Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5796
Gene name Gene Name - the full gene name approved by the HGNC.
Protein tyrosine phosphatase receptor type K
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTPRK
Synonyms (NCBI Gene) Gene synonyms aliases
R-PTP-kappa
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q22.33
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005161 hsa-miR-30a-5p pSILAC 18668040
MIRT007126 hsa-miR-133b Luciferase reporter assay 23451058
MIRT007126 hsa-miR-133b Luciferase reporter assay 23451058
MIRT021457 hsa-miR-9-5p Microarray 17612493
MIRT005161 hsa-miR-30a-5p Proteomics;Other 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004725 Function Protein tyrosine phosphatase activity IBA 21873635
GO:0004725 Function Protein tyrosine phosphatase activity IDA 8663237, 16263724, 16849327
GO:0005001 Function Transmembrane receptor protein tyrosine phosphatase activity NAS 9047348
GO:0005515 Function Protein binding IPI 15899872, 19167335, 21690299
GO:0005886 Component Plasma membrane IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602545 9674 ENSG00000152894
Protein
UniProt ID Q15262
Protein name Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)
Protein function Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may b
PDB 2C7S , 8A1F
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00629 MAM 36 193 MAM domain, meprin/A5/mu Domain
PF07679 I-set 197 288 Immunoglobulin I-set domain Domain
PF00041 fn3 292 376 Fibronectin type III domain Domain
PF00041 fn3 493 583 Fibronectin type III domain Domain
PF18861 PTP_tm 621 778 Transmembrane domain of protein tyrosine phosphatase, receptor type J Family
PF00102 Y_phosphatase 910 1140 Protein-tyrosine phosphatase Domain
PF00102 Y_phosphatase 1200 1434 Protein-tyrosine phosphatase Domain
Tissue specificity TISSUE SPECIFICITY: High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
Sequence
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV
SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP
GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCD
KSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV
AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIV
REPPRPIAPPQL
LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
IRVLLTRPGEGGTGLP
GPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC
HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE
TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV
AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT
AINVTTNISAPTLPDYE
GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN
AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE
TKTQCVRIATKAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSK
LA
KKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAES
SRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA
SWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQG
PVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLA
EYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVV
HCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE

ACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRN
HDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWR
LVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNL
TRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGG
GRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
YLESS
Sequence length 1439
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    EGFR downregulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Epilepsy Epilepsy, Generalized rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670
View all (165 more)
30531953
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)
22535842, 22842228
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma, Childhood asthma 30929738, 31619474 ClinVar, GWAS
Celiac disease Celiac Disease, Celiac disease 22057235 ClinVar, GWAS
Eczema Eczema GWAS
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 28987514
Breast Neoplasms Associate 23552869
Carcinogenesis Associate 30838170, 36129915
Carcinoma Non Small Cell Lung Inhibit 30838170
Celiac Disease Associate 23820479, 36611909
Colorectal Neoplasms Associate 23552869, 28100566, 36129915
Diabetes Mellitus Associate 35986039
Diabetes Mellitus Type 1 Associate 28983737, 35986039
Disease Associate 25052311
GATA2 Deficiency Associate 25612622