Gene Gene information from NCBI Gene database.
Entrez ID 5586
Gene name Protein kinase N2
Gene symbol PKN2
Synonyms (NCBI Gene)
PAK2PRK2PRKCL2PRO2042Pak-2STK7
Chromosome 1
Chromosome location 1p22.2
miRNA miRNA information provided by mirtarbase database.
556
miRTarBase ID miRNA Experiments Reference
MIRT001524 hsa-miR-155-5p pSILAC 18668040
MIRT001524 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT001524 hsa-miR-155-5p Proteomics 18668040
MIRT655058 hsa-miR-548ae-3p HITS-CLIP 23824327
MIRT655057 hsa-miR-548ah-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
63
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0004672 Function Protein kinase activity IEA
GO:0004672 Function Protein kinase activity TAS 7851406
GO:0004674 Function Protein serine/threonine kinase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602549 9406 ENSG00000065243
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q16513
Protein name Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)
Protein function PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migrati
PDB 4CRS , 4RRV , 6CCY , 6GBE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02185 HR1 49 111 Hr1 repeat Family
PF02185 HR1 137 204 Hr1 repeat Family
PF02185 HR1 218 285 Hr1 repeat Family
PF00069 Pkinase 657 916 Protein kinase domain Domain
PF00433 Pkinase_C 937 979 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:21754995}.
Sequence
MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKEL
KIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSD
PEDITDCPR
TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL
QDSKTKIEVIRMQILQAVQTNELA
FDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM
KLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKN
HPKSRIIIEELSLVA
ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWS
PSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK
FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN
PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV
PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG
QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC
AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL
VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY
RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW
WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL
GASEKDAEDVKKHPFF
RLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP
REPRILSEEEQEMFRDFDY
IADWC
Sequence length 984
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  PI3K-Akt signaling pathway
NOD-like receptor signaling pathway
Yersinia infection
  RHO GTPases activate PKNs
Associated diseases Disease associations from ClinVar (Causal/Unknown) and external databases: GenCC, Orphanet, ClinGen, HPO, DisGeNET, CTD, GWAS Catalog.
23
Unknown Evidence from ClinVar (non-pathogenic variants) or external databases: GenCC, Orphanet, ClinGen, HPO, DisGeNET, CTD, GWAS Catalog.
Evidence from ClinVar (non-pathogenic) or external databases: GenCC, Orphanet, ClinGen, HPO, DisGeNET, CTD, GWAS Catalog
Phenotype Name References (PMID) Source
CHRONIC OBSTRUCTIVE PULMONARY DISEASE 30940143 GWAS catalog
CORONARY ARTERY DISEASE 29212778 GWAS catalog
HYPERTENSION 30940143 GWAS catalog
Associations from Text MiningDisease associations identified through Pubtator text-mining of PubMed literature.
Disease Name Relationship Type References
Adenocarcinoma Associate 26296974
Asthma Associate 30737985
Atrial Fibrillation Associate 23593175
Breast Neoplasms Associate 31759986
Colorectal Neoplasms Associate 29368606, 33658394
Diabetes Mellitus Type 2 Associate 21084393, 38034011
Myopathies Structural Congenital Associate 29368606
Neoplasm Metastasis Associate 34455760
Neoplasms Associate 26296974, 34455760
Neoplasms Inhibit 29368606, 31759986