Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	57016
Gene name	Aldo-keto reductase family 1 member B10
Gene symbol	AKR1B10
Synonyms (NCBI Gene)	AKR1B11AKR1B12ALDRLnARL-1ARL1HISHSI
Chromosome	7
Chromosome location	7q33
Summary	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021442	hsa-miR-9-5p	Microarray	17612493
MIRT021503	hsa-miR-145-5p	Reporter assay;Microarray	21351259
MIRT027833	hsa-miR-98-5p	Microarray	19088304
MIRT510048	hsa-miR-3123	PAR-CLIP	20371350
MIRT510047	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT510046	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT510045	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT510044	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT510043	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT510042	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT510040	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT510041	hsa-miR-6760-5p	PAR-CLIP	20371350
MIRT510039	hsa-miR-3919	PAR-CLIP	20371350
MIRT510038	hsa-miR-922	PAR-CLIP	20371350
MIRT510037	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT510048	hsa-miR-3123	PAR-CLIP	20371350
MIRT510047	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT510046	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT510045	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT510044	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT510043	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT510042	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT510040	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT564349	hsa-miR-3940-3p	PAR-CLIP	20371350
MIRT510041	hsa-miR-6760-5p	PAR-CLIP	20371350
MIRT510039	hsa-miR-3919	PAR-CLIP	20371350
MIRT510038	hsa-miR-922	PAR-CLIP	20371350
MIRT564348	hsa-miR-7515	PAR-CLIP	20371350
MIRT564347	hsa-miR-3179	PAR-CLIP	20371350
MIRT510037	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT564346	hsa-miR-6864-5p	PAR-CLIP	20371350
MIRT510048	hsa-miR-3123	PAR-CLIP	23446348
MIRT510047	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT510046	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT510045	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT510044	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT510043	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT510042	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT510040	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT510041	hsa-miR-6760-5p	PAR-CLIP	23446348
MIRT510039	hsa-miR-3919	PAR-CLIP	23446348
MIRT510038	hsa-miR-922	PAR-CLIP	23446348
MIRT510037	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT498198	hsa-miR-142-3p	PAR-CLIP	22291592
MIRT498197	hsa-miR-452-5p	PAR-CLIP	22291592
MIRT498196	hsa-miR-4676-3p	PAR-CLIP	22291592
MIRT498195	hsa-miR-892c-3p	PAR-CLIP	22291592
MIRT498194	hsa-miR-1244	PAR-CLIP	22291592
MIRT498193	hsa-miR-648	PAR-CLIP	22291592
MIRT498192	hsa-miR-628-3p	PAR-CLIP	22291592
MIRT498191	hsa-miR-325	PAR-CLIP	22291592
MIRT498190	hsa-miR-548ao-5p	PAR-CLIP	22291592
MIRT498189	hsa-miR-548ax	PAR-CLIP	22291592
MIRT498188	hsa-miR-5585-5p	PAR-CLIP	22291592
MIRT498187	hsa-miR-3136-5p	PAR-CLIP	22291592
MIRT498186	hsa-miR-4439	PAR-CLIP	22291592
MIRT498185	hsa-miR-943	PAR-CLIP	22291592
MIRT498184	hsa-miR-3611	PAR-CLIP	22291592
MIRT510048	hsa-miR-3123	PAR-CLIP	20371350
MIRT510047	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT510046	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT510045	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT510044	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT510043	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT510042	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT510040	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT510041	hsa-miR-6760-5p	PAR-CLIP	20371350
MIRT510039	hsa-miR-3919	PAR-CLIP	20371350
MIRT510038	hsa-miR-922	PAR-CLIP	20371350
MIRT510037	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT510048	hsa-miR-3123	PAR-CLIP	20371350
MIRT510047	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT510046	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT510045	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT510044	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT510043	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT510042	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT510040	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT564349	hsa-miR-3940-3p	PAR-CLIP	20371350
MIRT510041	hsa-miR-6760-5p	PAR-CLIP	20371350
MIRT510039	hsa-miR-3919	PAR-CLIP	20371350
MIRT510038	hsa-miR-922	PAR-CLIP	20371350
MIRT564348	hsa-miR-7515	PAR-CLIP	20371350
MIRT564347	hsa-miR-3179	PAR-CLIP	20371350
MIRT510037	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT564346	hsa-miR-6864-5p	PAR-CLIP	20371350
MIRT510048	hsa-miR-3123	PAR-CLIP	23446348
MIRT510047	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT510046	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT510045	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT510044	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT510043	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT510042	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT510040	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT510041	hsa-miR-6760-5p	PAR-CLIP	23446348
MIRT510039	hsa-miR-3919	PAR-CLIP	23446348
MIRT510038	hsa-miR-922	PAR-CLIP	23446348
MIRT510037	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT498198	hsa-miR-142-3p	PAR-CLIP	22291592
MIRT498197	hsa-miR-452-5p	PAR-CLIP	22291592
MIRT498196	hsa-miR-4676-3p	PAR-CLIP	22291592
MIRT498195	hsa-miR-892c-3p	PAR-CLIP	22291592
MIRT498194	hsa-miR-1244	PAR-CLIP	22291592
MIRT498193	hsa-miR-648	PAR-CLIP	22291592
MIRT498192	hsa-miR-628-3p	PAR-CLIP	22291592
MIRT498191	hsa-miR-325	PAR-CLIP	22291592
MIRT498190	hsa-miR-548ao-5p	PAR-CLIP	22291592
MIRT498189	hsa-miR-548ax	PAR-CLIP	22291592
MIRT498188	hsa-miR-5585-5p	PAR-CLIP	22291592
MIRT498187	hsa-miR-3136-5p	PAR-CLIP	22291592
MIRT498186	hsa-miR-4439	PAR-CLIP	22291592
MIRT498185	hsa-miR-943	PAR-CLIP	22291592
MIRT498184	hsa-miR-3611	PAR-CLIP	22291592

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IDA	12732097
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0001758	Function	Retinal dehydrogenase (NAD+) activity	IDA	21851338
GO:0004032	Function	Aldose reductase (NADPH) activity	IBA
GO:0005515	Function	Protein binding	IPI	18056116, 21044950, 33961781
GO:0005576	Component	Extracellular region	IDA	21585341
GO:0005576	Component	Extracellular region	IEA
GO:0005739	Component	Mitochondrion	IBA
GO:0005764	Component	Lysosome	IDA	21585341
GO:0005764	Component	Lysosome	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008106	Function	Alcohol dehydrogenase (NADP+) activity	IDA	19013440
GO:0008106	Function	Alcohol dehydrogenase (NADP+) activity	TAS	9565553
GO:0016488	Process	Farnesol catabolic process	IDA	21187079
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0042572	Process	Retinol metabolic process	IEA
GO:0044597	Process	Daunorubicin metabolic process	IMP	20837989
GO:0044598	Process	Doxorubicin metabolic process	IMP	20837989
GO:0045550	Function	Geranylgeranyl reductase activity	IDA	21187079
GO:0047655	Function	Allyl-alcohol dehydrogenase activity	IEA
GO:0047718	Function	Indanol dehydrogenase activity	IDA	20837989
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	IDA	12732097
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	IEA
GO:0110095	Process	Cellular detoxification of aldehyde	IDA	19013440, 19563777

MIM	HGNC	e!Ensembl
604707	382	ENSG00000198074

O60218

Protein name

Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase)

Protein function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity t

PDB

1ZUA , 4GA8 , 4GAB , 4GQ0 , 4GQG , 4I5X , 4ICC , 4JIH , 4JII , 4WEV , 4XZL , 4XZM , 4XZN , 5LIK , 5LIU , 5LIW , 5LIX , 5LIY , 5M2F , 5Y7N

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00248	Aldo_ket_red	15 → 294	Aldo/keto reductase family	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. {ECO:0000269|PubMed:9565553}.

Sequence

MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ
EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD
DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
VLQSSHLEDYPFNAEY

Sequence length

316

Interactions

View interactions

	KEGG		Reactome
	Pentose and glucuronate interconversions Fructose and mannose metabolism Galactose metabolism Glycerolipid metabolism Folate biosynthesis Metabolic pathways		Retinoid metabolism and transport

AKR1B10 (aldo-keto reductase family 1 member B10)