Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5806
Gene name Gene Name - the full gene name approved by the HGNC.	Pentraxin 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PTX3
Synonyms (NCBI Gene) Gene synonyms aliases	TNFAIP5, TSG-14
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q25.32
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005954	hsa-miR-21-5p	Luciferase reporter assay	21131358
MIRT054880	hsa-miR-224-5p	Luciferase reporter assay, qRT-PCR, Western blot	24470395
MIRT736826	hsa-miR-377-3p	RNA-seq, qRT-PCR	33477862
MIRT1276844	hsa-miR-101	CLIP-seq
MIRT1276845	hsa-miR-144	CLIP-seq
MIRT1276846	hsa-miR-3163	CLIP-seq
MIRT1276847	hsa-miR-340	CLIP-seq
MIRT1276848	hsa-miR-4699-3p	CLIP-seq
MIRT1276849	hsa-miR-582-5p	CLIP-seq
MIRT1276850	hsa-miR-936	CLIP-seq
MIRT1552748	hsa-miR-129-5p	CLIP-seq
MIRT1552749	hsa-miR-142-5p	CLIP-seq
MIRT1552750	hsa-miR-1910	CLIP-seq
MIRT1552751	hsa-miR-2054	CLIP-seq
MIRT1552752	hsa-miR-29a	CLIP-seq
MIRT1552753	hsa-miR-29b	CLIP-seq
MIRT1552754	hsa-miR-29c	CLIP-seq
MIRT1552755	hsa-miR-3065-5p	CLIP-seq
MIRT1552756	hsa-miR-3143	CLIP-seq
MIRT1552757	hsa-miR-325	CLIP-seq
MIRT1552758	hsa-miR-337-3p	CLIP-seq
MIRT1552759	hsa-miR-3613-3p	CLIP-seq
MIRT1552760	hsa-miR-3622b-5p	CLIP-seq
MIRT1552761	hsa-miR-371-5p	CLIP-seq
MIRT1552762	hsa-miR-371b-5p	CLIP-seq
MIRT1552763	hsa-miR-3942-3p	CLIP-seq
MIRT1552764	hsa-miR-421	CLIP-seq
MIRT1552765	hsa-miR-4282	CLIP-seq
MIRT1552766	hsa-miR-4326	CLIP-seq
MIRT1552767	hsa-miR-4495	CLIP-seq
MIRT1552768	hsa-miR-4646-3p	CLIP-seq
MIRT1552769	hsa-miR-4682	CLIP-seq
MIRT1552770	hsa-miR-4693-3p	CLIP-seq
MIRT1552771	hsa-miR-4720-5p	CLIP-seq
MIRT1552772	hsa-miR-4760-3p	CLIP-seq
MIRT1552773	hsa-miR-4762-5p	CLIP-seq
MIRT1552774	hsa-miR-4766-5p	CLIP-seq
MIRT1552775	hsa-miR-4789-3p	CLIP-seq
MIRT1552776	hsa-miR-4799-3p	CLIP-seq
MIRT1552777	hsa-miR-513c	CLIP-seq
MIRT1552778	hsa-miR-514b-5p	CLIP-seq
MIRT1552779	hsa-miR-543	CLIP-seq
MIRT1552780	hsa-miR-548ag	CLIP-seq
MIRT1552781	hsa-miR-548ai	CLIP-seq
MIRT1552782	hsa-miR-548g	CLIP-seq
MIRT1552783	hsa-miR-548s	CLIP-seq
MIRT1552784	hsa-miR-628-3p	CLIP-seq
MIRT1552785	hsa-miR-642a	CLIP-seq
MIRT1552786	hsa-miR-767-5p	CLIP-seq
MIRT1552787	hsa-miR-802	CLIP-seq
MIRT1552788	hsa-miR-942	CLIP-seq
MIRT1552789	hsa-miR-944	CLIP-seq
MIRT1552749	hsa-miR-142-5p	CLIP-seq
MIRT1552752	hsa-miR-29a	CLIP-seq
MIRT1552753	hsa-miR-29b	CLIP-seq
MIRT1552754	hsa-miR-29c	CLIP-seq
MIRT1552758	hsa-miR-337-3p	CLIP-seq
MIRT1556895	hsa-miR-4255	CLIP-seq
MIRT1552766	hsa-miR-4326	CLIP-seq
MIRT1556896	hsa-miR-4474-5p	CLIP-seq
MIRT1556897	hsa-miR-450b-5p	CLIP-seq
MIRT1556898	hsa-miR-4753-3p	CLIP-seq
MIRT1556899	hsa-miR-491-3p	CLIP-seq
MIRT1556900	hsa-miR-501-3p	CLIP-seq
MIRT1556901	hsa-miR-502-3p	CLIP-seq
MIRT1556902	hsa-miR-507	CLIP-seq
MIRT1552777	hsa-miR-513c	CLIP-seq
MIRT1552778	hsa-miR-514b-5p	CLIP-seq
MIRT1556903	hsa-miR-557	CLIP-seq
MIRT1552786	hsa-miR-767-5p	CLIP-seq
MIRT1276844	hsa-miR-101	CLIP-seq
MIRT1276845	hsa-miR-144	CLIP-seq
MIRT1276846	hsa-miR-3163	CLIP-seq
MIRT1276848	hsa-miR-4699-3p	CLIP-seq
MIRT2081486	hsa-miR-4732-5p	CLIP-seq
MIRT1276849	hsa-miR-582-5p	CLIP-seq
MIRT1276850	hsa-miR-936	CLIP-seq
MIRT1552763	hsa-miR-3942-3p	CLIP-seq
MIRT1552769	hsa-miR-4682	CLIP-seq
MIRT1552749	hsa-miR-142-5p	CLIP-seq
MIRT1552750	hsa-miR-1910	CLIP-seq
MIRT1552751	hsa-miR-2054	CLIP-seq
MIRT1552752	hsa-miR-29a	CLIP-seq
MIRT1552753	hsa-miR-29b	CLIP-seq
MIRT1552754	hsa-miR-29c	CLIP-seq
MIRT1552755	hsa-miR-3065-5p	CLIP-seq
MIRT1552756	hsa-miR-3143	CLIP-seq
MIRT2432344	hsa-miR-3200-5p	CLIP-seq
MIRT1552757	hsa-miR-325	CLIP-seq
MIRT1552760	hsa-miR-3622b-5p	CLIP-seq
MIRT2432345	hsa-miR-3660	CLIP-seq
MIRT1552762	hsa-miR-371b-5p	CLIP-seq
MIRT1552764	hsa-miR-421	CLIP-seq
MIRT2432346	hsa-miR-4310	CLIP-seq
MIRT2432347	hsa-miR-4526	CLIP-seq
MIRT1552768	hsa-miR-4646-3p	CLIP-seq
MIRT1552770	hsa-miR-4693-3p	CLIP-seq
MIRT2081486	hsa-miR-4732-5p	CLIP-seq
MIRT1556898	hsa-miR-4753-3p	CLIP-seq
MIRT1552773	hsa-miR-4762-5p	CLIP-seq
MIRT1552774	hsa-miR-4766-5p	CLIP-seq
MIRT2432348	hsa-miR-520d-5p	CLIP-seq
MIRT2432349	hsa-miR-524-5p	CLIP-seq
MIRT1552779	hsa-miR-543	CLIP-seq
MIRT1552780	hsa-miR-548ag	CLIP-seq
MIRT1552781	hsa-miR-548ai	CLIP-seq
MIRT1552782	hsa-miR-548g	CLIP-seq
MIRT2432350	hsa-miR-595	CLIP-seq
MIRT1552784	hsa-miR-628-3p	CLIP-seq
MIRT1552785	hsa-miR-642a	CLIP-seq
MIRT1552786	hsa-miR-767-5p	CLIP-seq
MIRT1552787	hsa-miR-802	CLIP-seq
MIRT2432351	hsa-miR-9	CLIP-seq
MIRT1552789	hsa-miR-944	CLIP-seq
MIRT1552749	hsa-miR-142-5p	CLIP-seq
MIRT2604993	hsa-miR-205	CLIP-seq
MIRT1552752	hsa-miR-29a	CLIP-seq
MIRT1552753	hsa-miR-29b	CLIP-seq
MIRT1552754	hsa-miR-29c	CLIP-seq
MIRT2604994	hsa-miR-3124-3p	CLIP-seq
MIRT1552756	hsa-miR-3143	CLIP-seq
MIRT1552757	hsa-miR-325	CLIP-seq
MIRT1552762	hsa-miR-371b-5p	CLIP-seq
MIRT2432346	hsa-miR-4310	CLIP-seq
MIRT1552774	hsa-miR-4766-5p	CLIP-seq
MIRT2604995	hsa-miR-511	CLIP-seq
MIRT1552779	hsa-miR-543	CLIP-seq
MIRT1552782	hsa-miR-548g	CLIP-seq
MIRT1552784	hsa-miR-628-3p	CLIP-seq
MIRT1552786	hsa-miR-767-5p	CLIP-seq
MIRT1552787	hsa-miR-802	CLIP-seq
MIRT1552749	hsa-miR-142-5p	CLIP-seq
MIRT2604993	hsa-miR-205	CLIP-seq
MIRT1552752	hsa-miR-29a	CLIP-seq
MIRT1552753	hsa-miR-29b	CLIP-seq
MIRT1552754	hsa-miR-29c	CLIP-seq
MIRT2604994	hsa-miR-3124-3p	CLIP-seq
MIRT1552756	hsa-miR-3143	CLIP-seq
MIRT1552757	hsa-miR-325	CLIP-seq
MIRT1552762	hsa-miR-371b-5p	CLIP-seq
MIRT2432346	hsa-miR-4310	CLIP-seq
MIRT1552774	hsa-miR-4766-5p	CLIP-seq
MIRT2604995	hsa-miR-511	CLIP-seq
MIRT1552779	hsa-miR-543	CLIP-seq
MIRT1552782	hsa-miR-548g	CLIP-seq
MIRT1552784	hsa-miR-628-3p	CLIP-seq
MIRT1552786	hsa-miR-767-5p	CLIP-seq
MIRT1552787	hsa-miR-802	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001550	Process	Ovarian cumulus expansion	IEA
GO:0001849	Function	Complement component C1q complex binding	IBA
GO:0001849	Function	Complement component C1q complex binding	IDA	23544079
GO:0001872	Function	(1->3)-beta-D-glucan binding	IEA
GO:0001878	Process	Response to yeast	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	19050261, 19632990, 20363749, 21490156, 22267482, 22786770, 28533443, 29374201, 35102342
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS	1429570
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	23544079
GO:0006954	Process	Inflammatory response	TAS	1429570
GO:0006955	Process	Immune response	IEA
GO:0008228	Process	Opsonization	IEA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0035580	Component	Specific granule lumen	TAS
GO:0042802	Function	Identical protein binding	IPI	20363749
GO:0044793	Process	Host-mediated suppression of viral proces	IBA
GO:0044871	Process	Negative regulation by host of viral glycoprotein metabolic process	IDA	23544079
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IDA	23544079
GO:0045429	Process	Positive regulation of nitric oxide biosynthetic process	IEA
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IDA	23544079
GO:0046790	Function	Virion binding	IDA	23544079
GO:0050766	Process	Positive regulation of phagocytosis	IEA
GO:0051707	Process	Response to other organism	IEA
GO:1903019	Process	Negative regulation of glycoprotein metabolic process	IDA	23544079
GO:1904724	Component	Tertiary granule lumen	TAS

MIM	HGNC	e!Ensembl
602492	9692	ENSG00000163661

Protein

UniProt ID

P26022

Protein name

Pentraxin-related protein PTX3 (Pentaxin-related protein PTX3) (Tumor necrosis factor alpha-induced protein 5) (TNF alpha-induced protein 5) (Tumor necrosis factor-inducible gene 14 protein) (TSG-14)

Protein function

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.

PDB

7ZL1 , 8PVQ , 8S50

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00354	Pentaxin	181 → 379	Pentaxin family	Domain

Sequence

MHLLAILFCALWSAVLAENSDDYDLMYVNLDNEIDNGLHPTEDPTPCACGQEHSEWDKLF
IMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDEL
LQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCE
TAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYL
SYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGH
IVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIR
GNIVGWGVTEIQPHGGAQYVS

Sequence length

381

Interactions

View interactions

	Reactome
			Neutrophil degranulation

PTX3 (pentraxin 3)