic cancer
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Inflammatory bowel disease
Diabetic cardiomyopathy
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis

Reactome:

Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Purinergic signaling in leishmaniasis infection

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Childhood-onset schizophrenia	Likely pathogenic	rs863223356	RCV000202330
Mucocutaneous ulceration	Likely pathogenic	rs1590931704	RCV000853280
Mucocutaneous ulceration, chronic	Pathogenic; Likely pathogenic	rs2496824516, rs2496833014, rs2496827835, rs749716796, rs1565191003, rs1326268854	RCV003159249 RCV003159250 RCV003494566 RCV003994785 RCV000754619 RCV003147591
RELA-related disorder	Likely pathogenic; Pathogenic	rs2496867941, rs1856484601	RCV003894623 RCV003396687

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Uncertain significance	rs2135573626	RCV005925472
Gastric cancer	Uncertain significance	rs12721571	RCV005923953
Lung cancer	Likely benign	rs1565188326	RCV005931593

Associations from Text Mining
Disease Name	Relationship Type	References
Acidosis	Associate	25504433
Acute Disease	Associate	19079204
Acute Kidney Injury	Stimulate	24607031
Acute Lung Injury	Associate	31054328, 35269738
Adenocarcinoma	Associate	15256061
Adenocarcinoma	Stimulate	22384099
Adenocarcinoma of Lung	Associate	25820700, 32873769, 35379924
Alcoholic Intoxication	Inhibit	17895971
Alcoholism	Associate	17895971
Alcoholism	Stimulate	36577732
Alzheimer Disease	Stimulate	21329555
Alzheimer Disease	Associate	31666081, 36159817, 38340719
Amyotrophic Lateral Sclerosis	Associate	26785371, 27512062
Anemia Diamond Blackfan	Associate	29745857
Anemia Sickle Cell	Associate	19957349
Anophthalmia with pulmonary hypoplasia	Associate	32347623
Anxiety Disorders	Associate	33849116
Aortic Aneurysm Abdominal	Associate	20031636, 39321955
Arthritis Infectious	Associate	20740673
Arthritis Psoriatic	Associate	10857783, 15955104, 24587411
Arthritis Rheumatoid	Associate	11598150, 32365786, 33483588
Arthritis Rheumatoid	Stimulate	21515993, 25077978
Asthma	Associate	30738043, 40650018
Astrocytoma	Associate	29228370
Atherosclerosis	Associate	15064395, 31362988
Autoimmune Diseases	Associate	36181724
Behcet Syndrome	Stimulate	36333776
Behcet Syndrome	Associate	36926348
Bicuspid Aortic Valve Disease	Stimulate	34648622
Brain Neoplasms	Associate	33481105
Breast Neoplasms	Associate	19687301, 20124457, 20482821, 22249250, 23056468, 23317209, 25833211, 26011589, 26218882, 26460486, 26745120, 28423692, 28629477, 29938218, 30553016, 31382678, 35838496, 36412644, 36555293, 37101128, 37507347, 37539706, 37651838, 37977037, 39278618, 39844241, 9681829
Bronchopulmonary Dysplasia	Associate	29644893
Burkitt Lymphoma	Associate	15790788
Burns	Associate	25844669
Calcinosis Cutis	Associate	11775058
Cap Myopathy	Associate	19661309
Carcinogenesis	Associate	14716817, 25376541, 26801246, 31723122, 35210364, 37203408
Carcinoma Basal Cell	Stimulate	23803172
Carcinoma Hepatocellular	Stimulate	14760757
Carcinoma Hepatocellular	Associate	16778086, 20010875, 20628843, 21771706, 22930530, 25169545, 25289898, 26458400, 26655845, 29089476, 31059053, 32003539, 32720731, 35378926, 36069218, 36829052, 37006050, 37730133, 37976890
Carcinoma Non Small Cell Lung	Associate	18215193, 18390835, 26336823, 27224551, 29251177, 29363879, 29532994, 36408734
Carcinoma Ovarian Epithelial	Associate	24530737, 34071938, 37175530
Carcinoma Pancreatic Ductal	Associate	20556833, 25299780, 32364285, 35707377, 35864095, 36596765
Carcinoma Renal Cell	Associate	18925694, 28629334, 31097685, 31723229, 35130882
Carcinoma Squamous Cell	Associate	20051109, 20564339, 23803172, 31222140, 35756488, 37303736
Carcinoma Squamous Cell	Stimulate	37059366
Cardiomyopathies	Associate	39294340
Cerebral Hemorrhage	Stimulate	20420814
Chemical and Drug Induced Liver Injury	Inhibit	11679977
Chemical and Drug Induced Liver Injury	Associate	17660862
Cholangiocarcinoma	Associate	21325634, 23992017
Cholestasis	Associate	34971708
Choriocarcinoma	Associate	28259870
Chronic Disease	Associate	26931128
Cognition Disorders	Associate	40508027
Cognitive Dysfunction	Stimulate	24690380
Cognitive Dysfunction	Associate	36159817
Colitis Ulcerative	Associate	15753535, 20806430, 33299870
Colitis Ulcerative	Stimulate	9616307
Colonic Neoplasms	Associate	17142966, 25556496, 36246978
Colorectal Neoplasms	Associate	15161011, 15484295, 16619535, 19172851, 19513071, 24518414, 25412312, 27264420, 29770434, 30091007, 31180548, 31299935, 31723122, 31802830, 33213490, 33859619
Congenital myasthenic syndrome with episodic apnea	Associate	25829454
Conjunctivitis	Associate	36926348
Coronary Artery Disease	Associate	35801781
Coronary Disease	Associate	33849106, 40184077
COVID 19	Associate	33029094, 33440148, 34031419, 34260684, 34456333, 36790534
COVID 19	Inhibit	36121927
Coxa Magna	Associate	25653475
Crohn Disease	Associate	10517905, 25956706, 34629811
Crohn Disease	Stimulate	9616307
Cryptogenic Organizing Pneumonia	Inhibit	31545224
Cystitis	Stimulate	25369740
Death	Associate	17660862, 18215193
Death	Stimulate	24355259
Dermatitis Atopic	Associate	28713916
Diabetes Gestational	Stimulate	26053136
Diabetes Gestational	Associate	33019392, 36499008
Diabetes Mellitus	Stimulate	24936866, 30367115, 37174649
Diabetes Mellitus	Associate	34260684
Diabetes Mellitus Type 2	Stimulate	20067962, 35032412
Diabetes Mellitus Type 2	Associate	24936866, 33562405, 37047308
Diabetic Retinopathy	Associate	29853786
Diarrhea 5 With Tufting Enteropathy Congenital	Associate	24607031
Disease	Associate	27435858
Distal myopathy Nonaka type	Associate	11159171
Down Syndrome	Associate	23830204
Drug Related Side Effects and Adverse Reactions	Associate	18269916, 18636537, 19509265, 33864076, 35176168
Drug Related Side Effects and Adverse Reactions	Inhibit	22305266
Emanuel syndrome	Associate	15090459
Endometrial Neoplasms	Associate	24042437
Endometriosis	Associate	22196717, 31551156
Endometriosis	Stimulate	37095705
Ependymoma	Associate	25388523, 28371821, 28510691, 28561706, 29350470, 30053291, 30325077, 30483834, 30514397, 30876455, 31324163, 31375768, 32023450, 32509846, 32909151, 33481105, 33536079, 33576087, 34314101, 34389065, 35460555, 35640920, 35986385, 37947008
Epidermal Nevus	Associate	15016307
Epiretinal Membrane	Associate	28402943
Epstein Barr Virus Infections	Associate	25200074
Erythema elevatum diutinum	Associate	25974126
Esophageal Neoplasms	Associate	19435811, 26662448, 30450849, 34182081
Esophageal Squamous Cell Carcinoma	Associate	16680372, 28832500, 29428966, 33374641, 33572115, 34182081
Exanthema	Associate	36926348
Familial cylindromatosis	Inhibit	32901872
Familial Mediterranean Fever	Associate	39684669
Familial Primary Pulmonary Hypertension	Associate	24124488
Fetal Growth Retardation	Associate	34697371
Fever	Associate	36926348
Fibrocartilaginous embolism	Associate	31927560, 34663388
Fibrosarcoma	Associate	15883164
Fibrosis	Inhibit	11679977
Fibrosis	Associate	9990294
Forearm Injuries	Associate	28248815
Gallbladder Neoplasms	Associate	18497548
Gastroesophageal Reflux	Associate	27694141
GATA2 Deficiency	Associate	19965620
Glaucoma	Associate	19816602
Glioblastoma	Associate	11381677, 20669099, 24413684, 27994064, 31992226, 33446690, 35770335
Glioma	Associate	17404102, 21279667, 22509977, 23797602, 26502849, 28465487, 29769161, 32127518, 33127881, 40530904
Glomerulonephritis IGA	Associate	19037255
Glucocorticoid Receptor Deficiency	Associate	15200413, 30738043
Glucosephosphate Dehydrogenase Deficiency	Associate	26366417
Glycogen Storage Disease Type IV	Stimulate	34994235
Head and Neck Neoplasms	Associate	19789307, 35176168, 37685940
Heart Diseases	Associate	25821786
Heart Failure	Associate	23640436
Heart Rupture	Associate	29949169
HELLP Syndrome	Stimulate	23905607
Hematologic Diseases	Associate	30245189
Hematoma Subdural Chronic	Associate	32479555
Hepatitis C Chronic	Associate	11679977
Hereditary Autoinflammatory Diseases	Associate	36926348
Hereditary leiomyomatosis and renal cell cancer	Associate	10556199
Hirschsprung Disease	Associate	39199380
HIV Infections	Inhibit	15270850
HIV Infections	Stimulate	26601824
Hodgkin Disease	Associate	8630409
HTLV I Infections	Stimulate	8394446
Hyperglycemic Hyperosmolar Nonketotic Coma	Associate	35981264
Hyperoxia	Stimulate	14617515
Hyperphosphatemia	Inhibit	21858050
Hyperplasia	Associate	20051109
Hypopharyngeal Neoplasms	Associate	36273237
Hypoxia	Stimulate	10383461, 17468103, 26743692, 35186183
Hypoxia	Associate	10825178, 20157762, 24593195, 28874504, 29769799, 30091007
Hypoxia Brain	Associate	17468103, 17599377, 30468453
Ichthyosis Vulgaris	Associate	37960775
Idiopathic Pulmonary Fibrosis	Associate	31545224
Immunologic Deficiency Syndromes	Associate	25615602
Infections	Associate	15270850, 20038977, 30680725, 31061469, 35130882
Infections	Stimulate	23797008, 29244796
Infertility	Associate	28617068
Inflammation	Associate	12509469, 14630924, 15731292, 15994321, 18241676, 18257903, 19079204, 19957349, 20806430, 21131967, 21795584, 22430136, 22579587, 22708120, 22842493, 23625552, 24553063, 24759787, 25149528, 25376541, 25963228, 26053099, 26053616, 26287168, 26307981, 26586569, 26745120, 27076634, 27456850, 27470422, 27694141, 27846267, 28480404, 28617068, 28874504, 29115381, 29257236, 29331583, 29748238, 29752208, 29968158, 30138617, 31083232, 31212975, 31469428, 31518335, 32066788, 32401747, 32755955, 32792588, 33030503, 33856026, 33859619, 33974755, 33998855, 34200774, 34553218, 34679084, 34697371, 34753027, 34917094, 34974796, 34975834, 35306433, 35563204, 35622188, 35631163, 35812413, 36402602, 36498945, 36498953, 36827822, 36903482, 36926348, 37033952, 37095705, 37175530, 37272109, 37403139, 37549925, 37858201, 38203340, 39295455, 39561439, 40239861, 40435035, 40508027
Inflammation	Stimulate	24315792, 25974126, 39199380
Inflammatory Breast Neoplasms	Associate	18248671, 23418456, 28460441
Infratentorial Neoplasms	Associate	30514397
Intervertebral Disc Degeneration	Stimulate	29617687, 32705171
Intervertebral Disc Degeneration	Associate	30717434
Intervertebral disc disease	Associate	37222533
Intestinal Diseases	Stimulate	14966904
Intracranial Embolism	Associate	28460441
Iron Overload	Inhibit	25500022
Keratosis Seborrheic	Stimulate	23803172
Kidney Diseases	Associate	18201972
Kidney Neoplasms	Inhibit	15004148
Kidney Neoplasms	Associate	23981302, 29991691, 31187116, 37047552
Kotzot Richter syndrome	Associate	39596634
Labor Pain	Associate	30235753
Laryngeal cleft	Associate	16778086
Lead Poisoning Nervous System	Associate	24607031
Leiomyoma	Associate	26453978, 32199621
Leprosy Lepromatous	Inhibit	9453602
Leukemia	Associate	15964800, 18952893, 23445492, 28832545
Leukemia Lymphocytic Chronic B Cell	Associate	18227347, 23515408, 27524613, 29945498, 31409670, 39596634, 9680368
Leukemia Lymphocytic Chronic B Cell	Stimulate	23072591
Leukemia Lymphocytic Chronic B Cell	Inhibit	25633905
Leukemia Lymphoma Adult T Cell	Associate	10090947, 25706397, 35210364
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	24041577
Leukemia Myeloid	Associate	33439746
Leukemia Myeloid Acute	Associate	23077289, 23667654, 27342972, 34719869, 35316152
Leukemia Prolymphocytic T Cell	Associate	24219331
Leukoencephalopathy Progressive Multifocal	Associate	25791343, 26531763
Lichen Planus Oral	Associate	31999637
Liposarcoma	Associate	11278855
Liver Cirrhosis	Associate	11679977, 30926424
Liver Failure	Associate	15723090, 30926424, 34971708
Liver Failure Acute	Associate	17660862
Lung Diseases	Associate	33810600, 33973530
Lung Neoplasms	Associate	18424438, 18636537, 22693540, 26526492, 26689593, 29850505, 38058058, 39327549
Lupus Erythematosus Systemic	Associate	23874208, 36482627
Lupus Nephritis	Associate	28338190
Lymphatic Metastasis	Stimulate	14716817, 18215193, 20009901, 26662448, 34994235
Lymphoma AIDS Related	Associate	40450975
Lymphoma B Cell	Associate	23555990, 30199532
Lymphoma Large B Cell Diffuse	Associate	27941215, 28039454, 28256087, 30534553, 30941572, 39914494
Lymphoma Large Cell Anaplastic	Associate	19131627
Lymphoma Mantle Cell	Associate	27127301
Lymphoma T Cell Cutaneous	Associate	21224428
Magnesium Deficiency	Associate	33210606
Malaria	Associate	22682094
Malaria Cerebral	Stimulate	23890318
Malaria Falciparum	Inhibit	22682094
Malignant mesenchymal tumor	Associate	33576087
MASS syndrome	Associate	26178921
Melanoma	Associate	11775058, 12665595, 15016307, 18668140, 21738696, 22022384, 22095230, 28627651, 32466509, 37843471
Memory Disorders	Associate	24690380
Meningioma	Associate	35986385
Meningococcal Infections	Associate	31061469
Metabolic Diseases	Associate	30926763
Metabolic Syndrome	Associate	31816875
Mitochondrial Diseases	Associate	21742773
Mixed Tumor Malignant	Associate	30325077
Mohr Tranebjaerg syndrome	Stimulate	32400857
Mouth Neoplasms	Associate	27632526, 35396527
Multiple Myeloma	Associate	16497877, 21816815, 25565020, 30387821, 32977994, 36867577
Multiple Sclerosis	Associate	17258784, 30463275, 32241259
Muscle Neoplasms	Associate	19816602, 26931128
Muscular Atrophy	Stimulate	35800215
Myofibroma	Associate	28248815, 31478943
Myopathies Structural Congenital	Stimulate	36069218
Myopericytoma	Associate	28248815, 31478943
Nasopharyngeal Carcinoma	Associate	17151784, 20051109, 24961145, 25974126, 34994235, 35463684
Nasopharyngeal Neoplasms	Associate	20051109, 25487615
Necrosis	Associate	31324163
Neoplasm Invasiveness	Associate	15769641
Neoplasm Metastasis	Associate	16278667, 21765477, 24127926, 24287876, 26871511, 30553016
Neoplasm Metastasis	Stimulate	20414006, 32668608
Neoplasms	Associate	15016307, 15256061, 15484295, 15682491, 15985719, 16002723, 16219794, 17622249, 17885672, 18334025, 18457675, 18925694, 19038492, 19706766, 19775294, 19912635, 20009901, 20164024, 20556833, 20585448, 21426933, 22065587, 22430136, 22952718, 23803172, 24127926, 24355259, 24593195, 25371209, 25487615, 25615602, 25844669, 25903579, 25974126, 26017781, 26460486, 26494004, 26513020, 26655845, 26745120, 26801246, 26871511, 27329104, 28423692, 28627601, 28874504, 29065834, 29620225, 30274235, 30325077, 30372446, 30514397, 30876455, 30978440, 31284710, 31324163, 31375768, 32474813, 33328215, 33481105, 33576087, 33637015, 33863364, 34183436, 34314101, 34319022, 34508613, 34994235, 35640920, 35770335, 35969010, 36273237, 36516693, 37019972, 37175530, 37471521, 37858201, 37976890, 39181686, 39278618, 9694722
Neoplasms	Inhibit	18720533, 36433652
Neoplasms	Stimulate	19857958, 20414006, 23317209, 26053616, 26186215, 28460441, 29350470, 31001962, 36412644, 37730133
Neoplasms Neuroepithelial	Associate	30876455
Neoplasms Squamous Cell	Associate	22292433
Neoplasms Squamous Cell	Stimulate	35756488
Nephrotic Syndrome	Inhibit	15200413
Nerve Degeneration	Associate	36577732
Neuroblastoma	Associate	23071666, 39905449
Neurologic Manifestations	Associate	17250678, 24690380
Non alcoholic Fatty Liver Disease	Associate	37861538
Obesity	Associate	37047308, 37174649, 37403139
Optic Nerve Glioma	Stimulate	11381677
Osteoarthritis	Associate	15731292, 28537665, 30081074, 32633338, 33953899, 34737366, 36281111, 36619785
Osteoarthritis	Stimulate	30135182
Osteoporosis	Associate	36011257
Osteosarcoma	Associate	31690262, 39190380
Osteosclerosis	Associate	26178921
Ovarian Diseases	Associate	24963474
Ovarian Neoplasms	Associate	20564628, 20585448, 24337575, 24963474, 25376541, 26617813, 27012551, 27982283, 30983127, 34626802, 37210768, 40313149, 9914486
Overweight	Associate	28617068
Pain	Stimulate	23377438
Pancreatic Neoplasms	Associate	17622249, 19670328, 19912635, 20484017, 24136929, 33098056, 36596765
Pancreatitis Chronic	Associate	17962362
Paraparesis Tropical Spastic	Associate	40508027
Parkinson Disease	Associate	23669642, 35802825, 40435035
Periodic fever familial autosomal dominant	Associate	18163488, 31009059
Periodontitis	Associate	25037760, 35032412, 37351818
Peritoneal Fibrosis	Associate	12753293
Plaque Atherosclerotic	Associate	37189131
Polycystic Ovary Syndrome	Stimulate	28617068, 35485360
Pre Eclampsia	Associate	24140080
Precancerous Conditions	Stimulate	23803172
Precancerous Conditions	Associate	37240039
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	26593250
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	20701602, 35805156
Prodromal Symptoms	Associate	27941215
Prodromal Symptoms	Stimulate	34994235
Prostatic Hyperplasia	Associate	27435858
Prostatic Intraepithelial Neoplasia	Associate	16278667
Prostatic Neoplasms	Associate	16205698, 16278667, 18942118, 23991415, 24066029, 24080497, 25971429, 26186215, 27435858, 27673408, 28208611, 31539119, 31600936, 31730277, 34445612, 35805202, 37716704
Prostatic Neoplasms	Inhibit	32324163
Prostatic Neoplasms Castration Resistant	Associate	24466341
Prostatitis	Associate	36613950
pseudofolliculitis barbae	Associate	34314101
Pulmonary Disease Chronic Obstructive	Stimulate	12358328, 26809128
Pulmonary Disease Chronic Obstructive	Associate	19296848, 26617776, 40508027
Pulmonary edema of mountaineers	Associate	24465776
Pulmonary Embolism	Associate	33810533
Pyruvate Carboxylase Deficiency Disease	Stimulate	22384099
Renal Insufficiency	Associate	24997640
Renal Insufficiency Chronic	Associate	26678048
Retinal Dysplasia	Stimulate	14716817, 14966904
Rhabdomyosarcoma	Associate	23797008
Sarcoidosis	Inhibit	21177920, 21653741
Sarcoma	Associate	25388523
Sarcoma Kaposi	Associate	30029010
Schizophrenia	Associate	33562405
Sepsis	Associate	25880845
Sertoli Cell Only Syndrome	Associate	37033952
Sezary Syndrome	Associate	16219794
Sjogren's Syndrome	Associate	22157716, 29600938
Skin Diseases	Associate	28713916
Skin Manifestations	Associate	36402602
Sleep Apnea Obstructive	Associate	24293770, 33335174
Sleep Apnea Obstructive	Stimulate	27754829, 34768848
Small Cell Lung Carcinoma	Associate	32767507
Spinal Cord Injuries	Associate	26931128
Squamous Cell Carcinoma of Head and Neck	Associate	11044363, 19789307, 22641218, 25868613, 26395262, 28386055, 34553218, 35176168, 37134043, 37391526
ST Elevation Myocardial Infarction	Associate	28371821
Status Asthmaticus	Associate	19734226
Stomach Neoplasms	Associate	14716817, 15682491, 18720533, 23002344, 23824821, 24127926, 24587255, 26801246, 27042000, 28347236, 30106137, 31556767, 31992226, 33637015, 35969010, 36336860, 37858201, 39181686
Stomach Neoplasms	Stimulate	14966904
Stroke	Associate	19957349
Supratentorial Neoplasms	Associate	30514397, 31375768, 32474813, 32909151, 33135735, 33481105, 34314101
Tertiary Lymphoid Structures	Associate	25903579
Thrombosis	Associate	33810533
Thyroid Cancer Papillary	Associate	35543351
Thyroid Neoplasms	Associate	16024612, 37960775
Triple Negative Breast Neoplasms	Associate	26494004, 30089134, 30269739, 31731625, 35955813, 39278618
Tuberculosis Meningeal	Associate	24636003
Ulcer	Associate	36926348
Upton Young syndrome	Stimulate	15016307
Urinary Bladder Neoplasms	Stimulate	25369740
Urinary Bladder Neoplasms	Associate	28629334, 31262971, 34517533
Uterine Cervical Dysplasia	Stimulate	23640294
Uterine Cervical Neoplasms	Associate	22390170, 23640294, 28545028, 31128029, 39707317
Uterine Cervicitis	Associate	40141137
Uveitis	Associate	37653797
Vascular Diseases	Associate	29115381
Vascular System Injuries	Associate	25821786
Virus Diseases	Associate	20038977, 34031419
Vitiligo	Associate	37287971
Waldenstrom Macroglobulinemia	Associate	22931316
Weight Loss	Associate	18356846
Werner Syndrome	Associate	26037922