PRSS2 (serine protease 2)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5645
Gene name Gene Name - the full gene name approved by the HGNC.
Serine protease 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRSS2
Synonyms (NCBI Gene) Gene synonyms aliases
TRY2, TRY8, TRYP2
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q34
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysin
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(30)
GO ID Ontology Definition Evidence Reference
GO:0004222 Function Metalloendopeptidase activity TAS
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IDA 12709065, 12731883
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0004252 Function Serine-type endopeptidase activity TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601564 9483 ENSG00000275896
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P07478
Protein name Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II)
Protein function In the ileum, may be involved in defensin processing, including DEFA5.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 24 → 239 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in Paneth cells, at the base of small intestinal crypts. {ECO:0000269|PubMed:12021776}.
Sequence
Sequence length 247
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Pancreatic secretion
Protein digestion and absorption
Influenza A 		  Collagen degradation
Alpha-defensins
Activation of Matrix Metalloproteinases
Neutrophil degranulation
Antimicrobial peptides
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Oligodendroglioma Oligodendroglioma N/A N/A GWAS
Pancreatitis Pancreatitis, chronic, protection against N/A N/A ClinVar
Show/Hide Text Mining Associations (21)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Anemia Aplastic Associate 35435273
Carcinogenesis Associate 37022096
Cerebral Palsy Ataxic Autosomal Recessive Associate 19096130
Colorectal Neoplasms Associate 29193645
Cystic Fibrosis Associate 36386424
Dyskinesia Drug Induced Associate 25982926
Hodgkin Disease Associate 18179710
Lewy Body Disease Associate 25982926
Lymphoma Large Cell Anaplastic Associate 18179710
Meconium Ileus Associate 36386424