KYAT3 (kynurenine aminotransferase 3)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
56267
Gene name Gene Name - the full gene name approved by the HGNC.
Kynurenine aminotransferase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KYAT3
Synonyms (NCBI Gene) Gene synonyms aliases
CCBL2, KAT3, KATIII
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(16)
miRTarBase ID miRNA Experiments Reference
MIRT544244 hsa-miR-208a-5p PAR-CLIP 21572407
MIRT544243 hsa-miR-208b-5p PAR-CLIP 21572407
MIRT544242 hsa-miR-369-3p PAR-CLIP 21572407
MIRT544241 hsa-miR-5692b PAR-CLIP 21572407
MIRT544240 hsa-miR-5692c PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(14)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22681889
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005739 Component Mitochondrion IBA 21873635
GO:0006103 Process 2-oxoglutarate metabolic process IEA
GO:0006520 Process Cellular amino acid metabolic process ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610656 33238 ENSG00000137944
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q6YP21
Protein name Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate
Protein function Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory a
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00155 Aminotran_1_2 63 → 446 Aminotransferase class I and II Domain
Sequence
Sequence length 454
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Cysteine and methionine metabolism
Tryptophan metabolism
Selenocompound metabolism
Metabolic pathways 		 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Mental depression Major depression, single episode, Unipolar Depression, Major Depressive Disorder 21492941 ClinVar
Show/Hide Text Mining Associations (6)
Associations from Text Mining
Disease Name Relationship Type References
Anorexia Nervosa Associate 33498837
Breast Neoplasms Associate 35771747
Neoplasms Associate 35715314
Neurodegenerative Diseases Associate 21845542
Obesity Associate 26347385
Uveal melanoma Associate 21845542