SLC2A4RG (SLC2A4 regulator)

Gene

• Entrez ID: 56731
• Gene name: SLC2A4 regulator
• Gene symbol: SLC2A4RG
• Synonyms (NCBI Gene): GEF, HDBP-1, HDBP1, Si-1-2, Si-1-2-19
• Chromosome: 20
• Chromosome location: 20q13.33
• Summary: The protein encoded by this gene is a nuclear transcription factor involved in the activation of the solute carrier family 2 member 4 gene. The encoded protein interacts with another transcription factor, myocyte enhancer factor 2, to activate transcripti

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022491	hsa-miR-124-3p	Microarray	18668037
MIRT029272	hsa-miR-26b-5p	Microarray	19088304
MIRT037461	hsa-miR-744-5p	CLASH	23622248
MIRT037461	hsa-miR-744-5p	CLASH	23622248
MIRT500115	hsa-miR-1178-5p	PAR-CLIP	24398324
MIRT500113	hsa-miR-4690-3p	PAR-CLIP	24398324
MIRT500114	hsa-miR-5685	PAR-CLIP	24398324
MIRT500112	hsa-miR-6823-5p	PAR-CLIP	24398324
MIRT500111	hsa-miR-7108-3p	PAR-CLIP	24398324
MIRT500110	hsa-miR-3127-5p	PAR-CLIP	24398324
MIRT500115	hsa-miR-1178-5p	PAR-CLIP	26701625
MIRT500110	hsa-miR-3127-5p	PAR-CLIP	26701625
MIRT500113	hsa-miR-4690-3p	PAR-CLIP	26701625
MIRT500114	hsa-miR-5685	PAR-CLIP	26701625
MIRT500112	hsa-miR-6823-5p	PAR-CLIP	26701625
MIRT500111	hsa-miR-7108-3p	PAR-CLIP	26701625
MIRT500115	hsa-miR-1178-5p	PAR-CLIP	24398324
MIRT500113	hsa-miR-4690-3p	PAR-CLIP	24398324
MIRT500114	hsa-miR-5685	PAR-CLIP	24398324
MIRT500112	hsa-miR-6823-5p	PAR-CLIP	24398324
MIRT500111	hsa-miR-7108-3p	PAR-CLIP	24398324
MIRT500110	hsa-miR-3127-5p	PAR-CLIP	24398324
MIRT1358913	hsa-miR-106a	CLIP-seq
MIRT1358914	hsa-miR-106b	CLIP-seq
MIRT1358915	hsa-miR-1245b-3p	CLIP-seq
MIRT1358916	hsa-miR-1273g	CLIP-seq
MIRT1358917	hsa-miR-1275	CLIP-seq
MIRT1358918	hsa-miR-1289	CLIP-seq
MIRT1358919	hsa-miR-1303	CLIP-seq
MIRT1358920	hsa-miR-130a	CLIP-seq
MIRT1358921	hsa-miR-130b	CLIP-seq
MIRT1358922	hsa-miR-17	CLIP-seq
MIRT1358923	hsa-miR-1908	CLIP-seq
MIRT1358924	hsa-miR-1915	CLIP-seq
MIRT1358925	hsa-miR-193a-3p	CLIP-seq
MIRT1358926	hsa-miR-193b	CLIP-seq
MIRT1358927	hsa-miR-19a	CLIP-seq
MIRT1358928	hsa-miR-19b	CLIP-seq
MIRT1358929	hsa-miR-20a	CLIP-seq
MIRT1358930	hsa-miR-20b	CLIP-seq
MIRT1358931	hsa-miR-2277-3p	CLIP-seq
MIRT1358932	hsa-miR-301a	CLIP-seq
MIRT1358933	hsa-miR-301b	CLIP-seq
MIRT1358934	hsa-miR-302a	CLIP-seq
MIRT1358935	hsa-miR-302b	CLIP-seq
MIRT1358936	hsa-miR-302c	CLIP-seq
MIRT1358937	hsa-miR-302d	CLIP-seq
MIRT1358938	hsa-miR-302e	CLIP-seq
MIRT1358939	hsa-miR-3119	CLIP-seq
MIRT1358940	hsa-miR-3189-3p	CLIP-seq
MIRT1358941	hsa-miR-3199	CLIP-seq
MIRT1358942	hsa-miR-320a	CLIP-seq
MIRT1358943	hsa-miR-320b	CLIP-seq
MIRT1358944	hsa-miR-320c	CLIP-seq
MIRT1358945	hsa-miR-320d	CLIP-seq
MIRT1358946	hsa-miR-320e	CLIP-seq
MIRT1358947	hsa-miR-3591-5p	CLIP-seq
MIRT1358948	hsa-miR-361-3p	CLIP-seq
MIRT1358949	hsa-miR-3649	CLIP-seq
MIRT1358950	hsa-miR-3661	CLIP-seq
MIRT1358951	hsa-miR-3666	CLIP-seq
MIRT1358952	hsa-miR-3667-3p	CLIP-seq
MIRT1358953	hsa-miR-372	CLIP-seq
MIRT1358954	hsa-miR-373	CLIP-seq
MIRT1358955	hsa-miR-3918	CLIP-seq
MIRT1358956	hsa-miR-3936	CLIP-seq
MIRT1358957	hsa-miR-3973	CLIP-seq
MIRT1358958	hsa-miR-4260	CLIP-seq
MIRT1358959	hsa-miR-4283	CLIP-seq
MIRT1358960	hsa-miR-4295	CLIP-seq
MIRT1358961	hsa-miR-4323	CLIP-seq
MIRT1358962	hsa-miR-4330	CLIP-seq
MIRT1358963	hsa-miR-4424	CLIP-seq
MIRT1358964	hsa-miR-4429	CLIP-seq
MIRT1358965	hsa-miR-4447	CLIP-seq
MIRT1358966	hsa-miR-4472	CLIP-seq
MIRT1358967	hsa-miR-4473	CLIP-seq
MIRT1358968	hsa-miR-4481	CLIP-seq
MIRT1358969	hsa-miR-4489	CLIP-seq
MIRT1358970	hsa-miR-4515	CLIP-seq
MIRT1358971	hsa-miR-4525	CLIP-seq
MIRT1358972	hsa-miR-454	CLIP-seq
MIRT1358973	hsa-miR-4648	CLIP-seq
MIRT1358974	hsa-miR-4658	CLIP-seq
MIRT1358975	hsa-miR-4665-5p	CLIP-seq
MIRT1358976	hsa-miR-4671-3p	CLIP-seq
MIRT1358977	hsa-miR-4685-5p	CLIP-seq
MIRT1358978	hsa-miR-4691-5p	CLIP-seq
MIRT1358979	hsa-miR-4740-3p	CLIP-seq
MIRT1358980	hsa-miR-4745-5p	CLIP-seq
MIRT1358981	hsa-miR-4758-5p	CLIP-seq
MIRT1358982	hsa-miR-515-5p	CLIP-seq
MIRT1358983	hsa-miR-519a	CLIP-seq
MIRT1358984	hsa-miR-519b-3p	CLIP-seq
MIRT1358985	hsa-miR-519c-3p	CLIP-seq
MIRT1358986	hsa-miR-519d	CLIP-seq
MIRT1358987	hsa-miR-520a-3p	CLIP-seq
MIRT1358988	hsa-miR-520b	CLIP-seq
MIRT1358989	hsa-miR-520c-3p	CLIP-seq
MIRT1358990	hsa-miR-520d-3p	CLIP-seq
MIRT1358991	hsa-miR-520e	CLIP-seq
MIRT1358992	hsa-miR-520g	CLIP-seq
MIRT1358993	hsa-miR-520h	CLIP-seq
MIRT1358994	hsa-miR-541	CLIP-seq
MIRT1358995	hsa-miR-548ac	CLIP-seq
MIRT1358996	hsa-miR-548ae	CLIP-seq
MIRT1358997	hsa-miR-548aj	CLIP-seq
MIRT1358998	hsa-miR-548am	CLIP-seq
MIRT1358999	hsa-miR-548d-3p	CLIP-seq
MIRT1359000	hsa-miR-548x	CLIP-seq
MIRT1359001	hsa-miR-548z	CLIP-seq
MIRT1359002	hsa-miR-625	CLIP-seq
MIRT1359003	hsa-miR-631	CLIP-seq
MIRT1359004	hsa-miR-654-5p	CLIP-seq
MIRT1359005	hsa-miR-663	CLIP-seq
MIRT1359006	hsa-miR-877	CLIP-seq
MIRT1359007	hsa-miR-93	CLIP-seq
MIRT1358916	hsa-miR-1273g	CLIP-seq
MIRT1358917	hsa-miR-1275	CLIP-seq
MIRT1358919	hsa-miR-1303	CLIP-seq
MIRT1358920	hsa-miR-130a	CLIP-seq
MIRT1358921	hsa-miR-130b	CLIP-seq
MIRT1358923	hsa-miR-1908	CLIP-seq
MIRT1358927	hsa-miR-19a	CLIP-seq
MIRT1358928	hsa-miR-19b	CLIP-seq
MIRT2106269	hsa-miR-21	CLIP-seq
MIRT1358932	hsa-miR-301a	CLIP-seq
MIRT1358933	hsa-miR-301b	CLIP-seq
MIRT1358939	hsa-miR-3119	CLIP-seq
MIRT2106270	hsa-miR-3149	CLIP-seq
MIRT2106271	hsa-miR-3150a-3p	CLIP-seq
MIRT2106272	hsa-miR-3175	CLIP-seq
MIRT1358942	hsa-miR-320a	CLIP-seq
MIRT1358943	hsa-miR-320b	CLIP-seq
MIRT1358944	hsa-miR-320c	CLIP-seq
MIRT1358945	hsa-miR-320d	CLIP-seq
MIRT1358946	hsa-miR-320e	CLIP-seq
MIRT2106273	hsa-miR-340	CLIP-seq
MIRT1358947	hsa-miR-3591-5p	CLIP-seq
MIRT2106274	hsa-miR-3613-3p	CLIP-seq
MIRT2106275	hsa-miR-3618	CLIP-seq
MIRT2106276	hsa-miR-3622a-3p	CLIP-seq
MIRT2106277	hsa-miR-3622b-3p	CLIP-seq
MIRT2106278	hsa-miR-362-5p	CLIP-seq
MIRT1358949	hsa-miR-3649	CLIP-seq
MIRT1358950	hsa-miR-3661	CLIP-seq
MIRT1358951	hsa-miR-3666	CLIP-seq
MIRT2106279	hsa-miR-4254	CLIP-seq
MIRT2106280	hsa-miR-4271	CLIP-seq
MIRT1358960	hsa-miR-4295	CLIP-seq
MIRT2106281	hsa-miR-4419a	CLIP-seq
MIRT1358964	hsa-miR-4429	CLIP-seq
MIRT2106282	hsa-miR-4434	CLIP-seq
MIRT1358967	hsa-miR-4473	CLIP-seq
MIRT1358968	hsa-miR-4481	CLIP-seq
MIRT2106283	hsa-miR-4510	CLIP-seq
MIRT2106284	hsa-miR-4516	CLIP-seq
MIRT1358971	hsa-miR-4525	CLIP-seq
MIRT2106285	hsa-miR-4536	CLIP-seq
MIRT1358972	hsa-miR-454	CLIP-seq
MIRT1358973	hsa-miR-4648	CLIP-seq
MIRT2106286	hsa-miR-4651	CLIP-seq
MIRT1358974	hsa-miR-4658	CLIP-seq
MIRT1358975	hsa-miR-4665-5p	CLIP-seq
MIRT1358976	hsa-miR-4671-3p	CLIP-seq
MIRT2106287	hsa-miR-4711-3p	CLIP-seq
MIRT2106288	hsa-miR-4725-3p	CLIP-seq
MIRT1358980	hsa-miR-4745-5p	CLIP-seq
MIRT1358981	hsa-miR-4758-5p	CLIP-seq
MIRT2106289	hsa-miR-491-5p	CLIP-seq
MIRT2106290	hsa-miR-495	CLIP-seq
MIRT2106291	hsa-miR-500b	CLIP-seq
MIRT2106292	hsa-miR-502-5p	CLIP-seq
MIRT2106293	hsa-miR-518a-5p	CLIP-seq
MIRT1358983	hsa-miR-519a	CLIP-seq
MIRT1358984	hsa-miR-519b-3p	CLIP-seq
MIRT1358985	hsa-miR-519c-3p	CLIP-seq
MIRT2106294	hsa-miR-527	CLIP-seq
MIRT1358994	hsa-miR-541	CLIP-seq
MIRT2106295	hsa-miR-576-3p	CLIP-seq
MIRT2106296	hsa-miR-590-5p	CLIP-seq
MIRT2106297	hsa-miR-608	CLIP-seq
MIRT1359002	hsa-miR-625	CLIP-seq
MIRT1359003	hsa-miR-631	CLIP-seq
MIRT2106298	hsa-miR-649	CLIP-seq
MIRT1359004	hsa-miR-654-5p	CLIP-seq
MIRT1359005	hsa-miR-663	CLIP-seq
MIRT1359006	hsa-miR-877	CLIP-seq
MIRT2106299	hsa-miR-934	CLIP-seq
MIRT2106300	hsa-miR-939	CLIP-seq
MIRT2330584	hsa-miR-1236	CLIP-seq
MIRT2330585	hsa-miR-1254	CLIP-seq
MIRT1358916	hsa-miR-1273g	CLIP-seq
MIRT2330586	hsa-miR-1913	CLIP-seq
MIRT1358924	hsa-miR-1915	CLIP-seq
MIRT2106269	hsa-miR-21	CLIP-seq
MIRT1358931	hsa-miR-2277-3p	CLIP-seq
MIRT2330587	hsa-miR-2861	CLIP-seq
MIRT2330588	hsa-miR-3116	CLIP-seq
MIRT1358939	hsa-miR-3119	CLIP-seq
MIRT2106271	hsa-miR-3150a-3p	CLIP-seq
MIRT2106272	hsa-miR-3175	CLIP-seq
MIRT1358940	hsa-miR-3189-3p	CLIP-seq
MIRT2330589	hsa-miR-3194-5p	CLIP-seq
MIRT2330590	hsa-miR-324-3p	CLIP-seq
MIRT2330591	hsa-miR-331-3p	CLIP-seq
MIRT2106274	hsa-miR-3613-3p	CLIP-seq
MIRT1358948	hsa-miR-361-3p	CLIP-seq
MIRT2106276	hsa-miR-3622a-3p	CLIP-seq
MIRT2106277	hsa-miR-3622b-3p	CLIP-seq
MIRT2330592	hsa-miR-3691-3p	CLIP-seq
MIRT1358955	hsa-miR-3918	CLIP-seq
MIRT1358956	hsa-miR-3936	CLIP-seq
MIRT2330593	hsa-miR-3944-5p	CLIP-seq
MIRT2106279	hsa-miR-4254	CLIP-seq
MIRT1358958	hsa-miR-4260	CLIP-seq
MIRT1358959	hsa-miR-4283	CLIP-seq
MIRT2330594	hsa-miR-4292	CLIP-seq
MIRT2330595	hsa-miR-4313	CLIP-seq
MIRT1358961	hsa-miR-4323	CLIP-seq
MIRT2106281	hsa-miR-4419a	CLIP-seq
MIRT1358963	hsa-miR-4424	CLIP-seq
MIRT2106282	hsa-miR-4434	CLIP-seq
MIRT1358968	hsa-miR-4481	CLIP-seq
MIRT1358969	hsa-miR-4489	CLIP-seq
MIRT2106283	hsa-miR-4510	CLIP-seq
MIRT2106284	hsa-miR-4516	CLIP-seq
MIRT2106285	hsa-miR-4536	CLIP-seq
MIRT2106286	hsa-miR-4651	CLIP-seq
MIRT1358977	hsa-miR-4685-5p	CLIP-seq
MIRT2330596	hsa-miR-4727-5p	CLIP-seq
MIRT1358979	hsa-miR-4740-3p	CLIP-seq
MIRT1358980	hsa-miR-4745-5p	CLIP-seq
MIRT2330597	hsa-miR-4746-3p	CLIP-seq
MIRT2330598	hsa-miR-4762-5p	CLIP-seq
MIRT2330599	hsa-miR-4768-5p	CLIP-seq
MIRT2330600	hsa-miR-4775	CLIP-seq
MIRT2106289	hsa-miR-491-5p	CLIP-seq
MIRT2106290	hsa-miR-495	CLIP-seq
MIRT1358982	hsa-miR-515-5p	CLIP-seq
MIRT1358983	hsa-miR-519a	CLIP-seq
MIRT1358984	hsa-miR-519b-3p	CLIP-seq
MIRT1358985	hsa-miR-519c-3p	CLIP-seq
MIRT2330601	hsa-miR-544	CLIP-seq
MIRT1358995	hsa-miR-548ac	CLIP-seq
MIRT1358996	hsa-miR-548ae	CLIP-seq
MIRT1358997	hsa-miR-548aj	CLIP-seq
MIRT1358998	hsa-miR-548am	CLIP-seq
MIRT1358999	hsa-miR-548d-3p	CLIP-seq
MIRT2330602	hsa-miR-548q	CLIP-seq
MIRT1359000	hsa-miR-548x	CLIP-seq
MIRT1359001	hsa-miR-548z	CLIP-seq
MIRT2106296	hsa-miR-590-5p	CLIP-seq
MIRT2330603	hsa-miR-604	CLIP-seq
MIRT2106297	hsa-miR-608	CLIP-seq
MIRT2330604	hsa-miR-627	CLIP-seq
MIRT2330605	hsa-miR-647	CLIP-seq
MIRT2330606	hsa-miR-924	CLIP-seq
MIRT2106300	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IBA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	10825161
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	10825161
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IDA	10825161
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 609493
• HGNC: 15930
• e!Ensembl: ENSG00000125520

Protein

• UniProt ID: Q9NR83
• Protein name: SLC2A4 regulator (GLUT4 enhancer factor) (GEF) (Huntington disease gene regulatory region-binding protein 1) (HDBP-1)
• Protein function: Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'.
• PDB: 7DTA
• Tissue specificity: TISSUE SPECIFICITY: According to PubMed:14630949, expressed in heart, skeletal muscle, liver, kidney and pancreas; undetectable in lung, placenta or brain. According to PubMed:14625278, ubiquitously expressed, with lowest expression in brain and ileum. {E
• Sequence:

  MERPPPRAAGRDPSALRAEAPWLRAEGPGPRAAPVTVPTPPQGSSVGGGFAGLEFARPQE
  SEPRASDLGAPRTWTGAAAGPRTPSAHIPVPAQRATPGKARLDEVMAAAALTSLSTSPLL
  LGAPVAAFSPEPGLEPWKEALVRPPGSYSSSSNSGDWGWDLASDQSSPSTPSPPLPPEAA
  HFLFGEPTLRKRKSPAQVMFQCLWKSCGKVLSTASAMQRHIRLVHLGRQAEPEQSDGEED
  FYYTELDVGVDTLTDGLSSLTPVSPTASMPPAFPRLELPELLEPPALPSPLRPPAPPLPP
  PPVLSTVANPQSCHSDRVYQGCLTPARLEPQPTEVGACPPALSSRIGVTLRKPRGDAKKC
  RKVYGMERRDLWCTACRWKKACQRFLD

• Sequence length: 387

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar GWAS catalog	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Atherosclerosis	Associate	24819318	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	21172654	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	21172654	★☆☆☆☆ Found in Text Mining only
Drug Related Side Effects and Adverse Reactions	Associate	33767353	★☆☆☆☆ Found in Text Mining only
Glioma	Associate	27677590	★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Associate	31932686, 32518073, 36991503	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasm Metastasis	Associate	32657779	★☆☆☆☆ Found in Text Mining only