Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	56672
Gene name Gene Name - the full gene name approved by the HGNC.	A-kinase interacting protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	AKIP1
Synonyms (NCBI Gene) Gene synonyms aliases	BCA3, C11orf17
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p15.4
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants hav

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miRTarBase ID	miRNA	Experiments	Reference
MIRT036485	hsa-miR-1226-3p	CLASH	23622248
MIRT680293	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT680292	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT680291	hsa-miR-4284	HITS-CLIP	23824327
MIRT680290	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT680289	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT680288	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT680287	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT680286	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT680285	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT680284	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT680283	hsa-miR-3178	HITS-CLIP	23824327
MIRT680282	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT680281	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT680280	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT680279	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT680278	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT680277	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT680276	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT680275	hsa-miR-3689c	HITS-CLIP	23824327
MIRT680274	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT680273	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT680272	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT680271	hsa-miR-3122	HITS-CLIP	23824327
MIRT680270	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT680269	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT680268	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT648362	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT664369	hsa-miR-154-3p	HITS-CLIP	23824327
MIRT664368	hsa-miR-487a-3p	HITS-CLIP	23824327
MIRT648360	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT648361	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648358	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT648357	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT648356	hsa-miR-5696	HITS-CLIP	23824327
MIRT648355	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT648354	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT648353	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT648362	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT648360	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT648361	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648359	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT648358	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT648357	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT648356	hsa-miR-5696	HITS-CLIP	23824327
MIRT648355	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT648354	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT648353	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT680293	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT680292	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT680291	hsa-miR-4284	HITS-CLIP	23824327
MIRT680290	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT680289	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT680288	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT680287	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT680286	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT680285	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT680284	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT680283	hsa-miR-3178	HITS-CLIP	23824327
MIRT680282	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT680281	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT680280	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT680279	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT680278	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT680277	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT680276	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT680275	hsa-miR-3689c	HITS-CLIP	23824327
MIRT680274	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT680273	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT680272	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT680271	hsa-miR-3122	HITS-CLIP	23824327
MIRT680270	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT680269	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT680268	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT648362	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT664369	hsa-miR-154-3p	HITS-CLIP	23824327
MIRT664368	hsa-miR-487a-3p	HITS-CLIP	23824327
MIRT648360	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT648361	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648358	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT648357	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT648356	hsa-miR-5696	HITS-CLIP	23824327
MIRT648355	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT648354	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT648353	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT648362	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT648360	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT648361	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648359	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT648358	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT648357	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT648356	hsa-miR-5696	HITS-CLIP	23824327
MIRT648355	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT648354	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT648353	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT776065	hsa-miR-3119	CLIP-seq
MIRT776066	hsa-miR-34a	CLIP-seq
MIRT776067	hsa-miR-34c-5p	CLIP-seq
MIRT776068	hsa-miR-449a	CLIP-seq
MIRT776069	hsa-miR-449b	CLIP-seq
MIRT776070	hsa-miR-485-3p	CLIP-seq
MIRT776071	hsa-miR-487a	CLIP-seq
MIRT776072	hsa-miR-550b	CLIP-seq
MIRT776073	hsa-miR-1202	CLIP-seq
MIRT776074	hsa-miR-142-3p	CLIP-seq
MIRT776075	hsa-miR-1827	CLIP-seq
MIRT776076	hsa-miR-3194-5p	CLIP-seq
MIRT776077	hsa-miR-3650	CLIP-seq
MIRT776078	hsa-miR-371-3p	CLIP-seq
MIRT776079	hsa-miR-371b-3p	CLIP-seq
MIRT776080	hsa-miR-3929	CLIP-seq
MIRT776081	hsa-miR-3972	CLIP-seq
MIRT776082	hsa-miR-4419b	CLIP-seq
MIRT776083	hsa-miR-4478	CLIP-seq
MIRT776084	hsa-miR-4649-3p	CLIP-seq
MIRT776085	hsa-miR-4722-5p	CLIP-seq
MIRT776086	hsa-miR-4768-3p	CLIP-seq
MIRT776087	hsa-miR-4790-3p	CLIP-seq
MIRT776088	hsa-miR-485-5p	CLIP-seq
MIRT776089	hsa-miR-515-3p	CLIP-seq
MIRT776090	hsa-miR-519e	CLIP-seq
MIRT776091	hsa-miR-940	CLIP-seq
MIRT776080	hsa-miR-3929	CLIP-seq
MIRT776082	hsa-miR-4419b	CLIP-seq
MIRT776083	hsa-miR-4478	CLIP-seq
MIRT776073	hsa-miR-1202	CLIP-seq
MIRT776074	hsa-miR-142-3p	CLIP-seq
MIRT776076	hsa-miR-3194-5p	CLIP-seq
MIRT776078	hsa-miR-371-3p	CLIP-seq
MIRT776079	hsa-miR-371b-3p	CLIP-seq
MIRT776080	hsa-miR-3929	CLIP-seq
MIRT776081	hsa-miR-3972	CLIP-seq
MIRT776082	hsa-miR-4419b	CLIP-seq
MIRT776083	hsa-miR-4478	CLIP-seq
MIRT776088	hsa-miR-485-5p	CLIP-seq
MIRT776089	hsa-miR-515-3p	CLIP-seq
MIRT776090	hsa-miR-519e	CLIP-seq
MIRT2384049	hsa-miR-550a	CLIP-seq
MIRT2443501	hsa-miR-3613-3p	CLIP-seq
MIRT2443502	hsa-miR-3622b-5p	CLIP-seq
MIRT2443503	hsa-miR-4253	CLIP-seq
MIRT2443504	hsa-miR-4684-5p	CLIP-seq
MIRT2443505	hsa-miR-548c-3p	CLIP-seq
MIRT2443501	hsa-miR-3613-3p	CLIP-seq
MIRT2443502	hsa-miR-3622b-5p	CLIP-seq
MIRT2443503	hsa-miR-4253	CLIP-seq
MIRT2443504	hsa-miR-4684-5p	CLIP-seq
MIRT2443505	hsa-miR-548c-3p	CLIP-seq
MIRT2472535	hsa-miR-1285	CLIP-seq
MIRT2472536	hsa-miR-1293	CLIP-seq
MIRT2472537	hsa-miR-145	CLIP-seq
MIRT776075	hsa-miR-1827	CLIP-seq
MIRT2472538	hsa-miR-3065-3p	CLIP-seq
MIRT776065	hsa-miR-3119	CLIP-seq
MIRT2472539	hsa-miR-3123	CLIP-seq
MIRT2472540	hsa-miR-3130-5p	CLIP-seq
MIRT2472541	hsa-miR-3159	CLIP-seq
MIRT2472542	hsa-miR-3165	CLIP-seq
MIRT2472543	hsa-miR-3187-5p	CLIP-seq
MIRT2443501	hsa-miR-3613-3p	CLIP-seq
MIRT2443502	hsa-miR-3622b-5p	CLIP-seq
MIRT776077	hsa-miR-3650	CLIP-seq
MIRT2472544	hsa-miR-3672	CLIP-seq
MIRT2472545	hsa-miR-371-5p	CLIP-seq
MIRT2472546	hsa-miR-371b-5p	CLIP-seq
MIRT2472547	hsa-miR-3925-3p	CLIP-seq
MIRT776080	hsa-miR-3929	CLIP-seq
MIRT2472548	hsa-miR-4252	CLIP-seq
MIRT2443503	hsa-miR-4253	CLIP-seq
MIRT776082	hsa-miR-4419b	CLIP-seq
MIRT2472549	hsa-miR-4477a	CLIP-seq
MIRT776083	hsa-miR-4478	CLIP-seq
MIRT2472550	hsa-miR-4482	CLIP-seq
MIRT2472551	hsa-miR-4483	CLIP-seq
MIRT2443504	hsa-miR-4684-5p	CLIP-seq
MIRT776085	hsa-miR-4722-5p	CLIP-seq
MIRT2472552	hsa-miR-4761-5p	CLIP-seq
MIRT776086	hsa-miR-4768-3p	CLIP-seq
MIRT776087	hsa-miR-4790-3p	CLIP-seq
MIRT2472553	hsa-miR-4793-3p	CLIP-seq
MIRT2472554	hsa-miR-4797-5p	CLIP-seq
MIRT776070	hsa-miR-485-3p	CLIP-seq
MIRT776071	hsa-miR-487a	CLIP-seq
MIRT2472555	hsa-miR-508-5p	CLIP-seq
MIRT2472556	hsa-miR-548ac	CLIP-seq
MIRT2472557	hsa-miR-548ae	CLIP-seq
MIRT2472558	hsa-miR-548aj	CLIP-seq
MIRT2472559	hsa-miR-548am	CLIP-seq
MIRT2443505	hsa-miR-548c-3p	CLIP-seq
MIRT2472560	hsa-miR-548d-3p	CLIP-seq
MIRT2472561	hsa-miR-548x	CLIP-seq
MIRT2472562	hsa-miR-548z	CLIP-seq
MIRT776072	hsa-miR-550b	CLIP-seq
MIRT2472563	hsa-miR-612	CLIP-seq
MIRT2472564	hsa-miR-661	CLIP-seq
MIRT2472565	hsa-miR-759	CLIP-seq
MIRT2472566	hsa-miR-766	CLIP-seq
MIRT776091	hsa-miR-940	CLIP-seq
MIRT2472536	hsa-miR-1293	CLIP-seq
MIRT2472537	hsa-miR-145	CLIP-seq
MIRT776075	hsa-miR-1827	CLIP-seq
MIRT2674836	hsa-miR-1908	CLIP-seq
MIRT2472538	hsa-miR-3065-3p	CLIP-seq
MIRT776065	hsa-miR-3119	CLIP-seq
MIRT2472539	hsa-miR-3123	CLIP-seq
MIRT2472540	hsa-miR-3130-5p	CLIP-seq
MIRT2472541	hsa-miR-3159	CLIP-seq
MIRT2472542	hsa-miR-3165	CLIP-seq
MIRT2443501	hsa-miR-3613-3p	CLIP-seq
MIRT2443502	hsa-miR-3622b-5p	CLIP-seq
MIRT776077	hsa-miR-3650	CLIP-seq
MIRT2674837	hsa-miR-3656	CLIP-seq
MIRT2472544	hsa-miR-3672	CLIP-seq
MIRT2472545	hsa-miR-371-5p	CLIP-seq
MIRT2472546	hsa-miR-371b-5p	CLIP-seq
MIRT2472547	hsa-miR-3925-3p	CLIP-seq
MIRT776080	hsa-miR-3929	CLIP-seq
MIRT2443503	hsa-miR-4253	CLIP-seq
MIRT776082	hsa-miR-4419b	CLIP-seq
MIRT2472549	hsa-miR-4477a	CLIP-seq
MIRT776083	hsa-miR-4478	CLIP-seq
MIRT2472550	hsa-miR-4482	CLIP-seq
MIRT2472551	hsa-miR-4483	CLIP-seq
MIRT2443504	hsa-miR-4684-5p	CLIP-seq
MIRT776085	hsa-miR-4722-5p	CLIP-seq
MIRT2472552	hsa-miR-4761-5p	CLIP-seq
MIRT776086	hsa-miR-4768-3p	CLIP-seq
MIRT776087	hsa-miR-4790-3p	CLIP-seq
MIRT2472554	hsa-miR-4797-5p	CLIP-seq
MIRT776070	hsa-miR-485-3p	CLIP-seq
MIRT776071	hsa-miR-487a	CLIP-seq
MIRT2472555	hsa-miR-508-5p	CLIP-seq
MIRT2674838	hsa-miR-548aa	CLIP-seq
MIRT2472556	hsa-miR-548ac	CLIP-seq
MIRT2472557	hsa-miR-548ae	CLIP-seq
MIRT2472558	hsa-miR-548aj	CLIP-seq
MIRT2472559	hsa-miR-548am	CLIP-seq
MIRT2443505	hsa-miR-548c-3p	CLIP-seq
MIRT2472560	hsa-miR-548d-3p	CLIP-seq
MIRT2472561	hsa-miR-548x	CLIP-seq
MIRT2472562	hsa-miR-548z	CLIP-seq
MIRT2674839	hsa-miR-663	CLIP-seq
MIRT2472565	hsa-miR-759	CLIP-seq
MIRT776091	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15630084, 32296183, 32814053
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0034446	Process	Substrate adhesion-dependent cell spreading	IEA
GO:1901222	Process	Regulation of NIK/NF-kappaB signaling	IEA

MIM	HGNC	e!Ensembl
609191	1170	ENSG00000166452

Protein

UniProt ID

Q9NQ31

Protein name

A-kinase-interacting protein 1 (Breast cancer-associated gene 3 protein) (PKA-interacting protein) (Proline-rich protein BCA3)

Protein function

Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway o

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain. {ECO:0000269|PubMed:12527432,

Sequence

MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE
KQPAAGPQRVLPGEREERPPTLSASFRTMAEFMDYTSSQCGKYYSSVPEEGGATHVYRYH
RGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEASQPAENISKDLYIEVYPGTY
SVTVGSNDLTKKTHVVAVDSGQSVDLVFPV

Sequence length

210

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Heart failure	Heart Failure, Diastolic		29556499	ClinVar

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining
Astrocytoma	Associate	38019246
Breast Neoplasms	Associate	20562110, 25526186, 32401379
Carcinoma Hepatocellular	Associate	32133702
Carcinoma Non Small Cell Lung	Associate	31782840, 31828834
Carcinoma Renal Cell	Stimulate	32541526
Glioma	Associate	33530151, 35111846
Leukemia Myeloid Acute	Associate	31617252, 32356617
Lymphatic Metastasis	Stimulate	31782840, 31828834, 32401379, 33832094
Multiple Myeloma	Stimulate	32799782
Neoplasm Metastasis	Stimulate	32401379
Neoplasms	Associate	25526186, 31828834, 32133702, 32339056, 32541526, 32643206
Neoplasms	Stimulate	31782840, 33832094
Prostatic Neoplasms	Associate	32339056
Squamous Cell Carcinoma of Head and Neck	Associate	33832094
Thyroid Cancer Papillary	Associate	32643206
Uterine Cervical Neoplasms	Stimulate	32401379

AKIP1 (A-kinase interacting protein 1)