BARX1 (BARX homeobox 1)

Gene

• Entrez ID: 56033
• Gene name: BARX homeobox 1
• Gene symbol: BARX1
• Synonyms (NCBI Gene): -
• Chromosome: 9
• Chromosome location: 9q22.32
• Summary: This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may al

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022812	hsa-miR-124-3p	Microarray	18668037
MIRT500192	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT500191	hsa-miR-151a-5p	PAR-CLIP	20371350
MIRT500190	hsa-miR-151b	PAR-CLIP	20371350
MIRT500189	hsa-miR-744-5p	PAR-CLIP	20371350
MIRT500188	hsa-miR-1268a	PAR-CLIP	20371350
MIRT500187	hsa-miR-1268b	PAR-CLIP	20371350
MIRT500186	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT500185	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT500192	hsa-miR-4781-5p	PAR-CLIP	24398324
MIRT500191	hsa-miR-151a-5p	PAR-CLIP	24398324
MIRT500190	hsa-miR-151b	PAR-CLIP	24398324
MIRT500189	hsa-miR-744-5p	PAR-CLIP	24398324
MIRT500188	hsa-miR-1268a	PAR-CLIP	24398324
MIRT500187	hsa-miR-1268b	PAR-CLIP	24398324
MIRT500186	hsa-miR-6511b-5p	PAR-CLIP	24398324
MIRT500185	hsa-miR-6811-5p	PAR-CLIP	24398324
MIRT500192	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT500191	hsa-miR-151a-5p	PAR-CLIP	20371350
MIRT500190	hsa-miR-151b	PAR-CLIP	20371350
MIRT500189	hsa-miR-744-5p	PAR-CLIP	20371350
MIRT500188	hsa-miR-1268a	PAR-CLIP	20371350
MIRT500187	hsa-miR-1268b	PAR-CLIP	20371350
MIRT500186	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT500185	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT500192	hsa-miR-4781-5p	PAR-CLIP	24398324
MIRT500191	hsa-miR-151a-5p	PAR-CLIP	24398324
MIRT500190	hsa-miR-151b	PAR-CLIP	24398324
MIRT500189	hsa-miR-744-5p	PAR-CLIP	24398324
MIRT500188	hsa-miR-1268a	PAR-CLIP	24398324
MIRT500187	hsa-miR-1268b	PAR-CLIP	24398324
MIRT500186	hsa-miR-6511b-5p	PAR-CLIP	24398324
MIRT500185	hsa-miR-6811-5p	PAR-CLIP	24398324
MIRT815913	hsa-miR-1225-3p	CLIP-seq
MIRT815914	hsa-miR-1233	CLIP-seq
MIRT815915	hsa-miR-2467-5p	CLIP-seq
MIRT815916	hsa-miR-3612	CLIP-seq
MIRT815917	hsa-miR-3616-3p	CLIP-seq
MIRT815918	hsa-miR-4254	CLIP-seq
MIRT815919	hsa-miR-4436b-3p	CLIP-seq
MIRT815920	hsa-miR-4443	CLIP-seq
MIRT815921	hsa-miR-4476	CLIP-seq
MIRT815922	hsa-miR-4707-5p	CLIP-seq
MIRT815923	hsa-miR-4728-5p	CLIP-seq
MIRT815924	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	10995576
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007267	Process	Cell-cell signaling	IEA
GO:0009888	Process	Tissue development	IEA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IEA
GO:0045446	Process	Endothelial cell differentiation	IEA
GO:0048513	Process	Animal organ development	IEA
GO:0048536	Process	Spleen development	IEA
GO:0055123	Process	Digestive system development	IEA

Other IDs

• MIM: 603260
• HGNC: 955
• e!Ensembl: ENSG00000131668

Protein

• UniProt ID: Q9HBU1
• Protein name: Homeobox protein BarH-like 1
• Protein function: Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarit
• PDB: 2DMT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00046	Homeodomain	143 → 199	Homeodomain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed at higher levels in testis and heart. Detected in craniofacial tissue and adult iris, but not in lymphocytes, fibroblasts, choroid retina, retinal pigment epithelium, kidney, or fetal liver.
• Sequence:

  MQRPGEPGAARFGPPEGCADHRPHRYRSFMIEEILTEPPGPKGAAPAAAAAAAGELLKFG
  VQALLAARPFHSHLAVLKAEQAAVFKFPLAPLGCSGLSSALLAAGPGLPGAAGAPHLPLE
  LQLRGKLEAAGPGEPGTKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLG
  LSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKP
  AEVPGEPSDRSRED

• Sequence length: 254