PTGDS (prostaglandin D2 synthase)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5730
Gene name Gene Name - the full gene name approved by the HGNC.
Prostaglandin D2 synthase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTGDS
Synonyms (NCBI Gene) Gene synonyms aliases
L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
PDS
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervou
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(6)
miRTarBase ID miRNA Experiments Reference
MIRT017585 hsa-miR-335-5p Microarray 18185580
MIRT1272594 hsa-miR-1252 CLIP-seq
MIRT1272595 hsa-miR-2278 CLIP-seq
MIRT1272596 hsa-miR-4468 CLIP-seq
MIRT1272597 hsa-miR-4533 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(5)
Transcription factor Regulation Reference
HES1 Repression 15743775
NFKB1 Activation 19094210
TFAP2B Activation 15743775
USF1 Activation 17574780
USF1 Repression 18817855
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
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GO ID Ontology Definition Evidence Reference
GO:0001516 Process Prostaglandin biosynthetic process IDA 20347284, 20667974
GO:0001516 Process Prostaglandin biosynthetic process ISS
GO:0004667 Function Prostaglandin-D synthase activity IDA 20347284, 20667974
GO:0004667 Function Prostaglandin-D synthase activity ISS
GO:0004667 Function Prostaglandin-D synthase activity TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
176803 9592 ENSG00000107317
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID P41222
Protein name Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (L-PGDS) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2)
Protein function Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:20667974). Involved in a variety of CNS functions, such as sedation, NREM sleep and
PDB 2WWP , 3O19 , 3O22 , 3O2Y , 4IMN , 4IMO , 4ORR , 4ORS , 4ORU , 4ORW , 4ORX , 4ORY , 4OS0 , 4OS3 , 4OS8 , 5WY9 , 8HTA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 40 → 184 Lipocalin / cytosolic fatty-acid binding protein family Domain
Tissue specificity TISSUE SPECIFICITY: Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, e
Sequence
Sequence length 190
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
  KEGG   Reactome
  Arachidonic acid metabolism
Metabolic pathways 		  Synthesis of Prostaglandins (PG) and Thromboxanes (TX)