NDRG2 (NDRG family member 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 57447
Gene name NDRG family member 2
Gene symbol NDRG2
Synonyms (NCBI Gene)
SYLD
Chromosome 14
Chromosome location 14q11.2
Summary This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblast
miRNA miRNA information provided by mirtarbase database.
47
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT006183 hsa-miR-650 ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 21352815
MIRT006183 hsa-miR-650 ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 21352815
MIRT006183 hsa-miR-650 ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 21352815
MIRT021510 hsa-miR-145-5p Reporter assay;Microarray 21351259
MIRT736634 hsa-miR-576-3p qRT-PCRELISA 32592365
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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Transcription factor Regulation Reference
WT1 Activation 17688410
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001818 Process Negative regulation of cytokine production IEA
GO:0005515 Function Protein binding IPI 21217774, 23068607
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
605272 14460 ENSG00000165795
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UN36
Protein name Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613)
Protein function Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron different
PDB 2XMQ , 2XMR , 2XMS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03096 Ndr 40 → 318 Ndr family Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; abs
Sequence
Sequence length 371
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Clear cell carcinoma of kidney Uncertain significance rs200458592 RCV005926850
Lung cancer Uncertain significance rs200458592 RCV005926851
Show/Hide Text Mining Associations (70)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acromegaly Inhibit 28390436
Adenocarcinoma Associate 17935612
Adenocarcinoma of Lung Associate 27072586
Adenoma Inhibit 17935612
Adenomatous Polyposis Coli Associate 19237607
Alzheimer Disease Associate 22043305
Arthritis Rheumatoid Associate 30096164
Brain Ischemia Associate 23451161
Breast Neoplasms Inhibit 21226903, 25256221
Breast Neoplasms Associate 21338239, 22647880, 27400234, 28423695