Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5724
Gene name Gene Name - the full gene name approved by the HGNC.
Platelet activating factor receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTAFR
Synonyms (NCBI Gene) Gene synonyms aliases
PAFR
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p35.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that play
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017043 hsa-miR-335-5p Microarray 18185580
MIRT632521 hsa-miR-4485-5p HITS-CLIP 23824327
MIRT666785 hsa-miR-5193 HITS-CLIP 23824327
MIRT632520 hsa-miR-1281 HITS-CLIP 23824327
MIRT666784 hsa-miR-1307-3p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
NFKB1 Activation 11502209
NR1I2 Activation 19703903
RELA Activation 11502209
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001530 Function Lipopolysaccharide binding IEA
GO:0001875 Function Lipopolysaccharide immune receptor activity IEA
GO:0002693 Process Positive regulation of cellular extravasation IEA
GO:0004930 Function G protein-coupled receptor activity TAS 1322356
GO:0004992 Function Platelet activating factor receptor activity IDA 1281995, 1656963, 1657923
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
173393 9582 ENSG00000169403
Protein
UniProt ID P25105
Protein name Platelet-activating factor receptor (PAF-R) (PAFr)
Protein function Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinosito
PDB 5ZKP , 5ZKQ , 8XYD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 32 293 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes. {ECO:0000269|PubMed:1281995, ECO:0000269|PubMed:1656963, ECO:0000269|PubMed:1657923}.
Sequence
Sequence length 342
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
  Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interleukin-10 signaling
Neutrophil degranulation
Interferon gamma signaling