Gene Gene information from NCBI Gene database.
Entrez ID 57486
Gene name Neurolysin
Gene symbol NLN
Synonyms (NCBI Gene)
AGTBPEP24.16MEPMOP
Chromosome 5
Chromosome location 5q12.3
Summary This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the n
miRNA miRNA information provided by mirtarbase database.
757
miRTarBase ID miRNA Experiments Reference
MIRT713390 hsa-miR-26a-1-3p HITS-CLIP 19536157
MIRT713389 hsa-miR-26a-2-3p HITS-CLIP 19536157
MIRT713388 hsa-miR-2116-3p HITS-CLIP 19536157
MIRT713387 hsa-miR-6845-3p HITS-CLIP 19536157
MIRT713386 hsa-miR-7110-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0004222 Function Metalloendopeptidase activity IBA
GO:0004222 Function Metalloendopeptidase activity IEA
GO:0004222 Function Metalloendopeptidase activity TAS
GO:0005576 Component Extracellular region TAS
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611530 16058 ENSG00000123213
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BYT8
Protein name Neurolysin, mitochondrial (EC 3.4.24.16) (Angiotensin-binding protein) (Microsomal endopeptidase) (MEP) (Mitochondrial oligopeptidase M) (Neurotensin endopeptidase)
Protein function Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By si
PDB 5LUZ , 5LV0 , 8VJU , 8VJV , 8VJW , 8VJX , 8VJY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01432 Peptidase_M3 251 701 Peptidase family M3 Family
Sequence
Sequence length 704
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Renin-angiotensin system   Peptide ligand-binding receptors