ACKR3 (atypical chemokine receptor 3)

Gene
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57007
Gene name Gene Name - the full gene name approved by the HGNC.
Atypical chemokine receptor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ACKR3
Synonyms (NCBI Gene) Gene synonyms aliases
CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q37.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not b
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
HIC1 Repression 23340301
HIC1 Unknown 19525223
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(39)
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001570 Process Vasculogenesis IEA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0005044 Function Scavenger receptor activity IMP 22300987
GO:0005515 Function Protein binding IPI 19380869, 21730065, 22300987, 22457824, 25775528, 27331810, 28862946, 29386406
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610376 23692 ENSG00000144476
Protein
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P25106
Protein name Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor 159) (G-protein coupled receptor RDC1 homolog) (RDC-1)
Protein function Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation,
PDB 6K3F , 7SK3 , 7SK4 , 7SK5 , 7SK6 , 7SK7 , 7SK8 , 7SK9 , 8TII , 8TIL , 8TIN , 8TIO , 8VJ9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 61 → 315 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and
Sequence
Sequence length 362
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast Cancer Breast cancer in childhood cancer survivors, Triple-negative breast cancer The knockout of the CXCR4 and CXCR7 genes affects the binding capacity and functions of CXCL12, inhibits the malignant progression of TNBC cells significantly, and may become a potential target for the treatment of TNBC. 31190884 GWAS, CBGDA
Pancreatic cancer Pancreatic cancer N/A N/A GWAS
Prostate cancer Prostate cancer The results showed that ACKR3 knockout or S100A4 knockdown was sufficient to reduce Doc-resistant PCa cell viability 31895690 CBGDA
Show/Hide Text Mining Associations (116)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 34905596
Acute Disease Associate 36536281
Adenocarcinoma of Lung Stimulate 35768814
Adenoma Chromophobe Associate 22245330
Adenoma Oxyphilic Associate 22245330
Adrenal Gland Neoplasms Associate 33281749
Adrenocortical Carcinoma Associate 33281749
Allergic Fungal Sinusitis Associate 26996902
Astrocytoma Associate 24970694, 38174684
Atherosclerosis Associate 34905596