Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57486
Gene name Gene Name - the full gene name approved by the HGNC.
Neurolysin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NLN
Synonyms (NCBI Gene) Gene synonyms aliases
AGTBP, EP24.16, MEP, MOP
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q12.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the n
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT713390 hsa-miR-26a-1-3p HITS-CLIP 19536157
MIRT713389 hsa-miR-26a-2-3p HITS-CLIP 19536157
MIRT713388 hsa-miR-2116-3p HITS-CLIP 19536157
MIRT713387 hsa-miR-6845-3p HITS-CLIP 19536157
MIRT713386 hsa-miR-7110-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004222 Function Metalloendopeptidase activity IBA
GO:0004222 Function Metalloendopeptidase activity IEA
GO:0004222 Function Metalloendopeptidase activity TAS
GO:0005576 Component Extracellular region TAS
GO:0005737 Component Cytoplasm IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611530 16058 ENSG00000123213
Protein
UniProt ID Q9BYT8
Protein name Neurolysin, mitochondrial (EC 3.4.24.16) (Angiotensin-binding protein) (Microsomal endopeptidase) (MEP) (Mitochondrial oligopeptidase M) (Neurotensin endopeptidase)
Protein function Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By si
PDB 5LUZ , 5LV0 , 8VJU , 8VJV , 8VJW , 8VJX , 8VJY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01432 Peptidase_M3 251 701 Peptidase family M3 Family
Sequence
Sequence length 704
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Renin-angiotensin system   Peptide ligand-binding receptors
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Moyamoya Disease Moyamoya disease N/A N/A GWAS
Uterine Fibroids Uterine fibroids N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 27307030
Colorectal Neoplasms Inhibit 34285715
Mitral Valve Insufficiency Inhibit 30581499
Parkinson Disease Associate 33276480