Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
56929
Gene name Gene Name - the full gene name approved by the HGNC.
Fem-1 homolog C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FEM1C
Synonyms (NCBI Gene) Gene synonyms aliases
EUROIMAGE686608, EUROIMAGE783647, FEM1A
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q22.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027153 hsa-miR-103a-3p Sequencing 20371350
MIRT028176 hsa-miR-93-5p Sequencing 20371350
MIRT031336 hsa-miR-18a-5p Sequencing 20371350
MIRT031848 hsa-miR-16-5p Sequencing 20371350
MIRT238220 hsa-miR-6835-3p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IBA 21873635
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005654 Component Nucleoplasm IDA
GO:0005829 Component Cytosol IDA
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608767 16933 ENSG00000145780
Protein
UniProt ID Q96JP0
Protein name Protein fem-1 homolog C (FEM1c) (FEM1-gamma)
Protein function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their
PDB 6LBG , 6LBN , 6LDP , 6LE6 , 6LEN , 6LEY , 6LF0 , 6XKC , 7JYA , 8PQL , 8Q7R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12796 Ank_2 2 72 Ankyrin repeats (3 copies) Repeat
PF12796 Ank_2 86 179 Ankyrin repeats (3 copies) Repeat
PF13857 Ank_5 514 568 Repeat
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis. Expressed at lower levels in other tissues, including cartilage. {ECO:0000269|PubMed:11733146, ECO:0000269|PubMed:14527725}.
Sequence
MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL
LEQCSASIEVGG
SVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL
RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKS
V
KGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTS
KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK
EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL
WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL
EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGK
NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH
PDIMNLLIKSGAHFDATNLHKQTASDLL
DEKEIAKNLIQPINHTTLQCLAARVIVNHRIY
YKGHIPEKLETFVSLHR
Sequence length 617
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Unknown
Disease term Disease name Evidence References Source
Neurodevelopmental Disorders complex neurodevelopmental disorder GenCC
Associations from Text Mining
Disease Name Relationship Type References
Polycystic Ovary Syndrome Associate 18757445