Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5602
Gene name Gene Name - the full gene name approved by the HGNC.
Mitogen-activated protein kinase 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAPK10
Synonyms (NCBI Gene) Gene synonyms aliases
JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcrip
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT053727 hsa-miR-221-3p Microarray 22942087
MIRT667467 hsa-miR-3617-5p HITS-CLIP 23824327
MIRT667466 hsa-miR-641 HITS-CLIP 23824327
MIRT607689 hsa-miR-6867-5p HITS-CLIP 23824327
MIRT667465 hsa-miR-3152-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000187 Process Activation of MAPK activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004705 Function JUN kinase activity IBA 21873635
GO:0004705 Function JUN kinase activity ISS 8654373
GO:0004707 Function MAP kinase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602897 6872 ENSG00000109339
Protein
UniProt ID P53779
Protein name Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
Protein function Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-
PDB 1JNK , 1PMN , 1PMU , 1PMV , 2B1P , 2EXC , 2O0U , 2O2U , 2OK1 , 2P33 , 2R9S , 2WAJ , 2ZDT , 2ZDU , 3CGF , 3CGO , 3DA6 , 3FI2 , 3FI3 , 3FV8 , 3G90 , 3G9L , 3G9N , 3KVX , 3OXI , 3OY1 , 3PTG , 3RTP , 3TTI , 3TTJ , 3V6R , 3V6S , 4H36 , 4H39 , 4H3B , 4KKE , 4KKG , 4KKH , 4U79 , 4W4V , 4W4W , 4W4X , 4W4Y , 4WHZ , 4X21 , 4Y46 , 4Y5H , 4Z9L , 6EKD , 6EMH , 6EQ9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 64 359 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
Sequence
Sequence length 464
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
cAMP signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Mitophagy - animal
Autophagy - animal
Protein processing in endoplasmic reticulum
Apoptosis
Apoptosis - multiple species
Necroptosis
Wnt signaling pathway
Osteoclast differentiation
Focal adhesion
Tight junction
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
C-type lectin receptor signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Adipocytokine signaling pathway
Relaxin signaling pathway
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Growth hormone synthesis, secretion and action
Alcoholic liver disease
Alzheimer disease
Parkinson disease
Huntington disease
Spinocerebellar ataxia
Prion disease
Pathways of neurodegeneration - multiple diseases
Epithelial cell signaling in Helicobacter pylori infection
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pertussis
Yersinia infection
Chagas disease
Toxoplasmosis
Tuberculosis
Hepatitis B
Measles
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Coronavirus disease - COVID-19
Pathways in cancer
Chemical carcinogenesis - reactive oxygen species
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancer
Diabetic cardiomyopathy
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Autism Autistic behavior rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
Epileptic encephalopathy Encephalopathies, Epileptic encephalopathy rs587776508, rs121918334, rs121918317, rs121918321, rs74315390, rs28939684, rs74315391, rs74315392, rs118192244, rs121918622, rs121918623, rs121917953, rs121917955, rs121918624, rs121918625
View all (860 more)
23329067
Langer-giedion syndrome Langer-Giedion Syndrome rs886040971, rs1554617582 23329067
Lennox-gastaut syndrome Lennox-Gastaut syndrome rs796052504 16249883, 23329067
Unknown
Disease term Disease name Evidence References Source
Absence seizure Atypical absence seizure ClinVar
Multiple Sclerosis Multiple Sclerosis GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 30170437
Alzheimer Disease Associate 21811019, 37236204, 7826642
Beckwith Wiedemann Syndrome Associate 35507738
Breast Neoplasms Associate 30670769, 32947764
Burkitt Lymphoma Associate 12967475
Carcinogenesis Associate 32987560
Carcinoma Hepatocellular Associate 32572915
Carcinoma Non Small Cell Lung Associate 32468043
Carcinoma Pancreatic Ductal Associate 32119844
Cognition Disorders Stimulate 37236204