PTBP1 (polypyrimidine tract binding protein 1)

Gene

• Entrez ID: 5725
• Gene name: Polypyrimidine tract binding protein 1
• Gene symbol: PTBP1
• Synonyms (NCBI Gene): HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in th

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001345	hsa-miR-1-3p	pSILAC	18668040
MIRT002647	hsa-miR-124-3p	Microarray	15685193
MIRT002647	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT002647	hsa-miR-124-3p	Microarray	15685193
MIRT001345	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT050898	hsa-miR-17-5p	CLASH	23622248
MIRT050776	hsa-miR-17-3p	CLASH	23622248
MIRT049932	hsa-miR-30a-5p	CLASH	23622248
MIRT049413	hsa-miR-92a-3p	CLASH	23622248
MIRT046541	hsa-miR-15b-5p	CLASH	23622248
MIRT043938	hsa-miR-378a-3p	CLASH	23622248
MIRT040624	hsa-miR-92b-3p	CLASH	23622248
MIRT039680	hsa-miR-615-3p	CLASH	23622248
MIRT002647	hsa-miR-124-3p	Luciferase reporter assay, qRT-PCR, Western blot	23853098
MIRT002647	hsa-miR-124-3p	Luciferase reporter assay, qRT-PCR, Western blot	22895557
MIRT054397	hsa-miR-340-5p	Luciferase reporter assay, qRT-PCR, Western blot	22895557
MIRT002647	hsa-miR-124-3p	Western blot, qRT-PCR	24865424
MIRT002647	hsa-miR-124-3p	Luciferase reporter assay, qRT-PCR, Western blot	24122720
MIRT002647	hsa-miR-124-3p	Luciferase reporter assay, qRT-PCR, Western blot	24122720
MIRT002647	hsa-miR-124-3p	Luciferase reporter assay, qRT-PCR, Western blot	24122720
MIRT700572	hsa-miR-6854-5p	HITS-CLIP	23313552
MIRT700571	hsa-miR-6798-5p	HITS-CLIP	23313552
MIRT700570	hsa-miR-3127-3p	HITS-CLIP	23313552
MIRT700569	hsa-miR-6756-3p	HITS-CLIP	23313552
MIRT700568	hsa-miR-7108-3p	HITS-CLIP	23313552
MIRT700567	hsa-miR-4732-3p	HITS-CLIP	23313552
MIRT700566	hsa-miR-125a-5p	HITS-CLIP	23313552
MIRT700565	hsa-miR-125b-5p	HITS-CLIP	23313552
MIRT700564	hsa-miR-4319	HITS-CLIP	23313552
MIRT700563	hsa-miR-6734-3p	HITS-CLIP	23313552
MIRT700562	hsa-miR-1266-5p	HITS-CLIP	23313552
MIRT700561	hsa-miR-4518	HITS-CLIP	23313552
MIRT700560	hsa-miR-3928-5p	HITS-CLIP	23313552
MIRT700559	hsa-miR-6806-3p	HITS-CLIP	23313552
MIRT700558	hsa-miR-6087	HITS-CLIP	23313552
MIRT700557	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT700556	hsa-miR-3934-3p	HITS-CLIP	23313552
MIRT700555	hsa-miR-1273a	HITS-CLIP	23313552
MIRT700554	hsa-miR-4467	HITS-CLIP	23313552
MIRT700553	hsa-miR-670-5p	HITS-CLIP	23313552
MIRT700552	hsa-miR-127-5p	HITS-CLIP	23313552
MIRT700551	hsa-miR-659-5p	HITS-CLIP	23313552
MIRT002647	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT002647	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT406909	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT406915	hsa-miR-3714	PAR-CLIP	20371350
MIRT566259	hsa-miR-3910	PAR-CLIP	20371350
MIRT295094	hsa-miR-4476	PAR-CLIP	20371350
MIRT295099	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT152408	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT406920	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT406921	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT406912	hsa-miR-940	PAR-CLIP	20371350
MIRT406908	hsa-miR-329-5p	PAR-CLIP	20371350
MIRT295098	hsa-miR-6830-5p	PAR-CLIP	20371350
MIRT349266	hsa-miR-4457	PAR-CLIP	20371350
MIRT566258	hsa-miR-3691-3p	PAR-CLIP	20371350
MIRT566257	hsa-miR-1205	PAR-CLIP	20371350
MIRT566256	hsa-miR-4786-3p	PAR-CLIP	20371350
MIRT406910	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT566255	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT566254	hsa-miR-1286	PAR-CLIP	20371350
MIRT566253	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT406911	hsa-miR-657	PAR-CLIP	20371350
MIRT566252	hsa-miR-4480	PAR-CLIP	20371350
MIRT566251	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT406917	hsa-miR-4736	PAR-CLIP	20371350
MIRT566250	hsa-miR-604	PAR-CLIP	20371350
MIRT566248	hsa-miR-6762-3p	PAR-CLIP	20371350
MIRT566249	hsa-miR-4440	PAR-CLIP	20371350
MIRT566247	hsa-miR-647	PAR-CLIP	20371350
MIRT566246	hsa-miR-4477b	PAR-CLIP	20371350
MIRT406922	hsa-miR-7856-5p	PAR-CLIP	20371350
MIRT295092	hsa-miR-548n	PAR-CLIP	21572407
MIRT295097	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT295093	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT083022	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT083039	hsa-miR-548ab	PAR-CLIP	21572407
MIRT083040	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT083041	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT083042	hsa-miR-548ak	PAR-CLIP	21572407
MIRT083043	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT083046	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT083047	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT083048	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT083049	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT083050	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT083052	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT083021	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT083055	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT083023	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT083025	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT083031	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT083032	hsa-miR-548i	PAR-CLIP	21572407
MIRT083028	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT083038	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT083033	hsa-miR-548w	PAR-CLIP	21572407
MIRT083036	hsa-miR-548y	PAR-CLIP	21572407
MIRT083020	hsa-miR-559	PAR-CLIP	21572407
MIRT295104	hsa-miR-624-3p	PAR-CLIP	21572407
MIRT295105	hsa-miR-802	PAR-CLIP	21572407
MIRT295108	hsa-miR-3163	PAR-CLIP	21572407
MIRT295098	hsa-miR-6830-5p	PAR-CLIP	21572407
MIRT295101	hsa-miR-194-5p	PAR-CLIP	21572407
MIRT083018	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT083018	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT001345	hsa-miR-1-3p	Luciferase reporter assay, qRT-PCR, Western blot	26980745
MIRT001345	hsa-miR-1-3p	Luciferase reporter assay, qRT-PCR, Western blot	26980745
MIRT002647	hsa-miR-124-3p	PAR-CLIP	26701625
MIRT406908	hsa-miR-329-5p	PAR-CLIP	26701625
MIRT406915	hsa-miR-3714	PAR-CLIP	26701625
MIRT566259	hsa-miR-3910	PAR-CLIP	26701625
MIRT349266	hsa-miR-4457	PAR-CLIP	26701625
MIRT566246	hsa-miR-4477b	PAR-CLIP	26701625
MIRT566252	hsa-miR-4480	PAR-CLIP	26701625
MIRT406917	hsa-miR-4736	PAR-CLIP	26701625
MIRT566256	hsa-miR-4786-3p	PAR-CLIP	26701625
MIRT406909	hsa-miR-506-3p	PAR-CLIP	26701625
MIRT152408	hsa-miR-5582-5p	PAR-CLIP	26701625
MIRT406910	hsa-miR-605-3p	PAR-CLIP	26701625
MIRT406911	hsa-miR-657	PAR-CLIP	26701625
MIRT566251	hsa-miR-671-5p	PAR-CLIP	26701625
MIRT406920	hsa-miR-6808-5p	PAR-CLIP	26701625
MIRT295098	hsa-miR-6830-5p	PAR-CLIP	26701625
MIRT406921	hsa-miR-6893-5p	PAR-CLIP	26701625
MIRT406922	hsa-miR-7856-5p	PAR-CLIP	26701625
MIRT406912	hsa-miR-940	PAR-CLIP	26701625
MIRT732526	hsa-miR-133a-3p	Immunohistochemistry (IHC), Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR	33654410
MIRT733111	hsa-miR-644a	Immunofluorescence, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blotting	33520363
MIRT737171	hsa-miR-501-5p	RNA-seq, qRT-PCR	34148372
MIRT700572	hsa-miR-6854-5p	HITS-CLIP	23313552
MIRT700571	hsa-miR-6798-5p	HITS-CLIP	23313552
MIRT700570	hsa-miR-3127-3p	HITS-CLIP	23313552
MIRT700569	hsa-miR-6756-3p	HITS-CLIP	23313552
MIRT700568	hsa-miR-7108-3p	HITS-CLIP	23313552
MIRT700567	hsa-miR-4732-3p	HITS-CLIP	23313552
MIRT700566	hsa-miR-125a-5p	HITS-CLIP	23313552
MIRT700565	hsa-miR-125b-5p	HITS-CLIP	23313552
MIRT700564	hsa-miR-4319	HITS-CLIP	23313552
MIRT700563	hsa-miR-6734-3p	HITS-CLIP	23313552
MIRT700562	hsa-miR-1266-5p	HITS-CLIP	23313552
MIRT700561	hsa-miR-4518	HITS-CLIP	23313552
MIRT700560	hsa-miR-3928-5p	HITS-CLIP	23313552
MIRT700559	hsa-miR-6806-3p	HITS-CLIP	23313552
MIRT700558	hsa-miR-6087	HITS-CLIP	23313552
MIRT700557	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT700556	hsa-miR-3934-3p	HITS-CLIP	23313552
MIRT700555	hsa-miR-1273a	HITS-CLIP	23313552
MIRT700554	hsa-miR-4467	HITS-CLIP	23313552
MIRT700553	hsa-miR-670-5p	HITS-CLIP	23313552
MIRT700552	hsa-miR-127-5p	HITS-CLIP	23313552
MIRT700551	hsa-miR-659-5p	HITS-CLIP	23313552
MIRT002647	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT002647	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT406909	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT406915	hsa-miR-3714	PAR-CLIP	20371350
MIRT566259	hsa-miR-3910	PAR-CLIP	20371350
MIRT295094	hsa-miR-4476	PAR-CLIP	20371350
MIRT295099	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT152408	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT406920	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT406921	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT406912	hsa-miR-940	PAR-CLIP	20371350
MIRT406908	hsa-miR-329-5p	PAR-CLIP	20371350
MIRT295098	hsa-miR-6830-5p	PAR-CLIP	20371350
MIRT349266	hsa-miR-4457	PAR-CLIP	20371350
MIRT566258	hsa-miR-3691-3p	PAR-CLIP	20371350
MIRT566257	hsa-miR-1205	PAR-CLIP	20371350
MIRT566256	hsa-miR-4786-3p	PAR-CLIP	20371350
MIRT406910	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT566255	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT566254	hsa-miR-1286	PAR-CLIP	20371350
MIRT566253	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT406911	hsa-miR-657	PAR-CLIP	20371350
MIRT566252	hsa-miR-4480	PAR-CLIP	20371350
MIRT566251	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT406917	hsa-miR-4736	PAR-CLIP	20371350
MIRT566250	hsa-miR-604	PAR-CLIP	20371350
MIRT566248	hsa-miR-6762-3p	PAR-CLIP	20371350
MIRT566249	hsa-miR-4440	PAR-CLIP	20371350
MIRT566247	hsa-miR-647	PAR-CLIP	20371350
MIRT566246	hsa-miR-4477b	PAR-CLIP	20371350
MIRT406922	hsa-miR-7856-5p	PAR-CLIP	20371350
MIRT295092	hsa-miR-548n	PAR-CLIP	21572407
MIRT295097	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT295093	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT083022	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT083039	hsa-miR-548ab	PAR-CLIP	21572407
MIRT083040	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT083041	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT083042	hsa-miR-548ak	PAR-CLIP	21572407
MIRT083043	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT083046	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT083047	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT083048	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT083049	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT083050	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT083052	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT083021	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT083055	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT083023	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT083025	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT083031	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT083032	hsa-miR-548i	PAR-CLIP	21572407
MIRT083028	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT083038	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT083033	hsa-miR-548w	PAR-CLIP	21572407
MIRT083036	hsa-miR-548y	PAR-CLIP	21572407
MIRT083020	hsa-miR-559	PAR-CLIP	21572407
MIRT295104	hsa-miR-624-3p	PAR-CLIP	21572407
MIRT295105	hsa-miR-802	PAR-CLIP	21572407
MIRT295108	hsa-miR-3163	PAR-CLIP	21572407
MIRT295098	hsa-miR-6830-5p	PAR-CLIP	21572407
MIRT295101	hsa-miR-194-5p	PAR-CLIP	21572407
MIRT755324	hsa-mir-506-3p	Luciferase reporter assay, Western blotting	37169555
MIRT1271674	hsa-miR-1197	CLIP-seq
MIRT1271675	hsa-miR-147	CLIP-seq
MIRT1271676	hsa-miR-2355-5p	CLIP-seq
MIRT1271677	hsa-miR-2964a-3p	CLIP-seq
MIRT1271678	hsa-miR-302f	CLIP-seq
MIRT1271679	hsa-miR-3189-3p	CLIP-seq
MIRT1271680	hsa-miR-3650	CLIP-seq
MIRT1271681	hsa-miR-3911	CLIP-seq
MIRT1271682	hsa-miR-4436a	CLIP-seq
MIRT1271683	hsa-miR-4455	CLIP-seq
MIRT1271684	hsa-miR-4474-3p	CLIP-seq
MIRT1271685	hsa-miR-4766-3p	CLIP-seq
MIRT1271686	hsa-miR-548p	CLIP-seq
MIRT1271687	hsa-miR-599	CLIP-seq
MIRT1271688	hsa-miR-609	CLIP-seq
MIRT1271689	hsa-miR-644	CLIP-seq
MIRT1271690	hsa-miR-124	CLIP-seq
MIRT1271691	hsa-miR-125a-3p	CLIP-seq
MIRT1271692	hsa-miR-3665	CLIP-seq
MIRT1271693	hsa-miR-4418	CLIP-seq
MIRT1271694	hsa-miR-4493	CLIP-seq
MIRT1271695	hsa-miR-506	CLIP-seq
MIRT1271696	hsa-miR-509-3-5p	CLIP-seq
MIRT1271697	hsa-miR-509-5p	CLIP-seq
MIRT1271698	hsa-miR-645	CLIP-seq
MIRT1271699	hsa-miR-1	CLIP-seq
MIRT1271700	hsa-miR-106a	CLIP-seq
MIRT1271701	hsa-miR-106b	CLIP-seq
MIRT1271702	hsa-miR-1207-3p	CLIP-seq
MIRT1271690	hsa-miR-124	CLIP-seq
MIRT1271703	hsa-miR-1252	CLIP-seq
MIRT1271704	hsa-miR-1254	CLIP-seq
MIRT1271705	hsa-miR-1291	CLIP-seq
MIRT1271706	hsa-miR-1299	CLIP-seq
MIRT1271707	hsa-miR-133a	CLIP-seq
MIRT1271708	hsa-miR-137	CLIP-seq
MIRT1271709	hsa-miR-153	CLIP-seq
MIRT1271710	hsa-miR-17	CLIP-seq
MIRT1271711	hsa-miR-1827	CLIP-seq
MIRT1271712	hsa-miR-1908	CLIP-seq
MIRT1271713	hsa-miR-191	CLIP-seq
MIRT1271714	hsa-miR-193b	CLIP-seq
MIRT1271715	hsa-miR-194	CLIP-seq
MIRT1271716	hsa-miR-200b	CLIP-seq
MIRT1271717	hsa-miR-200c	CLIP-seq
MIRT1271718	hsa-miR-206	CLIP-seq
MIRT1271719	hsa-miR-20a	CLIP-seq
MIRT1271720	hsa-miR-20b	CLIP-seq
MIRT1271721	hsa-miR-210	CLIP-seq
MIRT1271722	hsa-miR-2117	CLIP-seq
MIRT1271723	hsa-miR-2276	CLIP-seq
MIRT1271724	hsa-miR-298	CLIP-seq
MIRT1271725	hsa-miR-300	CLIP-seq
MIRT1271726	hsa-miR-3116	CLIP-seq
MIRT1271727	hsa-miR-3119	CLIP-seq
MIRT1271728	hsa-miR-3135b	CLIP-seq
MIRT1271729	hsa-miR-3154	CLIP-seq
MIRT1271730	hsa-miR-3164	CLIP-seq
MIRT1271731	hsa-miR-3179	CLIP-seq
MIRT1271732	hsa-miR-3180	CLIP-seq
MIRT1271733	hsa-miR-3180-3p	CLIP-seq
MIRT1271734	hsa-miR-3196	CLIP-seq
MIRT1271735	hsa-miR-326	CLIP-seq
MIRT1271736	hsa-miR-330-5p	CLIP-seq
MIRT1271737	hsa-miR-331-3p	CLIP-seq
MIRT1271738	hsa-miR-338-3p	CLIP-seq
MIRT1271739	hsa-miR-342-3p	CLIP-seq
MIRT1271740	hsa-miR-3609	CLIP-seq
MIRT1271741	hsa-miR-3610	CLIP-seq
MIRT1271742	hsa-miR-3622a-5p	CLIP-seq
MIRT1271743	hsa-miR-3646	CLIP-seq
MIRT1271744	hsa-miR-369-3p	CLIP-seq
MIRT1271745	hsa-miR-374a	CLIP-seq
MIRT1271746	hsa-miR-374b	CLIP-seq
MIRT1271747	hsa-miR-374c	CLIP-seq
MIRT1271748	hsa-miR-381	CLIP-seq
MIRT1271749	hsa-miR-3973	CLIP-seq
MIRT1271750	hsa-miR-410	CLIP-seq
MIRT1271751	hsa-miR-4257	CLIP-seq
MIRT1271752	hsa-miR-4267	CLIP-seq
MIRT1271753	hsa-miR-4282	CLIP-seq
MIRT1271754	hsa-miR-429	CLIP-seq
MIRT1271755	hsa-miR-4292	CLIP-seq
MIRT1271756	hsa-miR-4423-3p	CLIP-seq
MIRT1271684	hsa-miR-4474-3p	CLIP-seq
MIRT1271757	hsa-miR-448	CLIP-seq
MIRT1271758	hsa-miR-4488	CLIP-seq
MIRT1271759	hsa-miR-450b-5p	CLIP-seq
MIRT1271760	hsa-miR-4632	CLIP-seq
MIRT1271761	hsa-miR-4670-3p	CLIP-seq
MIRT1271762	hsa-miR-4697-5p	CLIP-seq
MIRT1271763	hsa-miR-4706	CLIP-seq
MIRT1271764	hsa-miR-4711-5p	CLIP-seq
MIRT1271765	hsa-miR-4742-5p	CLIP-seq
MIRT1271766	hsa-miR-4749-3p	CLIP-seq
MIRT1271767	hsa-miR-4749-5p	CLIP-seq
MIRT1271768	hsa-miR-4756-3p	CLIP-seq
MIRT1271769	hsa-miR-4760-5p	CLIP-seq
MIRT1271770	hsa-miR-4768-5p	CLIP-seq
MIRT1271771	hsa-miR-4772-3p	CLIP-seq
MIRT1271772	hsa-miR-4781-5p	CLIP-seq
MIRT1271773	hsa-miR-4796-3p	CLIP-seq
MIRT1271774	hsa-miR-4797-5p	CLIP-seq
MIRT1271775	hsa-miR-486-3p	CLIP-seq
MIRT1271776	hsa-miR-503	CLIP-seq
MIRT1271695	hsa-miR-506	CLIP-seq
MIRT1271777	hsa-miR-507	CLIP-seq
MIRT1271778	hsa-miR-513b	CLIP-seq
MIRT1271779	hsa-miR-518a-5p	CLIP-seq
MIRT1271780	hsa-miR-519d	CLIP-seq
MIRT1271781	hsa-miR-527	CLIP-seq
MIRT1271782	hsa-miR-548a-3p	CLIP-seq
MIRT1271783	hsa-miR-548ac	CLIP-seq
MIRT1271784	hsa-miR-548ag	CLIP-seq
MIRT1271785	hsa-miR-548ah	CLIP-seq
MIRT1271786	hsa-miR-548ai	CLIP-seq
MIRT1271787	hsa-miR-548d-3p	CLIP-seq
MIRT1271788	hsa-miR-548e	CLIP-seq
MIRT1271789	hsa-miR-548f	CLIP-seq
MIRT1271790	hsa-miR-548h	CLIP-seq
MIRT1271791	hsa-miR-548j	CLIP-seq
MIRT1271792	hsa-miR-548l	CLIP-seq
MIRT1271793	hsa-miR-548t	CLIP-seq
MIRT1271794	hsa-miR-548z	CLIP-seq
MIRT1271795	hsa-miR-553	CLIP-seq
MIRT1271796	hsa-miR-555	CLIP-seq
MIRT1271797	hsa-miR-557	CLIP-seq
MIRT1271798	hsa-miR-613	CLIP-seq
MIRT1271799	hsa-miR-615-5p	CLIP-seq
MIRT1271800	hsa-miR-624	CLIP-seq
MIRT1271801	hsa-miR-637	CLIP-seq
MIRT1271802	hsa-miR-655	CLIP-seq
MIRT1271803	hsa-miR-661	CLIP-seq
MIRT1271804	hsa-miR-663	CLIP-seq
MIRT1271805	hsa-miR-875-3p	CLIP-seq
MIRT1271806	hsa-miR-891b	CLIP-seq
MIRT1271807	hsa-miR-93	CLIP-seq
MIRT1271808	hsa-miR-939	CLIP-seq
MIRT1271699	hsa-miR-1	CLIP-seq
MIRT1271702	hsa-miR-1207-3p	CLIP-seq
MIRT1271690	hsa-miR-124	CLIP-seq
MIRT2079865	hsa-miR-125b	CLIP-seq
MIRT2079866	hsa-miR-1266	CLIP-seq
MIRT1271706	hsa-miR-1299	CLIP-seq
MIRT1271707	hsa-miR-133a	CLIP-seq
MIRT1271713	hsa-miR-191	CLIP-seq
MIRT2079867	hsa-miR-1914	CLIP-seq
MIRT1271716	hsa-miR-200b	CLIP-seq
MIRT1271717	hsa-miR-200c	CLIP-seq
MIRT1271718	hsa-miR-206	CLIP-seq
MIRT1271721	hsa-miR-210	CLIP-seq
MIRT1271722	hsa-miR-2117	CLIP-seq
MIRT1271723	hsa-miR-2276	CLIP-seq
MIRT1271735	hsa-miR-326	CLIP-seq
MIRT1271736	hsa-miR-330-5p	CLIP-seq
MIRT2079868	hsa-miR-339-5p	CLIP-seq
MIRT1271741	hsa-miR-3610	CLIP-seq
MIRT2079869	hsa-miR-3672	CLIP-seq
MIRT1271744	hsa-miR-369-3p	CLIP-seq
MIRT1271745	hsa-miR-374a	CLIP-seq
MIRT1271746	hsa-miR-374b	CLIP-seq
MIRT1271747	hsa-miR-374c	CLIP-seq
MIRT1271749	hsa-miR-3973	CLIP-seq
MIRT2079870	hsa-miR-3974	CLIP-seq
MIRT1271750	hsa-miR-410	CLIP-seq
MIRT1271753	hsa-miR-4282	CLIP-seq
MIRT2079871	hsa-miR-4283	CLIP-seq
MIRT1271754	hsa-miR-429	CLIP-seq
MIRT2079872	hsa-miR-4486	CLIP-seq
MIRT2079873	hsa-miR-4508	CLIP-seq
MIRT2079874	hsa-miR-4639-5p	CLIP-seq
MIRT2079875	hsa-miR-4655-5p	CLIP-seq
MIRT2079876	hsa-miR-4662a-3p	CLIP-seq
MIRT1271768	hsa-miR-4756-3p	CLIP-seq
MIRT1271770	hsa-miR-4768-5p	CLIP-seq
MIRT1271771	hsa-miR-4772-3p	CLIP-seq
MIRT1271774	hsa-miR-4797-5p	CLIP-seq
MIRT1271695	hsa-miR-506	CLIP-seq
MIRT1271778	hsa-miR-513b	CLIP-seq
MIRT1271779	hsa-miR-518a-5p	CLIP-seq
MIRT1271781	hsa-miR-527	CLIP-seq
MIRT1271792	hsa-miR-548l	CLIP-seq
MIRT1271796	hsa-miR-555	CLIP-seq
MIRT2079877	hsa-miR-592	CLIP-seq
MIRT2079878	hsa-miR-597	CLIP-seq
MIRT1271687	hsa-miR-599	CLIP-seq
MIRT1271798	hsa-miR-613	CLIP-seq
MIRT1271802	hsa-miR-655	CLIP-seq
MIRT2079879	hsa-miR-670	CLIP-seq
MIRT1271805	hsa-miR-875-3p	CLIP-seq
MIRT1271806	hsa-miR-891b	CLIP-seq
MIRT2079880	hsa-miR-9	CLIP-seq
MIRT1271699	hsa-miR-1	CLIP-seq
MIRT1271702	hsa-miR-1207-3p	CLIP-seq
MIRT2306180	hsa-miR-1224-3p	CLIP-seq
MIRT2306181	hsa-miR-1225-3p	CLIP-seq
MIRT1271690	hsa-miR-124	CLIP-seq
MIRT1271704	hsa-miR-1254	CLIP-seq
MIRT1271691	hsa-miR-125a-3p	CLIP-seq
MIRT1271705	hsa-miR-1291	CLIP-seq
MIRT1271706	hsa-miR-1299	CLIP-seq
MIRT2306182	hsa-miR-1321	CLIP-seq
MIRT1271707	hsa-miR-133a	CLIP-seq
MIRT1271708	hsa-miR-137	CLIP-seq
MIRT1271711	hsa-miR-1827	CLIP-seq
MIRT1271712	hsa-miR-1908	CLIP-seq
MIRT1271713	hsa-miR-191	CLIP-seq
MIRT1271714	hsa-miR-193b	CLIP-seq
MIRT1271716	hsa-miR-200b	CLIP-seq
MIRT1271717	hsa-miR-200c	CLIP-seq
MIRT1271718	hsa-miR-206	CLIP-seq
MIRT1271721	hsa-miR-210	CLIP-seq
MIRT1271723	hsa-miR-2276	CLIP-seq
MIRT1271724	hsa-miR-298	CLIP-seq
MIRT1271725	hsa-miR-300	CLIP-seq
MIRT1271726	hsa-miR-3116	CLIP-seq
MIRT1271728	hsa-miR-3135b	CLIP-seq
MIRT1271729	hsa-miR-3154	CLIP-seq
MIRT1271730	hsa-miR-3164	CLIP-seq
MIRT1271731	hsa-miR-3179	CLIP-seq
MIRT1271732	hsa-miR-3180	CLIP-seq
MIRT1271733	hsa-miR-3180-3p	CLIP-seq
MIRT1271734	hsa-miR-3196	CLIP-seq
MIRT1271735	hsa-miR-326	CLIP-seq
MIRT1271736	hsa-miR-330-5p	CLIP-seq
MIRT1271737	hsa-miR-331-3p	CLIP-seq
MIRT2306183	hsa-miR-335	CLIP-seq
MIRT1271738	hsa-miR-338-3p	CLIP-seq
MIRT1271742	hsa-miR-3622a-5p	CLIP-seq
MIRT2306184	hsa-miR-3622b-5p	CLIP-seq
MIRT1271692	hsa-miR-3665	CLIP-seq
MIRT1271744	hsa-miR-369-3p	CLIP-seq
MIRT2306185	hsa-miR-371-5p	CLIP-seq
MIRT2306186	hsa-miR-371b-5p	CLIP-seq
MIRT1271745	hsa-miR-374a	CLIP-seq
MIRT1271746	hsa-miR-374b	CLIP-seq
MIRT1271747	hsa-miR-374c	CLIP-seq
MIRT1271748	hsa-miR-381	CLIP-seq
MIRT2306187	hsa-miR-3943	CLIP-seq
MIRT1271749	hsa-miR-3973	CLIP-seq
MIRT1271750	hsa-miR-410	CLIP-seq
MIRT1271751	hsa-miR-4257	CLIP-seq
MIRT1271752	hsa-miR-4267	CLIP-seq
MIRT1271754	hsa-miR-429	CLIP-seq
MIRT1271755	hsa-miR-4292	CLIP-seq
MIRT2306188	hsa-miR-4293	CLIP-seq
MIRT2306189	hsa-miR-4305	CLIP-seq
MIRT1271693	hsa-miR-4418	CLIP-seq
MIRT1271756	hsa-miR-4423-3p	CLIP-seq
MIRT1271684	hsa-miR-4474-3p	CLIP-seq
MIRT1271758	hsa-miR-4488	CLIP-seq
MIRT1271694	hsa-miR-4493	CLIP-seq
MIRT2079873	hsa-miR-4508	CLIP-seq
MIRT1271762	hsa-miR-4697-5p	CLIP-seq
MIRT2306190	hsa-miR-4700-3p	CLIP-seq
MIRT2306191	hsa-miR-4704-3p	CLIP-seq
MIRT1271763	hsa-miR-4706	CLIP-seq
MIRT1271764	hsa-miR-4711-5p	CLIP-seq
MIRT2306192	hsa-miR-4739	CLIP-seq
MIRT1271765	hsa-miR-4742-5p	CLIP-seq
MIRT2306193	hsa-miR-4747-5p	CLIP-seq
MIRT1271767	hsa-miR-4749-5p	CLIP-seq
MIRT1271768	hsa-miR-4756-3p	CLIP-seq
MIRT2306194	hsa-miR-4756-5p	CLIP-seq
MIRT2306195	hsa-miR-4758-3p	CLIP-seq
MIRT1271769	hsa-miR-4760-5p	CLIP-seq
MIRT1271771	hsa-miR-4772-3p	CLIP-seq
MIRT1271772	hsa-miR-4781-5p	CLIP-seq
MIRT1271774	hsa-miR-4797-5p	CLIP-seq
MIRT1271775	hsa-miR-486-3p	CLIP-seq
MIRT1271776	hsa-miR-503	CLIP-seq
MIRT1271695	hsa-miR-506	CLIP-seq
MIRT1271696	hsa-miR-509-3-5p	CLIP-seq
MIRT1271697	hsa-miR-509-5p	CLIP-seq
MIRT2306196	hsa-miR-513c	CLIP-seq
MIRT2306197	hsa-miR-514b-5p	CLIP-seq
MIRT1271779	hsa-miR-518a-5p	CLIP-seq
MIRT1271781	hsa-miR-527	CLIP-seq
MIRT1271784	hsa-miR-548ag	CLIP-seq
MIRT1271786	hsa-miR-548ai	CLIP-seq
MIRT1271792	hsa-miR-548l	CLIP-seq
MIRT1271795	hsa-miR-553	CLIP-seq
MIRT1271798	hsa-miR-613	CLIP-seq
MIRT1271799	hsa-miR-615-5p	CLIP-seq
MIRT1271800	hsa-miR-624	CLIP-seq
MIRT1271801	hsa-miR-637	CLIP-seq
MIRT1271698	hsa-miR-645	CLIP-seq
MIRT1271802	hsa-miR-655	CLIP-seq
MIRT1271803	hsa-miR-661	CLIP-seq
MIRT1271804	hsa-miR-663	CLIP-seq
MIRT2306198	hsa-miR-765	CLIP-seq
MIRT1271805	hsa-miR-875-3p	CLIP-seq
MIRT1271806	hsa-miR-891b	CLIP-seq
MIRT1271808	hsa-miR-939	CLIP-seq
MIRT1271706	hsa-miR-1299	CLIP-seq
MIRT2603469	hsa-miR-134	CLIP-seq
MIRT2603470	hsa-miR-3118	CLIP-seq
MIRT1271730	hsa-miR-3164	CLIP-seq
MIRT1271735	hsa-miR-326	CLIP-seq
MIRT1271736	hsa-miR-330-5p	CLIP-seq
MIRT2603471	hsa-miR-4261	CLIP-seq
MIRT2079872	hsa-miR-4486	CLIP-seq
MIRT2603472	hsa-miR-4722-3p	CLIP-seq
MIRT2603473	hsa-miR-4738-3p	CLIP-seq
MIRT1271805	hsa-miR-875-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MYC	Activation	20010808

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IDA	16260624, 21518792
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	1906036
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	10653975, 11514619, 16189514, 16373488, 16713569, 21911577, 22365833, 25416956, 26871637, 29924966, 31324722, 31515488, 32814053, 36012204, 39009827
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS	1641332
GO:0005730	Component	Nucleolus	TAS	1641332
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	TAS	1906036
GO:0008187	Function	Poly-pyrimidine tract binding	TAS	1906036
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	1906036
GO:0010467	Process	Gene expression	IEA
GO:0010467	Process	Gene expression	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022008	Process	Neurogenesis	IEA
GO:0033119	Process	Negative regulation of RNA splicing	IDA	18335065
GO:0033119	Process	Negative regulation of RNA splicing	IEA
GO:0036002	Function	Pre-mRNA binding	IDA	16260624
GO:0043484	Process	Regulation of RNA splicing	IBA
GO:0045595	Process	Regulation of cell differentiation	IBA
GO:0045665	Process	Negative regulation of neuron differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048025	Process	Negative regulation of mRNA splicing, via spliceosome	IDA	15009664
GO:0048025	Process	Negative regulation of mRNA splicing, via spliceosome	IEA
GO:0051148	Process	Negative regulation of muscle cell differentiation	IDA	21518792
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	IMP	23853098
GO:0075522	Process	IRES-dependent viral translational initiation	IDA	17947529
GO:0075522	Process	IRES-dependent viral translational initiation	IMP	21518806
GO:1903312	Process	Negative regulation of mRNA metabolic process	IEA

Other IDs

• MIM: 600693
• HGNC: 9583
• e!Ensembl: ENSG00000011304

Protein

• UniProt ID: P26599
• Protein name: Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)
• Protein function: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bo
• PDB: 1QM9, 1SJQ, 1SJR, 2AD9, 2ADB, 2ADC, 2EVZ, 2N3O, 3ZZY, 3ZZZ, 8BGF, 8BWF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13893	RRM_5	40 → 152		Domain
  PF00076	RRM_1	186 → 252	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF13893	RRM_5	309 → 433		Domain
  PF00076	RRM_1	456 → 521	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Sequence:

  MDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRV
  IHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPV
  LRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQ
  SPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLS
  LDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFGLS
  VPNVHGALAPLAIPSAAAAAAAAGRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGV
  YGDVQRVKILFNKKENALVQMADGNQAQLAMSHLNGHKLHGKPIRITLSKHQNVQLPREG
  QEDQGLTKDYGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEEDLKVLFSSNGGV
  VKGFKFFQKDRKMALIQMGSVEEAVQALIDLHNHDLGENHHLRVSFSKSTI

• Sequence length: 531

Pathways

Reactome:

FGFR2 alternative splicing
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
PTBP1-related neurodevelopmental disorder with skeletal dysplasia	Pathogenic	rs2145008460, rs1599210325	RCV006252383 RCV006252382

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Gastric cancer	Benign	rs1058275	RCV005913224
Malignant tumor of esophagus	Benign	rs1058275	RCV005913223
Melanoma	Benign	rs1058275	RCV005913225

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	19887373
Adenocarcinoma of Lung	Stimulate	36595978
Adrenocortical Carcinoma	Stimulate	36595978
Alzheimer Disease	Associate	21846794, 31208978
Amyotrophic Lateral Sclerosis	Associate	32217641
Asthma	Associate	37717070
Astrocytoma	Associate	14769134
Autoimmune Diseases	Associate	12509450
Bohring syndrome	Associate	33141183
Bone Cysts Aneurysmal	Associate	33147323
Breast Neoplasms	Associate	22911749, 25913416, 29453318, 38176460
Carcinogenesis	Associate	17310993, 21976412, 26860615, 29453318, 30696738, 31729427, 35651729, 36595978
Carcinoma Hepatocellular	Associate	36529521, 38230456, 40264052
Carcinoma Hepatocellular	Stimulate	36595978
Carcinoma Non Small Cell Lung	Associate	23536791
Carcinoma Ovarian Epithelial	Associate	17310993, 20856201
Carcinoma Pancreatic Ductal	Associate	26234680
Carcinoma Squamous Cell	Associate	36970727
Cell Transformation Neoplastic	Associate	36635500
Cholangiocarcinoma	Associate	36635270
Cognition Disorders	Associate	26566043
Cognitive Dysfunction	Associate	21099291
Colorectal Neoplasms	Associate	26860615, 30219676, 34158864, 36727289, 38273088
Composite Lymphoma	Associate	34862698, 37658696
COVID 19	Associate	38290414
Demyelinating Diseases	Associate	32217641
Diabetes Mellitus	Inhibit	21099291
Diabetes Mellitus	Associate	25927630
Diabetic Nephropathies	Associate	36792603
Duane Retraction Syndrome	Associate	26234680
Embolism Fat	Associate	30901032
Frontotemporal Lobar Degeneration	Associate	36949537
Glioblastoma	Associate	21976412, 24865424, 29415469, 29592812, 33141183, 35871232
Glioma	Associate	14769134, 16729017, 19506066, 21655185, 24286314, 26047657, 31253583, 31862871, 35299889, 36171198
Heart Diseases	Associate	29518215
Helicobacter Infections	Associate	38394397
Hereditary Breast and Ovarian Cancer Syndrome	Associate	29453318
Hirschsprung Disease	Associate	37061531
Inflammation	Associate	26293469, 38394397
Lung Neoplasms	Associate	30568224, 31729427
Medulloblastoma	Associate	14769134
Melanoma	Associate	25169209
Melanoma Cutaneous Malignant	Stimulate	36595978
Mitochondrial Diseases	Inhibit	39206910
Multiple Myeloma	Associate	32655719
Multiple Sclerosis	Associate	32217641
Myasthenic Syndromes Congenital	Associate	19147685
Neoplasm Metastasis	Associate	32991341, 35651729
Neoplasms	Stimulate	16729017, 22972848, 23536791, 32655719, 38394397
Neoplasms	Associate	17310993, 19506066, 21289045, 21976412, 26416554, 26683771, 26860615, 27367564, 30568224, 33141183, 35651729, 36595978, 36635500, 36958328, 39206910, 9166399
Neoplasms	Inhibit	31729427, 36529521
Neuroblastoma	Associate	26683771, 9094658
Neurodegenerative Diseases	Associate	32217641, 33254518
Neuroendocrine Tumors	Associate	32991341, 34862698, 37658696
Osteosarcoma	Associate	33621196
Ovarian Neoplasms	Associate	17310993, 20856201, 22972848
Pancreatic Neoplasms	Associate	31355266
Parkinson Disease	Associate	25646437, 26566043
Parkinson Disease Secondary	Associate	33254518
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	36875548
Prostatic Neoplasms	Associate	33893085
Sarcoma	Associate	35651729
Scleroderma Systemic	Associate	8843857
Stomach Neoplasms	Associate	27696637, 36635500
Urinary Bladder Neoplasms	Associate	28380435
Uterine Cervical Neoplasms	Associate	37042849, 39206910
Uterine Cervicitis	Associate	30696738
Vascular Diseases	Associate	26293469
Wounds and Injuries	Associate	36792603