Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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57522
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Gene name
Gene Name - the full gene name approved by the HGNC.
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SLIT-ROBO Rho GTPase activating protein 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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SRGAP1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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ARHGAP13, NMTC2 |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
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NMTC2 |
Chromosome
Chromosome number
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12 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12q14.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016] |
UniProt ID |
Q7Z6B7
|
Protein name |
SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) |
Protein function |
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1 |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00611
|
FCH |
31 → 116 |
Fes/CIP4, and EFC/F-BAR homology domain |
Family |
PF00620
|
RhoGAP |
520 → 672 |
RhoGAP domain |
Domain |
PF00018
|
SH3_1 |
749 → 794 |
SH3 domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Expressed in brain, lung, kidney, and testis. {ECO:0000269|PubMed:11672528}. |
Sequence |
|
Sequence length |
1085 |
Interactions |
View interactions
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Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Congenital anomalies of kidney and urinary tract |
Cakut |
rs267606865, rs121908436, rs281875326, rs879255515, rs75462234, rs869320679, rs760905589, rs797045022, rs869320624, rs745597204, rs1114167358, rs1555879360, rs1577330805, rs1008555507 |
26026792 |
Ovarian cancer |
Epithelial ovarian cancer |
rs34424986, rs137853060, rs28934575, rs79658334, rs121913021, rs62625308, rs80356898, rs80357579, rs41293497, rs80356904, rs80357471, rs80357522, rs80357234, rs80357912, rs80357828, rs80357208, rs55770810, rs80358165, rs80358010, rs587780226, rs536907995, rs139414606, rs371638537, rs574552037, rs730881647, rs747993448, rs786202125, rs786202962, rs121913321, rs189261858, rs869320800, rs753023295, rs779466229, rs752411477, rs80357438, rs191486604, rs760874290, rs752780954, rs760782298, rs1555591361, rs1555578360, rs1555588460, rs1555587401, rs747427602, rs112675807, rs80357393 View all (31 more) |
25134534 |
Thyroid cancer |
Thyroid cancer, follicular, THYROID CANCER, NONMEDULLARY, 2 |
rs119486096, rs104894171, rs28933406, rs11554290, rs121913364, rs797044990, rs1564566774, rs200989342 |
23539728 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Pancreatic adenocarcinoma |
Pancreatic adenocarcinoma |
PDAC patients with high expression of PSMA6 having a significantly shorter overall survival rate. |
|
GWAS, CBGDA |
Colorectal Cancer |
Colorectal Cancer |
In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. |
|
GWAS, CBGDA |
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Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Carcinoma Ovarian Epithelial |
Associate
|
25134534 |
Colorectal Neoplasms |
Inhibit
|
27923383 |
Neoplasms |
Inhibit
|
27923383 |
Thyroid Cancer Papillary |
Associate
|
23539728 |
Thyroid Neoplasms |
Associate
|
27530615 |
|