Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5597
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Mitogen-activated protein kinase 6 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
MAPK6 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
ERK3, HsT17250, PRKM6, p97MAPK |
Chromosome
Chromosome number
|
15 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
15q21.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated throu |
UniProt ID |
Q16659
|
Protein name |
Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) |
Protein function |
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction |
PDB |
6YKY
,
6YLC
,
6YLL
,
7AQB
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069
|
Pkinase |
20 → 316 |
Protein kinase domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. |
Sequence |
|
Sequence length |
721 |
Interactions |
View interactions
|
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Alzheimer disease |
Alzheimer disease |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Breast Neoplasms |
Associate
|
26588708, 33336740, 33495824, 36895010 |
Carcinogenesis |
Associate
|
29764463 |
Carcinoma Hepatocellular |
Associate
|
29764463 |
Cell Transformation Neoplastic |
Associate
|
32802869 |
Colorectal Neoplasms |
Associate
|
29101390, 32802869 |
Epilepsy |
Associate
|
36250437 |
Head and Neck Neoplasms |
Associate
|
28079973 |
Head and Neck Neoplasms |
Stimulate
|
33579235 |
Inflammation |
Associate
|
33300070, 36250437 |
Laryngeal Neoplasms |
Associate
|
30229830, 37215982 |
Liver Failure |
Associate
|
29764463 |
Liver Neoplasms |
Associate
|
29764463 |
Lung Neoplasms |
Associate
|
29101390, 30166347 |
Lung Neoplasms |
Stimulate
|
33579235 |
Neoplasm Metastasis |
Associate
|
29101390 |
Neoplasms |
Associate
|
15655810, 29101390, 30166347, 33336740, 37215982 |
Neoplasms |
Stimulate
|
28079973, 33579235 |
Pneumonia |
Associate
|
33300070 |
Skin Neoplasms |
Associate
|
33579235 |
Stomach Neoplasms |
Associate
|
15655810 |
|