RAD9A (RAD9 checkpoint clamp component A)

Gene

• Entrez ID: 5883
• Gene name: RAD9 checkpoint clamp component A
• Gene symbol: RAD9A
• Synonyms (NCBI Gene): RAD9
• Chromosome: 11
• Chromosome location: 11q13.2
• Summary: This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3` to 5` exonuclease activity, which may contribute to its role in sensing

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026047	hsa-miR-196a-5p	Sequencing	20371350
MIRT032159	hsa-let-7d-5p	Sequencing	20371350
MIRT1288244	hsa-let-7a	CLIP-seq
MIRT1288245	hsa-let-7b	CLIP-seq
MIRT1288246	hsa-let-7c	CLIP-seq
MIRT1288247	hsa-let-7d	CLIP-seq
MIRT1288248	hsa-let-7e	CLIP-seq
MIRT1288249	hsa-let-7f	CLIP-seq
MIRT1288250	hsa-let-7g	CLIP-seq
MIRT1288251	hsa-let-7i	CLIP-seq
MIRT1288252	hsa-miR-1207-3p	CLIP-seq
MIRT1288253	hsa-miR-1226	CLIP-seq
MIRT1288254	hsa-miR-1244	CLIP-seq
MIRT1288255	hsa-miR-1287	CLIP-seq
MIRT1288256	hsa-miR-1299	CLIP-seq
MIRT1288257	hsa-miR-15a	CLIP-seq
MIRT1288258	hsa-miR-15b	CLIP-seq
MIRT1288259	hsa-miR-16	CLIP-seq
MIRT1288260	hsa-miR-1915	CLIP-seq
MIRT1288261	hsa-miR-195	CLIP-seq
MIRT1288262	hsa-miR-199a-3p	CLIP-seq
MIRT1288263	hsa-miR-199b-3p	CLIP-seq
MIRT1288264	hsa-miR-2115	CLIP-seq
MIRT1288265	hsa-miR-2467-5p	CLIP-seq
MIRT1288266	hsa-miR-3074-5p	CLIP-seq
MIRT1288267	hsa-miR-3127-5p	CLIP-seq
MIRT1288268	hsa-miR-3129-5p	CLIP-seq
MIRT1288269	hsa-miR-3130-3p	CLIP-seq
MIRT1288270	hsa-miR-3135b	CLIP-seq
MIRT1288271	hsa-miR-3150a-3p	CLIP-seq
MIRT1288272	hsa-miR-3151	CLIP-seq
MIRT1288273	hsa-miR-3175	CLIP-seq
MIRT1288274	hsa-miR-3188	CLIP-seq
MIRT1288275	hsa-miR-320e	CLIP-seq
MIRT1288276	hsa-miR-337-5p	CLIP-seq
MIRT1288277	hsa-miR-342-3p	CLIP-seq
MIRT1288278	hsa-miR-361-3p	CLIP-seq
MIRT1288279	hsa-miR-3651	CLIP-seq
MIRT1288280	hsa-miR-3652	CLIP-seq
MIRT1288281	hsa-miR-3691-3p	CLIP-seq
MIRT1288282	hsa-miR-3914	CLIP-seq
MIRT1288283	hsa-miR-3918	CLIP-seq
MIRT1288284	hsa-miR-3919	CLIP-seq
MIRT1288285	hsa-miR-3975	CLIP-seq
MIRT1288286	hsa-miR-3978	CLIP-seq
MIRT1288287	hsa-miR-424	CLIP-seq
MIRT1288288	hsa-miR-4265	CLIP-seq
MIRT1288289	hsa-miR-4293	CLIP-seq
MIRT1288290	hsa-miR-4296	CLIP-seq
MIRT1288291	hsa-miR-4320	CLIP-seq
MIRT1288292	hsa-miR-4322	CLIP-seq
MIRT1288293	hsa-miR-433	CLIP-seq
MIRT1288294	hsa-miR-4430	CLIP-seq
MIRT1288295	hsa-miR-4435	CLIP-seq
MIRT1288296	hsa-miR-4446-3p	CLIP-seq
MIRT1288297	hsa-miR-4447	CLIP-seq
MIRT1288298	hsa-miR-4458	CLIP-seq
MIRT1288299	hsa-miR-4472	CLIP-seq
MIRT1288300	hsa-miR-4480	CLIP-seq
MIRT1288301	hsa-miR-4485	CLIP-seq
MIRT1288302	hsa-miR-4500	CLIP-seq
MIRT1288303	hsa-miR-4505	CLIP-seq
MIRT1288304	hsa-miR-4524	CLIP-seq
MIRT1288305	hsa-miR-4640-5p	CLIP-seq
MIRT1288306	hsa-miR-4649-3p	CLIP-seq
MIRT1288307	hsa-miR-4685-5p	CLIP-seq
MIRT1288308	hsa-miR-4722-3p	CLIP-seq
MIRT1288309	hsa-miR-4726-5p	CLIP-seq
MIRT1288310	hsa-miR-4731-5p	CLIP-seq
MIRT1288311	hsa-miR-4733-3p	CLIP-seq
MIRT1288312	hsa-miR-4746-3p	CLIP-seq
MIRT1288313	hsa-miR-4757-5p	CLIP-seq
MIRT1288314	hsa-miR-4763-5p	CLIP-seq
MIRT1288315	hsa-miR-485-5p	CLIP-seq
MIRT1288316	hsa-miR-491-5p	CLIP-seq
MIRT1288317	hsa-miR-497	CLIP-seq
MIRT1288318	hsa-miR-503	CLIP-seq
MIRT1288319	hsa-miR-509-3p	CLIP-seq
MIRT1288320	hsa-miR-516a-3p	CLIP-seq
MIRT1288321	hsa-miR-539	CLIP-seq
MIRT1288322	hsa-miR-544b	CLIP-seq
MIRT1288323	hsa-miR-596	CLIP-seq
MIRT1288324	hsa-miR-637	CLIP-seq
MIRT1288325	hsa-miR-646	CLIP-seq
MIRT1288326	hsa-miR-647	CLIP-seq
MIRT1288327	hsa-miR-875-3p	CLIP-seq
MIRT1288328	hsa-miR-936	CLIP-seq
MIRT1288329	hsa-miR-939	CLIP-seq
MIRT1288330	hsa-miR-98	CLIP-seq
MIRT1288252	hsa-miR-1207-3p	CLIP-seq
MIRT1288254	hsa-miR-1244	CLIP-seq
MIRT2085344	hsa-miR-1252	CLIP-seq
MIRT2085345	hsa-miR-1254	CLIP-seq
MIRT1288256	hsa-miR-1299	CLIP-seq
MIRT2085346	hsa-miR-1307	CLIP-seq
MIRT1288257	hsa-miR-15a	CLIP-seq
MIRT1288258	hsa-miR-15b	CLIP-seq
MIRT1288259	hsa-miR-16	CLIP-seq
MIRT1288260	hsa-miR-1915	CLIP-seq
MIRT1288261	hsa-miR-195	CLIP-seq
MIRT1288262	hsa-miR-199a-3p	CLIP-seq
MIRT1288263	hsa-miR-199b-3p	CLIP-seq
MIRT1288265	hsa-miR-2467-5p	CLIP-seq
MIRT2085347	hsa-miR-296-5p	CLIP-seq
MIRT2085348	hsa-miR-3116	CLIP-seq
MIRT2085349	hsa-miR-3126-5p	CLIP-seq
MIRT1288267	hsa-miR-3127-5p	CLIP-seq
MIRT1288268	hsa-miR-3129-5p	CLIP-seq
MIRT1288269	hsa-miR-3130-3p	CLIP-seq
MIRT1288270	hsa-miR-3135b	CLIP-seq
MIRT2085350	hsa-miR-3180-5p	CLIP-seq
MIRT2085351	hsa-miR-3182	CLIP-seq
MIRT2085352	hsa-miR-3187-3p	CLIP-seq
MIRT1288274	hsa-miR-3188	CLIP-seq
MIRT1288277	hsa-miR-342-3p	CLIP-seq
MIRT1288279	hsa-miR-3651	CLIP-seq
MIRT1288280	hsa-miR-3652	CLIP-seq
MIRT2085353	hsa-miR-3689a-3p	CLIP-seq
MIRT2085354	hsa-miR-3689c	CLIP-seq
MIRT1288281	hsa-miR-3691-3p	CLIP-seq
MIRT1288283	hsa-miR-3918	CLIP-seq
MIRT1288285	hsa-miR-3975	CLIP-seq
MIRT1288286	hsa-miR-3978	CLIP-seq
MIRT1288287	hsa-miR-424	CLIP-seq
MIRT2085355	hsa-miR-4252	CLIP-seq
MIRT2085356	hsa-miR-4277	CLIP-seq
MIRT1288289	hsa-miR-4293	CLIP-seq
MIRT2085357	hsa-miR-4294	CLIP-seq
MIRT2085358	hsa-miR-4419a	CLIP-seq
MIRT1288294	hsa-miR-4430	CLIP-seq
MIRT1288295	hsa-miR-4435	CLIP-seq
MIRT2085359	hsa-miR-4476	CLIP-seq
MIRT1288300	hsa-miR-4480	CLIP-seq
MIRT1288303	hsa-miR-4505	CLIP-seq
MIRT2085360	hsa-miR-4510	CLIP-seq
MIRT2085361	hsa-miR-4533	CLIP-seq
MIRT2085362	hsa-miR-4638-5p	CLIP-seq
MIRT1288306	hsa-miR-4649-3p	CLIP-seq
MIRT2085363	hsa-miR-4660	CLIP-seq
MIRT1288307	hsa-miR-4685-5p	CLIP-seq
MIRT2085364	hsa-miR-4701-5p	CLIP-seq
MIRT2085365	hsa-miR-4727-5p	CLIP-seq
MIRT1288310	hsa-miR-4731-5p	CLIP-seq
MIRT1288313	hsa-miR-4757-5p	CLIP-seq
MIRT2085366	hsa-miR-4769-3p	CLIP-seq
MIRT2085367	hsa-miR-4792	CLIP-seq
MIRT2085368	hsa-miR-4793-3p	CLIP-seq
MIRT1288315	hsa-miR-485-5p	CLIP-seq
MIRT1288317	hsa-miR-497	CLIP-seq
MIRT2085369	hsa-miR-544	CLIP-seq
MIRT1288322	hsa-miR-544b	CLIP-seq
MIRT2085370	hsa-miR-548s	CLIP-seq
MIRT2085371	hsa-miR-588	CLIP-seq
MIRT1288323	hsa-miR-596	CLIP-seq
MIRT2085372	hsa-miR-603	CLIP-seq
MIRT2085373	hsa-miR-661	CLIP-seq
MIRT2085374	hsa-miR-873	CLIP-seq
MIRT1288327	hsa-miR-875-3p	CLIP-seq
MIRT2085375	hsa-miR-885-3p	CLIP-seq
MIRT2085376	hsa-miR-892b	CLIP-seq
MIRT1288328	hsa-miR-936	CLIP-seq
MIRT1288244	hsa-let-7a	CLIP-seq
MIRT1288245	hsa-let-7b	CLIP-seq
MIRT1288246	hsa-let-7c	CLIP-seq
MIRT1288247	hsa-let-7d	CLIP-seq
MIRT1288248	hsa-let-7e	CLIP-seq
MIRT1288249	hsa-let-7f	CLIP-seq
MIRT1288250	hsa-let-7g	CLIP-seq
MIRT1288251	hsa-let-7i	CLIP-seq
MIRT1288252	hsa-miR-1207-3p	CLIP-seq
MIRT1288253	hsa-miR-1226	CLIP-seq
MIRT1288254	hsa-miR-1244	CLIP-seq
MIRT2085344	hsa-miR-1252	CLIP-seq
MIRT2085345	hsa-miR-1254	CLIP-seq
MIRT1288255	hsa-miR-1287	CLIP-seq
MIRT1288257	hsa-miR-15a	CLIP-seq
MIRT1288258	hsa-miR-15b	CLIP-seq
MIRT1288259	hsa-miR-16	CLIP-seq
MIRT2310773	hsa-miR-1827	CLIP-seq
MIRT1288260	hsa-miR-1915	CLIP-seq
MIRT1288261	hsa-miR-195	CLIP-seq
MIRT1288262	hsa-miR-199a-3p	CLIP-seq
MIRT1288263	hsa-miR-199b-3p	CLIP-seq
MIRT2310774	hsa-miR-2277-3p	CLIP-seq
MIRT1288265	hsa-miR-2467-5p	CLIP-seq
MIRT2310775	hsa-miR-2682	CLIP-seq
MIRT2310776	hsa-miR-2861	CLIP-seq
MIRT2085347	hsa-miR-296-5p	CLIP-seq
MIRT2085348	hsa-miR-3116	CLIP-seq
MIRT1288267	hsa-miR-3127-5p	CLIP-seq
MIRT1288268	hsa-miR-3129-5p	CLIP-seq
MIRT1288270	hsa-miR-3135b	CLIP-seq
MIRT1288274	hsa-miR-3188	CLIP-seq
MIRT1288275	hsa-miR-320e	CLIP-seq
MIRT1288277	hsa-miR-342-3p	CLIP-seq
MIRT2310777	hsa-miR-34a	CLIP-seq
MIRT2310778	hsa-miR-34c-5p	CLIP-seq
MIRT2310779	hsa-miR-3617	CLIP-seq
MIRT1288279	hsa-miR-3651	CLIP-seq
MIRT1288280	hsa-miR-3652	CLIP-seq
MIRT1288281	hsa-miR-3691-3p	CLIP-seq
MIRT1288282	hsa-miR-3914	CLIP-seq
MIRT1288283	hsa-miR-3918	CLIP-seq
MIRT2310780	hsa-miR-3974	CLIP-seq
MIRT1288285	hsa-miR-3975	CLIP-seq
MIRT1288287	hsa-miR-424	CLIP-seq
MIRT1288289	hsa-miR-4293	CLIP-seq
MIRT1288293	hsa-miR-433	CLIP-seq
MIRT1288294	hsa-miR-4430	CLIP-seq
MIRT1288298	hsa-miR-4458	CLIP-seq
MIRT2085359	hsa-miR-4476	CLIP-seq
MIRT1288300	hsa-miR-4480	CLIP-seq
MIRT2310781	hsa-miR-449a	CLIP-seq
MIRT2310782	hsa-miR-449b	CLIP-seq
MIRT2310783	hsa-miR-449c	CLIP-seq
MIRT1288302	hsa-miR-4500	CLIP-seq
MIRT1288303	hsa-miR-4505	CLIP-seq
MIRT2085361	hsa-miR-4533	CLIP-seq
MIRT1288306	hsa-miR-4649-3p	CLIP-seq
MIRT1288307	hsa-miR-4685-5p	CLIP-seq
MIRT1288310	hsa-miR-4731-5p	CLIP-seq
MIRT1288311	hsa-miR-4733-3p	CLIP-seq
MIRT2310784	hsa-miR-4787-5p	CLIP-seq
MIRT1288315	hsa-miR-485-5p	CLIP-seq
MIRT1288317	hsa-miR-497	CLIP-seq
MIRT1288321	hsa-miR-539	CLIP-seq
MIRT2310785	hsa-miR-542-3p	CLIP-seq
MIRT1288322	hsa-miR-544b	CLIP-seq
MIRT2310786	hsa-miR-548m	CLIP-seq
MIRT2310787	hsa-miR-582-5p	CLIP-seq
MIRT1288323	hsa-miR-596	CLIP-seq
MIRT2085372	hsa-miR-603	CLIP-seq
MIRT2310788	hsa-miR-615-5p	CLIP-seq
MIRT2310789	hsa-miR-641	CLIP-seq
MIRT2085373	hsa-miR-661	CLIP-seq
MIRT2310790	hsa-miR-766	CLIP-seq
MIRT2085374	hsa-miR-873	CLIP-seq
MIRT2085375	hsa-miR-885-3p	CLIP-seq
MIRT1288328	hsa-miR-936	CLIP-seq
MIRT1288330	hsa-miR-98	CLIP-seq
MIRT1288254	hsa-miR-1244	CLIP-seq
MIRT1288260	hsa-miR-1915	CLIP-seq
MIRT1288262	hsa-miR-199a-3p	CLIP-seq
MIRT1288263	hsa-miR-199b-3p	CLIP-seq
MIRT1288267	hsa-miR-3127-5p	CLIP-seq
MIRT1288268	hsa-miR-3129-5p	CLIP-seq
MIRT1288281	hsa-miR-3691-3p	CLIP-seq
MIRT1288283	hsa-miR-3918	CLIP-seq
MIRT1288289	hsa-miR-4293	CLIP-seq
MIRT1288300	hsa-miR-4480	CLIP-seq
MIRT1288307	hsa-miR-4685-5p	CLIP-seq
MIRT1288321	hsa-miR-539	CLIP-seq
MIRT1288322	hsa-miR-544b	CLIP-seq
MIRT1288328	hsa-miR-936	CLIP-seq
MIRT2689294	hsa-miR-1273d	CLIP-seq
MIRT2689295	hsa-miR-127-3p	CLIP-seq
MIRT2689296	hsa-miR-1343	CLIP-seq
MIRT2689297	hsa-miR-486-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
YBX1	Activation	20596676

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000076	Process	DNA replication checkpoint signaling	IBA
GO:0000076	Process	DNA replication checkpoint signaling	TAS	8943031
GO:0000077	Process	DNA damage checkpoint signaling	IEA
GO:0000077	Process	DNA damage checkpoint signaling	IMP	21659603
GO:0000077	Process	DNA damage checkpoint signaling	NAS	19464297
GO:0000077	Process	DNA damage checkpoint signaling	TAS	8943031
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0005515	Function	Protein binding	IPI	10359610, 10884395, 11971963, 14500360, 14624239, 15897895, 19464297, 20424596, 21659603, 28514442, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	12628935
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006281	Process	DNA repair	IBA
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	TAS	8943031
GO:0006974	Process	DNA damage response	IDA	9872989
GO:0006974	Process	DNA damage response	IEA
GO:0008311	Function	Double-stranded DNA 3'-5' DNA exonuclease activity	IEA
GO:0008408	Function	3'-5' exonuclease activity	IDA	10713044
GO:0008630	Process	Intrinsic apoptotic signaling pathway in response to DNA damage	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0017124	Function	SH3 domain binding	IPI	11971963
GO:0019899	Function	Enzyme binding	IPI	15326225
GO:0019901	Function	Protein kinase binding	IPI	12628935
GO:0030896	Component	Checkpoint clamp complex	IBA
GO:0030896	Component	Checkpoint clamp complex	IDA	31776186, 36841485
GO:0030896	Component	Checkpoint clamp complex	IEA
GO:0030896	Component	Checkpoint clamp complex	IPI	19464297
GO:0031573	Process	Mitotic intra-S DNA damage checkpoint signaling	IBA
GO:0031573	Process	Mitotic intra-S DNA damage checkpoint signaling	IEA
GO:0042826	Function	Histone deacetylase binding	IPI	10846170
GO:0071479	Process	Cellular response to ionizing radiation	IBA
GO:0071479	Process	Cellular response to ionizing radiation	IDA	21659603
GO:1902231	Process	Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA

Other IDs

• MIM: 603761
• HGNC: 9827
• e!Ensembl: ENSG00000172613

Protein

• UniProt ID: Q99638
• Protein name: Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A)
• Protein function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage b
• PDB: 3A1J, 3G65, 3GGR, 6HM5, 6J8Y, 7Z6H, 8GNN, 8JZY, 8WU8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04139	Rad9	13 → 265	Rad9	Family

• Sequence:

  MKCLVTGGNVKVLGKAVHSLSRIGDELYLEPLEDGLSLRTVNSSRSAYACFLFAPLFFQQ
  YQAATPGQDLLRCKILMKSFLSVFRSLAMLEKTVEKCCISLNGRSSRLVVQLHCKFGVRK
  THNLSFQDCESLQAVFDPASCPHMLRAPARVLGEAVLPFSPALAEVTLGIGRGRRVILRS
  YHEEEADSTAKAMVTEMCLGEEDFQQLQAQEGVAITFCLKEFRGLLSFAESANLNLSIHF
  DAPGRPAIFTIKDSLLDGHFVLATLSDTDSHSQDLGSPERHQPVPQLQAHSTPHPDDFAN
  DDIDSYMIAMETTIGNEGSRVLPSISLSPGPQPPKSPGPHSEEEDEAEPSTVPGTPPPKK
  FRSLFFGSILAPVRSPQGPSPVLAEDSEGEG

• Sequence length: 391

Pathways

KEGG:

Cellular senescence

Reactome:

Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint