Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57055
Gene name Gene Name - the full gene name approved by the HGNC.	Deleted in azoospermia 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DAZ2
Synonyms (NCBI Gene) Gene synonyms aliases	pDP1678
Chromosome Chromosome number	Y
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Yq11.223
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important

Show/Hide all(39)

miRTarBase ID	miRNA	Experiments
MIRT923348	hsa-miR-1270	CLIP-seq
MIRT923349	hsa-miR-203	CLIP-seq
MIRT923350	hsa-miR-3140-5p	CLIP-seq
MIRT923351	hsa-miR-3682-5p	CLIP-seq
MIRT923352	hsa-miR-3923	CLIP-seq
MIRT923353	hsa-miR-4276	CLIP-seq
MIRT923354	hsa-miR-4302	CLIP-seq
MIRT923355	hsa-miR-432	CLIP-seq
MIRT923356	hsa-miR-4434	CLIP-seq
MIRT923357	hsa-miR-4516	CLIP-seq
MIRT923358	hsa-miR-4531	CLIP-seq
MIRT923359	hsa-miR-4766-5p	CLIP-seq
MIRT923360	hsa-miR-548u	CLIP-seq
MIRT923361	hsa-miR-561	CLIP-seq
MIRT923362	hsa-miR-620	CLIP-seq
MIRT923363	hsa-miR-628-3p	CLIP-seq
MIRT923364	hsa-let-7a	CLIP-seq
MIRT923365	hsa-let-7b	CLIP-seq
MIRT923366	hsa-let-7c	CLIP-seq
MIRT923367	hsa-let-7d	CLIP-seq
MIRT923368	hsa-let-7e	CLIP-seq
MIRT923369	hsa-let-7f	CLIP-seq
MIRT923370	hsa-let-7g	CLIP-seq
MIRT923371	hsa-let-7i	CLIP-seq
MIRT923372	hsa-miR-1304	CLIP-seq
MIRT923373	hsa-miR-202	CLIP-seq
MIRT923374	hsa-miR-3140-3p	CLIP-seq
MIRT923375	hsa-miR-4458	CLIP-seq
MIRT923376	hsa-miR-4500	CLIP-seq
MIRT923377	hsa-miR-4777-5p	CLIP-seq
MIRT923378	hsa-miR-513a-3p	CLIP-seq
MIRT923379	hsa-miR-518d-5p	CLIP-seq
MIRT923380	hsa-miR-519b-5p	CLIP-seq
MIRT923381	hsa-miR-519c-5p	CLIP-seq
MIRT923382	hsa-miR-520c-5p	CLIP-seq
MIRT923383	hsa-miR-526a	CLIP-seq
MIRT923384	hsa-miR-98	CLIP-seq
MIRT923385	hsa-miR-4733-5p	CLIP-seq
MIRT923386	hsa-miR-606	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	TAS	7670487
GO:0003730	Function	MRNA 3'-UTR binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10857750
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0007275	Process	Multicellular organism development	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007338	Process	Single fertilization	TAS	8896558
GO:0008494	Function	Translation activator activity	IBA	21873635
GO:0030154	Process	Cell differentiation	IEA
GO:0032991	Component	Protein-containing complex	IDA	10857750
GO:0045948	Process	Positive regulation of translational initiation	IBA	21873635
GO:0070935	Process	3'-UTR-mediated mRNA stabilization	IBA	21873635

MIM	HGNC	e!Ensembl
400026	15964	ENSG00000205944

Protein

UniProt ID

Q13117

Protein name

Deleted in azoospermia protein 2

Protein function

RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	42 → 109	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF18872	Daz	170 → 190	Daz repeat	Repeat
PF18872	Daz	194 → 214	Daz repeat	Repeat
PF18872	Daz	218 → 238	Daz repeat	Repeat
PF18872	Daz	242 → 262	Daz repeat	Repeat
PF18872	Daz	266 → 286	Daz repeat	Repeat
PF18872	Daz	290 → 310	Daz repeat	Repeat
PF18872	Daz	314 → 334	Daz repeat	Repeat
PF18872	Daz	338 → 358	Daz repeat	Repeat
PF18872	Daz	362 → 382	Daz repeat	Repeat
PF18872	Daz	386 → 406	Daz repeat	Repeat
PF18872	Daz	410 → 430	Daz repeat	Repeat
PF18872	Daz	434 → 454	Daz repeat	Repeat
PF18872	Daz	458 → 478	Daz repeat	Repeat
PF18872	Daz	482 → 502	Daz repeat	Repeat
PF18872	Daz	506 → 526	Daz repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:10936047}.

Sequence

MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCF
GRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLC
ARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVIT
GCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAF
PAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVAT
GYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAF
PAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTT
GYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAF
PAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNL
WTEAYKWWYLVCLIQRRD

Sequence length

558

Interactions

View interactions

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID
Causal
Azoospermia	Azoospermia	rs200969445, rs144567652, rs765353898
Cryptorchidism	Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886
Non-obstructive azoospermia	Non-obstructive azoospermia	rs587777872, rs879253743, rs1600840291, rs1600877766, rs753462162, rs1588618614, rs1602684496, rs377712900
Oligospermia	Oligospermia	rs1602125411, rs377712900

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Infertility Male	Associate	15744033, 37365340
Sertoli Cell Only Syndrome	Associate	20823911
Spermatogenic Failure Nonobstructive Y Linked	Associate	15744033, 16580401

DAZ2 (deleted in azoospermia 2)