Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57419
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 24 member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC24A3
Synonyms (NCBI Gene) Gene synonyms aliases	NCKX3
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20p11.23
Summary Summary of gene provided in NCBI Entrez Gene.	Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 pota

Show/Hide all(183)

miRTarBase ID	miRNA	Experiments
MIRT1354854	hsa-miR-1224-5p	CLIP-seq
MIRT1354855	hsa-miR-1282	CLIP-seq
MIRT1354856	hsa-miR-1302	CLIP-seq
MIRT1354857	hsa-miR-130a	CLIP-seq
MIRT1354858	hsa-miR-130b	CLIP-seq
MIRT1354859	hsa-miR-148a	CLIP-seq
MIRT1354860	hsa-miR-148b	CLIP-seq
MIRT1354861	hsa-miR-152	CLIP-seq
MIRT1354862	hsa-miR-154	CLIP-seq
MIRT1354863	hsa-miR-1825	CLIP-seq
MIRT1354864	hsa-miR-199a-5p	CLIP-seq
MIRT1354865	hsa-miR-199b-5p	CLIP-seq
MIRT1354866	hsa-miR-19a	CLIP-seq
MIRT1354867	hsa-miR-19b	CLIP-seq
MIRT1354868	hsa-miR-301a	CLIP-seq
MIRT1354869	hsa-miR-301b	CLIP-seq
MIRT1354870	hsa-miR-3122	CLIP-seq
MIRT1354871	hsa-miR-3199	CLIP-seq
MIRT1354872	hsa-miR-335	CLIP-seq
MIRT1354873	hsa-miR-3545-5p	CLIP-seq
MIRT1354874	hsa-miR-3666	CLIP-seq
MIRT1354875	hsa-miR-3671	CLIP-seq
MIRT1354876	hsa-miR-3674	CLIP-seq
MIRT1354877	hsa-miR-3688-5p	CLIP-seq
MIRT1354878	hsa-miR-3913-5p	CLIP-seq
MIRT1354879	hsa-miR-4291	CLIP-seq
MIRT1354880	hsa-miR-4295	CLIP-seq
MIRT1354881	hsa-miR-4298	CLIP-seq
MIRT1354882	hsa-miR-4310	CLIP-seq
MIRT1354883	hsa-miR-4470	CLIP-seq
MIRT1354884	hsa-miR-454	CLIP-seq
MIRT1354885	hsa-miR-4676-5p	CLIP-seq
MIRT1354886	hsa-miR-4690-5p	CLIP-seq
MIRT1354887	hsa-miR-4698	CLIP-seq
MIRT1354888	hsa-miR-4751	CLIP-seq
MIRT1354889	hsa-miR-4760-3p	CLIP-seq
MIRT1354890	hsa-miR-485-3p	CLIP-seq
MIRT1354891	hsa-miR-487a	CLIP-seq
MIRT1354892	hsa-miR-544b	CLIP-seq
MIRT1354893	hsa-miR-570	CLIP-seq
MIRT1354894	hsa-miR-575	CLIP-seq
MIRT1354895	hsa-miR-627	CLIP-seq
MIRT1354896	hsa-miR-657	CLIP-seq
MIRT1354897	hsa-miR-658	CLIP-seq
MIRT1354898	hsa-miR-888	CLIP-seq
MIRT1354899	hsa-miR-924	CLIP-seq
MIRT2105123	hsa-miR-1193	CLIP-seq
MIRT2105124	hsa-miR-137	CLIP-seq
MIRT1354866	hsa-miR-19a	CLIP-seq
MIRT1354867	hsa-miR-19b	CLIP-seq
MIRT2105125	hsa-miR-296-5p	CLIP-seq
MIRT2105126	hsa-miR-3132	CLIP-seq
MIRT2105127	hsa-miR-3650	CLIP-seq
MIRT2105128	hsa-miR-3714	CLIP-seq
MIRT2105129	hsa-miR-4313	CLIP-seq
MIRT2105130	hsa-miR-4519	CLIP-seq
MIRT2105131	hsa-miR-4711-3p	CLIP-seq
MIRT2105132	hsa-miR-4757-5p	CLIP-seq
MIRT2105133	hsa-miR-490-5p	CLIP-seq
MIRT2105134	hsa-miR-582-3p	CLIP-seq
MIRT2105135	hsa-miR-661	CLIP-seq
MIRT2105136	hsa-miR-940	CLIP-seq
MIRT2329685	hsa-miR-105	CLIP-seq
MIRT2329686	hsa-miR-106a	CLIP-seq
MIRT2329687	hsa-miR-106b	CLIP-seq
MIRT2105123	hsa-miR-1193	CLIP-seq
MIRT2329688	hsa-miR-1208	CLIP-seq
MIRT2329689	hsa-miR-1267	CLIP-seq
MIRT1354857	hsa-miR-130a	CLIP-seq
MIRT1354858	hsa-miR-130b	CLIP-seq
MIRT2329690	hsa-miR-136	CLIP-seq
MIRT2105124	hsa-miR-137	CLIP-seq
MIRT1354859	hsa-miR-148a	CLIP-seq
MIRT1354860	hsa-miR-148b	CLIP-seq
MIRT2329691	hsa-miR-149	CLIP-seq
MIRT1354861	hsa-miR-152	CLIP-seq
MIRT2329692	hsa-miR-15a	CLIP-seq
MIRT2329693	hsa-miR-15b	CLIP-seq
MIRT2329694	hsa-miR-16	CLIP-seq
MIRT2329695	hsa-miR-17	CLIP-seq
MIRT1354863	hsa-miR-1825	CLIP-seq
MIRT2329696	hsa-miR-1915	CLIP-seq
MIRT2329697	hsa-miR-194	CLIP-seq
MIRT2329698	hsa-miR-195	CLIP-seq
MIRT2329699	hsa-miR-1972	CLIP-seq
MIRT1354866	hsa-miR-19a	CLIP-seq
MIRT1354867	hsa-miR-19b	CLIP-seq
MIRT2329700	hsa-miR-20a	CLIP-seq
MIRT2329701	hsa-miR-20b	CLIP-seq
MIRT2329702	hsa-miR-216a	CLIP-seq
MIRT2329703	hsa-miR-24	CLIP-seq
MIRT2105125	hsa-miR-296-5p	CLIP-seq
MIRT2329704	hsa-miR-300	CLIP-seq
MIRT1354868	hsa-miR-301a	CLIP-seq
MIRT1354869	hsa-miR-301b	CLIP-seq
MIRT2329705	hsa-miR-31	CLIP-seq
MIRT2105126	hsa-miR-3132	CLIP-seq
MIRT2329706	hsa-miR-3197	CLIP-seq
MIRT1354872	hsa-miR-335	CLIP-seq
MIRT2329707	hsa-miR-3607-3p	CLIP-seq
MIRT2329708	hsa-miR-3613-3p	CLIP-seq
MIRT2329709	hsa-miR-3665	CLIP-seq
MIRT1354874	hsa-miR-3666	CLIP-seq
MIRT2329710	hsa-miR-3686	CLIP-seq
MIRT1354877	hsa-miR-3688-5p	CLIP-seq
MIRT2105128	hsa-miR-3714	CLIP-seq
MIRT2329711	hsa-miR-377	CLIP-seq
MIRT2329712	hsa-miR-381	CLIP-seq
MIRT2329713	hsa-miR-3944-5p	CLIP-seq
MIRT2329714	hsa-miR-412	CLIP-seq
MIRT2329715	hsa-miR-424	CLIP-seq
MIRT2329716	hsa-miR-4264	CLIP-seq
MIRT2329717	hsa-miR-4284	CLIP-seq
MIRT1354880	hsa-miR-4295	CLIP-seq
MIRT2105129	hsa-miR-4313	CLIP-seq
MIRT2329718	hsa-miR-4328	CLIP-seq
MIRT2329719	hsa-miR-4446-3p	CLIP-seq
MIRT2329720	hsa-miR-4468	CLIP-seq
MIRT1354883	hsa-miR-4470	CLIP-seq
MIRT2105130	hsa-miR-4519	CLIP-seq
MIRT2329721	hsa-miR-4524	CLIP-seq
MIRT1354884	hsa-miR-454	CLIP-seq
MIRT2329722	hsa-miR-4633-5p	CLIP-seq
MIRT2329723	hsa-miR-4650-5p	CLIP-seq
MIRT2329724	hsa-miR-4660	CLIP-seq
MIRT2329725	hsa-miR-4667-3p	CLIP-seq
MIRT2329726	hsa-miR-4675	CLIP-seq
MIRT1354885	hsa-miR-4676-5p	CLIP-seq
MIRT2329727	hsa-miR-4687-3p	CLIP-seq
MIRT1354886	hsa-miR-4690-5p	CLIP-seq
MIRT2329728	hsa-miR-4694-3p	CLIP-seq
MIRT1354887	hsa-miR-4698	CLIP-seq
MIRT2329729	hsa-miR-4704-3p	CLIP-seq
MIRT2329730	hsa-miR-4704-5p	CLIP-seq
MIRT2329731	hsa-miR-4719	CLIP-seq
MIRT2329732	hsa-miR-4730	CLIP-seq
MIRT2329733	hsa-miR-4736	CLIP-seq
MIRT2329734	hsa-miR-4741	CLIP-seq
MIRT1354889	hsa-miR-4760-3p	CLIP-seq
MIRT2329735	hsa-miR-4764-5p	CLIP-seq
MIRT2329736	hsa-miR-4768-5p	CLIP-seq
MIRT2329737	hsa-miR-4777-5p	CLIP-seq
MIRT2329738	hsa-miR-4781-3p	CLIP-seq
MIRT2329739	hsa-miR-4797-3p	CLIP-seq
MIRT2329740	hsa-miR-4800-3p	CLIP-seq
MIRT1354890	hsa-miR-485-3p	CLIP-seq
MIRT2105133	hsa-miR-490-5p	CLIP-seq
MIRT2329741	hsa-miR-497	CLIP-seq
MIRT2329742	hsa-miR-503	CLIP-seq
MIRT2329743	hsa-miR-509-3p	CLIP-seq
MIRT2329744	hsa-miR-513b	CLIP-seq
MIRT2329745	hsa-miR-518a-5p	CLIP-seq
MIRT2329746	hsa-miR-518d-5p	CLIP-seq
MIRT2329747	hsa-miR-519b-5p	CLIP-seq
MIRT2329748	hsa-miR-519c-5p	CLIP-seq
MIRT2329749	hsa-miR-519d	CLIP-seq
MIRT2329750	hsa-miR-520a-5p	CLIP-seq
MIRT2329751	hsa-miR-520c-5p	CLIP-seq
MIRT2329752	hsa-miR-520g	CLIP-seq
MIRT2329753	hsa-miR-520h	CLIP-seq
MIRT2329754	hsa-miR-525-5p	CLIP-seq
MIRT2329755	hsa-miR-526a	CLIP-seq
MIRT2329756	hsa-miR-527	CLIP-seq
MIRT1354893	hsa-miR-570	CLIP-seq
MIRT1354894	hsa-miR-575	CLIP-seq
MIRT2105134	hsa-miR-582-3p	CLIP-seq
MIRT2329757	hsa-miR-595	CLIP-seq
MIRT2329758	hsa-miR-624	CLIP-seq
MIRT2329759	hsa-miR-646	CLIP-seq
MIRT1354897	hsa-miR-658	CLIP-seq
MIRT2329760	hsa-miR-764	CLIP-seq
MIRT2329761	hsa-miR-885-3p	CLIP-seq
MIRT1354898	hsa-miR-888	CLIP-seq
MIRT2329762	hsa-miR-93	CLIP-seq
MIRT2105136	hsa-miR-940	CLIP-seq
MIRT2329763	hsa-miR-942	CLIP-seq
MIRT2329764	hsa-miR-95	CLIP-seq
MIRT1354866	hsa-miR-19a	CLIP-seq
MIRT1354867	hsa-miR-19b	CLIP-seq
MIRT1354893	hsa-miR-570	CLIP-seq
MIRT2105125	hsa-miR-296-5p	CLIP-seq
MIRT2105129	hsa-miR-4313	CLIP-seq
MIRT2105134	hsa-miR-582-3p	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005262	Function	Calcium channel activity	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	26631410
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006811	Process	Ion transport	TAS
GO:0006874	Process	Cellular calcium ion homeostasis	IBA	21873635
GO:0006874	Process	Cellular calcium ion homeostasis	IDA	26631410
GO:0006874	Process	Cellular calcium ion homeostasis	ISS
GO:0008273	Function	Calcium, potassium:sodium antiporter activity	IBA	21873635
GO:0008273	Function	Calcium, potassium:sodium antiporter activity	IDA	26631410
GO:0008273	Function	Calcium, potassium:sodium antiporter activity	ISS
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0010629	Process	Negative regulation of gene expression	ISS
GO:0015293	Function	Symporter activity	IEA
GO:0030282	Process	Bone mineralization	ISS
GO:0035725	Process	Sodium ion transmembrane transport	IDA	26631410
GO:0044214	Component	Spanning component of plasma membrane	RCA	26631410
GO:0070588	Process	Calcium ion transmembrane transport	IBA	21873635
GO:0070588	Process	Calcium ion transmembrane transport	IDA	26631410
GO:0071805	Process	Potassium ion transmembrane transport	IDA	26631410
GO:0071944	Component	Cell periphery	IDA	21321244
GO:0071944	Component	Cell periphery	ISS
GO:0098656	Process	Anion transmembrane transport	IEA
GO:0150104	Process	Transport across blood-brain barrier	NAS	30280653

MIM	HGNC	e!Ensembl
609839	10977	ENSG00000185052

Protein

UniProt ID

Q9HC58

Protein name

Sodium/potassium/calcium exchanger 3 (Na(+)/K(+)/Ca(2+)-exchange protein 3) (Solute carrier family 24 member 3)

Protein function

Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01699	Na_Ca_ex	113 → 257	Sodium/calcium exchanger protein	Family
PF01699	Na_Ca_ex	475 → 627	Sodium/calcium exchanger protein	Family

Tissue specificity

TISSUE SPECIFICITY: Abundant in the brain (PubMed:11294880). Expressed at low levels in the aorta, uterus and intestine (PubMed:11294880). {ECO:0000269|PubMed:11294880}.

Sequence

MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRK
WMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYM
FYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGV
GTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWE
SLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKK
ANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLIN
SRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNEN
DEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTF
ASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDM
AVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVH
LNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH

Sequence length

644

Interactions

View interactions

	Reactome
			Sodium/Calcium exchangers

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Adenocarcinoma	Adenoid Cystic Carcinoma	rs121913530, rs886039394, rs121913474	16762588
Migraine	Migraine Disorders	rs794727411	27182965, 27322543
Neuroblastoma	Neuroblastoma	rs113994087, rs113994089, rs281864719, rs863225285, rs863225284, rs863225283, rs281864720, rs863225282, rs863225281, rs1057519698, rs915983602, rs1469271544	18463370

Show/Hide Unknown Diseases (7)

Disease term	Disease name	Evidence	Source
Unknown
Intracranial Aneurysm	Intracranial Aneurysm		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Dementia	Dementia		GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA
Ischemic Stroke	Ischemic Stroke		GWAS
Fibromuscular Dysplasia	Fibromuscular Dysplasia		GWAS
Diabetes	Diabetes		GWAS

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	36798148
Breast Neoplasms	Associate	36046013
Carcinoma Pancreatic Ductal	Associate	28413183
Carcinoma Squamous Cell	Associate	36798148, 37746966
Glaucoma Open Angle	Associate	18648523
Glioblastoma	Associate	37628853
Migraine Disorders	Associate	39333847
Neoplasms	Associate	34498424, 35131032
Neoplasms	Inhibit	36798148
Pain	Associate	36798148
Paroxysmal ventricular fibrillation	Associate	33167779
Pigmentation Disorders	Associate	27129268
Reperfusion Injury	Associate	37300940
Uterine Cervical Neoplasms	Associate	34498424

SLC24A3 (solute carrier family 24 member 3)