PANX2 (pannexin 2)

Gene

• Entrez ID: 56666
• Gene name: Pannexin 2
• Gene symbol: PANX2
• Synonyms (NCBI Gene): PX2, hPANX2
• Chromosome: 22
• Chromosome location: 22q13.33
• Summary: The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neur

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1212427	hsa-let-7a	CLIP-seq
MIRT1212428	hsa-let-7b	CLIP-seq
MIRT1212429	hsa-let-7c	CLIP-seq
MIRT1212430	hsa-let-7d	CLIP-seq
MIRT1212431	hsa-let-7e	CLIP-seq
MIRT1212432	hsa-let-7f	CLIP-seq
MIRT1212433	hsa-let-7g	CLIP-seq
MIRT1212434	hsa-let-7i	CLIP-seq
MIRT1212435	hsa-miR-1273d	CLIP-seq
MIRT1212436	hsa-miR-1286	CLIP-seq
MIRT1212437	hsa-miR-136	CLIP-seq
MIRT1212438	hsa-miR-202	CLIP-seq
MIRT1212439	hsa-miR-3170	CLIP-seq
MIRT1212440	hsa-miR-329	CLIP-seq
MIRT1212441	hsa-miR-342-5p	CLIP-seq
MIRT1212442	hsa-miR-362-3p	CLIP-seq
MIRT1212443	hsa-miR-3649	CLIP-seq
MIRT1212444	hsa-miR-370	CLIP-seq
MIRT1212445	hsa-miR-377	CLIP-seq
MIRT1212446	hsa-miR-4260	CLIP-seq
MIRT1212447	hsa-miR-4458	CLIP-seq
MIRT1212448	hsa-miR-4500	CLIP-seq
MIRT1212449	hsa-miR-4508	CLIP-seq
MIRT1212450	hsa-miR-4648	CLIP-seq
MIRT1212451	hsa-miR-4651	CLIP-seq
MIRT1212452	hsa-miR-4664-5p	CLIP-seq
MIRT1212453	hsa-miR-4678	CLIP-seq
MIRT1212454	hsa-miR-4722-5p	CLIP-seq
MIRT1212455	hsa-miR-4747-5p	CLIP-seq
MIRT1212456	hsa-miR-4793-5p	CLIP-seq
MIRT1212457	hsa-miR-574-3p	CLIP-seq
MIRT1212458	hsa-miR-608	CLIP-seq
MIRT1212459	hsa-miR-767-3p	CLIP-seq
MIRT1212460	hsa-miR-98	CLIP-seq
MIRT1212435	hsa-miR-1273d	CLIP-seq
MIRT1212444	hsa-miR-370	CLIP-seq
MIRT1212456	hsa-miR-4793-5p	CLIP-seq
MIRT2289718	hsa-miR-1976	CLIP-seq
MIRT2289719	hsa-miR-3667-3p	CLIP-seq
MIRT2289720	hsa-miR-3682-3p	CLIP-seq
MIRT2289721	hsa-miR-4421	CLIP-seq
MIRT2289722	hsa-miR-4502	CLIP-seq
MIRT1212456	hsa-miR-4793-5p	CLIP-seq
MIRT2392094	hsa-miR-1224-3p	CLIP-seq
MIRT2392095	hsa-miR-1236	CLIP-seq
MIRT1212435	hsa-miR-1273d	CLIP-seq
MIRT2392096	hsa-miR-1285	CLIP-seq
MIRT2392097	hsa-miR-149	CLIP-seq
MIRT2392098	hsa-miR-3187-5p	CLIP-seq
MIRT2392099	hsa-miR-3622a-3p	CLIP-seq
MIRT2392100	hsa-miR-3622b-3p	CLIP-seq
MIRT2289719	hsa-miR-3667-3p	CLIP-seq
MIRT1212444	hsa-miR-370	CLIP-seq
MIRT2392101	hsa-miR-4292	CLIP-seq
MIRT2392102	hsa-miR-4308	CLIP-seq
MIRT2392103	hsa-miR-4505	CLIP-seq
MIRT1212456	hsa-miR-4793-5p	CLIP-seq
MIRT2392104	hsa-miR-612	CLIP-seq
MIRT2392105	hsa-miR-670	CLIP-seq
MIRT2392106	hsa-miR-760	CLIP-seq
MIRT2687053	hsa-miR-3940-3p	CLIP-seq
MIRT2687054	hsa-miR-4532	CLIP-seq
MIRT2687055	hsa-miR-4640-5p	CLIP-seq
MIRT2687056	hsa-miR-4726-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0002931	Process	Response to ischemia	IEA
GO:0005198	Function	Structural molecule activity	ISS
GO:0005243	Function	Gap junction channel activity	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006812	Process	Monoatomic cation transport	IBA
GO:0006812	Process	Monoatomic cation transport	IEA
GO:0007267	Process	Cell-cell signaling	IBA
GO:0007267	Process	Cell-cell signaling	IEA
GO:0015267	Function	Channel activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0022829	Function	Wide pore channel activity	IBA
GO:0032732	Process	Positive regulation of interleukin-1 production	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0055077	Function	Gap junction hemi-channel activity	ISS

Other IDs

• MIM: 608421
• HGNC: 8600
• e!Ensembl: ENSG00000073150

Protein

• UniProt ID: Q96RD6
• Protein name: Pannexin-2
• Protein function: Ion channel with a slight anion preference (PubMed:36973289). Also able to release ATP (PubMed:36869038). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q6IMP4, ECO:0000269|PubMed:3
• PDB: 7XLB, 8F7C, 8GYQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00876	Innexin	49 → 358	Innexin	Family

• Sequence:

  MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVL
  VPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFE
  HKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQI
  QSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAV
  PISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCV
  MNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKS
  LNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEP
  PVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRS
  AHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASR
  SQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAV
  APLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQI
  LIATFDEPRTVVSTVEF

• Sequence length: 677

Pathways

Reactome:

Electric Transmission Across Gap Junctions