CCL28 (C-C motif chemokine ligand 28)

Gene

• Entrez ID: 56477
• Gene name: C-C motif chemokine ligand 28
• Gene symbol: CCL28
• Synonyms (NCBI Gene): CCK1, MEC, SCYA28
• Chromosome: 5
• Chromosome location: 5p12
• Summary: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cy

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019466	hsa-miR-148b-3p	Microarray	17612493
MIRT871041	hsa-miR-1245	CLIP-seq
MIRT871042	hsa-miR-129-5p	CLIP-seq
MIRT871043	hsa-miR-1912	CLIP-seq
MIRT871044	hsa-miR-3130-5p	CLIP-seq
MIRT871045	hsa-miR-3663-5p	CLIP-seq
MIRT871046	hsa-miR-371-5p	CLIP-seq
MIRT871047	hsa-miR-371b-5p	CLIP-seq
MIRT871048	hsa-miR-4482	CLIP-seq
MIRT871049	hsa-miR-4676-5p	CLIP-seq
MIRT871050	hsa-miR-513c	CLIP-seq
MIRT871051	hsa-miR-514b-5p	CLIP-seq
MIRT871052	hsa-miR-575	CLIP-seq
MIRT871041	hsa-miR-1245	CLIP-seq
MIRT1958629	hsa-miR-1976	CLIP-seq
MIRT1958630	hsa-miR-302a	CLIP-seq
MIRT1958631	hsa-miR-302b	CLIP-seq
MIRT1958632	hsa-miR-302c	CLIP-seq
MIRT1958633	hsa-miR-302d	CLIP-seq
MIRT1958634	hsa-miR-302e	CLIP-seq
MIRT871045	hsa-miR-3663-5p	CLIP-seq
MIRT871046	hsa-miR-371-5p	CLIP-seq
MIRT871047	hsa-miR-371b-5p	CLIP-seq
MIRT1958635	hsa-miR-372	CLIP-seq
MIRT1958636	hsa-miR-373	CLIP-seq
MIRT1958637	hsa-miR-431	CLIP-seq
MIRT1958638	hsa-miR-4423-5p	CLIP-seq
MIRT1958639	hsa-miR-4722-3p	CLIP-seq
MIRT1958640	hsa-miR-4731-5p	CLIP-seq
MIRT1958641	hsa-miR-4781-3p	CLIP-seq
MIRT1958642	hsa-miR-512-3p	CLIP-seq
MIRT871050	hsa-miR-513c	CLIP-seq
MIRT871051	hsa-miR-514b-5p	CLIP-seq
MIRT1958643	hsa-miR-520a-3p	CLIP-seq
MIRT1958644	hsa-miR-520b	CLIP-seq
MIRT1958645	hsa-miR-520c-3p	CLIP-seq
MIRT1958646	hsa-miR-520d-3p	CLIP-seq
MIRT1958647	hsa-miR-520e	CLIP-seq
MIRT1958648	hsa-miR-579	CLIP-seq
MIRT871041	hsa-miR-1245	CLIP-seq
MIRT1958629	hsa-miR-1976	CLIP-seq
MIRT1958630	hsa-miR-302a	CLIP-seq
MIRT1958631	hsa-miR-302b	CLIP-seq
MIRT1958632	hsa-miR-302c	CLIP-seq
MIRT1958633	hsa-miR-302d	CLIP-seq
MIRT1958634	hsa-miR-302e	CLIP-seq
MIRT1958635	hsa-miR-372	CLIP-seq
MIRT1958636	hsa-miR-373	CLIP-seq
MIRT1958639	hsa-miR-4722-3p	CLIP-seq
MIRT1958643	hsa-miR-520a-3p	CLIP-seq
MIRT1958644	hsa-miR-520b	CLIP-seq
MIRT1958645	hsa-miR-520c-3p	CLIP-seq
MIRT1958646	hsa-miR-520d-3p	CLIP-seq
MIRT1958647	hsa-miR-520e	CLIP-seq
MIRT871045	hsa-miR-3663-5p	CLIP-seq
MIRT871046	hsa-miR-371-5p	CLIP-seq
MIRT871047	hsa-miR-371b-5p	CLIP-seq
MIRT1958637	hsa-miR-431	CLIP-seq
MIRT1958638	hsa-miR-4423-5p	CLIP-seq
MIRT1958641	hsa-miR-4781-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001954	Process	Positive regulation of cell-matrix adhesion	IBA
GO:0001954	Process	Positive regulation of cell-matrix adhesion	IDA	18308860
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 28381538, 31515488, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	12538707
GO:0005615	Component	Extracellular space	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	TAS	10781587
GO:0006954	Process	Inflammatory response	IBA
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007584	Process	Response to nutrient	IEA
GO:0008009	Function	Chemokine activity	IBA
GO:0008009	Function	Chemokine activity	IDA	18308860
GO:0008009	Function	Chemokine activity	IEA
GO:0008009	Function	Chemokine activity	TAS	10781587
GO:0030141	Component	Secretory granule	IDA	12538707
GO:0030593	Process	Neutrophil chemotaxis	IBA
GO:0031640	Process	Killing of cells of another organism	IMP	12538707
GO:0042379	Function	Chemokine receptor binding	IEA
GO:0045236	Function	CXCR chemokine receptor binding	IBA
GO:0051715	Process	Cytolysis in another organism	IMP	12538707
GO:0060326	Process	Cell chemotaxis	IDA	18308860
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IMP	12538707
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA
GO:1903237	Process	Negative regulation of leukocyte tethering or rolling	IDA	18308860

Other IDs

• MIM: 605240
• HGNC: 17700
• e!Ensembl: ENSG00000151882

Protein

• UniProt ID: Q9NRJ3
• Protein name: C-C motif chemokine 28 (Mucosae-associated epithelial chemokine) (MEC) (Protein CCK1) (Small-inducible cytokine A28)
• Protein function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
• PDB: 6CWS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00048	IL8	28 → 87	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

• Tissue specificity: TISSUE SPECIFICITY: Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in
• Sequence:

  MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDL
  AAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHET
  YGHKTPY

• Sequence length: 127

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Intestinal immune network for IgA production

Reactome:

Chemokine receptors bind chemokines
G alpha (i) signalling events