Gene Gene information from NCBI Gene database.
Entrez ID 57142
Gene name Reticulon 4
Gene symbol RTN4
Synonyms (NCBI Gene)
ASYNI220/250NOGONOGOANOGOBNSPNSP-CLNbla00271Nbla10545RTN-XRTN4-ARTN4-B1RTN4-B2RTN4-C
Chromosome 2
Chromosome location 2p16.1
Summary This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent ne
miRNA miRNA information provided by mirtarbase database.
896
miRTarBase ID miRNA Experiments Reference
MIRT000167 hsa-miR-21-5p Luciferase reporter assayQuantitative proteomic approach 19253296
MIRT001421 hsa-miR-16-5p pSILAC 18668040
MIRT019491 hsa-miR-148b-3p Microarray 17612493
MIRT021845 hsa-miR-132-3p Microarray 17612493
MIRT024991 hsa-miR-183-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
87
GO ID Ontology Definition Evidence Reference
GO:0001825 Process Blastocyst formation IEA
GO:0002523 Process Leukocyte migration involved in inflammatory response ISS
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 11126360, 15286784, 16189514, 16752908, 16965550, 19665976, 21516116, 22119785, 25416956, 25612671, 26906412, 29892012, 31515488, 32075961, 32296183, 33826365, 33961781, 35271311
GO:0005635 Component Nuclear envelope IDA 11126360
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604475 14085 ENSG00000115310
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NQC3
Protein name Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)
Protein function Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, Pub
PDB 2G31 , 2JV5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02453 Reticulon 1005 1169 Reticulon Family
Tissue specificity TISSUE SPECIFICITY: Isoform A: is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform B: widely expressed except for the liver. Highly expressed in endothelial cells and vascular smooth muscle cells, including blood
Sequence
MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA
AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP
SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG
SSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAGQEDFPSVLLETAASLPSLSP
LSAASFKEHEYLGNLSTVLPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEM
GSSFSVSPKAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVV
SSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKV
DKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIF
PLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTE
EVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSF
EESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYE
EAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSE
MAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMI
EYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVY
SNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEI
ANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALAT
QAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVV
FGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESE
VAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTL
LILALISLFSVPVIYERHQAQIDHYLGLA
NKNVKDAMAKIQAKIPGLKRKAE
Sequence length 1192
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Alzheimer disease   Axonal growth inhibition (RHOA activation)
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Clear cell carcinoma of kidney Uncertain significance rs148322379 RCV005939181
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Stimulate 25912905
Angina Stable Stimulate 25912905
Atherosclerosis Inhibit 19654939
Attention Deficit Disorder with Hyperactivity Associate 27364329
Breast Neoplasms Associate 24223763
Carcinogenesis Associate 24966913
Carcinoma Hepatocellular Inhibit 24966913
Carcinoma Hepatocellular Associate 28144881
Carcinoma Non Small Cell Lung Associate 25040983, 28144881
Carcinoma Non Small Cell Lung Stimulate 37569873