Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5756
Gene name Gene Name - the full gene name approved by the HGNC.
Twinfilin actin binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TWF1
Synonyms (NCBI Gene) Gene synonyms aliases
A6, PTK9
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005164 hsa-miR-30a-5p pSILAC 18668040
MIRT005246 hsa-miR-155-5p pSILAC 18668040
MIRT005089 hsa-miR-1-3p pSILAC 18668040
MIRT005089 hsa-miR-1-3p Microarray 15685193
MIRT005089 hsa-miR-1-3p Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot 20571053
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IDA 28493397
GO:0003785 Function Actin monomer binding IBA 21873635
GO:0003785 Function Actin monomer binding ISS 12807912, 18837697
GO:0004713 Function Protein tyrosine kinase activity IDA 10406962
GO:0005515 Function Protein binding IPI 28493397, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610932 9620 ENSG00000151239
Protein
UniProt ID Q12792
Protein name Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)
Protein function Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin
PDB 7CCC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00241 Cofilin_ADF 9 136 Cofilin/tropomyosin-type actin-binding protein Domain
PF00241 Cofilin_ADF 184 311 Cofilin/tropomyosin-type actin-binding protein Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. {ECO:0000269|PubMed:7507208}.
Sequence
Sequence length 350
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lymphoma Lymphoma rs11540652, rs1592119138, rs1592123162, rs1599367044 19783987
Unknown
Disease term Disease name Evidence References Source
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Bone Diseases Associate 17900349
Carcinoma Hepatocellular Associate 34519634, 40362400
Colorectal Neoplasms Associate 19422682
COVID 19 Associate 37150240
Male Infertility with Large Headed Multiflagellar Polyploid Spermatozoa Associate 26662397
Mohr Tranebjaerg syndrome Associate 34519634
Osteoarthritis Associate 17900349
Pancreatic Neoplasms Associate 31619579
Rhinitis Allergic Associate 21738793