PTPN9 (protein tyrosine phosphatase non-receptor type 9)

Gene

• Entrez ID: 5780
• Gene name: Protein tyrosine phosphatase non-receptor type 9
• Gene symbol: PTPN9
• Synonyms (NCBI Gene): MEG2, PTPMEG2
• Chromosome: 15
• Chromosome location: 15q24.2
• Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016099	hsa-miR-769-5p	Sequencing	20371350
MIRT021174	hsa-miR-186-5p	Sequencing	20371350
MIRT023053	hsa-miR-124-3p	Microarray	18668037
MIRT035526	hsa-miR-24-3p	Luciferase reporter assay	23418360
MIRT035526	hsa-miR-24-3p	Luciferase reporter assay	23418360
MIRT048461	hsa-miR-100-5p	CLASH	23622248
MIRT047068	hsa-miR-183-5p	CLASH	23622248
MIRT044505	hsa-miR-320a	CLASH	23622248
MIRT038760	hsa-miR-93-3p	CLASH	23622248
MIRT038760	hsa-miR-93-3p	CLASH	23622248
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT632516	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT632515	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT632514	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT632516	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT632515	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT632514	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT726832	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT726831	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT731565	hsa-miR-96-5p	Luciferase reporter assay, qRT-PCR, Western blot	27857177
MIRT731565	hsa-miR-96-5p	Luciferase reporter assay, qRT-PCR, Western blot	27857177
MIRT731565	hsa-miR-96-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27857177
MIRT731565	hsa-miR-96-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27857177
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT632516	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT632515	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT632514	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT632516	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT632515	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT632514	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT756015	hsa-miR-197-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP)	35156900
MIRT756015	hsa-miR-197-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP)	35156900
MIRT1275770	hsa-miR-1207-3p	CLIP-seq
MIRT1275771	hsa-miR-124	CLIP-seq
MIRT1275772	hsa-miR-1299	CLIP-seq
MIRT1275773	hsa-miR-1321	CLIP-seq
MIRT1275774	hsa-miR-135a	CLIP-seq
MIRT1275775	hsa-miR-135b	CLIP-seq
MIRT1275776	hsa-miR-140-5p	CLIP-seq
MIRT1275777	hsa-miR-1910	CLIP-seq
MIRT1275778	hsa-miR-198	CLIP-seq
MIRT1275779	hsa-miR-22	CLIP-seq
MIRT1275780	hsa-miR-2355-5p	CLIP-seq
MIRT1275781	hsa-miR-24	CLIP-seq
MIRT1275782	hsa-miR-3146	CLIP-seq
MIRT1275783	hsa-miR-3150b-3p	CLIP-seq
MIRT1275784	hsa-miR-3169	CLIP-seq
MIRT1275785	hsa-miR-3173-3p	CLIP-seq
MIRT1275786	hsa-miR-3182	CLIP-seq
MIRT1275787	hsa-miR-3545-5p	CLIP-seq
MIRT1275788	hsa-miR-3653	CLIP-seq
MIRT1275789	hsa-miR-3657	CLIP-seq
MIRT1275790	hsa-miR-3658	CLIP-seq
MIRT1275791	hsa-miR-3667-3p	CLIP-seq
MIRT1275792	hsa-miR-3688-3p	CLIP-seq
MIRT1275793	hsa-miR-3714	CLIP-seq
MIRT1275794	hsa-miR-383	CLIP-seq
MIRT1275795	hsa-miR-3909	CLIP-seq
MIRT1275796	hsa-miR-3910	CLIP-seq
MIRT1275797	hsa-miR-3978	CLIP-seq
MIRT1275798	hsa-miR-4264	CLIP-seq
MIRT1275799	hsa-miR-4311	CLIP-seq
MIRT1275800	hsa-miR-4419a	CLIP-seq
MIRT1275801	hsa-miR-4427	CLIP-seq
MIRT1275802	hsa-miR-4460	CLIP-seq
MIRT1275803	hsa-miR-4461	CLIP-seq
MIRT1275804	hsa-miR-4476	CLIP-seq
MIRT1275805	hsa-miR-4477b	CLIP-seq
MIRT1275806	hsa-miR-4481	CLIP-seq
MIRT1275807	hsa-miR-4494	CLIP-seq
MIRT1275808	hsa-miR-4496	CLIP-seq
MIRT1275809	hsa-miR-4510	CLIP-seq
MIRT1275810	hsa-miR-4511	CLIP-seq
MIRT1275811	hsa-miR-4515	CLIP-seq
MIRT1275812	hsa-miR-4533	CLIP-seq
MIRT1275813	hsa-miR-455-3p	CLIP-seq
MIRT1275814	hsa-miR-4669	CLIP-seq
MIRT1275815	hsa-miR-4680-3p	CLIP-seq
MIRT1275816	hsa-miR-4685-5p	CLIP-seq
MIRT1275817	hsa-miR-4714-3p	CLIP-seq
MIRT1275818	hsa-miR-4727-3p	CLIP-seq
MIRT1275819	hsa-miR-4739	CLIP-seq
MIRT1275820	hsa-miR-4745-5p	CLIP-seq
MIRT1275821	hsa-miR-4747-5p	CLIP-seq
MIRT1275822	hsa-miR-4756-5p	CLIP-seq
MIRT1275823	hsa-miR-4762-3p	CLIP-seq
MIRT1275824	hsa-miR-4772-5p	CLIP-seq
MIRT1275825	hsa-miR-4779	CLIP-seq
MIRT1275826	hsa-miR-4782-5p	CLIP-seq
MIRT1275827	hsa-miR-4784	CLIP-seq
MIRT1275828	hsa-miR-4802-5p	CLIP-seq
MIRT1275829	hsa-miR-499a-5p	CLIP-seq
MIRT1275830	hsa-miR-506	CLIP-seq
MIRT1275831	hsa-miR-516b	CLIP-seq
MIRT1275832	hsa-miR-548b-3p	CLIP-seq
MIRT1275833	hsa-miR-576-3p	CLIP-seq
MIRT1275834	hsa-miR-640	CLIP-seq
MIRT1275835	hsa-miR-659	CLIP-seq
MIRT1275836	hsa-miR-765	CLIP-seq
MIRT1275837	hsa-miR-873	CLIP-seq
MIRT1275838	hsa-miR-875-3p	CLIP-seq
MIRT1275839	hsa-miR-944	CLIP-seq
MIRT1556873	hsa-miR-1236	CLIP-seq
MIRT1275783	hsa-miR-3150b-3p	CLIP-seq
MIRT1275789	hsa-miR-3657	CLIP-seq
MIRT1275795	hsa-miR-3909	CLIP-seq
MIRT1275814	hsa-miR-4669	CLIP-seq
MIRT1275827	hsa-miR-4784	CLIP-seq
MIRT1275833	hsa-miR-576-3p	CLIP-seq
MIRT2081140	hsa-miR-1	CLIP-seq
MIRT2081141	hsa-miR-105	CLIP-seq
MIRT2081142	hsa-miR-1182	CLIP-seq
MIRT2081143	hsa-miR-1225-3p	CLIP-seq
MIRT2081144	hsa-miR-1273f	CLIP-seq
MIRT2081145	hsa-miR-1290	CLIP-seq
MIRT2081146	hsa-miR-1291	CLIP-seq
MIRT2081147	hsa-miR-129-5p	CLIP-seq
MIRT1275772	hsa-miR-1299	CLIP-seq
MIRT2081148	hsa-miR-1304	CLIP-seq
MIRT2081149	hsa-miR-1343	CLIP-seq
MIRT2081150	hsa-miR-197	CLIP-seq
MIRT2081151	hsa-miR-206	CLIP-seq
MIRT2081152	hsa-miR-3122	CLIP-seq
MIRT2081153	hsa-miR-3130-5p	CLIP-seq
MIRT2081154	hsa-miR-3150a-3p	CLIP-seq
MIRT2081155	hsa-miR-3175	CLIP-seq
MIRT2081156	hsa-miR-326	CLIP-seq
MIRT2081157	hsa-miR-328	CLIP-seq
MIRT2081158	hsa-miR-330-5p	CLIP-seq
MIRT2081159	hsa-miR-3677-5p	CLIP-seq
MIRT2081160	hsa-miR-3688-5p	CLIP-seq
MIRT2081161	hsa-miR-3913-5p	CLIP-seq
MIRT2081162	hsa-miR-3945	CLIP-seq
MIRT1275797	hsa-miR-3978	CLIP-seq
MIRT2081163	hsa-miR-4253	CLIP-seq
MIRT2081164	hsa-miR-4266	CLIP-seq
MIRT2081165	hsa-miR-4271	CLIP-seq
MIRT2081166	hsa-miR-4323	CLIP-seq
MIRT2081167	hsa-miR-4482	CLIP-seq
MIRT2081168	hsa-miR-4667-5p	CLIP-seq
MIRT2081169	hsa-miR-4700-5p	CLIP-seq
MIRT2081170	hsa-miR-4725-3p	CLIP-seq
MIRT2081171	hsa-miR-4729	CLIP-seq
MIRT1275821	hsa-miR-4747-5p	CLIP-seq
MIRT1275826	hsa-miR-4782-5p	CLIP-seq
MIRT2081172	hsa-miR-5096	CLIP-seq
MIRT2081173	hsa-miR-513a-5p	CLIP-seq
MIRT1275831	hsa-miR-516b	CLIP-seq
MIRT2081174	hsa-miR-548an	CLIP-seq
MIRT2081175	hsa-miR-601	CLIP-seq
MIRT2081176	hsa-miR-613	CLIP-seq
MIRT2081177	hsa-miR-621	CLIP-seq
MIRT2081178	hsa-miR-637	CLIP-seq
MIRT2081179	hsa-miR-651	CLIP-seq
MIRT1275837	hsa-miR-873	CLIP-seq
MIRT1275838	hsa-miR-875-3p	CLIP-seq
MIRT2081180	hsa-miR-939	CLIP-seq
MIRT2081141	hsa-miR-105	CLIP-seq
MIRT2081142	hsa-miR-1182	CLIP-seq
MIRT1275771	hsa-miR-124	CLIP-seq
MIRT2307073	hsa-miR-1289	CLIP-seq
MIRT2081146	hsa-miR-1291	CLIP-seq
MIRT1275777	hsa-miR-1910	CLIP-seq
MIRT2307074	hsa-miR-193b	CLIP-seq
MIRT2081153	hsa-miR-3130-5p	CLIP-seq
MIRT2307075	hsa-miR-3140-5p	CLIP-seq
MIRT2081154	hsa-miR-3150a-3p	CLIP-seq
MIRT2081155	hsa-miR-3175	CLIP-seq
MIRT2081156	hsa-miR-326	CLIP-seq
MIRT2081158	hsa-miR-330-5p	CLIP-seq
MIRT2307076	hsa-miR-3545-3p	CLIP-seq
MIRT1275793	hsa-miR-3714	CLIP-seq
MIRT1275796	hsa-miR-3910	CLIP-seq
MIRT1275798	hsa-miR-4264	CLIP-seq
MIRT1275801	hsa-miR-4427	CLIP-seq
MIRT1275804	hsa-miR-4476	CLIP-seq
MIRT1275805	hsa-miR-4477b	CLIP-seq
MIRT2081167	hsa-miR-4482	CLIP-seq
MIRT1275807	hsa-miR-4494	CLIP-seq
MIRT2307077	hsa-miR-4539	CLIP-seq
MIRT1275813	hsa-miR-455-3p	CLIP-seq
MIRT2081168	hsa-miR-4667-5p	CLIP-seq
MIRT1275815	hsa-miR-4680-3p	CLIP-seq
MIRT2081169	hsa-miR-4700-5p	CLIP-seq
MIRT1275823	hsa-miR-4762-3p	CLIP-seq
MIRT2307078	hsa-miR-4772-3p	CLIP-seq
MIRT1275829	hsa-miR-499a-5p	CLIP-seq
MIRT1275830	hsa-miR-506	CLIP-seq
MIRT2081174	hsa-miR-548an	CLIP-seq
MIRT2081178	hsa-miR-637	CLIP-seq
MIRT1275837	hsa-miR-873	CLIP-seq
MIRT2307079	hsa-miR-892b	CLIP-seq
MIRT2081180	hsa-miR-939	CLIP-seq
MIRT1275806	hsa-miR-4481	CLIP-seq
MIRT1275808	hsa-miR-4496	CLIP-seq
MIRT1275812	hsa-miR-4533	CLIP-seq
MIRT1275820	hsa-miR-4745-5p	CLIP-seq
MIRT1275821	hsa-miR-4747-5p	CLIP-seq
MIRT2081142	hsa-miR-1182	CLIP-seq
MIRT1275783	hsa-miR-3150b-3p	CLIP-seq
MIRT1275827	hsa-miR-4784	CLIP-seq
MIRT2081140	hsa-miR-1	CLIP-seq
MIRT2081142	hsa-miR-1182	CLIP-seq
MIRT2689087	hsa-miR-122	CLIP-seq
MIRT2307073	hsa-miR-1289	CLIP-seq
MIRT2081145	hsa-miR-1290	CLIP-seq
MIRT2081147	hsa-miR-129-5p	CLIP-seq
MIRT2081149	hsa-miR-1343	CLIP-seq
MIRT2081151	hsa-miR-206	CLIP-seq
MIRT2689088	hsa-miR-3121-3p	CLIP-seq
MIRT2081152	hsa-miR-3122	CLIP-seq
MIRT1275783	hsa-miR-3150b-3p	CLIP-seq
MIRT2081161	hsa-miR-3913-5p	CLIP-seq
MIRT2081164	hsa-miR-4266	CLIP-seq
MIRT2081165	hsa-miR-4271	CLIP-seq
MIRT2689089	hsa-miR-4491	CLIP-seq
MIRT2689090	hsa-miR-4657	CLIP-seq
MIRT2689091	hsa-miR-4663	CLIP-seq
MIRT2081170	hsa-miR-4725-3p	CLIP-seq
MIRT1275821	hsa-miR-4747-5p	CLIP-seq
MIRT1275827	hsa-miR-4784	CLIP-seq
MIRT2689092	hsa-miR-512-3p	CLIP-seq
MIRT2081173	hsa-miR-513a-5p	CLIP-seq
MIRT2689093	hsa-miR-554	CLIP-seq
MIRT2081176	hsa-miR-613	CLIP-seq
MIRT2081179	hsa-miR-651	CLIP-seq
MIRT2689094	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	19167335, 27655914
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004726	Function	Non-membrane spanning protein tyrosine phosphatase activity	TAS	1557404
GO:0005515	Function	Protein binding	IPI	12907755, 15322554, 16189514, 21516116, 25416956, 31515488, 32296183
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	10940933
GO:0005737	Component	Cytoplasm	IEA
GO:0006470	Process	Protein dephosphorylation	TAS	1557404
GO:0007165	Process	Signal transduction	IBA
GO:0010977	Process	Negative regulation of neuron projection development	IDA	27655914
GO:0016787	Function	Hydrolase activity	IEA
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IDA	27655914
GO:0044306	Component	Neuron projection terminus	IDA	27655914
GO:0044306	Component	Neuron projection terminus	IEA
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IDA	27655914

Other IDs

• MIM: 600768
• HGNC: 9661
• e!Ensembl: ENSG00000169410

Protein

• UniProt ID: P43378
• Protein name: Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2)
• Protein function: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
• PDB: 2PA5, 4GE2, 4GE5, 4GE6, 4ICZ, 6KZQ, 6L03
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00650	CRAL_TRIO	89 → 238	CRAL/TRIO domain	Domain
  PF00102	Y_phosphatase	327 → 573	Protein-tyrosine phosphatase	Domain

• Sequence:

  MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLR
  AIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPH
  KSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP
  ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVK
  IDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQK
  QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINA
  SFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK
  DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASL
  IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT
  LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ

• Sequence length: 593

Pathways

Reactome:

Interleukin-37 signaling