Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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5796
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Protein tyrosine phosphatase receptor type K |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PTPRK |
Synonyms (NCBI Gene)
Gene synonyms aliases
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R-PTP-kappa |
Chromosome
Chromosome number
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6 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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6q22.33 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran |
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Epilepsy |
Epilepsy, Generalized |
rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670, rs768241563, rs587776973, rs587776974, rs587776975, rs879255234, rs587776976, rs587776977, rs121917993, rs398123588, rs13306758, rs587777458, rs587777459, rs541024038, rs797044545, rs730882240, rs786205703, rs794726859, rs796053126, rs796053035, rs796053216, rs796052839, rs869025201, rs797044999, rs797044998, rs797045045, rs794726762, rs869312971, rs869312972, rs879255652, rs886037938, rs886037958, rs886037959, rs886037960, rs886037961, rs886037962, rs886037965, rs886037966, rs886039245, rs886039246, rs886039251, rs886039252, rs772872014, rs886039253, rs886039256, rs757511744, rs886039261, rs886039263, rs578185749, rs886039266, rs886039268, rs886039269, rs886039273, rs368820286, rs1057518801, rs1057518688, rs1057519107, rs1057519273, rs752753379, rs767795673, rs1057519424, rs755946598, rs760609867, rs1057521066, rs1057524233, rs1060501488, rs1060501487, rs755127868, rs751533302, rs771373457, rs1475605360, rs1555401942, rs1553567864, rs200661329, rs766667249, rs1556607762, rs1555882921, rs1555882867, rs1555900914, rs1553546836, rs77216276, rs755595256, rs747661902, rs2105890565, rs1021001959, rs1555441032, rs1555439541, rs1556526609, rs1315483224, rs759952667, rs1555885023, rs1553456695, rs1555942720, rs1569083500, rs1559127505, rs1206309859, rs1567139896, rs1567134495, rs1431914212, rs1569166925, rs1569255443, rs1568955379, rs1567152003, rs374158137, rs1567129567, rs1569523728, rs1568991466, rs1569186093, rs1569254004, rs1372605067, rs1569067939, rs1568963062, rs1563959514, rs1569012755, rs1559118914, rs1602338615, rs1596522356, rs1364913665, rs1596522300, rs1596526976, rs1229740428, rs1596385588, rs1596500172, rs1596505517, rs1601925213, rs1601970168, rs1602010382, rs1602903591, rs1603014297, rs1603014708, rs1601875057, rs1601970824, rs1601755632, rs1587393982, rs1592977444, rs1575562076, rs1570998206, rs1588057922, rs1596528731, rs1602349641, rs1587401875, rs2065899210, rs1596526915, rs2093486364, rs2056165149, rs2056100951, rs781482552, rs1899868619, rs1900088045, rs1898675878, rs1898686157, rs1898837245, rs1898844513, rs2082841677, rs2085727988, rs2092933941, rs2091657024, rs1899864955, rs1898844907, rs2083056830, rs2084070588, rs1899713412, rs2082695884, rs1977106116, rs1977105425, rs1443687532 View all (165 more) |
30531953 |
Melanoma |
melanoma |
rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050 View all (64 more) |
22535842, 22842228 |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
17013881 |
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Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Asthma |
Asthma, Childhood asthma |
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30929738, 31619474 |
ClinVar, GWAS |
Celiac disease |
Celiac Disease, Celiac disease |
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22057235 |
ClinVar, GWAS |
Eczema |
Eczema |
|
|
GWAS |
Schizophrenia |
Schizophrenia |
|
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GWAS |
Multiple Sclerosis |
Multiple Sclerosis |
|
|
GWAS |
Crohn Disease |
Crohn Disease |
|
|
GWAS |
Inflammatory Bowel Disease |
Inflammatory Bowel Disease |
|
|
GWAS |
Astrocytoma |
Astrocytoma |
|
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GWAS |
Glioblastoma |
Glioblastoma |
CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 |
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GWAS, CBGDA |
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Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Alzheimer Disease |
Associate
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28987514 |
Breast Neoplasms |
Associate
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23552869 |
Carcinogenesis |
Associate
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30838170, 36129915 |
Carcinoma Non Small Cell Lung |
Inhibit
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30838170 |
Celiac Disease |
Associate
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23820479, 36611909 |
Colorectal Neoplasms |
Associate
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23552869, 28100566, 36129915 |
Diabetes Mellitus |
Associate
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35986039 |
Diabetes Mellitus Type 1 |
Associate
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28983737, 35986039 |
Disease |
Associate
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25052311 |
GATA2 Deficiency |
Associate
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25612622 |
Glioma |
Associate
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23696788 |
Hereditary leiomyomatosis and renal cell cancer |
Associate
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17720884 |
Hodgkin Disease |
Associate
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17720884 |
Lymphatic Metastasis |
Inhibit
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30838170 |
Lymphoma |
Associate
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23552869 |
Lymphoma Extranodal NK T Cell |
Associate
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25612622 |
Mental Disorders |
Associate
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28987514 |
Neoplasm Metastasis |
Associate
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20212451, 23552869, 30838170 |
Neoplasms |
Associate
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15899872, 23696788, 28987514, 31069394, 36129915 |
Neoplasms |
Inhibit
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18645192, 20212451, 23552869, 25612622, 26432421, 30838170, 30924770 |
Ovarian Neoplasms |
Associate
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31027318 |
Rhabdoid Tumor |
Associate
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20212451 |
Squamous Cell Carcinoma of Head and Neck |
Associate
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31069394 |
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