RGL3 (ral guanine nucleotide dissociation stimulator like 3)

Gene

• Entrez ID: 57139
• Gene name: Ral guanine nucleotide dissociation stimulator like 3
• Gene symbol: RGL3
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2089933	hsa-miR-1226	CLIP-seq
MIRT2089934	hsa-miR-3670	CLIP-seq
MIRT2089935	hsa-miR-4691-3p	CLIP-seq
MIRT2314769	hsa-miR-128	CLIP-seq
MIRT2314770	hsa-miR-1343	CLIP-seq
MIRT2314771	hsa-miR-3150a-3p	CLIP-seq
MIRT2314772	hsa-miR-3175	CLIP-seq
MIRT2314773	hsa-miR-326	CLIP-seq
MIRT2314774	hsa-miR-330-5p	CLIP-seq
MIRT2314775	hsa-miR-3663-5p	CLIP-seq
MIRT2314776	hsa-miR-3677-5p	CLIP-seq
MIRT2314777	hsa-miR-4667-5p	CLIP-seq
MIRT2314778	hsa-miR-4672	CLIP-seq
MIRT2314779	hsa-miR-4700-5p	CLIP-seq
MIRT2314780	hsa-miR-4728-5p	CLIP-seq
MIRT2314781	hsa-miR-4757-5p	CLIP-seq
MIRT2314782	hsa-miR-4768-5p	CLIP-seq
MIRT2314783	hsa-miR-618	CLIP-seq
MIRT2314784	hsa-miR-637	CLIP-seq
MIRT2314785	hsa-miR-668	CLIP-seq
MIRT2314786	hsa-miR-939	CLIP-seq
MIRT2089933	hsa-miR-1226	CLIP-seq
MIRT2089934	hsa-miR-3670	CLIP-seq
MIRT2089935	hsa-miR-4691-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0007264	Process	Small GTPase mediated signal transduction	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IEA

Other IDs

• MIM: 616743
• HGNC: 30282
• e!Ensembl: ENSG00000205517

Protein

• UniProt ID: Q3MIN7
• Protein name: Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3)
• Protein function: Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00618	RasGEF_N	68 → 174	RasGEF N-terminal motif	Domain
  PF00617	RasGEF	250 → 453	RasGEF domain	Family
  PF00788	RA	613 → 700	Ras association (RalGDS/AF-6) domain	Domain

• Sequence:

  MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH
  YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP
  PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP
  GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG
  PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
  VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR
  SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP
  VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI
  LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS
  PGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLG
  SPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACD
  YQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS

• Sequence length: 710

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Hypertension	Hypertensive disease	rs13306026	27618448, 27618447

Unknown
Disease term	Disease name	Evidence	References	Source
Coronary artery disease	Coronary artery disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Glaucoma	Associate	36833422
Glaucoma Angle Closure	Associate	36833422
Hypertension	Associate	37175507
Pre Eclampsia	Associate	37285119
Pulmonary Arterial Hypertension	Associate	37176017