Gene Gene information from NCBI Gene database.
Entrez ID 57610
Gene name RAN binding protein 10
Gene symbol RANBP10
Synonyms (NCBI Gene)
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Chromosome 16
Chromosome location 16q22.1
Summary RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protei
miRNA miRNA information provided by mirtarbase database.
417
miRTarBase ID miRNA Experiments Reference
MIRT022988 hsa-miR-124-3p Microarray 18668037
MIRT046829 hsa-miR-222-3p CLASH 23622248
MIRT046500 hsa-miR-15b-5p CLASH 23622248
MIRT045170 hsa-miR-186-5p CLASH 23622248
MIRT039744 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IDA 29911972
GO:0000226 Process Microtubule cytoskeleton organization IEA
GO:0005085 Function Guanyl-nucleotide exchange factor activity IEA
GO:0005515 Function Protein binding IPI 20580816, 32296183
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614031 29285 ENSG00000141084
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6VN20
Protein name Ran-binding protein 10 (RanBP10)
Protein function May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination a
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00622 SPRY 102 220 SPRY domain Family
PF08513 LisH 256 279 LisH Domain
PF10607 CLTH 291 602 CTLH/CRA C-terminal to LisH motif domain Domain
Tissue specificity TISSUE SPECIFICITY: Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:14684163}.
Sequence
Sequence length 620
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    MET activates RAS signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Marfanoid habitus and intellectual disability Uncertain significance rs537689953 RCV000850431
Ovarian serous cystadenocarcinoma Uncertain significance rs138529417 RCV005932238