RAD23A (RAD23 nucleotide excision repair protein A)

Gene

• Entrez ID: 5886
• Gene name: RAD23 nucleotide excision repair protein A
• Gene symbol: RAD23A
• Synonyms (NCBI Gene): HHR23A, HR23A
• Chromosome: 19
• Chromosome location: 19p13.13
• Summary: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiqui

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044607	hsa-miR-320a	CLASH	23622248
MIRT042965	hsa-miR-324-3p	CLASH	23622248
MIRT040146	hsa-miR-615-3p	CLASH	23622248
MIRT037882	hsa-miR-455-3p	CLASH	23622248
MIRT1287710	hsa-miR-1266	CLIP-seq
MIRT1287711	hsa-miR-1323	CLIP-seq
MIRT1287712	hsa-miR-185	CLIP-seq
MIRT1287713	hsa-miR-2392	CLIP-seq
MIRT1287714	hsa-miR-3145-5p	CLIP-seq
MIRT1287715	hsa-miR-342-5p	CLIP-seq
MIRT1287716	hsa-miR-3605-5p	CLIP-seq
MIRT1287717	hsa-miR-361-5p	CLIP-seq
MIRT1287718	hsa-miR-3919	CLIP-seq
MIRT1287719	hsa-miR-3973	CLIP-seq
MIRT1287720	hsa-miR-4259	CLIP-seq
MIRT1287721	hsa-miR-4306	CLIP-seq
MIRT1287722	hsa-miR-4314	CLIP-seq
MIRT1287723	hsa-miR-4447	CLIP-seq
MIRT1287724	hsa-miR-4462	CLIP-seq
MIRT1287725	hsa-miR-4472	CLIP-seq
MIRT1287726	hsa-miR-4518	CLIP-seq
MIRT1287727	hsa-miR-4534	CLIP-seq
MIRT1287728	hsa-miR-4640-5p	CLIP-seq
MIRT1287729	hsa-miR-4644	CLIP-seq
MIRT1287730	hsa-miR-4651	CLIP-seq
MIRT1287731	hsa-miR-4652-3p	CLIP-seq
MIRT1287732	hsa-miR-4664-5p	CLIP-seq
MIRT1287733	hsa-miR-4667-5p	CLIP-seq
MIRT1287734	hsa-miR-4700-5p	CLIP-seq
MIRT1287735	hsa-miR-4726-5p	CLIP-seq
MIRT1287736	hsa-miR-4756-3p	CLIP-seq
MIRT1287737	hsa-miR-4802-5p	CLIP-seq
MIRT1287738	hsa-miR-520g	CLIP-seq
MIRT1287739	hsa-miR-520h	CLIP-seq
MIRT1287740	hsa-miR-548a-3p	CLIP-seq
MIRT1287741	hsa-miR-548e	CLIP-seq
MIRT1287742	hsa-miR-548f	CLIP-seq
MIRT1287743	hsa-miR-548o	CLIP-seq
MIRT1287744	hsa-miR-587	CLIP-seq
MIRT1287745	hsa-miR-608	CLIP-seq
MIRT1287746	hsa-miR-637	CLIP-seq
MIRT1287747	hsa-miR-765	CLIP-seq
MIRT1287710	hsa-miR-1266	CLIP-seq
MIRT2085197	hsa-miR-1269	CLIP-seq
MIRT2085198	hsa-miR-1269b	CLIP-seq
MIRT2085199	hsa-miR-1288	CLIP-seq
MIRT1287711	hsa-miR-1323	CLIP-seq
MIRT1287713	hsa-miR-2392	CLIP-seq
MIRT1287714	hsa-miR-3145-5p	CLIP-seq
MIRT2085200	hsa-miR-3160-3p	CLIP-seq
MIRT2085201	hsa-miR-320e	CLIP-seq
MIRT1287715	hsa-miR-342-5p	CLIP-seq
MIRT1287716	hsa-miR-3605-5p	CLIP-seq
MIRT1287717	hsa-miR-361-5p	CLIP-seq
MIRT2085202	hsa-miR-378	CLIP-seq
MIRT2085203	hsa-miR-378b	CLIP-seq
MIRT2085204	hsa-miR-378c	CLIP-seq
MIRT2085205	hsa-miR-378d	CLIP-seq
MIRT2085206	hsa-miR-378e	CLIP-seq
MIRT2085207	hsa-miR-378f	CLIP-seq
MIRT2085208	hsa-miR-378h	CLIP-seq
MIRT2085209	hsa-miR-378i	CLIP-seq
MIRT1287718	hsa-miR-3919	CLIP-seq
MIRT1287719	hsa-miR-3973	CLIP-seq
MIRT2085210	hsa-miR-422a	CLIP-seq
MIRT1287720	hsa-miR-4259	CLIP-seq
MIRT2085211	hsa-miR-4260	CLIP-seq
MIRT2085212	hsa-miR-4266	CLIP-seq
MIRT2085213	hsa-miR-4267	CLIP-seq
MIRT2085214	hsa-miR-4283	CLIP-seq
MIRT1287722	hsa-miR-4314	CLIP-seq
MIRT1287723	hsa-miR-4447	CLIP-seq
MIRT1287724	hsa-miR-4462	CLIP-seq
MIRT1287725	hsa-miR-4472	CLIP-seq
MIRT2085215	hsa-miR-4487	CLIP-seq
MIRT2085216	hsa-miR-4489	CLIP-seq
MIRT2085217	hsa-miR-4515	CLIP-seq
MIRT1287726	hsa-miR-4518	CLIP-seq
MIRT2085218	hsa-miR-452	CLIP-seq
MIRT1287730	hsa-miR-4651	CLIP-seq
MIRT1287731	hsa-miR-4652-3p	CLIP-seq
MIRT1287732	hsa-miR-4664-5p	CLIP-seq
MIRT1287733	hsa-miR-4667-5p	CLIP-seq
MIRT2085219	hsa-miR-4676-3p	CLIP-seq
MIRT2085220	hsa-miR-4695-5p	CLIP-seq
MIRT1287734	hsa-miR-4700-5p	CLIP-seq
MIRT2085221	hsa-miR-4740-5p	CLIP-seq
MIRT1287736	hsa-miR-4756-3p	CLIP-seq
MIRT2085222	hsa-miR-4779	CLIP-seq
MIRT2085223	hsa-miR-4793-5p	CLIP-seq
MIRT1287737	hsa-miR-4802-5p	CLIP-seq
MIRT1287738	hsa-miR-520g	CLIP-seq
MIRT1287739	hsa-miR-520h	CLIP-seq
MIRT1287740	hsa-miR-548a-3p	CLIP-seq
MIRT1287741	hsa-miR-548e	CLIP-seq
MIRT1287742	hsa-miR-548f	CLIP-seq
MIRT1287743	hsa-miR-548o	CLIP-seq
MIRT2085224	hsa-miR-556-5p	CLIP-seq
MIRT2085225	hsa-miR-558	CLIP-seq
MIRT1287745	hsa-miR-608	CLIP-seq
MIRT2085226	hsa-miR-615-5p	CLIP-seq
MIRT1287746	hsa-miR-637	CLIP-seq
MIRT1287747	hsa-miR-765	CLIP-seq
MIRT2085227	hsa-miR-766	CLIP-seq
MIRT2310662	hsa-miR-3135b	CLIP-seq
MIRT1287715	hsa-miR-342-5p	CLIP-seq
MIRT2310663	hsa-miR-3612	CLIP-seq
MIRT2310664	hsa-miR-3652	CLIP-seq
MIRT2310665	hsa-miR-3922-5p	CLIP-seq
MIRT2310666	hsa-miR-3925-3p	CLIP-seq
MIRT2085211	hsa-miR-4260	CLIP-seq
MIRT2085213	hsa-miR-4267	CLIP-seq
MIRT2085214	hsa-miR-4283	CLIP-seq
MIRT1287722	hsa-miR-4314	CLIP-seq
MIRT2310667	hsa-miR-4430	CLIP-seq
MIRT2310668	hsa-miR-4443	CLIP-seq
MIRT1287723	hsa-miR-4447	CLIP-seq
MIRT1287725	hsa-miR-4472	CLIP-seq
MIRT2085215	hsa-miR-4487	CLIP-seq
MIRT2310669	hsa-miR-4488	CLIP-seq
MIRT2085216	hsa-miR-4489	CLIP-seq
MIRT2310670	hsa-miR-4645-5p	CLIP-seq
MIRT1287730	hsa-miR-4651	CLIP-seq
MIRT1287731	hsa-miR-4652-3p	CLIP-seq
MIRT1287732	hsa-miR-4664-5p	CLIP-seq
MIRT1287733	hsa-miR-4667-5p	CLIP-seq
MIRT2310671	hsa-miR-4673	CLIP-seq
MIRT2310672	hsa-miR-4697-5p	CLIP-seq
MIRT1287734	hsa-miR-4700-5p	CLIP-seq
MIRT2310673	hsa-miR-4753-5p	CLIP-seq
MIRT2085223	hsa-miR-4793-5p	CLIP-seq
MIRT2310674	hsa-miR-490-5p	CLIP-seq
MIRT2310675	hsa-miR-515-5p	CLIP-seq
MIRT1287745	hsa-miR-608	CLIP-seq
MIRT1287746	hsa-miR-637	CLIP-seq
MIRT2310676	hsa-miR-650	CLIP-seq
MIRT2085227	hsa-miR-766	CLIP-seq
MIRT2393383	hsa-miR-1587	CLIP-seq
MIRT1287715	hsa-miR-342-5p	CLIP-seq
MIRT2393384	hsa-miR-378g	CLIP-seq
MIRT2393385	hsa-miR-3921	CLIP-seq
MIRT2393386	hsa-miR-4303	CLIP-seq
MIRT1287722	hsa-miR-4314	CLIP-seq
MIRT1287723	hsa-miR-4447	CLIP-seq
MIRT1287724	hsa-miR-4462	CLIP-seq
MIRT2393387	hsa-miR-4468	CLIP-seq
MIRT1287725	hsa-miR-4472	CLIP-seq
MIRT2393388	hsa-miR-4492	CLIP-seq
MIRT2393389	hsa-miR-4498	CLIP-seq
MIRT2393390	hsa-miR-4505	CLIP-seq
MIRT1287730	hsa-miR-4651	CLIP-seq
MIRT1287731	hsa-miR-4652-3p	CLIP-seq
MIRT2393391	hsa-miR-4653-5p	CLIP-seq
MIRT2393392	hsa-miR-4656	CLIP-seq
MIRT1287732	hsa-miR-4664-5p	CLIP-seq
MIRT1287733	hsa-miR-4667-5p	CLIP-seq
MIRT2393393	hsa-miR-4675	CLIP-seq
MIRT2393394	hsa-miR-4690-5p	CLIP-seq
MIRT1287734	hsa-miR-4700-5p	CLIP-seq
MIRT2393395	hsa-miR-4741	CLIP-seq
MIRT1287745	hsa-miR-608	CLIP-seq
MIRT1287746	hsa-miR-637	CLIP-seq
MIRT2393396	hsa-miR-762	CLIP-seq
MIRT2393397	hsa-miR-942	CLIP-seq
MIRT2607028	hsa-miR-129-3p	CLIP-seq
MIRT2085200	hsa-miR-3160-3p	CLIP-seq
MIRT2310664	hsa-miR-3652	CLIP-seq
MIRT2310666	hsa-miR-3925-3p	CLIP-seq
MIRT2310667	hsa-miR-4430	CLIP-seq
MIRT2085215	hsa-miR-4487	CLIP-seq
MIRT2310670	hsa-miR-4645-5p	CLIP-seq
MIRT2310671	hsa-miR-4673	CLIP-seq
MIRT2607029	hsa-miR-4687-5p	CLIP-seq
MIRT2310675	hsa-miR-515-5p	CLIP-seq
MIRT2085224	hsa-miR-556-5p	CLIP-seq
MIRT2085225	hsa-miR-558	CLIP-seq
MIRT2085227	hsa-miR-766	CLIP-seq
MIRT2310662	hsa-miR-3135b	CLIP-seq
MIRT2310663	hsa-miR-3612	CLIP-seq
MIRT2310664	hsa-miR-3652	CLIP-seq
MIRT2310665	hsa-miR-3922-5p	CLIP-seq
MIRT2310666	hsa-miR-3925-3p	CLIP-seq
MIRT2310667	hsa-miR-4430	CLIP-seq
MIRT2310668	hsa-miR-4443	CLIP-seq
MIRT2310670	hsa-miR-4645-5p	CLIP-seq
MIRT2310671	hsa-miR-4673	CLIP-seq
MIRT2310673	hsa-miR-4753-5p	CLIP-seq
MIRT2310675	hsa-miR-515-5p	CLIP-seq
MIRT2310676	hsa-miR-650	CLIP-seq
MIRT2085227	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	IEA
GO:0003684	Function	Damaged DNA binding	IEA
GO:0003697	Function	Single-stranded DNA binding	TAS	8168482
GO:0005515	Function	Protein binding	IPI	10488153, 16189514, 16712842, 16713569, 16990800, 17098253, 20059542, 22575648, 25416956, 29997244, 30455355, 30659753, 31467278, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	26296656
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	26296656
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0006289	Process	Nucleotide-excision repair	IDA	9372924
GO:0016032	Process	Viral process	IEA
GO:0016579	Process	Protein deubiquitination	TAS
GO:0019900	Function	Kinase binding	IPI	26296656
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IBA	21873635
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IDA	12643283
GO:0031648	Process	Protein destabilization	IMP	26296656
GO:0032434	Process	Regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	12643283
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	26296656
GO:0032991	Component	Protein-containing complex	IMP	26296656
GO:0034451	Component	Centriolar satellite	IDA
GO:0043130	Function	Ubiquitin binding	IBA	21873635
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0045070	Process	Positive regulation of viral genome replication	IMP	20614012
GO:0045787	Process	Positive regulation of cell cycle	IMP	26296656
GO:0070628	Function	Proteasome binding	IBA	21873635
GO:1990381	Function	Ubiquitin-specific protease binding	IPI	22970133

Other IDs

• MIM: 600061
• HGNC: 9812
• e!Ensembl: ENSG00000179262

Protein

• UniProt ID: P54725
• Protein name: UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
• Protein function: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable
• PDB: 1DV0, 1F4I, 1IFY, 1OQY, 1P98, 1P9D, 1QZE, 1TP4, 2WYQ, 5XBO, 6W2G, 6W2H, 6W2I, 6XQI, 6XQJ, 7TGP, 8Q06
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00240	ubiquitin	5 → 79	Ubiquitin family	Domain
  PF00627	UBA	162 → 198	UBA/TS-N domain	Domain
  PF09280	XPC-binding	232 → 288	XPC-binding domain	Domain
  PF00627	UBA	319 → 355	UBA/TS-N domain	Domain

• Sequence:

  MAVTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGRDAFPVAGQKLIYAGKILSDDVP
  IRDYRIDEKNFVVVMVTKTKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAARE
  DKSPSEESAPTTSPESVSGSVPSSGSSGREEDAASTLVTGSEYETMLTEIMSMGYERERV
  VAALRASYNNPHRAVEYLLTGIPGSPEPEHGSVQESQVSEQPATEAAGENPLEFLRDQPQ
  FQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRHQEQFIQMLNEPPGELADISDVEGE
  VGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQNF
  DDE

• Sequence length: 363

Pathways

KEGG:

Nucleotide excision repair
Protein processing in endoplasmic reticulum

Reactome:

Josephin domain DUBs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	21364753

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	16712842, 22315970
Lung Neoplasms	Associate	31487504
Neoplasms	Inhibit	31487504
Neoplasms	Associate	35799780
Tachycardia Atrioventricular Nodal Reentry	Associate	22315970