Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	56666
Gene name Gene Name - the full gene name approved by the HGNC.	Pannexin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PANX2
Synonyms (NCBI Gene) Gene synonyms aliases	PX2, hPANX2
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.33
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neur

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miRTarBase ID	miRNA	Experiments
MIRT1212427	hsa-let-7a	CLIP-seq
MIRT1212428	hsa-let-7b	CLIP-seq
MIRT1212429	hsa-let-7c	CLIP-seq
MIRT1212430	hsa-let-7d	CLIP-seq
MIRT1212431	hsa-let-7e	CLIP-seq
MIRT1212432	hsa-let-7f	CLIP-seq
MIRT1212433	hsa-let-7g	CLIP-seq
MIRT1212434	hsa-let-7i	CLIP-seq
MIRT1212435	hsa-miR-1273d	CLIP-seq
MIRT1212436	hsa-miR-1286	CLIP-seq
MIRT1212437	hsa-miR-136	CLIP-seq
MIRT1212438	hsa-miR-202	CLIP-seq
MIRT1212439	hsa-miR-3170	CLIP-seq
MIRT1212440	hsa-miR-329	CLIP-seq
MIRT1212441	hsa-miR-342-5p	CLIP-seq
MIRT1212442	hsa-miR-362-3p	CLIP-seq
MIRT1212443	hsa-miR-3649	CLIP-seq
MIRT1212444	hsa-miR-370	CLIP-seq
MIRT1212445	hsa-miR-377	CLIP-seq
MIRT1212446	hsa-miR-4260	CLIP-seq
MIRT1212447	hsa-miR-4458	CLIP-seq
MIRT1212448	hsa-miR-4500	CLIP-seq
MIRT1212449	hsa-miR-4508	CLIP-seq
MIRT1212450	hsa-miR-4648	CLIP-seq
MIRT1212451	hsa-miR-4651	CLIP-seq
MIRT1212452	hsa-miR-4664-5p	CLIP-seq
MIRT1212453	hsa-miR-4678	CLIP-seq
MIRT1212454	hsa-miR-4722-5p	CLIP-seq
MIRT1212455	hsa-miR-4747-5p	CLIP-seq
MIRT1212456	hsa-miR-4793-5p	CLIP-seq
MIRT1212457	hsa-miR-574-3p	CLIP-seq
MIRT1212458	hsa-miR-608	CLIP-seq
MIRT1212459	hsa-miR-767-3p	CLIP-seq
MIRT1212460	hsa-miR-98	CLIP-seq
MIRT1212435	hsa-miR-1273d	CLIP-seq
MIRT1212444	hsa-miR-370	CLIP-seq
MIRT1212456	hsa-miR-4793-5p	CLIP-seq
MIRT2289718	hsa-miR-1976	CLIP-seq
MIRT2289719	hsa-miR-3667-3p	CLIP-seq
MIRT2289720	hsa-miR-3682-3p	CLIP-seq
MIRT2289721	hsa-miR-4421	CLIP-seq
MIRT2289722	hsa-miR-4502	CLIP-seq
MIRT1212456	hsa-miR-4793-5p	CLIP-seq
MIRT2392094	hsa-miR-1224-3p	CLIP-seq
MIRT2392095	hsa-miR-1236	CLIP-seq
MIRT1212435	hsa-miR-1273d	CLIP-seq
MIRT2392096	hsa-miR-1285	CLIP-seq
MIRT2392097	hsa-miR-149	CLIP-seq
MIRT2392098	hsa-miR-3187-5p	CLIP-seq
MIRT2392099	hsa-miR-3622a-3p	CLIP-seq
MIRT2392100	hsa-miR-3622b-3p	CLIP-seq
MIRT2289719	hsa-miR-3667-3p	CLIP-seq
MIRT1212444	hsa-miR-370	CLIP-seq
MIRT2392101	hsa-miR-4292	CLIP-seq
MIRT2392102	hsa-miR-4308	CLIP-seq
MIRT2392103	hsa-miR-4505	CLIP-seq
MIRT1212456	hsa-miR-4793-5p	CLIP-seq
MIRT2392104	hsa-miR-612	CLIP-seq
MIRT2392105	hsa-miR-670	CLIP-seq
MIRT2392106	hsa-miR-760	CLIP-seq
MIRT2687053	hsa-miR-3940-3p	CLIP-seq
MIRT2687054	hsa-miR-4532	CLIP-seq
MIRT2687055	hsa-miR-4640-5p	CLIP-seq
MIRT2687056	hsa-miR-4726-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002931	Process	Response to ischemia	IEA
GO:0005198	Function	Structural molecule activity	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005921	Component	Gap junction	IEA
GO:0006812	Process	Cation transport	IBA	21873635
GO:0007267	Process	Cell-cell signaling	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0022829	Function	Wide pore channel activity	IBA	21873635
GO:0032732	Process	Positive regulation of interleukin-1 production	IEA
GO:0055077	Function	Gap junction hemi-channel activity	ISS
GO:0055085	Process	Transmembrane transport	IEA

MIM	HGNC	e!Ensembl
608421	8600	ENSG00000073150

Protein

UniProt ID

Q96RD6

Protein name

Pannexin-2

Protein function

Ion channel with a slight anion preference (PubMed:36973289). Also able to release ATP (PubMed:36869038). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q6IMP4, ECO:0000269|PubMed:3

PDB

7XLB , 8F7C , 8GYQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00876	Innexin	49 → 358	Innexin	Family

Sequence

MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVL
VPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFE
HKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQI
QSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAV
PISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCV
MNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKS
LNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEP
PVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRS
AHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASR
SQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAV
APLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQI
LIATFDEPRTVVSTVEF

Sequence length

677

Interactions

View interactions

	Reactome
			Electric Transmission Across Gap Junctions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Diabetes	Diabetes	GWAS
Dyslexia	Dyslexia	GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Autism Spectrum Disorder	Associate	37939567
Epilepsy	Associate	28036289
Focal Cortical Dysplasia	Associate	28036289
Glioma	Associate	33913372
Lymphoma Non Hodgkin	Associate	33913372
Malformations of Cortical Development	Associate	28036289
Mouth Diseases	Stimulate	28036289
Neoplasms	Inhibit	26099202
Neoplasms	Associate	33913372
Niemann Pick Disease Type C	Associate	37939567

PANX2 (pannexin 2)