Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57556
Gene name Gene Name - the full gene name approved by the HGNC.	Semaphorin 6A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SEMA6A
Synonyms (NCBI Gene) Gene synonyms aliases	HT018, SEMA, SEMA6A1, SEMAQ, VIA
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q23.1
Summary Summary of gene provided in NCBI Entrez Gene.	The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]

Show/Hide all(175)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047836	hsa-miR-30c-5p	CLASH	23622248
MIRT052939	hsa-miR-27a-3p	Luciferase reporter assay, qRT-PCR, Western blot	22184411
MIRT052940	hsa-miR-27b-3p	ELISA, Luciferase reporter assay, qRT-PCR	22184411
MIRT052939	hsa-miR-27a-3p	Luciferase reporter assay, qRT-PCR, Western blot	22184411
MIRT052940	hsa-miR-27b-3p	Luciferase reporter assay	24177325
MIRT052940	hsa-miR-27b-3p	Luciferase reporter assay	24177325
MIRT052940	hsa-miR-27b-3p	Luciferase reporter assay	24177325
MIRT052940	hsa-miR-27b-3p	Luciferase reporter assay	24177325
MIRT653991	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT653990	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT653989	hsa-miR-30a-5p	HITS-CLIP	23824327
MIRT653988	hsa-miR-30b-5p	HITS-CLIP	23824327
MIRT047836	hsa-miR-30c-5p	HITS-CLIP	23824327
MIRT653987	hsa-miR-30d-5p	HITS-CLIP	23824327
MIRT653986	hsa-miR-30e-5p	HITS-CLIP	23824327
MIRT653984	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT653985	hsa-miR-147a	HITS-CLIP	23824327
MIRT492395	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT492394	hsa-miR-107	PAR-CLIP	23592263
MIRT492393	hsa-miR-4289	PAR-CLIP	23592263
MIRT492392	hsa-miR-7156-3p	PAR-CLIP	23592263
MIRT492391	hsa-miR-1301-3p	PAR-CLIP	23592263
MIRT492390	hsa-miR-5047	PAR-CLIP	23592263
MIRT492389	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT492388	hsa-miR-450b-5p	PAR-CLIP	23592263
MIRT492386	hsa-miR-507	PAR-CLIP	23592263
MIRT492387	hsa-miR-557	PAR-CLIP	23592263
MIRT492385	hsa-miR-3680-3p	PAR-CLIP	23592263
MIRT492384	hsa-miR-129-5p	PAR-CLIP	23592263
MIRT734260	hsa-miR-21-3p	Immunohistochemistry (IHC), qRT-PCR, Western blotting	31915154
MIRT653991	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT653990	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT653989	hsa-miR-30a-5p	HITS-CLIP	23824327
MIRT653988	hsa-miR-30b-5p	HITS-CLIP	23824327
MIRT047836	hsa-miR-30c-5p	HITS-CLIP	23824327
MIRT653987	hsa-miR-30d-5p	HITS-CLIP	23824327
MIRT653986	hsa-miR-30e-5p	HITS-CLIP	23824327
MIRT653984	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT653985	hsa-miR-147a	HITS-CLIP	23824327
MIRT492395	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT492394	hsa-miR-107	PAR-CLIP	23592263
MIRT492393	hsa-miR-4289	PAR-CLIP	23592263
MIRT492392	hsa-miR-7156-3p	PAR-CLIP	23592263
MIRT492391	hsa-miR-1301-3p	PAR-CLIP	23592263
MIRT492390	hsa-miR-5047	PAR-CLIP	23592263
MIRT492389	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT492388	hsa-miR-450b-5p	PAR-CLIP	23592263
MIRT492386	hsa-miR-507	PAR-CLIP	23592263
MIRT492387	hsa-miR-557	PAR-CLIP	23592263
MIRT492385	hsa-miR-3680-3p	PAR-CLIP	23592263
MIRT492384	hsa-miR-129-5p	PAR-CLIP	23592263
MIRT1335442	hsa-miR-1275	CLIP-seq
MIRT1335443	hsa-miR-128	CLIP-seq
MIRT1335444	hsa-miR-1299	CLIP-seq
MIRT1335445	hsa-miR-132	CLIP-seq
MIRT1335446	hsa-miR-144	CLIP-seq
MIRT1335447	hsa-miR-147	CLIP-seq
MIRT1335448	hsa-miR-2052	CLIP-seq
MIRT1335449	hsa-miR-210	CLIP-seq
MIRT1335450	hsa-miR-212	CLIP-seq
MIRT1335451	hsa-miR-27a	CLIP-seq
MIRT1335452	hsa-miR-27b	CLIP-seq
MIRT1335453	hsa-miR-297	CLIP-seq
MIRT1335454	hsa-miR-3123	CLIP-seq
MIRT1335455	hsa-miR-3127-5p	CLIP-seq
MIRT1335456	hsa-miR-3151	CLIP-seq
MIRT1335457	hsa-miR-3202	CLIP-seq
MIRT1335458	hsa-miR-3647-3p	CLIP-seq
MIRT1335459	hsa-miR-3665	CLIP-seq
MIRT1335460	hsa-miR-3911	CLIP-seq
MIRT1335461	hsa-miR-3925-5p	CLIP-seq
MIRT1335462	hsa-miR-4433	CLIP-seq
MIRT1335463	hsa-miR-4438	CLIP-seq
MIRT1335464	hsa-miR-4447	CLIP-seq
MIRT1335465	hsa-miR-4459	CLIP-seq
MIRT1335466	hsa-miR-4472	CLIP-seq
MIRT1335467	hsa-miR-4496	CLIP-seq
MIRT1335468	hsa-miR-4525	CLIP-seq
MIRT1335469	hsa-miR-4533	CLIP-seq
MIRT1335470	hsa-miR-4651	CLIP-seq
MIRT1335471	hsa-miR-4661-3p	CLIP-seq
MIRT1335472	hsa-miR-4665-5p	CLIP-seq
MIRT1335473	hsa-miR-4723-5p	CLIP-seq
MIRT1335474	hsa-miR-4735-5p	CLIP-seq
MIRT1335475	hsa-miR-4768-3p	CLIP-seq
MIRT1335476	hsa-miR-4773	CLIP-seq
MIRT1335477	hsa-miR-4777-5p	CLIP-seq
MIRT1335478	hsa-miR-491-5p	CLIP-seq
MIRT1335479	hsa-miR-513a-3p	CLIP-seq
MIRT1335480	hsa-miR-513a-5p	CLIP-seq
MIRT1335481	hsa-miR-518d-5p	CLIP-seq
MIRT1335482	hsa-miR-519b-5p	CLIP-seq
MIRT1335483	hsa-miR-519c-5p	CLIP-seq
MIRT1335484	hsa-miR-520c-5p	CLIP-seq
MIRT1335485	hsa-miR-526a	CLIP-seq
MIRT1335486	hsa-miR-526b	CLIP-seq
MIRT1335487	hsa-miR-544	CLIP-seq
MIRT1335488	hsa-miR-548v	CLIP-seq
MIRT1335489	hsa-miR-556-3p	CLIP-seq
MIRT1335490	hsa-miR-567	CLIP-seq
MIRT1335491	hsa-miR-570	CLIP-seq
MIRT1335492	hsa-miR-578	CLIP-seq
MIRT1335493	hsa-miR-599	CLIP-seq
MIRT1335494	hsa-miR-608	CLIP-seq
MIRT1335495	hsa-miR-625	CLIP-seq
MIRT1335496	hsa-miR-644	CLIP-seq
MIRT1335497	hsa-miR-651	CLIP-seq
MIRT1335498	hsa-miR-657	CLIP-seq
MIRT1335499	hsa-miR-711	CLIP-seq
MIRT1335500	hsa-miR-875-3p	CLIP-seq
MIRT2099165	hsa-miR-103a	CLIP-seq
MIRT1335444	hsa-miR-1299	CLIP-seq
MIRT2099166	hsa-miR-1301	CLIP-seq
MIRT2099167	hsa-miR-141	CLIP-seq
MIRT1335447	hsa-miR-147	CLIP-seq
MIRT2099168	hsa-miR-1913	CLIP-seq
MIRT2099169	hsa-miR-1915	CLIP-seq
MIRT2099170	hsa-miR-200a	CLIP-seq
MIRT1335451	hsa-miR-27a	CLIP-seq
MIRT1335452	hsa-miR-27b	CLIP-seq
MIRT1335453	hsa-miR-297	CLIP-seq
MIRT2099171	hsa-miR-3143	CLIP-seq
MIRT2099172	hsa-miR-3160-5p	CLIP-seq
MIRT1335457	hsa-miR-3202	CLIP-seq
MIRT2099173	hsa-miR-324-3p	CLIP-seq
MIRT2099174	hsa-miR-346	CLIP-seq
MIRT2099175	hsa-miR-3934	CLIP-seq
MIRT2099176	hsa-miR-4288	CLIP-seq
MIRT2099177	hsa-miR-4311	CLIP-seq
MIRT1335469	hsa-miR-4533	CLIP-seq
MIRT1335471	hsa-miR-4661-3p	CLIP-seq
MIRT2099178	hsa-miR-4726-3p	CLIP-seq
MIRT1335480	hsa-miR-513a-5p	CLIP-seq
MIRT1335490	hsa-miR-567	CLIP-seq
MIRT2099179	hsa-miR-632	CLIP-seq
MIRT1335497	hsa-miR-651	CLIP-seq
MIRT1335500	hsa-miR-875-3p	CLIP-seq
MIRT1335443	hsa-miR-128	CLIP-seq
MIRT2099167	hsa-miR-141	CLIP-seq
MIRT1335446	hsa-miR-144	CLIP-seq
MIRT2323960	hsa-miR-1908	CLIP-seq
MIRT2323961	hsa-miR-194	CLIP-seq
MIRT2099170	hsa-miR-200a	CLIP-seq
MIRT1335451	hsa-miR-27a	CLIP-seq
MIRT1335452	hsa-miR-27b	CLIP-seq
MIRT2323962	hsa-miR-4727-5p	CLIP-seq
MIRT2323963	hsa-miR-4769-3p	CLIP-seq
MIRT1335480	hsa-miR-513a-5p	CLIP-seq
MIRT2323964	hsa-miR-663	CLIP-seq
MIRT1335451	hsa-miR-27a	CLIP-seq
MIRT1335452	hsa-miR-27b	CLIP-seq
MIRT1335456	hsa-miR-3151	CLIP-seq
MIRT1335464	hsa-miR-4447	CLIP-seq
MIRT1335466	hsa-miR-4472	CLIP-seq
MIRT1335478	hsa-miR-491-5p	CLIP-seq
MIRT1335480	hsa-miR-513a-5p	CLIP-seq
MIRT2619800	hsa-miR-1283	CLIP-seq
MIRT2099167	hsa-miR-141	CLIP-seq
MIRT2619801	hsa-miR-1827	CLIP-seq
MIRT2099170	hsa-miR-200a	CLIP-seq
MIRT2619802	hsa-miR-2682	CLIP-seq
MIRT2619803	hsa-miR-34a	CLIP-seq
MIRT2619804	hsa-miR-34c-5p	CLIP-seq
MIRT2619805	hsa-miR-3615	CLIP-seq
MIRT2619806	hsa-miR-3654	CLIP-seq
MIRT2619807	hsa-miR-449a	CLIP-seq
MIRT2619808	hsa-miR-449b	CLIP-seq
MIRT2619809	hsa-miR-449c	CLIP-seq
MIRT2619810	hsa-miR-4638-3p	CLIP-seq
MIRT2619811	hsa-miR-4649-3p	CLIP-seq
MIRT2619812	hsa-miR-4712-5p	CLIP-seq
MIRT2619813	hsa-miR-4793-3p	CLIP-seq
MIRT2619814	hsa-miR-598	CLIP-seq
MIRT2619815	hsa-miR-642b	CLIP-seq
MIRT2619816	hsa-miR-770-5p	CLIP-seq

Transcription factors

Show/Hide all(3)

Transcription factor	Regulation	Reference
NANOG	Unknown	17671748
POU5F1	Unknown	17671748
SOX2	Unknown	17671748

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001755	Process	Neural crest cell migration	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10993894, 32302524
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006915	Process	Apoptotic process	NAS	10993894
GO:0007010	Process	Cytoskeleton organization	NAS	10993894
GO:0007166	Process	Cell surface receptor signaling pathway	NAS	10993894
GO:0007399	Process	Nervous system development	NAS	10993894
GO:0007411	Process	Axon guidance	IBA	21873635
GO:0007411	Process	Axon guidance	NAS	10993894
GO:0009887	Process	Animal organ morphogenesis	NAS	10993894
GO:0016021	Component	Integral component of membrane	NAS	10993894
GO:0016525	Process	Negative regulation of angiogenesis	IGI	24177325
GO:0030215	Function	Semaphorin receptor binding	IBA	21873635
GO:0030335	Process	Positive regulation of cell migration	IBA	21873635
GO:0030424	Component	Axon	NAS	10993894
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IDA	21536891
GO:0045499	Function	Chemorepellent activity	IBA	21873635
GO:0048843	Process	Negative regulation of axon extension involved in axon guidance	IBA	21873635
GO:0050919	Process	Negative chemotaxis	IBA	21873635
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IDA	21536891
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA	21873635
GO:0106089	Process	Negative regulation of cell adhesion involved in sprouting angiogenesis	IGI	24177325
GO:1900747	Process	Negative regulation of vascular endothelial growth factor signaling pathway	IDA	21536891
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IDA	22184411
GO:2001224	Process	Positive regulation of neuron migration	IBA	21873635

MIM	HGNC	e!Ensembl
605885	10738	ENSG00000092421

Protein

UniProt ID

Q9H2E6

Protein name

Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)

Protein function

Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon

PDB

6WTS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	61 → 480	Sema domain	Family
PF01437	PSI	514 → 569	Plexin repeat	Family

Sequence

MRSEALLLYFTLLHFAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQM
IMIMNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNF
IKVLLKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFADG
KLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIA
VEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVT
DVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDER
VPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRL
TKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYD
GVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERYGKCKKTCIASRDPYCGWIKEGG
ACSHLSPNSRLTFEQDIERGNTDGLGDCHNSFVALNGHSSSLLPSTTTSDSTAQEGYESR
GGMLDWKHLLDSPDSTDPLGAVSSHNHQDKKGVIRESYLKGHDQLVPVTLLAIAVILAFV
MGAVFSGITVYCVCDHRRKDVAVVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPE
AILTPLMHNGKLATPGNTAKMLIKADQHHLDLTALPTPESTPTLQQKRKPSRGSREWERN
QNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVAQ
MALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGASLSQTGL
SKRLEMHHSSSYGVDYKRSYPTNSLTRSHQATTLKRNNTNSSNSSHLSRNQSFGRGDNPP
PAPQRVDSIQVHSSQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLS
TSMKPNDACT

Sequence length

1030

Interactions

View interactions

	KEGG
	Axon guidance

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	References	Source
Unknown
Crohn disease	Crohn Disease		18587394	ClinVar
Alzheimer disease	Alzheimer disease			GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Associate	40248062
Carcinoma Renal Cell	Stimulate	36739418
Glioblastoma	Associate	26014517
Glioma	Associate	26223576
Granulomatosis with Polyangiitis	Associate	23740775
Lung Neoplasms	Inhibit	31527696
Melanoma	Associate	35440004
Mucocutaneous Lymph Node Syndrome	Associate	28886140
Neoplasms	Associate	24553122, 26014517, 35440004, 36739418
Neoplasms	Inhibit	31527696
Neuroendocrine Tumors	Associate	37453564
Small Cell Lung Carcinoma	Associate	36935366
Stomach Neoplasms	Associate	33316777

SEMA6A (semaphorin 6A)