SLURP1 (secreted LY6/PLAUR domain containing 1)

Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57152
Gene name Gene Name - the full gene name approved by the HGNC.
Secreted LY6/PLAUR domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLURP1
Synonyms (NCBI Gene) Gene synonyms aliases
ANUP, ARS, ArsB, LY6-MT, LY6LS, MDM
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q24.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare aut
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
SNP ID Visualize variation Clinical significance Consequence
rs28937888 C>G,T Pathogenic Coding sequence variant, missense variant
rs28937889 T>G Pathogenic Initiator codon variant, missense variant
rs62636565 A>G Conflicting-interpretations-of-pathogenicity Terminator codon variant, stop lost
rs121908317 G>A,C Pathogenic Missense variant, stop gained, coding sequence variant
rs121908318 A>G Pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(13)
miRTarBase ID miRNA Experiments Reference
MIRT2109929 hsa-miR-1227 CLIP-seq
MIRT2109930 hsa-miR-15a CLIP-seq
MIRT2109931 hsa-miR-15b CLIP-seq
MIRT2109932 hsa-miR-16 CLIP-seq
MIRT2109933 hsa-miR-1909 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
GO ID Ontology Definition Evidence Reference
GO:0001775 Process Cell activation NAS 11285253
GO:0005125 Function Cytokine activity IEA
GO:0005125 Function Cytokine activity NAS 8742060
GO:0005515 Function Protein binding IPI 25168896, 26905431, 33961781
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
606119 18746 ENSG00000126233
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P55000
Protein name Secreted Ly-6/uPAR-related protein 1 (SLURP-1) (ARS component B) (ARS(component B)-81/S) (Anti-neoplastic urinary protein) (ANUP)
Protein function Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:170088
PDB 6ZZE , 6ZZF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00021 UPAR_LY6 25 → 100 u-PAR/Ly-6 domain Domain
Tissue specificity TISSUE SPECIFICITY: Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine. {ECO:0000269|PubMed:14721776, EC
Sequence
Sequence length 103
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Neuroactive ligand-receptor interaction  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
acroerythrokeratoderma Acroerythrokeratoderma rs121908317, rs28937888, rs28937889, rs121908318, rs121908319, rs121908320, rs587776601, rs587776602 N/A
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Palmoplantar Keratosis palmoplantar keratosis N/A N/A GenCC
Show/Hide Text Mining Associations (18)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Carcinogenesis Associate 22369755
Cholestasis Stimulate 21779339
Death Associate 37752437
Dermatomyositis Associate 33305541
Dystonic Disorders Associate 31443639
Eosinophilic Esophagitis Associate 23503644
Gastroesophageal Reflux Associate 23503644
Genetic Diseases Inborn Associate 24093092
Infections Associate 19115125
Inflammation Associate 19115125