Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55920
Gene name Gene Name - the full gene name approved by the HGNC.
Regulator of chromosome condensation 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RCC2
Synonyms (NCBI Gene) Gene synonyms aliases
TD-60
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.13
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomark
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021351 hsa-miR-9-5p Microarray 17612493
MIRT022250 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT023502 hsa-miR-1-3p Proteomics 18668040
MIRT025685 hsa-miR-7-5p Microarray 17612493
MIRT049492 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005085 Function Guanyl-nucleotide exchange factor activity IEA
GO:0005515 Function Protein binding IPI 22282019, 25074804
GO:0005730 Component Nucleolus IEA
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609587 30297 ENSG00000179051
Protein
UniProt ID Q9P258
Protein name Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa)
Protein function Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, b
PDB 5GWN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00415 RCC1 168 217 Regulator of chromosome condensation (RCC1) repeat Repeat
PF00415 RCC1 220 269 Regulator of chromosome condensation (RCC1) repeat Repeat
PF00415 RCC1 272 345 Regulator of chromosome condensation (RCC1) repeat Repeat
PF00415 RCC1 349 399 Regulator of chromosome condensation (RCC1) repeat Repeat
Sequence
MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD
GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK
EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG
QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLAL
TETGSVFAFGENKMGQLGLGNQT
DAVPSPAQIMYNGQPITKMACGAEFSMIM
DCKGNLYSFGCPEYGQLGHNSDGKFIARAQR
IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVL
DSQKRVFSWGFGGYG
RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAV
SEVGGLFFWGATNTSRESTMY
PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT
LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL
Sequence length 522
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Basal cell neoplasm Basal Cell Neoplasm, Basal Cell Cancer rs587776578, rs587776579, rs2117956624, rs2118419579, rs2118365442, rs2118041703, rs2136689212, rs2118336503, rs1587692888, rs267606984, rs878853849, rs1554695110, rs1064793921, rs1588605348, rs1588568813 27539887, 31174203
Carcinoma Basal cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 31174203, 27539887
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 33170908
Carcinogenesis Associate 36441563
Colorectal Neoplasms Associate 25910952, 33219056
Glioma Associate 36116740
Leukemia Myeloid Acute Associate 35217832
Lung Neoplasms Stimulate 29321004
Lung Neoplasms Associate 29913439
Lymphatic Metastasis Associate 38008751
Melanoma Associate 24188633
Microsatellite Instability Associate 25910952