Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5784
Gene name Gene Name - the full gene name approved by the HGNC.
Protein tyrosine phosphatase non-receptor type 14
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTPN14
Synonyms (NCBI Gene) Gene synonyms aliases
CATLPH, PEZ, PTP36, PTPD2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CATLPH
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.3-q41
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1558092113 ->AA Pathogenic Coding sequence variant, frameshift variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018677 hsa-miR-335-5p Microarray 18185580
MIRT030954 hsa-miR-21-5p Microarray 20048743
MIRT042932 hsa-miR-324-3p CLASH 23622248
MIRT700519 hsa-miR-33a-3p HITS-CLIP 23313552
MIRT271178 hsa-miR-4491 HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001946 Process Lymphangiogenesis IBA 21873635
GO:0001946 Process Lymphangiogenesis IMP 20826270
GO:0003712 Function Transcription coregulator activity IMP 22525271
GO:0004725 Function Protein tyrosine phosphatase activity IBA 21873635
GO:0004725 Function Protein tyrosine phosphatase activity IMP 22525271
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603155 9647 ENSG00000152104
Protein
UniProt ID Q15678
Protein name Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)
Protein function Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchym
PDB 2BZL , 6IWD , 6JJW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09379 FERM_N 25 88 FERM N-terminal domain Domain
PF00373 FERM_M 105 220 FERM central domain Domain
PF09380 FERM_C 224 309 FERM C-terminal PH-like domain Domain
PF00102 Y_phosphatase 933 1179 Protein-tyrosine phosphatase Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH
YFGLWFLSKSQQARWVELEKPLKKHLDK
FANEPLLFFGVMFYVPNVSWLQQEATRYQYYL
QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE
ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIF
PVKDNHGNCVHLGIFFMGIF
VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK
FYKQNKICT
EQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFH
GNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDI
MRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQP
EDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTP
ELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTR
KVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKS
LHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPES
VPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARV
LRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSI
IEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTL
KKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNT
GYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH
RYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDH
GCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYC
LEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
FLQNSRLI
Sequence length 1187
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Interleukin-37 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Carcinoma Carcinoma, Basal Cell rs121912654, rs555607708, rs786202962, rs1564055259 26950094
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Lymphedema-posterior choanal atresia syndrome Lymphedema-posterior choanal atresia syndrome rs1558092113
Unknown
Disease term Disease name Evidence References Source
Melanoma Melanoma SMAD3 and SLC9A5 gain?of?function increases invasion capability of melanoma cells. GWAS, CBGDA
Pulmonary Fibrosis Pulmonary Fibrosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Arteriovenous Malformations Associate 29932521
Breast Neoplasms Associate 27485598, 30561551
Carcinogenesis Associate 31323018, 33431714
Carcinoma Renal Cell Associate 35718636
Colorectal Neoplasms Associate 28031238, 30537927
Esophageal Neoplasms Associate 34712552
Glioma Associate 30559405
Intracranial Hemorrhages Associate 29932521
Linitis Plastica Associate 36450891
Neoplasm Metastasis Associate 28485805, 31793993