PCDH10 (protocadherin 10)

Gene

• Entrez ID: 57575
• Gene name: Protocadherin 10
• Gene symbol: PCDH10
• Synonyms (NCBI Gene): OL-PCDH, PCDH19
• Chromosome: 4
• Chromosome location: 4q28.3
• Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The e

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045051	hsa-miR-186-5p	CLASH	23622248
MIRT519003	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT552018	hsa-miR-3924	HITS-CLIP	21572407
MIRT519000	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT519003	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT552018	hsa-miR-3924	HITS-CLIP	21572407
MIRT519000	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	23706177
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23706177
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23706177
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	23706177
MIRT552018	hsa-miR-3924	HITS-CLIP	23706177
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23706177
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	23706177
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23706177
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23706177
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	23706177
MIRT552018	hsa-miR-3924	HITS-CLIP	23706177
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23706177
MIRT519004	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT519003	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT552018	hsa-miR-3924	PAR-CLIP	21572407
MIRT519000	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT519004	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT519003	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT519002	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT519001	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT519000	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22291592
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22291592
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22291592
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22291592
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22100165
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22100165
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22100165
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22100165
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT727000	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT726999	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT726998	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726997	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726995	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726996	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726994	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT519003	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT519003	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT552018	hsa-miR-3924	HITS-CLIP	27418678
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT519000	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT519000	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT734494	hsa-miR-552-3p	ChIP-seq, Immunohistochemistry (IHC), In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blotting	33867818
MIRT519003	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT552018	hsa-miR-3924	HITS-CLIP	21572407
MIRT519000	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT519003	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT552018	hsa-miR-3924	HITS-CLIP	21572407
MIRT519000	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	23706177
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23706177
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23706177
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	23706177
MIRT552018	hsa-miR-3924	HITS-CLIP	23706177
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23706177
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	23706177
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23706177
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23706177
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	23706177
MIRT552018	hsa-miR-3924	HITS-CLIP	23706177
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23706177
MIRT519004	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT519003	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT552018	hsa-miR-3924	PAR-CLIP	21572407
MIRT519000	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT519004	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT519003	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT519002	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT519001	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT519000	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22291592
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22291592
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22291592
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22291592
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22100165
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22100165
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22100165
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22100165
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT1216561	hsa-miR-125a-3p	CLIP-seq
MIRT1216562	hsa-miR-1269	CLIP-seq
MIRT1216563	hsa-miR-1269b	CLIP-seq
MIRT1216564	hsa-miR-1288	CLIP-seq
MIRT1216565	hsa-miR-193a-5p	CLIP-seq
MIRT1216566	hsa-miR-19a	CLIP-seq
MIRT1216567	hsa-miR-19b	CLIP-seq
MIRT1216568	hsa-miR-200b	CLIP-seq
MIRT1216569	hsa-miR-200c	CLIP-seq
MIRT1216570	hsa-miR-2113	CLIP-seq
MIRT1216571	hsa-miR-25	CLIP-seq
MIRT1216572	hsa-miR-3065-5p	CLIP-seq
MIRT1216573	hsa-miR-30a	CLIP-seq
MIRT1216574	hsa-miR-30b	CLIP-seq
MIRT1216575	hsa-miR-30c	CLIP-seq
MIRT1216576	hsa-miR-30d	CLIP-seq
MIRT1216577	hsa-miR-30e	CLIP-seq
MIRT1216578	hsa-miR-3130-5p	CLIP-seq
MIRT1216579	hsa-miR-3138	CLIP-seq
MIRT1216580	hsa-miR-3145-3p	CLIP-seq
MIRT1216581	hsa-miR-32	CLIP-seq
MIRT1216582	hsa-miR-324-5p	CLIP-seq
MIRT1216583	hsa-miR-33a	CLIP-seq
MIRT1216584	hsa-miR-33b	CLIP-seq
MIRT1216585	hsa-miR-3607-3p	CLIP-seq
MIRT1216586	hsa-miR-363	CLIP-seq
MIRT1216587	hsa-miR-367	CLIP-seq
MIRT1216588	hsa-miR-3689a-5p	CLIP-seq
MIRT1216589	hsa-miR-3689b	CLIP-seq
MIRT1216590	hsa-miR-3689e	CLIP-seq
MIRT1216591	hsa-miR-3689f	CLIP-seq
MIRT1216592	hsa-miR-374a	CLIP-seq
MIRT1216593	hsa-miR-374b	CLIP-seq
MIRT1216594	hsa-miR-4263	CLIP-seq
MIRT1216595	hsa-miR-4265	CLIP-seq
MIRT1216596	hsa-miR-4269	CLIP-seq
MIRT1216597	hsa-miR-4275	CLIP-seq
MIRT1216598	hsa-miR-429	CLIP-seq
MIRT1216599	hsa-miR-4296	CLIP-seq
MIRT1216600	hsa-miR-4322	CLIP-seq
MIRT1216601	hsa-miR-4328	CLIP-seq
MIRT1216602	hsa-miR-4482	CLIP-seq
MIRT1216603	hsa-miR-450b-5p	CLIP-seq
MIRT1216604	hsa-miR-4515	CLIP-seq
MIRT1216605	hsa-miR-4718	CLIP-seq
MIRT1216606	hsa-miR-4719	CLIP-seq
MIRT1216607	hsa-miR-4724-5p	CLIP-seq
MIRT1216608	hsa-miR-4729	CLIP-seq
MIRT1216609	hsa-miR-4740-5p	CLIP-seq
MIRT1216610	hsa-miR-4800-5p	CLIP-seq
MIRT1216611	hsa-miR-4802-3p	CLIP-seq
MIRT1216612	hsa-miR-494	CLIP-seq
MIRT1216613	hsa-miR-511	CLIP-seq
MIRT1216614	hsa-miR-513a-3p	CLIP-seq
MIRT1216615	hsa-miR-548ac	CLIP-seq
MIRT1216616	hsa-miR-548ae	CLIP-seq
MIRT1216617	hsa-miR-548aj	CLIP-seq
MIRT1216618	hsa-miR-548am	CLIP-seq
MIRT1216619	hsa-miR-548d-3p	CLIP-seq
MIRT1216620	hsa-miR-548x	CLIP-seq
MIRT1216621	hsa-miR-548z	CLIP-seq
MIRT1216622	hsa-miR-552	CLIP-seq
MIRT1216623	hsa-miR-568	CLIP-seq
MIRT1216624	hsa-miR-576-5p	CLIP-seq
MIRT1216625	hsa-miR-586	CLIP-seq
MIRT1216626	hsa-miR-603	CLIP-seq
MIRT1216627	hsa-miR-892b	CLIP-seq
MIRT1216628	hsa-miR-92a	CLIP-seq
MIRT1216629	hsa-miR-92b	CLIP-seq
MIRT1216614	hsa-miR-513a-3p	CLIP-seq
MIRT2062543	hsa-miR-101	CLIP-seq
MIRT2062544	hsa-miR-132	CLIP-seq
MIRT2062545	hsa-miR-144	CLIP-seq
MIRT1216566	hsa-miR-19a	CLIP-seq
MIRT1216567	hsa-miR-19b	CLIP-seq
MIRT2062546	hsa-miR-203	CLIP-seq
MIRT1216570	hsa-miR-2113	CLIP-seq
MIRT2062547	hsa-miR-212	CLIP-seq
MIRT2062548	hsa-miR-224	CLIP-seq
MIRT1216573	hsa-miR-30a	CLIP-seq
MIRT1216574	hsa-miR-30b	CLIP-seq
MIRT1216575	hsa-miR-30c	CLIP-seq
MIRT1216576	hsa-miR-30d	CLIP-seq
MIRT1216577	hsa-miR-30e	CLIP-seq
MIRT1216580	hsa-miR-3145-3p	CLIP-seq
MIRT2062549	hsa-miR-3163	CLIP-seq
MIRT2062550	hsa-miR-3612	CLIP-seq
MIRT2062551	hsa-miR-377	CLIP-seq
MIRT2062552	hsa-miR-3977	CLIP-seq
MIRT1216603	hsa-miR-450b-5p	CLIP-seq
MIRT1216606	hsa-miR-4719	CLIP-seq
MIRT1216613	hsa-miR-511	CLIP-seq
MIRT2062553	hsa-miR-542-5p	CLIP-seq
MIRT1216623	hsa-miR-568	CLIP-seq
MIRT1216626	hsa-miR-603	CLIP-seq
MIRT2062554	hsa-miR-650	CLIP-seq
MIRT2455987	hsa-miR-141	CLIP-seq
MIRT2455988	hsa-miR-200a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0016020	Component	Membrane	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA
GO:0098978	Component	Glutamatergic synapse	IEA

Other IDs

• MIM: 608286
• HGNC: 13404
• e!Ensembl: ENSG00000138650

Protein

• UniProt ID: Q9P2E7
• Protein name: Protocadherin-10
• Protein function: Potential calcium-dependent cell-adhesion protein.; (Microbial infection) Acts as a receptor for Western equine encephalitis virus.
• PDB: 6VFQ, 6VFW, 6VG4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08266	Cadherin_2	19 → 101	Cadherin-like	Domain
  PF00028	Cadherin	127 → 241	Cadherin domain	Domain
  PF00028	Cadherin	255 → 349	Cadherin domain	Domain
  PF00028	Cadherin	364 → 454	Cadherin domain	Domain
  PF00028	Cadherin	468 → 565	Cadherin domain	Domain
  PF00028	Cadherin	589 → 679	Cadherin domain	Domain
  PF16492	Cadherin_C_2	713 → 838	Cadherin cytoplasmic C-terminal	Family

• Tissue specificity: TISSUE SPECIFICITY: Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested. {ECO:0000269|PubMed:11549318}.
• Sequence:

  MIVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSR
  TPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPP
  SFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRF
  AELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRV
  LDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRAREL
  FGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISF
  STVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAP
  LDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGA
  YIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFS
  FQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLL
  TRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEV
  RDHGQPPLSSTATLVVQLVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILII
  ALGSVSFIFLLAMIVLAVRCQKEKKLNIYTCLASDCCLCCCCCGGGGSTCCGRQARARKK
  KLSKSDIMLVQSSNVPSNPAQVPIEESGGFGSHHHNQNYCYQVCLTPESAKTDLMFLKPC
  SPSRSTDTEHNPCGAIVTGYTDQQPDIISNGSILSNETKHQRAELSYLVDRPRRVNSSAF
  QEADIVSSKDSGHGDSEQGDSDHDATNRAQSAGMDLFSNCTEECKALGHSDRCWMPSFVP
  SDGRQAADYRSNLHVPGMDSVPDTEVFETPEAQPGAERSFSTFGKEKALHSTLERKELDG
  LLTNTRAPYKPPYLTRKRIC

• Sequence length: 1040