Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	56944
Gene name Gene Name - the full gene name approved by the HGNC.	Olfactomedin like 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	OLFML3
Synonyms (NCBI Gene) Gene synonyms aliases	HNOEL-iso, OLF44
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-term

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017928	hsa-miR-335-5p	Microarray	18185580
MIRT1203277	hsa-miR-193a-3p	CLIP-seq
MIRT1203278	hsa-miR-193b	CLIP-seq
MIRT1203279	hsa-miR-3125	CLIP-seq
MIRT1203280	hsa-miR-3136-3p	CLIP-seq
MIRT1203281	hsa-miR-3916	CLIP-seq
MIRT1203282	hsa-miR-4293	CLIP-seq
MIRT1203283	hsa-miR-486-3p	CLIP-seq
MIRT1203284	hsa-miR-596	CLIP-seq
MIRT1203285	hsa-miR-877	CLIP-seq
MIRT2058701	hsa-miR-4722-5p	CLIP-seq
MIRT1203280	hsa-miR-3136-3p	CLIP-seq
MIRT2585209	hsa-miR-3185	CLIP-seq
MIRT2585210	hsa-miR-3591-5p	CLIP-seq
MIRT2585211	hsa-miR-369-3p	CLIP-seq
MIRT2585212	hsa-miR-374a	CLIP-seq
MIRT2585213	hsa-miR-374b	CLIP-seq
MIRT2585214	hsa-miR-3915	CLIP-seq
MIRT2585215	hsa-miR-3928	CLIP-seq
MIRT2585216	hsa-miR-4450	CLIP-seq
MIRT2585217	hsa-miR-4460	CLIP-seq
MIRT2585218	hsa-miR-4709-3p	CLIP-seq
MIRT2585219	hsa-miR-4727-3p	CLIP-seq
MIRT2585220	hsa-miR-491-5p	CLIP-seq
MIRT1203280	hsa-miR-3136-3p	CLIP-seq
MIRT2585209	hsa-miR-3185	CLIP-seq
MIRT2585210	hsa-miR-3591-5p	CLIP-seq
MIRT2585211	hsa-miR-369-3p	CLIP-seq
MIRT2585212	hsa-miR-374a	CLIP-seq
MIRT2585213	hsa-miR-374b	CLIP-seq
MIRT2585214	hsa-miR-3915	CLIP-seq
MIRT2585215	hsa-miR-3928	CLIP-seq
MIRT2585216	hsa-miR-4450	CLIP-seq
MIRT2585217	hsa-miR-4460	CLIP-seq
MIRT2585218	hsa-miR-4709-3p	CLIP-seq
MIRT2585219	hsa-miR-4727-3p	CLIP-seq
MIRT2585220	hsa-miR-491-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0007275	Process	Multicellular organism development	IEA
GO:1903561	Component	Extracellular vesicle	HDA	24769233

MIM	HGNC	e!Ensembl
610088	24956	ENSG00000116774

Protein

UniProt ID

Q9NRN5

Protein name

Olfactomedin-like protein 3 (HNOEL-iso) (hOLF44)

Protein function

Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the to

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02191	OLF	139 → 399	Olfactomedin-like domain	Family

Tissue specificity

TISSUE SPECIFICITY: Abundant in placenta, moderate in liver and heart, whereas fairly weak in other tissues examined. On term placenta, mainly localized extracellularly surrounding the syncytiotrophoblastic cells and very rarely expressed in the maternal

Sequence

MGPSTPLLILFLLSWSGPLQGQQHHLVEYMERRLAALEERLAQCQDQSSRHAAELRDFKN
KMLPLLEVAEKEREALRTEADTISGRVDRLEREVDYLETQNPALPCVEFDEKVTGGPGTK
GKGRRNEKYDMVTDCGYTISQVRSMKILKRFGGPAGLWTKDPLGQTEKIYVLDGTQNDTA
FVFPRLRDFTLAMAARKASRVRVPFPWVGTGQLVYGGFLYFARRPPGRPGGGGEMENTLQ
LIKFHLANRTVVDSSVFPAEGLIPPYGLTADTYIDLAADEEGLWAVYATREDDRHLCLAK
LDPQTLDTEQQWDTPCPRENAEAAFVICGTLYVVYNTRPASRARIQCSFDASGTLTPERA
ALPYFPRRYGAHASLRYNPRERQLYAWDDGYQIVYKLEMRKKEEEV

Sequence length

406

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Epilepsy	Epilepsy	rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670 View all (165 more)	30868120
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	32711556, 39380021
Fetal Growth Retardation	Associate	40285515
Pre Eclampsia	Inhibit	40285515

OLFML3 (olfactomedin like 3)