Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5586
Gene name Gene Name - the full gene name approved by the HGNC.
Protein kinase N2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PKN2
Synonyms (NCBI Gene) Gene synonyms aliases
PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p22.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001524 hsa-miR-155-5p pSILAC 18668040
MIRT001524 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT001524 hsa-miR-155-5p Proteomics 18668040
MIRT655058 hsa-miR-548ae-3p HITS-CLIP 23824327
MIRT655057 hsa-miR-548ah-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0004672 Function Protein kinase activity TAS 7851406
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 20188095
GO:0004698 Function Calcium-dependent protein kinase C activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602549 9406 ENSG00000065243
Protein
UniProt ID Q16513
Protein name Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)
Protein function PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migrati
PDB 4CRS , 4RRV , 6CCY , 6GBE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02185 HR1 49 111 Hr1 repeat Family
PF02185 HR1 137 204 Hr1 repeat Family
PF02185 HR1 218 285 Hr1 repeat Family
PF00069 Pkinase 657 916 Protein kinase domain Domain
PF00433 Pkinase_C 937 979 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:21754995}.
Sequence
MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKEL
KIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSD
PEDITDCPR
TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL
QDSKTKIEVIRMQILQAVQTNELA
FDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM
KLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKN
HPKSRIIIEELSLVA
ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWS
PSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK
FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN
PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV
PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG
QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC
AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL
VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY
RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW
WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL
GASEKDAEDVKKHPFF
RLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP
REPRILSEEEQEMFRDFDY
IADWC
Sequence length 984
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  PI3K-Akt signaling pathway
NOD-like receptor signaling pathway
Yersinia infection
  RHO GTPases activate PKNs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease 30940143 ClinVar
Diabetes Diabetes GWAS
Narcolepsy Narcolepsy GWAS
Glaucoma Glaucoma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 26296974
Asthma Associate 30737985
Atrial Fibrillation Associate 23593175
Breast Neoplasms Associate 31759986
Colorectal Neoplasms Associate 29368606, 33658394
Diabetes Mellitus Type 2 Associate 21084393, 38034011
Myopathies Structural Congenital Associate 29368606
Neoplasm Metastasis Associate 34455760
Neoplasms Associate 26296974, 34455760
Neoplasms Inhibit 29368606, 31759986