Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	5886
Gene name	RAD23 nucleotide excision repair protein A
Gene symbol	RAD23A
Synonyms (NCBI Gene)	HHR23AHR23A
Chromosome	19
Chromosome location	19p13.13
Summary	The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiqui

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miRTarBase ID	miRNA	Experiments	Reference
MIRT044607	hsa-miR-320a	CLASH	23622248
MIRT042965	hsa-miR-324-3p	CLASH	23622248
MIRT040146	hsa-miR-615-3p	CLASH	23622248
MIRT037882	hsa-miR-455-3p	CLASH	23622248
MIRT1287710	hsa-miR-1266	CLIP-seq
MIRT1287711	hsa-miR-1323	CLIP-seq
MIRT1287712	hsa-miR-185	CLIP-seq
MIRT1287713	hsa-miR-2392	CLIP-seq
MIRT1287714	hsa-miR-3145-5p	CLIP-seq
MIRT1287715	hsa-miR-342-5p	CLIP-seq
MIRT1287716	hsa-miR-3605-5p	CLIP-seq
MIRT1287717	hsa-miR-361-5p	CLIP-seq
MIRT1287718	hsa-miR-3919	CLIP-seq
MIRT1287719	hsa-miR-3973	CLIP-seq
MIRT1287720	hsa-miR-4259	CLIP-seq
MIRT1287721	hsa-miR-4306	CLIP-seq
MIRT1287722	hsa-miR-4314	CLIP-seq
MIRT1287723	hsa-miR-4447	CLIP-seq
MIRT1287724	hsa-miR-4462	CLIP-seq
MIRT1287725	hsa-miR-4472	CLIP-seq
MIRT1287726	hsa-miR-4518	CLIP-seq
MIRT1287727	hsa-miR-4534	CLIP-seq
MIRT1287728	hsa-miR-4640-5p	CLIP-seq
MIRT1287729	hsa-miR-4644	CLIP-seq
MIRT1287730	hsa-miR-4651	CLIP-seq
MIRT1287731	hsa-miR-4652-3p	CLIP-seq
MIRT1287732	hsa-miR-4664-5p	CLIP-seq
MIRT1287733	hsa-miR-4667-5p	CLIP-seq
MIRT1287734	hsa-miR-4700-5p	CLIP-seq
MIRT1287735	hsa-miR-4726-5p	CLIP-seq
MIRT1287736	hsa-miR-4756-3p	CLIP-seq
MIRT1287737	hsa-miR-4802-5p	CLIP-seq
MIRT1287738	hsa-miR-520g	CLIP-seq
MIRT1287739	hsa-miR-520h	CLIP-seq
MIRT1287740	hsa-miR-548a-3p	CLIP-seq
MIRT1287741	hsa-miR-548e	CLIP-seq
MIRT1287742	hsa-miR-548f	CLIP-seq
MIRT1287743	hsa-miR-548o	CLIP-seq
MIRT1287744	hsa-miR-587	CLIP-seq
MIRT1287745	hsa-miR-608	CLIP-seq
MIRT1287746	hsa-miR-637	CLIP-seq
MIRT1287747	hsa-miR-765	CLIP-seq
MIRT1287710	hsa-miR-1266	CLIP-seq
MIRT2085197	hsa-miR-1269	CLIP-seq
MIRT2085198	hsa-miR-1269b	CLIP-seq
MIRT2085199	hsa-miR-1288	CLIP-seq
MIRT1287711	hsa-miR-1323	CLIP-seq
MIRT1287713	hsa-miR-2392	CLIP-seq
MIRT1287714	hsa-miR-3145-5p	CLIP-seq
MIRT2085200	hsa-miR-3160-3p	CLIP-seq
MIRT2085201	hsa-miR-320e	CLIP-seq
MIRT1287715	hsa-miR-342-5p	CLIP-seq
MIRT1287716	hsa-miR-3605-5p	CLIP-seq
MIRT1287717	hsa-miR-361-5p	CLIP-seq
MIRT2085202	hsa-miR-378	CLIP-seq
MIRT2085203	hsa-miR-378b	CLIP-seq
MIRT2085204	hsa-miR-378c	CLIP-seq
MIRT2085205	hsa-miR-378d	CLIP-seq
MIRT2085206	hsa-miR-378e	CLIP-seq
MIRT2085207	hsa-miR-378f	CLIP-seq
MIRT2085208	hsa-miR-378h	CLIP-seq
MIRT2085209	hsa-miR-378i	CLIP-seq
MIRT1287718	hsa-miR-3919	CLIP-seq
MIRT1287719	hsa-miR-3973	CLIP-seq
MIRT2085210	hsa-miR-422a	CLIP-seq
MIRT1287720	hsa-miR-4259	CLIP-seq
MIRT2085211	hsa-miR-4260	CLIP-seq
MIRT2085212	hsa-miR-4266	CLIP-seq
MIRT2085213	hsa-miR-4267	CLIP-seq
MIRT2085214	hsa-miR-4283	CLIP-seq
MIRT1287722	hsa-miR-4314	CLIP-seq
MIRT1287723	hsa-miR-4447	CLIP-seq
MIRT1287724	hsa-miR-4462	CLIP-seq
MIRT1287725	hsa-miR-4472	CLIP-seq
MIRT2085215	hsa-miR-4487	CLIP-seq
MIRT2085216	hsa-miR-4489	CLIP-seq
MIRT2085217	hsa-miR-4515	CLIP-seq
MIRT1287726	hsa-miR-4518	CLIP-seq
MIRT2085218	hsa-miR-452	CLIP-seq
MIRT1287730	hsa-miR-4651	CLIP-seq
MIRT1287731	hsa-miR-4652-3p	CLIP-seq
MIRT1287732	hsa-miR-4664-5p	CLIP-seq
MIRT1287733	hsa-miR-4667-5p	CLIP-seq
MIRT2085219	hsa-miR-4676-3p	CLIP-seq
MIRT2085220	hsa-miR-4695-5p	CLIP-seq
MIRT1287734	hsa-miR-4700-5p	CLIP-seq
MIRT2085221	hsa-miR-4740-5p	CLIP-seq
MIRT1287736	hsa-miR-4756-3p	CLIP-seq
MIRT2085222	hsa-miR-4779	CLIP-seq
MIRT2085223	hsa-miR-4793-5p	CLIP-seq
MIRT1287737	hsa-miR-4802-5p	CLIP-seq
MIRT1287738	hsa-miR-520g	CLIP-seq
MIRT1287739	hsa-miR-520h	CLIP-seq
MIRT1287740	hsa-miR-548a-3p	CLIP-seq
MIRT1287741	hsa-miR-548e	CLIP-seq
MIRT1287742	hsa-miR-548f	CLIP-seq
MIRT1287743	hsa-miR-548o	CLIP-seq
MIRT2085224	hsa-miR-556-5p	CLIP-seq
MIRT2085225	hsa-miR-558	CLIP-seq
MIRT1287745	hsa-miR-608	CLIP-seq
MIRT2085226	hsa-miR-615-5p	CLIP-seq
MIRT1287746	hsa-miR-637	CLIP-seq
MIRT1287747	hsa-miR-765	CLIP-seq
MIRT2085227	hsa-miR-766	CLIP-seq
MIRT2310662	hsa-miR-3135b	CLIP-seq
MIRT1287715	hsa-miR-342-5p	CLIP-seq
MIRT2310663	hsa-miR-3612	CLIP-seq
MIRT2310664	hsa-miR-3652	CLIP-seq
MIRT2310665	hsa-miR-3922-5p	CLIP-seq
MIRT2310666	hsa-miR-3925-3p	CLIP-seq
MIRT2085211	hsa-miR-4260	CLIP-seq
MIRT2085213	hsa-miR-4267	CLIP-seq
MIRT2085214	hsa-miR-4283	CLIP-seq
MIRT1287722	hsa-miR-4314	CLIP-seq
MIRT2310667	hsa-miR-4430	CLIP-seq
MIRT2310668	hsa-miR-4443	CLIP-seq
MIRT1287723	hsa-miR-4447	CLIP-seq
MIRT1287725	hsa-miR-4472	CLIP-seq
MIRT2085215	hsa-miR-4487	CLIP-seq
MIRT2310669	hsa-miR-4488	CLIP-seq
MIRT2085216	hsa-miR-4489	CLIP-seq
MIRT2310670	hsa-miR-4645-5p	CLIP-seq
MIRT1287730	hsa-miR-4651	CLIP-seq
MIRT1287731	hsa-miR-4652-3p	CLIP-seq
MIRT1287732	hsa-miR-4664-5p	CLIP-seq
MIRT1287733	hsa-miR-4667-5p	CLIP-seq
MIRT2310671	hsa-miR-4673	CLIP-seq
MIRT2310672	hsa-miR-4697-5p	CLIP-seq
MIRT1287734	hsa-miR-4700-5p	CLIP-seq
MIRT2310673	hsa-miR-4753-5p	CLIP-seq
MIRT2085223	hsa-miR-4793-5p	CLIP-seq
MIRT2310674	hsa-miR-490-5p	CLIP-seq
MIRT2310675	hsa-miR-515-5p	CLIP-seq
MIRT1287745	hsa-miR-608	CLIP-seq
MIRT1287746	hsa-miR-637	CLIP-seq
MIRT2310676	hsa-miR-650	CLIP-seq
MIRT2085227	hsa-miR-766	CLIP-seq
MIRT2393383	hsa-miR-1587	CLIP-seq
MIRT1287715	hsa-miR-342-5p	CLIP-seq
MIRT2393384	hsa-miR-378g	CLIP-seq
MIRT2393385	hsa-miR-3921	CLIP-seq
MIRT2393386	hsa-miR-4303	CLIP-seq
MIRT1287722	hsa-miR-4314	CLIP-seq
MIRT1287723	hsa-miR-4447	CLIP-seq
MIRT1287724	hsa-miR-4462	CLIP-seq
MIRT2393387	hsa-miR-4468	CLIP-seq
MIRT1287725	hsa-miR-4472	CLIP-seq
MIRT2393388	hsa-miR-4492	CLIP-seq
MIRT2393389	hsa-miR-4498	CLIP-seq
MIRT2393390	hsa-miR-4505	CLIP-seq
MIRT1287730	hsa-miR-4651	CLIP-seq
MIRT1287731	hsa-miR-4652-3p	CLIP-seq
MIRT2393391	hsa-miR-4653-5p	CLIP-seq
MIRT2393392	hsa-miR-4656	CLIP-seq
MIRT1287732	hsa-miR-4664-5p	CLIP-seq
MIRT1287733	hsa-miR-4667-5p	CLIP-seq
MIRT2393393	hsa-miR-4675	CLIP-seq
MIRT2393394	hsa-miR-4690-5p	CLIP-seq
MIRT1287734	hsa-miR-4700-5p	CLIP-seq
MIRT2393395	hsa-miR-4741	CLIP-seq
MIRT1287745	hsa-miR-608	CLIP-seq
MIRT1287746	hsa-miR-637	CLIP-seq
MIRT2393396	hsa-miR-762	CLIP-seq
MIRT2393397	hsa-miR-942	CLIP-seq
MIRT2607028	hsa-miR-129-3p	CLIP-seq
MIRT2085200	hsa-miR-3160-3p	CLIP-seq
MIRT2310664	hsa-miR-3652	CLIP-seq
MIRT2310666	hsa-miR-3925-3p	CLIP-seq
MIRT2310667	hsa-miR-4430	CLIP-seq
MIRT2085215	hsa-miR-4487	CLIP-seq
MIRT2310670	hsa-miR-4645-5p	CLIP-seq
MIRT2310671	hsa-miR-4673	CLIP-seq
MIRT2607029	hsa-miR-4687-5p	CLIP-seq
MIRT2310675	hsa-miR-515-5p	CLIP-seq
MIRT2085224	hsa-miR-556-5p	CLIP-seq
MIRT2085225	hsa-miR-558	CLIP-seq
MIRT2085227	hsa-miR-766	CLIP-seq
MIRT2310662	hsa-miR-3135b	CLIP-seq
MIRT2310663	hsa-miR-3612	CLIP-seq
MIRT2310664	hsa-miR-3652	CLIP-seq
MIRT2310665	hsa-miR-3922-5p	CLIP-seq
MIRT2310666	hsa-miR-3925-3p	CLIP-seq
MIRT2310667	hsa-miR-4430	CLIP-seq
MIRT2310668	hsa-miR-4443	CLIP-seq
MIRT2310670	hsa-miR-4645-5p	CLIP-seq
MIRT2310671	hsa-miR-4673	CLIP-seq
MIRT2310673	hsa-miR-4753-5p	CLIP-seq
MIRT2310675	hsa-miR-515-5p	CLIP-seq
MIRT2310676	hsa-miR-650	CLIP-seq
MIRT2085227	hsa-miR-766	CLIP-seq

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	IEA
GO:0003684	Function	Damaged DNA binding	IEA
GO:0003697	Function	Single-stranded DNA binding	IEA
GO:0003697	Function	Single-stranded DNA binding	TAS	8168482
GO:0005515	Function	Protein binding	IPI	10488153, 16189514, 16712842, 16713569, 16990800, 17098253, 20059542, 22575648, 25416956, 29997244, 30455355, 30659753, 31467278, 31515488, 32296183, 32814053, 33961781, 37398436
GO:0005634	Component	Nucleus	IDA	26296656
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	26296656
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0006281	Process	DNA repair	IEA
GO:0006289	Process	Nucleotide-excision repair	IDA	9372924
GO:0006289	Process	Nucleotide-excision repair	IEA
GO:0006289	Process	Nucleotide-excision repair	TAS	8808275
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0019900	Function	Kinase binding	IPI	26296656
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IBA
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IDA	12643283
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IEA
GO:0031648	Process	Protein destabilization	IMP	26296656
GO:0032434	Process	Regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	12643283
GO:0032434	Process	Regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	26296656
GO:0032991	Component	Protein-containing complex	IMP	26296656
GO:0043130	Function	Ubiquitin binding	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0045070	Process	Positive regulation of viral genome replication	IMP	20614012
GO:0045787	Process	Positive regulation of cell cycle	IMP	26296656
GO:0070628	Function	Proteasome binding	IBA
GO:1990381	Function	Ubiquitin-specific protease binding	IPI	22970133

MIM	HGNC	e!Ensembl
600061	9812	ENSG00000179262

P54725

Protein name

UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)

Protein function

Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable

PDB

1DV0 , 1F4I , 1IFY , 1OQY , 1P98 , 1P9D , 1QZE , 1TP4 , 2WYQ , 5XBO , 6W2G , 6W2H , 6W2I , 6XQI , 6XQJ , 7TGP , 8Q06

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00240	ubiquitin	5 → 79	Ubiquitin family	Domain
PF00627	UBA	162 → 198	UBA/TS-N domain	Domain
PF09280	XPC-binding	232 → 288	XPC-binding domain	Domain
PF00627	UBA	319 → 355	UBA/TS-N domain	Domain

Sequence

MAVTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGRDAFPVAGQKLIYAGKILSDDVP
IRDYRIDEKNFVVVMVTKTKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAARE
DKSPSEESAPTTSPESVSGSVPSSGSSGREEDAASTLVTGSEYETMLTEIMSMGYERERV
VAALRASYNNPHRAVEYLLTGIPGSPEPEHGSVQESQVSEQPATEAAGENPLEFLRDQPQ
FQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRHQEQFIQMLNEPPGELADISDVEGE
VGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQNF
DDE

Sequence length

363

Interactions

View interactions

	KEGG		Reactome
	Nucleotide excision repair Protein processing in endoplasmic reticulum		Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER

RAD23A (RAD23 nucleotide excision repair protein A)