Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55816
Gene name Gene Name - the full gene name approved by the HGNC.	Docking protein 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DOK5
Synonyms (NCBI Gene) Gene synonyms aliases	C20orf180, IRS-6, IRS6
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and a

Show/Hide all(108)

miRTarBase ID	miRNA	Experiments
MIRT943132	hsa-miR-10a	CLIP-seq
MIRT943133	hsa-miR-10b	CLIP-seq
MIRT943134	hsa-miR-198	CLIP-seq
MIRT943135	hsa-miR-30a	CLIP-seq
MIRT943136	hsa-miR-30b	CLIP-seq
MIRT943137	hsa-miR-30c	CLIP-seq
MIRT943138	hsa-miR-30d	CLIP-seq
MIRT943139	hsa-miR-30e	CLIP-seq
MIRT943140	hsa-miR-3607-3p	CLIP-seq
MIRT943141	hsa-miR-4267	CLIP-seq
MIRT943142	hsa-miR-583	CLIP-seq
MIRT2214445	hsa-miR-200b	CLIP-seq
MIRT2214446	hsa-miR-200c	CLIP-seq
MIRT2214447	hsa-miR-3152-3p	CLIP-seq
MIRT2214448	hsa-miR-3202	CLIP-seq
MIRT2214449	hsa-miR-34a	CLIP-seq
MIRT2214450	hsa-miR-34c-5p	CLIP-seq
MIRT2214451	hsa-miR-3614-5p	CLIP-seq
MIRT2214452	hsa-miR-3915	CLIP-seq
MIRT2214453	hsa-miR-3928	CLIP-seq
MIRT2214454	hsa-miR-3936	CLIP-seq
MIRT2214455	hsa-miR-429	CLIP-seq
MIRT2214456	hsa-miR-4457	CLIP-seq
MIRT2214457	hsa-miR-449a	CLIP-seq
MIRT2214458	hsa-miR-449b	CLIP-seq
MIRT2214459	hsa-miR-4533	CLIP-seq
MIRT2214460	hsa-miR-494	CLIP-seq
MIRT2214461	hsa-miR-499-3p	CLIP-seq
MIRT2214462	hsa-miR-499a-3p	CLIP-seq
MIRT2214463	hsa-miR-513b	CLIP-seq
MIRT2214464	hsa-miR-595	CLIP-seq
MIRT2214465	hsa-miR-642b	CLIP-seq
MIRT2214466	hsa-miR-890	CLIP-seq
MIRT2214467	hsa-miR-935	CLIP-seq
MIRT2214468	hsa-miR-943	CLIP-seq
MIRT2448485	hsa-miR-1262	CLIP-seq
MIRT2448486	hsa-miR-3115	CLIP-seq
MIRT2448487	hsa-miR-3185	CLIP-seq
MIRT2448488	hsa-miR-4701-3p	CLIP-seq
MIRT2518698	hsa-miR-1252	CLIP-seq
MIRT2448485	hsa-miR-1262	CLIP-seq
MIRT2518699	hsa-miR-1283	CLIP-seq
MIRT2518700	hsa-miR-130a	CLIP-seq
MIRT2518701	hsa-miR-130b	CLIP-seq
MIRT2518702	hsa-miR-301a	CLIP-seq
MIRT2518703	hsa-miR-301b	CLIP-seq
MIRT2448486	hsa-miR-3115	CLIP-seq
MIRT2214447	hsa-miR-3152-3p	CLIP-seq
MIRT2448487	hsa-miR-3185	CLIP-seq
MIRT2214448	hsa-miR-3202	CLIP-seq
MIRT2518704	hsa-miR-338-5p	CLIP-seq
MIRT2214451	hsa-miR-3614-5p	CLIP-seq
MIRT2518705	hsa-miR-3666	CLIP-seq
MIRT2518706	hsa-miR-3919	CLIP-seq
MIRT2518707	hsa-miR-3973	CLIP-seq
MIRT2518708	hsa-miR-4295	CLIP-seq
MIRT2214456	hsa-miR-4457	CLIP-seq
MIRT2518709	hsa-miR-4475	CLIP-seq
MIRT2214459	hsa-miR-4533	CLIP-seq
MIRT2518710	hsa-miR-454	CLIP-seq
MIRT2448488	hsa-miR-4701-3p	CLIP-seq
MIRT2518711	hsa-miR-4708-3p	CLIP-seq
MIRT2518712	hsa-miR-4756-3p	CLIP-seq
MIRT2214460	hsa-miR-494	CLIP-seq
MIRT2214461	hsa-miR-499-3p	CLIP-seq
MIRT2214462	hsa-miR-499a-3p	CLIP-seq
MIRT2214463	hsa-miR-513b	CLIP-seq
MIRT2518713	hsa-miR-519a	CLIP-seq
MIRT2518714	hsa-miR-519b-3p	CLIP-seq
MIRT2518715	hsa-miR-519c-3p	CLIP-seq
MIRT2518716	hsa-miR-548l	CLIP-seq
MIRT2214464	hsa-miR-595	CLIP-seq
MIRT2214465	hsa-miR-642b	CLIP-seq
MIRT2214466	hsa-miR-890	CLIP-seq
MIRT2518698	hsa-miR-1252	CLIP-seq
MIRT2448485	hsa-miR-1262	CLIP-seq
MIRT2518699	hsa-miR-1283	CLIP-seq
MIRT2518700	hsa-miR-130a	CLIP-seq
MIRT2518701	hsa-miR-130b	CLIP-seq
MIRT2518702	hsa-miR-301a	CLIP-seq
MIRT2518703	hsa-miR-301b	CLIP-seq
MIRT2448486	hsa-miR-3115	CLIP-seq
MIRT2214447	hsa-miR-3152-3p	CLIP-seq
MIRT2448487	hsa-miR-3185	CLIP-seq
MIRT2214448	hsa-miR-3202	CLIP-seq
MIRT2214451	hsa-miR-3614-5p	CLIP-seq
MIRT2518705	hsa-miR-3666	CLIP-seq
MIRT2518706	hsa-miR-3919	CLIP-seq
MIRT2518707	hsa-miR-3973	CLIP-seq
MIRT2518708	hsa-miR-4295	CLIP-seq
MIRT2214456	hsa-miR-4457	CLIP-seq
MIRT2518709	hsa-miR-4475	CLIP-seq
MIRT2214459	hsa-miR-4533	CLIP-seq
MIRT2518710	hsa-miR-454	CLIP-seq
MIRT2448488	hsa-miR-4701-3p	CLIP-seq
MIRT2518711	hsa-miR-4708-3p	CLIP-seq
MIRT2518712	hsa-miR-4756-3p	CLIP-seq
MIRT2214460	hsa-miR-494	CLIP-seq
MIRT2214461	hsa-miR-499-3p	CLIP-seq
MIRT2214462	hsa-miR-499a-3p	CLIP-seq
MIRT2214463	hsa-miR-513b	CLIP-seq
MIRT2518713	hsa-miR-519a	CLIP-seq
MIRT2518714	hsa-miR-519b-3p	CLIP-seq
MIRT2518715	hsa-miR-519c-3p	CLIP-seq
MIRT2518716	hsa-miR-548l	CLIP-seq
MIRT2214464	hsa-miR-595	CLIP-seq
MIRT2214465	hsa-miR-642b	CLIP-seq
MIRT2214466	hsa-miR-890	CLIP-seq

Show/Hide all(8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0051386	Process	Regulation of neurotrophin TRK receptor signaling pathway	IMP	23954828

MIM	HGNC	e!Ensembl
608334	16173	ENSG00000101134

Protein

UniProt ID

Q9P104

Protein name

Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)

Protein function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activatio

PDB

1J0W

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02174	IRS	135 → 232	PTB domain (IRS-1 type)	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. {ECO:0000269|PubMed:12595900, ECO:0000269|PubMed:12730241}.

Sequence

MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVT
ELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDIS
LGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWP
LSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQS
VKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFP
AYRSEH

Sequence length

306

Interactions

View interactions

	Reactome
			RET signaling

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Celiac disease	Celiac disease	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Bipolar Disorder	Associate	20215924
Carcinoma Hepatocellular	Associate	32148377
Colorectal Neoplasms	Associate	28540987
Diabetes Mellitus Type 2	Associate	20187968, 22152676
Myopathies Structural Congenital	Associate	35036444
Neoplasms	Associate	28540987, 35036444
Obesity	Associate	20187968
Pheochromocytoma	Associate	20534969
Stomach Neoplasms	Associate	35036444

DOK5 (docking protein 5)