|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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5597
|
|
Gene name
Gene Name - the full gene name approved by the HGNC.
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Mitogen-activated protein kinase 6 |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
MAPK6 |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
ERK3, HsT17250, PRKM6, p97MAPK |
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Chromosome
Chromosome number
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15 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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15q21.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated throu |
| UniProt ID |
Q16659
|
| Protein name |
Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) |
| Protein function |
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction |
| PDB |
6YKY
,
6YLC
,
6YLL
,
7AQB
|
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
|
PF00069
|
Pkinase |
20 → 316 |
Protein kinase domain |
Domain |
|
| Tissue specificity |
TISSUE SPECIFICITY: Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. |
| Sequence |
|
| Sequence length |
721 |
| Interactions |
View interactions
|
|
Unknown
Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
|
| Disease merge term |
Disease name |
Evidence |
References |
Source |
| Alzheimer disease |
Alzheimer's disease or family history of Alzheimer's disease |
N/A |
N/A |
GWAS |
|
|
Associations from Text Mining
Disease associations identified through Pubtator
|
| Disease Name |
Relationship Type |
References |
| Breast Neoplasms |
Associate
|
26588708, 33336740, 33495824, 36895010 |
| Carcinogenesis |
Associate
|
29764463 |
| Carcinoma Hepatocellular |
Associate
|
29764463 |
| Cell Transformation Neoplastic |
Associate
|
32802869 |
| Colorectal Neoplasms |
Associate
|
29101390, 32802869 |
| Epilepsy |
Associate
|
36250437 |
| Head and Neck Neoplasms |
Associate
|
28079973 |
| Head and Neck Neoplasms |
Stimulate
|
33579235 |
| Inflammation |
Associate
|
33300070, 36250437 |
| Laryngeal Neoplasms |
Associate
|
30229830, 37215982 |
| Liver Failure |
Associate
|
29764463 |
| Liver Neoplasms |
Associate
|
29764463 |
| Lung Neoplasms |
Associate
|
29101390, 30166347 |
| Lung Neoplasms |
Stimulate
|
33579235 |
| Neoplasm Metastasis |
Associate
|
29101390 |
| Neoplasms |
Associate
|
15655810, 29101390, 30166347, 33336740, 37215982 |
| Neoplasms |
Stimulate
|
28079973, 33579235 |
| Pneumonia |
Associate
|
33300070 |
| Skin Neoplasms |
Associate
|
33579235 |
| Stomach Neoplasms |
Associate
|
15655810 |
|