AKR1B10 (aldo-keto reductase family 1 member B10)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57016
Gene name Gene Name - the full gene name approved by the HGNC.
Aldo-keto reductase family 1 member B10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AKR1B10
Synonyms (NCBI Gene) Gene synonyms aliases
AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(113)
miRTarBase ID miRNA Experiments Reference
MIRT021442 hsa-miR-9-5p Microarray 17612493
MIRT021503 hsa-miR-145-5p Reporter assay;Microarray 21351259
MIRT027833 hsa-miR-98-5p Microarray 19088304
MIRT510048 hsa-miR-3123 PAR-CLIP 20371350
MIRT510047 hsa-miR-15a-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(27)
GO ID Ontology Definition Evidence Reference
GO:0001523 Process Retinoid metabolic process IDA 12732097
GO:0001523 Process Retinoid metabolic process TAS
GO:0001758 Function Retinal dehydrogenase (NAD+) activity IDA 21851338
GO:0004032 Function Aldose reductase (NADPH) activity IBA
GO:0005515 Function Protein binding IPI 18056116, 21044950, 33961781
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604707 382 ENSG00000198074
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O60218
Protein name Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase)
Protein function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity t
PDB 1ZUA , 4GA8 , 4GAB , 4GQ0 , 4GQG , 4I5X , 4ICC , 4JIH , 4JII , 4WEV , 4XZL , 4XZM , 4XZN , 5LIK , 5LIU , 5LIW , 5LIX , 5LIY , 5M2F , 5Y7N
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00248 Aldo_ket_red 15 → 294 Aldo/keto reductase family Domain
Tissue specificity TISSUE SPECIFICITY: Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. {ECO:0000269|PubMed:9565553}.
Sequence
Sequence length 316
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Folate biosynthesis
Metabolic pathways 		  Retinoid metabolism and transport
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Hypertension Hypertension (confirmatory factor analysis Factor 12), Hypertension N/A N/A GWAS
Lung adenocarcinoma Familial lung adenocarcinoma N/A N/A GWAS
Show/Hide Text Mining Associations (56)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 19028477
Adenocarcinoma Inhibit 21829465
Adenocarcinoma of Lung Associate 18788756, 19236911, 30253058
Adrenocortical Carcinoma Inhibit 34027794
Bladder Exstrophy Associate 37509153
Brain Neoplasms Associate 31034948
Breast Neoplasms Associate 10864204, 18056116, 19028477, 24217247, 35807227, 37389562
Breast Neoplasms Stimulate 22014576, 28402270
Calcinosis Cutis Associate 26516929
Carcinogenesis Associate 18788756, 24656094, 28402270