Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57575
Gene name Gene Name - the full gene name approved by the HGNC.	Protocadherin 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PCDH10
Synonyms (NCBI Gene) Gene synonyms aliases	OL-PCDH, PCDH19
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q28.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The e

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miRTarBase ID	miRNA	Experiments	Reference
MIRT045051	hsa-miR-186-5p	CLASH	23622248
MIRT519003	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT552018	hsa-miR-3924	HITS-CLIP	21572407
MIRT519000	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT519003	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT552018	hsa-miR-3924	HITS-CLIP	21572407
MIRT519000	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	23706177
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23706177
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23706177
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	23706177
MIRT552018	hsa-miR-3924	HITS-CLIP	23706177
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23706177
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	23706177
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23706177
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23706177
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	23706177
MIRT552018	hsa-miR-3924	HITS-CLIP	23706177
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23706177
MIRT519004	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT519003	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT552018	hsa-miR-3924	PAR-CLIP	21572407
MIRT519000	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT519004	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT519003	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT519002	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT519001	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT519000	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22291592
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22291592
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22291592
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22291592
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22100165
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22100165
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22100165
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22100165
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT727000	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT726999	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT726998	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726997	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726995	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726996	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726994	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT519003	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT519003	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT552018	hsa-miR-3924	HITS-CLIP	27418678
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT519000	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT519000	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT734494	hsa-miR-552-3p	ChIP-seq, Immunohistochemistry (IHC), In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blotting	33867818
MIRT519003	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT552018	hsa-miR-3924	HITS-CLIP	21572407
MIRT519000	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT519003	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT552018	hsa-miR-3924	HITS-CLIP	21572407
MIRT519000	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	23706177
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23706177
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23706177
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	23706177
MIRT552018	hsa-miR-3924	HITS-CLIP	23706177
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23706177
MIRT519004	hsa-miR-5011-5p	HITS-CLIP	23706177
MIRT519003	hsa-miR-223-5p	HITS-CLIP	23706177
MIRT519002	hsa-miR-6867-5p	HITS-CLIP	23706177
MIRT519001	hsa-miR-190a-3p	HITS-CLIP	23706177
MIRT552018	hsa-miR-3924	HITS-CLIP	23706177
MIRT519000	hsa-miR-574-5p	HITS-CLIP	23706177
MIRT519004	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT519003	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT519002	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT519001	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT552018	hsa-miR-3924	PAR-CLIP	21572407
MIRT519000	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT519004	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT519003	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT519002	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT519001	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT519000	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22291592
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22291592
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22291592
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22291592
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22100165
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22100165
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT442496	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT442495	hsa-miR-365a-3p	PAR-CLIP	22100165
MIRT442494	hsa-miR-365b-3p	PAR-CLIP	22100165
MIRT442493	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT1216561	hsa-miR-125a-3p	CLIP-seq
MIRT1216562	hsa-miR-1269	CLIP-seq
MIRT1216563	hsa-miR-1269b	CLIP-seq
MIRT1216564	hsa-miR-1288	CLIP-seq
MIRT1216565	hsa-miR-193a-5p	CLIP-seq
MIRT1216566	hsa-miR-19a	CLIP-seq
MIRT1216567	hsa-miR-19b	CLIP-seq
MIRT1216568	hsa-miR-200b	CLIP-seq
MIRT1216569	hsa-miR-200c	CLIP-seq
MIRT1216570	hsa-miR-2113	CLIP-seq
MIRT1216571	hsa-miR-25	CLIP-seq
MIRT1216572	hsa-miR-3065-5p	CLIP-seq
MIRT1216573	hsa-miR-30a	CLIP-seq
MIRT1216574	hsa-miR-30b	CLIP-seq
MIRT1216575	hsa-miR-30c	CLIP-seq
MIRT1216576	hsa-miR-30d	CLIP-seq
MIRT1216577	hsa-miR-30e	CLIP-seq
MIRT1216578	hsa-miR-3130-5p	CLIP-seq
MIRT1216579	hsa-miR-3138	CLIP-seq
MIRT1216580	hsa-miR-3145-3p	CLIP-seq
MIRT1216581	hsa-miR-32	CLIP-seq
MIRT1216582	hsa-miR-324-5p	CLIP-seq
MIRT1216583	hsa-miR-33a	CLIP-seq
MIRT1216584	hsa-miR-33b	CLIP-seq
MIRT1216585	hsa-miR-3607-3p	CLIP-seq
MIRT1216586	hsa-miR-363	CLIP-seq
MIRT1216587	hsa-miR-367	CLIP-seq
MIRT1216588	hsa-miR-3689a-5p	CLIP-seq
MIRT1216589	hsa-miR-3689b	CLIP-seq
MIRT1216590	hsa-miR-3689e	CLIP-seq
MIRT1216591	hsa-miR-3689f	CLIP-seq
MIRT1216592	hsa-miR-374a	CLIP-seq
MIRT1216593	hsa-miR-374b	CLIP-seq
MIRT1216594	hsa-miR-4263	CLIP-seq
MIRT1216595	hsa-miR-4265	CLIP-seq
MIRT1216596	hsa-miR-4269	CLIP-seq
MIRT1216597	hsa-miR-4275	CLIP-seq
MIRT1216598	hsa-miR-429	CLIP-seq
MIRT1216599	hsa-miR-4296	CLIP-seq
MIRT1216600	hsa-miR-4322	CLIP-seq
MIRT1216601	hsa-miR-4328	CLIP-seq
MIRT1216602	hsa-miR-4482	CLIP-seq
MIRT1216603	hsa-miR-450b-5p	CLIP-seq
MIRT1216604	hsa-miR-4515	CLIP-seq
MIRT1216605	hsa-miR-4718	CLIP-seq
MIRT1216606	hsa-miR-4719	CLIP-seq
MIRT1216607	hsa-miR-4724-5p	CLIP-seq
MIRT1216608	hsa-miR-4729	CLIP-seq
MIRT1216609	hsa-miR-4740-5p	CLIP-seq
MIRT1216610	hsa-miR-4800-5p	CLIP-seq
MIRT1216611	hsa-miR-4802-3p	CLIP-seq
MIRT1216612	hsa-miR-494	CLIP-seq
MIRT1216613	hsa-miR-511	CLIP-seq
MIRT1216614	hsa-miR-513a-3p	CLIP-seq
MIRT1216615	hsa-miR-548ac	CLIP-seq
MIRT1216616	hsa-miR-548ae	CLIP-seq
MIRT1216617	hsa-miR-548aj	CLIP-seq
MIRT1216618	hsa-miR-548am	CLIP-seq
MIRT1216619	hsa-miR-548d-3p	CLIP-seq
MIRT1216620	hsa-miR-548x	CLIP-seq
MIRT1216621	hsa-miR-548z	CLIP-seq
MIRT1216622	hsa-miR-552	CLIP-seq
MIRT1216623	hsa-miR-568	CLIP-seq
MIRT1216624	hsa-miR-576-5p	CLIP-seq
MIRT1216625	hsa-miR-586	CLIP-seq
MIRT1216626	hsa-miR-603	CLIP-seq
MIRT1216627	hsa-miR-892b	CLIP-seq
MIRT1216628	hsa-miR-92a	CLIP-seq
MIRT1216629	hsa-miR-92b	CLIP-seq
MIRT1216614	hsa-miR-513a-3p	CLIP-seq
MIRT2062543	hsa-miR-101	CLIP-seq
MIRT2062544	hsa-miR-132	CLIP-seq
MIRT2062545	hsa-miR-144	CLIP-seq
MIRT1216566	hsa-miR-19a	CLIP-seq
MIRT1216567	hsa-miR-19b	CLIP-seq
MIRT2062546	hsa-miR-203	CLIP-seq
MIRT1216570	hsa-miR-2113	CLIP-seq
MIRT2062547	hsa-miR-212	CLIP-seq
MIRT2062548	hsa-miR-224	CLIP-seq
MIRT1216573	hsa-miR-30a	CLIP-seq
MIRT1216574	hsa-miR-30b	CLIP-seq
MIRT1216575	hsa-miR-30c	CLIP-seq
MIRT1216576	hsa-miR-30d	CLIP-seq
MIRT1216577	hsa-miR-30e	CLIP-seq
MIRT1216580	hsa-miR-3145-3p	CLIP-seq
MIRT2062549	hsa-miR-3163	CLIP-seq
MIRT2062550	hsa-miR-3612	CLIP-seq
MIRT2062551	hsa-miR-377	CLIP-seq
MIRT2062552	hsa-miR-3977	CLIP-seq
MIRT1216603	hsa-miR-450b-5p	CLIP-seq
MIRT1216606	hsa-miR-4719	CLIP-seq
MIRT1216613	hsa-miR-511	CLIP-seq
MIRT2062553	hsa-miR-542-5p	CLIP-seq
MIRT1216623	hsa-miR-568	CLIP-seq
MIRT1216626	hsa-miR-603	CLIP-seq
MIRT2062554	hsa-miR-650	CLIP-seq
MIRT2455987	hsa-miR-141	CLIP-seq
MIRT2455988	hsa-miR-200a	CLIP-seq

Show/Hide all(4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007155	Process	Cell adhesion	IBA	21873635
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA

MIM	HGNC	e!Ensembl
608286	13404	ENSG00000138650

Protein

UniProt ID

Q9P2E7

Protein name

Protocadherin-10

Protein function

Potential calcium-dependent cell-adhesion protein.; (Microbial infection) Acts as a receptor for Western equine encephalitis virus.

PDB

6VFQ , 6VFW , 6VG4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08266	Cadherin_2	19 → 101	Cadherin-like	Domain
PF00028	Cadherin	127 → 241	Cadherin domain	Domain
PF00028	Cadherin	255 → 349	Cadherin domain	Domain
PF00028	Cadherin	364 → 454	Cadherin domain	Domain
PF00028	Cadherin	468 → 565	Cadherin domain	Domain
PF00028	Cadherin	589 → 679	Cadherin domain	Domain
PF16492	Cadherin_C_2	713 → 838	Cadherin cytoplasmic C-terminal	Family

Tissue specificity

TISSUE SPECIFICITY: Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested. {ECO:0000269|PubMed:11549318}.

Sequence

MIVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSR
TPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPP
SFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRF
AELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRV
LDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRAREL
FGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISF
STVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAP
LDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGA
YIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFS
FQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLL
TRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEV
RDHGQPPLSSTATLVVQLVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILII
ALGSVSFIFLLAMIVLAVRCQKEKKLNIYTCLASDCCLCCCCCGGGGSTCCGRQARARKK
KLSKSDIMLVQSSNVPSNPAQVPIEESGGFGSHHHNQNYCYQVCLTPESAKTDLMFLKPC
SPSRSTDTEHNPCGAIVTGYTDQQPDIISNGSILSNETKHQRAELSYLVDRPRRVNSSAF
QEADIVSSKDSGHGDSEQGDSDHDATNRAQSAGMDLFSNCTEECKALGHSDRCWMPSFVP
SDGRQAADYRSNLHVPGMDSVPDTEVFETPEAQPGAERSFSTFGKEKALHSTLERKELDG
LLTNTRAPYKPPYLTRKRIC

Sequence length

1040

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699 View all (8 more)	18621663

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Hypertension	Hypertension		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.	GWAS, CBGDA

Show/Hide Text Mining Associations (44)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	36461127
Adenoma	Associate	27896617
Breast Neoplasms	Inhibit	33899544
Burkitt Lymphoma	Associate	17341268
Carcinogenesis	Associate	19709077
Carcinoma Hepatocellular	Inhibit	28498423
Carcinoma Hepatocellular	Associate	30170418
Carcinoma in Situ	Associate	19709077
Carcinoma Non Small Cell Lung	Associate	23321465, 26276761, 36461127
Carcinoma Pancreatic Ductal	Associate	31088413
Cardiovascular Diseases	Stimulate	38003275
Colorectal Neoplasms	Associate	23839493, 24309322, 34841662
Death	Associate	23569128
Diabetes Gestational	Stimulate	38003275
Endometrial Neoplasms	Associate	29693365
Endometriosis	Associate	36239569
Gastrointestinal Stromal Tumors	Associate	27659532
Hodgkin Disease	Associate	17341268
Hyperglycemia	Stimulate	38003275
Lung Neoplasms	Inhibit	23321465
Lymphatic Metastasis	Associate	25086586, 30170418
Lymphatic Metastasis	Inhibit	37147733
Lymphoma	Associate	17341268, 31210316
Lymphoma Large B Cell Diffuse	Associate	29202805
Multiple Myeloma	Associate	22245948
Neoplasm Invasiveness	Associate	25086586
Neoplasm Metastasis	Associate	19709077
Neoplasm Metastasis	Inhibit	37147733
Neoplasms	Associate	17341268, 23321168, 23569128, 23839493, 26683936
Neoplasms	Inhibit	19681120, 19709077, 23321465, 25086586, 26871474, 28498423, 29202805, 30170418, 33527791, 33867818, 37147733
Neoplasms Germ Cell and Embryonal	Associate	20051947
Obsessive Compulsive Disorder	Associate	25824302
Olfaction Disorders	Associate	27878761
Pancreatic Neoplasms	Associate	26683936, 33867818
Pediatric acute onset neuropsychiatric syndrome	Associate	27878761
Precancerous Conditions	Associate	24128875
Prostatic Neoplasms	Associate	25086586
Squamous Intraepithelial Lesions	Associate	19681120
Stomach Diseases	Associate	26269563
Stomach Neoplasms	Associate	24128875, 26871474, 33527791
Stomach Neoplasms	Inhibit	37147733
Urinary Bladder Neoplasms	Associate	23321168, 35958598
Urinary Bladder Neoplasms	Inhibit	23569128
Uterine Cervical Neoplasms	Associate	19681120, 19709077, 28351298

PCDH10 (protocadherin 10)