NSMCE3 (NSE3 component of SMC5/6 complex)

Gene
Gene Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
56160
Gene name Gene Name - the full gene name approved by the HGNC.
NSE3 component of SMC5/6 complex
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NSMCE3
Synonyms (NCBI Gene) Gene synonyms aliases
HCA4, LICS, MAGEG1, MAGEL3, NDNL2, NSE3
Disease Acronyms (UniProt) Disease acronyms from UniProt database
LICS
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q13.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways
Show/Hide all(13)
GO ID Ontology Definition Evidence Reference
GO:0000781 Component Chromosome, telomeric region IEA
GO:0005515 Function Protein binding IPI 18086888, 20864041, 21364888, 26496610, 27427983, 28514442
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm IEA
GO:0006281 Process DNA repair IMP 27427983
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
608243 7677 ENSG00000185115
Protein
Gene Gene ontology Other IDs Protein Pathways
UniProt ID Q96MG7
Protein name Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2)
Protein function Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1
PDB 5HVQ , 5WY5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01454 MAGE 92 → 261 MAGE family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11782285}.
Sequence 
MLQKPRNRGRSGGQAERDRDWSHSGNPGASRAGEDARVLRDGFAEEAPSTSRGPGGSQGS
QGPSPQGARRAQAAPAVGPRSQKQLELKVSELVQFLLIKDQKKIPIKRADILKHVIGDYK
DIFPDLFKRAAERLQYVFGYKLVELEPKSNTYILINTLEPVEEDAEMRGDQGTPTTGLLM
IVLGLIFMKGNTIKETEAWDFLRRLGVYPTKKHLIFGDPKKLITEDFVRQRYLEYRRIPH
TDPVDYEFQWGPRTNLETSKMKVLKFVAKVHNQDPKDWPAQYCEALADEENRARPQPSGP
APSS
Sequence length 304
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways
  Reactome
    SUMOylation of DNA damage response and repair proteins