Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	56926
Gene name Gene Name - the full gene name approved by the HGNC.	Nicalin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NCLN
Synonyms (NCBI Gene) Gene synonyms aliases	NET59
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.3

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1057519322	C>T	Likely-pathogenic	Coding sequence variant, stop gained

Show/Hide all(172)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051553	hsa-let-7e-5p	CLASH	23622248
MIRT043508	hsa-miR-331-3p	CLASH	23622248
MIRT039945	hsa-miR-615-3p	CLASH	23622248
MIRT039162	hsa-miR-769-5p	CLASH	23622248
MIRT039162	hsa-miR-769-5p	PAR-CLIP	27292025
MIRT1176596	hsa-miR-1197	CLIP-seq
MIRT1176597	hsa-miR-1908	CLIP-seq
MIRT1176598	hsa-miR-1915	CLIP-seq
MIRT1176599	hsa-miR-1976	CLIP-seq
MIRT1176600	hsa-miR-2355-5p	CLIP-seq
MIRT1176601	hsa-miR-31	CLIP-seq
MIRT1176602	hsa-miR-3130-5p	CLIP-seq
MIRT1176603	hsa-miR-3145-5p	CLIP-seq
MIRT1176604	hsa-miR-3191	CLIP-seq
MIRT1176605	hsa-miR-34a	CLIP-seq
MIRT1176606	hsa-miR-34c-5p	CLIP-seq
MIRT1176607	hsa-miR-3591-3p	CLIP-seq
MIRT1176608	hsa-miR-3960	CLIP-seq
MIRT1176609	hsa-miR-4261	CLIP-seq
MIRT1176610	hsa-miR-4269	CLIP-seq
MIRT1176611	hsa-miR-4270	CLIP-seq
MIRT1176612	hsa-miR-4290	CLIP-seq
MIRT1176613	hsa-miR-4441	CLIP-seq
MIRT1176614	hsa-miR-4468	CLIP-seq
MIRT1176615	hsa-miR-4482	CLIP-seq
MIRT1176616	hsa-miR-4496	CLIP-seq
MIRT1176617	hsa-miR-449a	CLIP-seq
MIRT1176618	hsa-miR-449b	CLIP-seq
MIRT1176619	hsa-miR-4632	CLIP-seq
MIRT1176620	hsa-miR-4645-5p	CLIP-seq
MIRT1176621	hsa-miR-4667-3p	CLIP-seq
MIRT1176622	hsa-miR-4673	CLIP-seq
MIRT1176623	hsa-miR-4691-5p	CLIP-seq
MIRT1176624	hsa-miR-4712-5p	CLIP-seq
MIRT1176625	hsa-miR-4722-3p	CLIP-seq
MIRT1176626	hsa-miR-4728-5p	CLIP-seq
MIRT1176627	hsa-miR-4733-3p	CLIP-seq
MIRT1176628	hsa-miR-4742-5p	CLIP-seq
MIRT1176629	hsa-miR-4756-3p	CLIP-seq
MIRT1176630	hsa-miR-486-3p	CLIP-seq
MIRT1176631	hsa-miR-508-5p	CLIP-seq
MIRT1176632	hsa-miR-542-5p	CLIP-seq
MIRT1176633	hsa-miR-577	CLIP-seq
MIRT1176634	hsa-miR-663	CLIP-seq
MIRT1176635	hsa-miR-744	CLIP-seq
MIRT1176636	hsa-miR-770-5p	CLIP-seq
MIRT1176637	hsa-miR-939	CLIP-seq
MIRT2051154	hsa-miR-1205	CLIP-seq
MIRT2051155	hsa-miR-1253	CLIP-seq
MIRT2051156	hsa-miR-150	CLIP-seq
MIRT2051157	hsa-miR-1587	CLIP-seq
MIRT2051158	hsa-miR-188-3p	CLIP-seq
MIRT2051159	hsa-miR-1909	CLIP-seq
MIRT1176598	hsa-miR-1915	CLIP-seq
MIRT1176599	hsa-miR-1976	CLIP-seq
MIRT1176603	hsa-miR-3145-5p	CLIP-seq
MIRT2051160	hsa-miR-3192	CLIP-seq
MIRT2051161	hsa-miR-3665	CLIP-seq
MIRT2051162	hsa-miR-3922-5p	CLIP-seq
MIRT2051163	hsa-miR-4279	CLIP-seq
MIRT2051164	hsa-miR-4293	CLIP-seq
MIRT2051165	hsa-miR-4434	CLIP-seq
MIRT2051166	hsa-miR-4457	CLIP-seq
MIRT2051167	hsa-miR-4462	CLIP-seq
MIRT2051168	hsa-miR-4492	CLIP-seq
MIRT2051169	hsa-miR-4498	CLIP-seq
MIRT2051170	hsa-miR-4505	CLIP-seq
MIRT2051171	hsa-miR-4516	CLIP-seq
MIRT1176620	hsa-miR-4645-5p	CLIP-seq
MIRT2051172	hsa-miR-4656	CLIP-seq
MIRT1176622	hsa-miR-4673	CLIP-seq
MIRT2051173	hsa-miR-4675	CLIP-seq
MIRT2051174	hsa-miR-4707-5p	CLIP-seq
MIRT1176624	hsa-miR-4712-5p	CLIP-seq
MIRT2051175	hsa-miR-4713-5p	CLIP-seq
MIRT1176625	hsa-miR-4722-3p	CLIP-seq
MIRT2051176	hsa-miR-4726-3p	CLIP-seq
MIRT2051177	hsa-miR-4741	CLIP-seq
MIRT2051178	hsa-miR-4743	CLIP-seq
MIRT1176631	hsa-miR-508-5p	CLIP-seq
MIRT2051179	hsa-miR-532-3p	CLIP-seq
MIRT1176632	hsa-miR-542-5p	CLIP-seq
MIRT2051180	hsa-miR-596	CLIP-seq
MIRT2051181	hsa-miR-657	CLIP-seq
MIRT2051182	hsa-miR-663b	CLIP-seq
MIRT2051183	hsa-miR-762	CLIP-seq
MIRT1176636	hsa-miR-770-5p	CLIP-seq
MIRT1176637	hsa-miR-939	CLIP-seq
MIRT2051154	hsa-miR-1205	CLIP-seq
MIRT2280268	hsa-miR-1262	CLIP-seq
MIRT2280269	hsa-miR-1301	CLIP-seq
MIRT2051159	hsa-miR-1909	CLIP-seq
MIRT1176598	hsa-miR-1915	CLIP-seq
MIRT2280270	hsa-miR-296-5p	CLIP-seq
MIRT2280271	hsa-miR-3154	CLIP-seq
MIRT2280272	hsa-miR-3169	CLIP-seq
MIRT2280273	hsa-miR-3179	CLIP-seq
MIRT2280274	hsa-miR-339-5p	CLIP-seq
MIRT2280275	hsa-miR-3607-3p	CLIP-seq
MIRT2280276	hsa-miR-3652	CLIP-seq
MIRT2280277	hsa-miR-3686	CLIP-seq
MIRT2280278	hsa-miR-4255	CLIP-seq
MIRT2280279	hsa-miR-4271	CLIP-seq
MIRT2280280	hsa-miR-4276	CLIP-seq
MIRT2280281	hsa-miR-4283	CLIP-seq
MIRT2280282	hsa-miR-4302	CLIP-seq
MIRT2280283	hsa-miR-4419a	CLIP-seq
MIRT2280284	hsa-miR-4430	CLIP-seq
MIRT2051165	hsa-miR-4434	CLIP-seq
MIRT2280285	hsa-miR-4436b-3p	CLIP-seq
MIRT2280286	hsa-miR-4446-3p	CLIP-seq
MIRT2280287	hsa-miR-4459	CLIP-seq
MIRT2051168	hsa-miR-4492	CLIP-seq
MIRT2051169	hsa-miR-4498	CLIP-seq
MIRT2051170	hsa-miR-4505	CLIP-seq
MIRT2280288	hsa-miR-4510	CLIP-seq
MIRT2280289	hsa-miR-4515	CLIP-seq
MIRT2051171	hsa-miR-4516	CLIP-seq
MIRT2280290	hsa-miR-4660	CLIP-seq
MIRT2280291	hsa-miR-4701-3p	CLIP-seq
MIRT2280292	hsa-miR-4721	CLIP-seq
MIRT2280293	hsa-miR-4725-3p	CLIP-seq
MIRT2280294	hsa-miR-4725-5p	CLIP-seq
MIRT2051176	hsa-miR-4726-3p	CLIP-seq
MIRT1176626	hsa-miR-4728-5p	CLIP-seq
MIRT2280295	hsa-miR-4747-5p	CLIP-seq
MIRT2280296	hsa-miR-4760-3p	CLIP-seq
MIRT2280297	hsa-miR-4779	CLIP-seq
MIRT2280298	hsa-miR-504	CLIP-seq
MIRT2280299	hsa-miR-5047	CLIP-seq
MIRT2280300	hsa-miR-516b	CLIP-seq
MIRT2280301	hsa-miR-602	CLIP-seq
MIRT2280302	hsa-miR-637	CLIP-seq
MIRT2051182	hsa-miR-663b	CLIP-seq
MIRT2280303	hsa-miR-665	CLIP-seq
MIRT2051183	hsa-miR-762	CLIP-seq
MIRT2391426	hsa-miR-154	CLIP-seq
MIRT1176597	hsa-miR-1908	CLIP-seq
MIRT2280270	hsa-miR-296-5p	CLIP-seq
MIRT2391427	hsa-miR-3132	CLIP-seq
MIRT2391428	hsa-miR-3189-3p	CLIP-seq
MIRT1176605	hsa-miR-34a	CLIP-seq
MIRT1176606	hsa-miR-34c-5p	CLIP-seq
MIRT2391429	hsa-miR-3918	CLIP-seq
MIRT1176608	hsa-miR-3960	CLIP-seq
MIRT1176617	hsa-miR-449a	CLIP-seq
MIRT1176618	hsa-miR-449b	CLIP-seq
MIRT1176619	hsa-miR-4632	CLIP-seq
MIRT2391430	hsa-miR-4695-5p	CLIP-seq
MIRT1176630	hsa-miR-486-3p	CLIP-seq
MIRT2391431	hsa-miR-521	CLIP-seq
MIRT2391432	hsa-miR-635	CLIP-seq
MIRT1176634	hsa-miR-663	CLIP-seq
MIRT1176635	hsa-miR-744	CLIP-seq
MIRT2438933	hsa-miR-125a-5p	CLIP-seq
MIRT2438934	hsa-miR-125b	CLIP-seq
MIRT2438935	hsa-miR-329	CLIP-seq
MIRT2438936	hsa-miR-362-3p	CLIP-seq
MIRT2438937	hsa-miR-3670	CLIP-seq
MIRT2438938	hsa-miR-4287	CLIP-seq
MIRT2438939	hsa-miR-4319	CLIP-seq
MIRT2438940	hsa-miR-4469	CLIP-seq
MIRT2438941	hsa-miR-4655-5p	CLIP-seq
MIRT2438942	hsa-miR-4685-3p	CLIP-seq
MIRT2438943	hsa-miR-4732-3p	CLIP-seq
MIRT2280301	hsa-miR-602	CLIP-seq
MIRT2438944	hsa-miR-670	CLIP-seq
MIRT2051154	hsa-miR-1205	CLIP-seq
MIRT2051161	hsa-miR-3665	CLIP-seq
MIRT2280285	hsa-miR-4436b-3p	CLIP-seq
MIRT2280300	hsa-miR-516b	CLIP-seq
MIRT2051181	hsa-miR-657	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17261586, 20538592, 32814053
GO:0005789	Component	Endoplasmic reticulum membrane	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	20538592
GO:0009966	Process	Regulation of signal transduction	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0032991	Component	Protein-containing complex	IDA	20538592
GO:0043254	Process	Regulation of protein-containing complex assembly	IDA	20538592
GO:0050821	Process	Protein stabilization	IMP	20538592
GO:0061635	Process	Regulation of protein complex stability	IDA	20538592

MIM	HGNC	e!Ensembl
609156	26923	ENSG00000125912

Protein

UniProt ID

Q969V3

Protein name

BOS complex subunit NCLN (Nicalin) (Nicastrin-like protein)

Protein function

Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following me

PDB

6W6L , 9C7U , 9C7V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04389	Peptidase_M28	201 → 421	Peptidase family M28	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. {ECO:0000269|PubMed:15257293}.

Sequence

MLEEAGEVLENMLKASCLPLGFIVFLPAVLLLVAPPLPAADAAHEFTVYRMQQYDLQGQP
YGTRNAVLNTEARTMAAEVLSRRCVLMRLLDFSYEQYQKALRQSAGAVVIILPRAMAAVP
QDVVRQFMEIEPEMLAMETAVPVYFAVEDEALLSIYKQTQAASASQGSASAAEVLLRTAT
ANGFQMVTSGVQSKAVSDWLIASVEGRLTGLGGEDLPTIVIVAHYDAFGVAPWLSLGADS
NGSGVSVLLELARLFSRLYTYKRTHAAYNLLFFASGGGKFNYQGTKRWLEDNLDHTDSSL
LQDNVAFVLCLDTVGRGSSLHLHVSKPPREGTLQHAFLRELETVAAHQFPEVRFSMVHKR
INLAEDVLAWEHERFAIRRLPAFTLSHLESHRDGQRSSIMDVRSRVDSKTLTRNTRIIAE
ALTRVIYNLTEKGTPPDMPVFTEQMQIQQEQLDSVMDWLTNQPRAAQLVDKDSTFLSTLE
HHLSRYLKDVKQHHVKADKRDPEFVFYDQLKQVMNAYRVKPAVFDLLLAVGIAAYLGMAY
VAVQHFSLLYKTVQRLLVKAKTQ

Sequence length

563

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Ovarian cancer	Ovarian cancer	Conditional KD of IL6 in the OCCA xenograft model delays tumor growth	GWAS, CBGDA
Diabetes	Diabetes		GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA

NCLN (nicalin)