Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	56616
Gene name	Diablo IAP-binding mitochondrial protein
Gene symbol	DIABLO
Synonyms (NCBI Gene)	DFNA64SMAC
Chromosome	12
Chromosome location	12q24.31
Summary	This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression o

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SNP ID	Visualize variation	Clinical significance	Consequence
rs370571609	A>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Intron variant
rs387906893	G>A	Pathogenic	Missense variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005907	hsa-miR-29a-3p	qRT-PCR	21169019
MIRT029197	hsa-miR-26b-5p	Microarray	19088304
MIRT031535	hsa-miR-16-5p	Proteomics	18668040
MIRT047377	hsa-miR-34a-5p	CLASH	23622248
MIRT508672	hsa-miR-4506	PAR-CLIP	20371350
MIRT508671	hsa-miR-2278	PAR-CLIP	20371350
MIRT508670	hsa-miR-646	PAR-CLIP	20371350
MIRT508669	hsa-let-7a-5p	PAR-CLIP	20371350
MIRT508668	hsa-let-7b-5p	PAR-CLIP	20371350
MIRT508667	hsa-let-7c-5p	PAR-CLIP	20371350
MIRT508666	hsa-let-7d-5p	PAR-CLIP	20371350
MIRT508665	hsa-let-7e-5p	PAR-CLIP	20371350
MIRT508664	hsa-let-7f-5p	PAR-CLIP	20371350
MIRT508663	hsa-let-7g-5p	PAR-CLIP	20371350
MIRT508662	hsa-let-7i-5p	PAR-CLIP	20371350
MIRT508661	hsa-miR-4458	PAR-CLIP	20371350
MIRT508660	hsa-miR-4500	PAR-CLIP	20371350
MIRT508659	hsa-miR-98-5p	PAR-CLIP	20371350
MIRT508658	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT508656	hsa-miR-555	PAR-CLIP	20371350
MIRT508655	hsa-miR-6772-5p	PAR-CLIP	20371350
MIRT508654	hsa-miR-4455	PAR-CLIP	20371350
MIRT508653	hsa-miR-609	PAR-CLIP	20371350
MIRT508652	hsa-miR-4316	PAR-CLIP	20371350
MIRT508651	hsa-miR-1294	PAR-CLIP	20371350
MIRT508650	hsa-miR-1262	PAR-CLIP	20371350
MIRT508649	hsa-miR-4701-3p	PAR-CLIP	20371350
MIRT508648	hsa-miR-6736-5p	PAR-CLIP	20371350
MIRT508647	hsa-miR-6741-5p	PAR-CLIP	20371350
MIRT508672	hsa-miR-4506	PAR-CLIP	23446348
MIRT508671	hsa-miR-2278	PAR-CLIP	23446348
MIRT508670	hsa-miR-646	PAR-CLIP	23446348
MIRT508669	hsa-let-7a-5p	PAR-CLIP	23446348
MIRT508668	hsa-let-7b-5p	PAR-CLIP	23446348
MIRT508667	hsa-let-7c-5p	PAR-CLIP	23446348
MIRT508666	hsa-let-7d-5p	PAR-CLIP	23446348
MIRT508665	hsa-let-7e-5p	PAR-CLIP	23446348
MIRT508664	hsa-let-7f-5p	PAR-CLIP	23446348
MIRT508663	hsa-let-7g-5p	PAR-CLIP	23446348
MIRT508662	hsa-let-7i-5p	PAR-CLIP	23446348
MIRT508661	hsa-miR-4458	PAR-CLIP	23446348
MIRT508660	hsa-miR-4500	PAR-CLIP	23446348
MIRT508659	hsa-miR-98-5p	PAR-CLIP	23446348
MIRT508658	hsa-miR-202-3p	PAR-CLIP	23446348
MIRT508657	hsa-miR-1251-3p	PAR-CLIP	23446348
MIRT508656	hsa-miR-555	PAR-CLIP	23446348
MIRT508655	hsa-miR-6772-5p	PAR-CLIP	23446348
MIRT508654	hsa-miR-4455	PAR-CLIP	23446348
MIRT508653	hsa-miR-609	PAR-CLIP	23446348
MIRT508652	hsa-miR-4316	PAR-CLIP	23446348
MIRT508651	hsa-miR-1294	PAR-CLIP	23446348
MIRT508650	hsa-miR-1262	PAR-CLIP	23446348
MIRT508649	hsa-miR-4701-3p	PAR-CLIP	23446348
MIRT508648	hsa-miR-6736-5p	PAR-CLIP	23446348
MIRT508647	hsa-miR-6741-5p	PAR-CLIP	23446348
MIRT440818	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440818	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT047377	hsa-miR-34a-5p	PCR array	28097098
MIRT508672	hsa-miR-4506	PAR-CLIP	20371350
MIRT508671	hsa-miR-2278	PAR-CLIP	20371350
MIRT508670	hsa-miR-646	PAR-CLIP	20371350
MIRT508669	hsa-let-7a-5p	PAR-CLIP	20371350
MIRT508668	hsa-let-7b-5p	PAR-CLIP	20371350
MIRT508667	hsa-let-7c-5p	PAR-CLIP	20371350
MIRT508666	hsa-let-7d-5p	PAR-CLIP	20371350
MIRT508665	hsa-let-7e-5p	PAR-CLIP	20371350
MIRT508664	hsa-let-7f-5p	PAR-CLIP	20371350
MIRT508663	hsa-let-7g-5p	PAR-CLIP	20371350
MIRT508662	hsa-let-7i-5p	PAR-CLIP	20371350
MIRT508661	hsa-miR-4458	PAR-CLIP	20371350
MIRT508660	hsa-miR-4500	PAR-CLIP	20371350
MIRT508659	hsa-miR-98-5p	PAR-CLIP	20371350
MIRT508658	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT508656	hsa-miR-555	PAR-CLIP	20371350
MIRT508655	hsa-miR-6772-5p	PAR-CLIP	20371350
MIRT508654	hsa-miR-4455	PAR-CLIP	20371350
MIRT508653	hsa-miR-609	PAR-CLIP	20371350
MIRT508652	hsa-miR-4316	PAR-CLIP	20371350
MIRT508651	hsa-miR-1294	PAR-CLIP	20371350
MIRT508650	hsa-miR-1262	PAR-CLIP	20371350
MIRT508649	hsa-miR-4701-3p	PAR-CLIP	20371350
MIRT508648	hsa-miR-6736-5p	PAR-CLIP	20371350
MIRT508647	hsa-miR-6741-5p	PAR-CLIP	20371350
MIRT508672	hsa-miR-4506	PAR-CLIP	23446348
MIRT508671	hsa-miR-2278	PAR-CLIP	23446348
MIRT508670	hsa-miR-646	PAR-CLIP	23446348
MIRT508669	hsa-let-7a-5p	PAR-CLIP	23446348
MIRT508668	hsa-let-7b-5p	PAR-CLIP	23446348
MIRT508667	hsa-let-7c-5p	PAR-CLIP	23446348
MIRT508666	hsa-let-7d-5p	PAR-CLIP	23446348
MIRT508665	hsa-let-7e-5p	PAR-CLIP	23446348
MIRT508664	hsa-let-7f-5p	PAR-CLIP	23446348
MIRT508663	hsa-let-7g-5p	PAR-CLIP	23446348
MIRT508662	hsa-let-7i-5p	PAR-CLIP	23446348
MIRT508661	hsa-miR-4458	PAR-CLIP	23446348
MIRT508660	hsa-miR-4500	PAR-CLIP	23446348
MIRT508659	hsa-miR-98-5p	PAR-CLIP	23446348
MIRT508658	hsa-miR-202-3p	PAR-CLIP	23446348
MIRT508657	hsa-miR-1251-3p	PAR-CLIP	23446348
MIRT508656	hsa-miR-555	PAR-CLIP	23446348
MIRT508655	hsa-miR-6772-5p	PAR-CLIP	23446348
MIRT508654	hsa-miR-4455	PAR-CLIP	23446348
MIRT508653	hsa-miR-609	PAR-CLIP	23446348
MIRT508652	hsa-miR-4316	PAR-CLIP	23446348
MIRT508651	hsa-miR-1294	PAR-CLIP	23446348
MIRT508650	hsa-miR-1262	PAR-CLIP	23446348
MIRT508649	hsa-miR-4701-3p	PAR-CLIP	23446348
MIRT508648	hsa-miR-6736-5p	PAR-CLIP	23446348
MIRT508647	hsa-miR-6741-5p	PAR-CLIP	23446348
MIRT935796	hsa-let-7a	CLIP-seq
MIRT935797	hsa-let-7b	CLIP-seq
MIRT935798	hsa-let-7c	CLIP-seq
MIRT935799	hsa-let-7d	CLIP-seq
MIRT935800	hsa-let-7e	CLIP-seq
MIRT935801	hsa-let-7f	CLIP-seq
MIRT935802	hsa-let-7g	CLIP-seq
MIRT935803	hsa-let-7i	CLIP-seq
MIRT935804	hsa-miR-1207-3p	CLIP-seq
MIRT935805	hsa-miR-202	CLIP-seq
MIRT935806	hsa-miR-3189-3p	CLIP-seq
MIRT935807	hsa-miR-383	CLIP-seq
MIRT935808	hsa-miR-3909	CLIP-seq
MIRT935809	hsa-miR-3919	CLIP-seq
MIRT935810	hsa-miR-3925-5p	CLIP-seq
MIRT935811	hsa-miR-4436a	CLIP-seq
MIRT935812	hsa-miR-4447	CLIP-seq
MIRT935813	hsa-miR-4464	CLIP-seq
MIRT935814	hsa-miR-4472	CLIP-seq
MIRT935815	hsa-miR-4488	CLIP-seq
MIRT935816	hsa-miR-4697-5p	CLIP-seq
MIRT935817	hsa-miR-4698	CLIP-seq
MIRT935818	hsa-miR-4700-3p	CLIP-seq
MIRT935819	hsa-miR-4726-3p	CLIP-seq
MIRT935820	hsa-miR-4748	CLIP-seq
MIRT935821	hsa-miR-4756-3p	CLIP-seq
MIRT935822	hsa-miR-4757-5p	CLIP-seq
MIRT935823	hsa-miR-483-3p	CLIP-seq
MIRT935824	hsa-miR-486-3p	CLIP-seq
MIRT935825	hsa-miR-5096	CLIP-seq
MIRT935826	hsa-miR-513a-5p	CLIP-seq
MIRT935827	hsa-miR-520d-5p	CLIP-seq
MIRT935828	hsa-miR-524-5p	CLIP-seq
MIRT935829	hsa-miR-98	CLIP-seq
MIRT935796	hsa-let-7a	CLIP-seq
MIRT935797	hsa-let-7b	CLIP-seq
MIRT935798	hsa-let-7c	CLIP-seq
MIRT935799	hsa-let-7d	CLIP-seq
MIRT935800	hsa-let-7e	CLIP-seq
MIRT935801	hsa-let-7f	CLIP-seq
MIRT935802	hsa-let-7g	CLIP-seq
MIRT935803	hsa-let-7i	CLIP-seq
MIRT935830	hsa-miR-1207-5p	CLIP-seq
MIRT935831	hsa-miR-1252	CLIP-seq
MIRT935832	hsa-miR-1285	CLIP-seq
MIRT935833	hsa-miR-1913	CLIP-seq
MIRT935805	hsa-miR-202	CLIP-seq
MIRT935834	hsa-miR-3152-3p	CLIP-seq
MIRT935835	hsa-miR-3160-5p	CLIP-seq
MIRT935836	hsa-miR-3187-5p	CLIP-seq
MIRT935837	hsa-miR-324-3p	CLIP-seq
MIRT935838	hsa-miR-3612	CLIP-seq
MIRT935839	hsa-miR-4292	CLIP-seq
MIRT935840	hsa-miR-4459	CLIP-seq
MIRT935841	hsa-miR-4476	CLIP-seq
MIRT935842	hsa-miR-4533	CLIP-seq
MIRT935843	hsa-miR-4642	CLIP-seq
MIRT935844	hsa-miR-4695-5p	CLIP-seq
MIRT935845	hsa-miR-4719	CLIP-seq
MIRT935846	hsa-miR-4749-3p	CLIP-seq
MIRT935847	hsa-miR-4763-3p	CLIP-seq
MIRT935848	hsa-miR-570	CLIP-seq
MIRT935849	hsa-miR-612	CLIP-seq
MIRT935850	hsa-miR-628-5p	CLIP-seq
MIRT935851	hsa-miR-650	CLIP-seq
MIRT935829	hsa-miR-98	CLIP-seq
MIRT935796	hsa-let-7a	CLIP-seq
MIRT935797	hsa-let-7b	CLIP-seq
MIRT935798	hsa-let-7c	CLIP-seq
MIRT935799	hsa-let-7d	CLIP-seq
MIRT935800	hsa-let-7e	CLIP-seq
MIRT935801	hsa-let-7f	CLIP-seq
MIRT935802	hsa-let-7g	CLIP-seq
MIRT935803	hsa-let-7i	CLIP-seq
MIRT935805	hsa-miR-202	CLIP-seq
MIRT935817	hsa-miR-4698	CLIP-seq
MIRT935829	hsa-miR-98	CLIP-seq
MIRT1976989	hsa-miR-3064-3p	CLIP-seq
MIRT935826	hsa-miR-513a-5p	CLIP-seq
MIRT935796	hsa-let-7a	CLIP-seq
MIRT935797	hsa-let-7b	CLIP-seq
MIRT935798	hsa-let-7c	CLIP-seq
MIRT935799	hsa-let-7d	CLIP-seq
MIRT935800	hsa-let-7e	CLIP-seq
MIRT935801	hsa-let-7f	CLIP-seq
MIRT935802	hsa-let-7g	CLIP-seq
MIRT935803	hsa-let-7i	CLIP-seq
MIRT935804	hsa-miR-1207-3p	CLIP-seq
MIRT2212425	hsa-miR-1267	CLIP-seq
MIRT935805	hsa-miR-202	CLIP-seq
MIRT2212426	hsa-miR-29a	CLIP-seq
MIRT2212427	hsa-miR-29b	CLIP-seq
MIRT2212428	hsa-miR-29c	CLIP-seq
MIRT1976989	hsa-miR-3064-3p	CLIP-seq
MIRT2212429	hsa-miR-30a	CLIP-seq
MIRT2212430	hsa-miR-30b	CLIP-seq
MIRT2212431	hsa-miR-30c	CLIP-seq
MIRT2212432	hsa-miR-30d	CLIP-seq
MIRT2212433	hsa-miR-30e	CLIP-seq
MIRT2212434	hsa-miR-3187-3p	CLIP-seq
MIRT935806	hsa-miR-3189-3p	CLIP-seq
MIRT2212435	hsa-miR-3663-3p	CLIP-seq
MIRT935807	hsa-miR-383	CLIP-seq
MIRT935808	hsa-miR-3909	CLIP-seq
MIRT935809	hsa-miR-3919	CLIP-seq
MIRT935810	hsa-miR-3925-5p	CLIP-seq
MIRT2212436	hsa-miR-4435	CLIP-seq
MIRT935811	hsa-miR-4436a	CLIP-seq
MIRT2212437	hsa-miR-4436b-3p	CLIP-seq
MIRT935812	hsa-miR-4447	CLIP-seq
MIRT935814	hsa-miR-4472	CLIP-seq
MIRT935815	hsa-miR-4488	CLIP-seq
MIRT2212438	hsa-miR-4685-5p	CLIP-seq
MIRT935816	hsa-miR-4697-5p	CLIP-seq
MIRT935817	hsa-miR-4698	CLIP-seq
MIRT935818	hsa-miR-4700-3p	CLIP-seq
MIRT2212439	hsa-miR-4701-5p	CLIP-seq
MIRT2212440	hsa-miR-4733-3p	CLIP-seq
MIRT935821	hsa-miR-4756-3p	CLIP-seq
MIRT935822	hsa-miR-4757-5p	CLIP-seq
MIRT935823	hsa-miR-483-3p	CLIP-seq
MIRT935824	hsa-miR-486-3p	CLIP-seq
MIRT2212441	hsa-miR-509-3p	CLIP-seq
MIRT935826	hsa-miR-513a-5p	CLIP-seq
MIRT2212442	hsa-miR-548s	CLIP-seq
MIRT2212443	hsa-miR-588	CLIP-seq
MIRT935829	hsa-miR-98	CLIP-seq
MIRT935796	hsa-let-7a	CLIP-seq
MIRT935797	hsa-let-7b	CLIP-seq
MIRT935798	hsa-let-7c	CLIP-seq
MIRT935799	hsa-let-7d	CLIP-seq
MIRT935800	hsa-let-7e	CLIP-seq
MIRT935801	hsa-let-7f	CLIP-seq
MIRT935802	hsa-let-7g	CLIP-seq
MIRT935803	hsa-let-7i	CLIP-seq
MIRT935830	hsa-miR-1207-5p	CLIP-seq
MIRT2516076	hsa-miR-1250	CLIP-seq
MIRT935832	hsa-miR-1285	CLIP-seq
MIRT2516077	hsa-miR-1324	CLIP-seq
MIRT2516078	hsa-miR-140-3p	CLIP-seq
MIRT935833	hsa-miR-1913	CLIP-seq
MIRT2516079	hsa-miR-1972	CLIP-seq
MIRT935805	hsa-miR-202	CLIP-seq
MIRT2516080	hsa-miR-203	CLIP-seq
MIRT2516081	hsa-miR-2355-5p	CLIP-seq
MIRT1976989	hsa-miR-3064-3p	CLIP-seq
MIRT2516082	hsa-miR-3150a-3p	CLIP-seq
MIRT935835	hsa-miR-3160-5p	CLIP-seq
MIRT2516083	hsa-miR-3175	CLIP-seq
MIRT2516084	hsa-miR-3186-5p	CLIP-seq
MIRT2212434	hsa-miR-3187-3p	CLIP-seq
MIRT935836	hsa-miR-3187-5p	CLIP-seq
MIRT935837	hsa-miR-324-3p	CLIP-seq
MIRT2516085	hsa-miR-324-5p	CLIP-seq
MIRT2516086	hsa-miR-342-5p	CLIP-seq
MIRT2516087	hsa-miR-34a	CLIP-seq
MIRT2516088	hsa-miR-34c-5p	CLIP-seq
MIRT935838	hsa-miR-3612	CLIP-seq
MIRT2516089	hsa-miR-3679-3p	CLIP-seq
MIRT2516090	hsa-miR-371b-3p	CLIP-seq
MIRT2516091	hsa-miR-4253	CLIP-seq
MIRT2516092	hsa-miR-4286	CLIP-seq
MIRT935839	hsa-miR-4292	CLIP-seq
MIRT2516093	hsa-miR-4302	CLIP-seq
MIRT2516094	hsa-miR-4432	CLIP-seq
MIRT2212436	hsa-miR-4435	CLIP-seq
MIRT2212437	hsa-miR-4436b-3p	CLIP-seq
MIRT935840	hsa-miR-4459	CLIP-seq
MIRT2516095	hsa-miR-4481	CLIP-seq
MIRT2516096	hsa-miR-4484	CLIP-seq
MIRT2516097	hsa-miR-4499	CLIP-seq
MIRT2516098	hsa-miR-449a	CLIP-seq
MIRT2516099	hsa-miR-449b	CLIP-seq
MIRT2516100	hsa-miR-4511	CLIP-seq
MIRT2516101	hsa-miR-4539	CLIP-seq
MIRT2516102	hsa-miR-4632	CLIP-seq
MIRT935843	hsa-miR-4642	CLIP-seq
MIRT2516103	hsa-miR-4650-5p	CLIP-seq
MIRT2516104	hsa-miR-4651	CLIP-seq
MIRT2516105	hsa-miR-4664-5p	CLIP-seq
MIRT2212438	hsa-miR-4685-5p	CLIP-seq
MIRT935844	hsa-miR-4695-5p	CLIP-seq
MIRT935817	hsa-miR-4698	CLIP-seq
MIRT2212439	hsa-miR-4701-5p	CLIP-seq
MIRT2516106	hsa-miR-4718	CLIP-seq
MIRT935845	hsa-miR-4719	CLIP-seq
MIRT2516107	hsa-miR-4720-5p	CLIP-seq
MIRT935819	hsa-miR-4726-3p	CLIP-seq
MIRT2516108	hsa-miR-4733-5p	CLIP-seq
MIRT2516109	hsa-miR-4738-5p	CLIP-seq
MIRT2516110	hsa-miR-4745-5p	CLIP-seq
MIRT935846	hsa-miR-4749-3p	CLIP-seq
MIRT2516111	hsa-miR-4758-5p	CLIP-seq
MIRT2516112	hsa-miR-4761-3p	CLIP-seq
MIRT935847	hsa-miR-4763-3p	CLIP-seq
MIRT2516113	hsa-miR-4786-5p	CLIP-seq
MIRT2516114	hsa-miR-4797-5p	CLIP-seq
MIRT2516115	hsa-miR-4799-3p	CLIP-seq
MIRT2516116	hsa-miR-491-5p	CLIP-seq
MIRT2516117	hsa-miR-499-5p	CLIP-seq
MIRT2212441	hsa-miR-509-3p	CLIP-seq
MIRT2516118	hsa-miR-548b-3p	CLIP-seq
MIRT2212442	hsa-miR-548s	CLIP-seq
MIRT935848	hsa-miR-570	CLIP-seq
MIRT2212443	hsa-miR-588	CLIP-seq
MIRT2516119	hsa-miR-608	CLIP-seq
MIRT935849	hsa-miR-612	CLIP-seq
MIRT935850	hsa-miR-628-5p	CLIP-seq
MIRT2516120	hsa-miR-648	CLIP-seq
MIRT935851	hsa-miR-650	CLIP-seq
MIRT2516121	hsa-miR-759	CLIP-seq
MIRT2516122	hsa-miR-769-5p	CLIP-seq
MIRT2516123	hsa-miR-939	CLIP-seq
MIRT2516124	hsa-miR-942	CLIP-seq
MIRT935829	hsa-miR-98	CLIP-seq
MIRT2516113	hsa-miR-4786-5p	CLIP-seq
MIRT2516122	hsa-miR-769-5p	CLIP-seq
MIRT935796	hsa-let-7a	CLIP-seq
MIRT935797	hsa-let-7b	CLIP-seq
MIRT935798	hsa-let-7c	CLIP-seq
MIRT935799	hsa-let-7d	CLIP-seq
MIRT935800	hsa-let-7e	CLIP-seq
MIRT935801	hsa-let-7f	CLIP-seq
MIRT935802	hsa-let-7g	CLIP-seq
MIRT935803	hsa-let-7i	CLIP-seq
MIRT935830	hsa-miR-1207-5p	CLIP-seq
MIRT2516076	hsa-miR-1250	CLIP-seq
MIRT935832	hsa-miR-1285	CLIP-seq
MIRT2516077	hsa-miR-1324	CLIP-seq
MIRT2516078	hsa-miR-140-3p	CLIP-seq
MIRT935833	hsa-miR-1913	CLIP-seq
MIRT935805	hsa-miR-202	CLIP-seq
MIRT2516080	hsa-miR-203	CLIP-seq
MIRT2516081	hsa-miR-2355-5p	CLIP-seq
MIRT1976989	hsa-miR-3064-3p	CLIP-seq
MIRT2516082	hsa-miR-3150a-3p	CLIP-seq
MIRT935835	hsa-miR-3160-5p	CLIP-seq
MIRT2516083	hsa-miR-3175	CLIP-seq
MIRT2516084	hsa-miR-3186-5p	CLIP-seq
MIRT2212434	hsa-miR-3187-3p	CLIP-seq
MIRT935836	hsa-miR-3187-5p	CLIP-seq
MIRT935837	hsa-miR-324-3p	CLIP-seq
MIRT2516085	hsa-miR-324-5p	CLIP-seq
MIRT2516086	hsa-miR-342-5p	CLIP-seq
MIRT2516087	hsa-miR-34a	CLIP-seq
MIRT2516088	hsa-miR-34c-5p	CLIP-seq
MIRT935838	hsa-miR-3612	CLIP-seq
MIRT2516089	hsa-miR-3679-3p	CLIP-seq
MIRT2516090	hsa-miR-371b-3p	CLIP-seq
MIRT2516092	hsa-miR-4286	CLIP-seq
MIRT935839	hsa-miR-4292	CLIP-seq
MIRT2516093	hsa-miR-4302	CLIP-seq
MIRT2516094	hsa-miR-4432	CLIP-seq
MIRT2212436	hsa-miR-4435	CLIP-seq
MIRT2212437	hsa-miR-4436b-3p	CLIP-seq
MIRT935840	hsa-miR-4459	CLIP-seq
MIRT2516095	hsa-miR-4481	CLIP-seq
MIRT2516096	hsa-miR-4484	CLIP-seq
MIRT2516097	hsa-miR-4499	CLIP-seq
MIRT2516098	hsa-miR-449a	CLIP-seq
MIRT2516099	hsa-miR-449b	CLIP-seq
MIRT2516100	hsa-miR-4511	CLIP-seq
MIRT2516101	hsa-miR-4539	CLIP-seq
MIRT2516102	hsa-miR-4632	CLIP-seq
MIRT935843	hsa-miR-4642	CLIP-seq
MIRT2516104	hsa-miR-4651	CLIP-seq
MIRT2516105	hsa-miR-4664-5p	CLIP-seq
MIRT2212438	hsa-miR-4685-5p	CLIP-seq
MIRT935844	hsa-miR-4695-5p	CLIP-seq
MIRT935817	hsa-miR-4698	CLIP-seq
MIRT2212439	hsa-miR-4701-5p	CLIP-seq
MIRT2516106	hsa-miR-4718	CLIP-seq
MIRT935845	hsa-miR-4719	CLIP-seq
MIRT2516107	hsa-miR-4720-5p	CLIP-seq
MIRT935819	hsa-miR-4726-3p	CLIP-seq
MIRT2516108	hsa-miR-4733-5p	CLIP-seq
MIRT2516109	hsa-miR-4738-5p	CLIP-seq
MIRT2516110	hsa-miR-4745-5p	CLIP-seq
MIRT935846	hsa-miR-4749-3p	CLIP-seq
MIRT2516111	hsa-miR-4758-5p	CLIP-seq
MIRT2516112	hsa-miR-4761-3p	CLIP-seq
MIRT935847	hsa-miR-4763-3p	CLIP-seq
MIRT2516113	hsa-miR-4786-5p	CLIP-seq
MIRT2516114	hsa-miR-4797-5p	CLIP-seq
MIRT2516115	hsa-miR-4799-3p	CLIP-seq
MIRT2516116	hsa-miR-491-5p	CLIP-seq
MIRT2516117	hsa-miR-499-5p	CLIP-seq
MIRT2212441	hsa-miR-509-3p	CLIP-seq
MIRT2516118	hsa-miR-548b-3p	CLIP-seq
MIRT2212442	hsa-miR-548s	CLIP-seq
MIRT935848	hsa-miR-570	CLIP-seq
MIRT2212443	hsa-miR-588	CLIP-seq
MIRT2516119	hsa-miR-608	CLIP-seq
MIRT935849	hsa-miR-612	CLIP-seq
MIRT935850	hsa-miR-628-5p	CLIP-seq
MIRT2516120	hsa-miR-648	CLIP-seq
MIRT935851	hsa-miR-650	CLIP-seq
MIRT2516121	hsa-miR-759	CLIP-seq
MIRT2516122	hsa-miR-769-5p	CLIP-seq
MIRT2516123	hsa-miR-939	CLIP-seq
MIRT2516124	hsa-miR-942	CLIP-seq
MIRT935829	hsa-miR-98	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11140638, 11604410, 11801603, 12559088, 15200957, 15628841, 16282325, 16729033, 19153467, 19667203, 21185211, 21536684, 21695558, 22465666, 23251006, 23479728, 25416956, 26871637, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	28288130
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	10929711
GO:0005758	Component	Mitochondrial intermembrane space	TAS	18309324
GO:0005829	Component	Cytosol	IDA	28288130
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	10929712
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	TAS	10950947
GO:0008631	Process	Intrinsic apoptotic signaling pathway in response to oxidative stress	IBA
GO:0008631	Process	Intrinsic apoptotic signaling pathway in response to oxidative stress	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	ISS
GO:0035631	Component	CD40 receptor complex	IEA
GO:0035631	Component	CD40 receptor complex	ISS
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	TAS	18309324
GO:0051402	Process	Neuron apoptotic process	IBA
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0097190	Process	Apoptotic signaling pathway	IMP	10972280
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IEA
GO:0097193	Process	Intrinsic apoptotic signaling pathway	TAS	18309324

MIM	HGNC	e!Ensembl
605219	21528	ENSG00000184047

Q9NR28

Protein name

Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspases) (SMAC) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]

Protein function

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases

PDB

1FEW , 1G3F , 1G73 , 1OXQ , 1TW6 , 1XB0 , 1XB1 , 3D9U , 3UIH , 3UIJ , 4TX5 , 6JX6 , 8ATO , 8AUW , 8E2I , 8E2J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09057	Smac_DIABLO	9 → 239	Second Mitochondria-derived Activator of Caspases	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. {EC

Sequence

MAALKSWLSRSVTSFFRYRQCLCVPVVANFKKRCFSELIRPWHKTVTIGFGVTLCAVPIA
QKSEPHSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSL
LGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQAS
ITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKTQEEGEERAESEQEAYLRED

Sequence length

239

Interactions

View interactions

	KEGG		Reactome
	Apoptosis Apoptosis - multiple species		Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Autosomal dominant nonsyndromic hearing loss 64	Likely pathogenic	rs2547123498, rs1954260410	RCV004585113 RCV004585114

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Autosomal dominant nonsyndromic hearing loss	Uncertain significance	rs1566025862	RCV001693506
DIABLO-related disorder	Likely benign; Conflicting classifications of pathogenicity; Benign; Uncertain significance	rs752361472, rs139511903, rs202028496, rs150199226, rs1954459100, rs375537524, rs137928955	RCV003978824 RCV003967588 RCV003929889 RCV003920139 RCV003416751 RCV003421058 RCV004730993
DIABLO-Related Hearing Loss	not provided	rs758602603	RCV001249576
Familial cancer of breast	Conflicting classifications of pathogenicity	rs370571609	RCV005895020
Hearing impairment	Uncertain significance	rs1057519151	RCV001375339
Malignant tumor of urinary bladder	Likely benign	rs202028496	RCV005895009
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	rs370571609	RCV005895021

Show/Hide Text Mining Associations (64)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	17067390, 22867709
Ascites	Associate	28852723
Barrett Esophagus	Associate	27431913
Breast Neoplasms	Associate	18590557, 21645409, 25006666, 26662313, 28460471, 29895124, 33239070, 33492282, 33770100, 35007560
Burkitt Lymphoma	Associate	33971465
Carcinogenesis	Associate	15560849, 31356194
Carcinoma Ductal	Associate	21645409
Carcinoma Hepatocellular	Associate	17997990
Carcinoma Non Small Cell Lung	Associate	24681884
Carcinoma Ovarian Epithelial	Associate	28852723
Carcinoma Renal Cell	Associate	15328523, 17922292
Carcinoma Squamous Cell	Associate	17067390
Cataract	Stimulate	28682901
Cholangiocarcinoma	Associate	37513508
Colonic Neoplasms	Associate	16998592
Colorectal Neoplasms	Associate	15557007, 23038270, 25198428, 26383618
Digestive System Diseases	Inhibit	20951133
Drug Related Side Effects and Adverse Reactions	Associate	16868249
Endometrial Neoplasms	Associate	21478115
Epilepsies Myoclonic	Stimulate	22152093
Glioblastoma	Associate	23538445, 26152356
Glioblastoma	Inhibit	26379193
HIV Infections	Inhibit	30344003
HIV Infections	Associate	30653393, 32719312
Hodgkin Disease	Associate	16868249
Hyperbilirubinemia Shunt	Associate	31461782
Infections	Associate	37594275
Leukemia Lymphocytic Chronic B Cell	Associate	15183896, 27078856
Leukemia Lymphocytic Chronic B Cell	Inhibit	21732781
Leukemia Myeloid Acute	Associate	11964312, 24030154, 27385100
Leukemia Myeloid Acute	Inhibit	24526787
Lung Neoplasms	Associate	24681884, 30016782, 34008478
Lymphoma Large B Cell Diffuse	Associate	21732781
Melanoma	Associate	11801603, 20461078, 22723988, 32054850, 35941108
Mitochondrial Diseases	Stimulate	16868249
Mitochondrial Diseases	Associate	23348591
Multiple Myeloma	Associate	12665525, 15070698, 27494845
Neoplasm Metastasis	Associate	17922292
Neoplasms	Associate	15328523, 15609401, 17922292, 21478115, 21738708, 24287697, 25586349, 26152356, 26788912, 29307797, 30055105, 31973107, 32155687, 32719312, 33492282, 33558564, 35007560 View all (2 more)
Neoplasms	Inhibit	30258062, 31412918
Neuroblastoma	Associate	15632181, 20444257, 22788920, 26575016, 27655666
Neurodegenerative Diseases	Associate	33558564
Non Muscle Invasive Bladder Neoplasms	Inhibit	22218530
Ovarian Neoplasms	Associate	22052903, 22558117, 28852723, 35281523
Ovarian Neoplasms	Inhibit	29226858
Pancreatic Neoplasms	Associate	22320973, 34462421
Pre Eclampsia	Associate	35373096
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	25079338, 30486609
Prostatic Hyperplasia	Associate	37378942
Prostatic Neoplasms	Associate	19275204, 19895686
Prostatic Neoplasms	Inhibit	37378942
Rectal Neoplasms	Associate	34496878
Rhabdoid Tumor	Associate	35613525
Rhabdomyosarcoma	Associate	36980247
Small Cell Lung Carcinoma	Associate	14560006, 18401527
Squamous Cell Carcinoma of Head and Neck	Associate	31517839, 33108350
Squamous Cell Carcinoma of Head and Neck	Inhibit	38490621
Stomach Neoplasms	Associate	15609401
Thyroid Neoplasms	Associate	31973107
Triple Negative Breast Neoplasms	Associate	27276707, 35631261, 37093683
Urethral Neoplasms	Associate	20814238
Urinary Bladder Neoplasms	Associate	20814238, 22517918
Urinary Bladder Neoplasms	Inhibit	22218530
Uterine Cervical Neoplasms	Associate	15560849, 17067390

DIABLO (diablo IAP-binding mitochondrial protein)