Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55816
Gene name Gene Name - the full gene name approved by the HGNC.	Docking protein 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DOK5
Synonyms (NCBI Gene) Gene synonyms aliases	C20orf180, IRS-6, IRS6
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and a

Show/Hide all(108)

miRTarBase ID	miRNA	Experiments
MIRT943132	hsa-miR-10a	CLIP-seq
MIRT943133	hsa-miR-10b	CLIP-seq
MIRT943134	hsa-miR-198	CLIP-seq
MIRT943135	hsa-miR-30a	CLIP-seq
MIRT943136	hsa-miR-30b	CLIP-seq
MIRT943137	hsa-miR-30c	CLIP-seq
MIRT943138	hsa-miR-30d	CLIP-seq
MIRT943139	hsa-miR-30e	CLIP-seq
MIRT943140	hsa-miR-3607-3p	CLIP-seq
MIRT943141	hsa-miR-4267	CLIP-seq
MIRT943142	hsa-miR-583	CLIP-seq
MIRT2214445	hsa-miR-200b	CLIP-seq
MIRT2214446	hsa-miR-200c	CLIP-seq
MIRT2214447	hsa-miR-3152-3p	CLIP-seq
MIRT2214448	hsa-miR-3202	CLIP-seq
MIRT2214449	hsa-miR-34a	CLIP-seq
MIRT2214450	hsa-miR-34c-5p	CLIP-seq
MIRT2214451	hsa-miR-3614-5p	CLIP-seq
MIRT2214452	hsa-miR-3915	CLIP-seq
MIRT2214453	hsa-miR-3928	CLIP-seq
MIRT2214454	hsa-miR-3936	CLIP-seq
MIRT2214455	hsa-miR-429	CLIP-seq
MIRT2214456	hsa-miR-4457	CLIP-seq
MIRT2214457	hsa-miR-449a	CLIP-seq
MIRT2214458	hsa-miR-449b	CLIP-seq
MIRT2214459	hsa-miR-4533	CLIP-seq
MIRT2214460	hsa-miR-494	CLIP-seq
MIRT2214461	hsa-miR-499-3p	CLIP-seq
MIRT2214462	hsa-miR-499a-3p	CLIP-seq
MIRT2214463	hsa-miR-513b	CLIP-seq
MIRT2214464	hsa-miR-595	CLIP-seq
MIRT2214465	hsa-miR-642b	CLIP-seq
MIRT2214466	hsa-miR-890	CLIP-seq
MIRT2214467	hsa-miR-935	CLIP-seq
MIRT2214468	hsa-miR-943	CLIP-seq
MIRT2448485	hsa-miR-1262	CLIP-seq
MIRT2448486	hsa-miR-3115	CLIP-seq
MIRT2448487	hsa-miR-3185	CLIP-seq
MIRT2448488	hsa-miR-4701-3p	CLIP-seq
MIRT2518698	hsa-miR-1252	CLIP-seq
MIRT2448485	hsa-miR-1262	CLIP-seq
MIRT2518699	hsa-miR-1283	CLIP-seq
MIRT2518700	hsa-miR-130a	CLIP-seq
MIRT2518701	hsa-miR-130b	CLIP-seq
MIRT2518702	hsa-miR-301a	CLIP-seq
MIRT2518703	hsa-miR-301b	CLIP-seq
MIRT2448486	hsa-miR-3115	CLIP-seq
MIRT2214447	hsa-miR-3152-3p	CLIP-seq
MIRT2448487	hsa-miR-3185	CLIP-seq
MIRT2214448	hsa-miR-3202	CLIP-seq
MIRT2518704	hsa-miR-338-5p	CLIP-seq
MIRT2214451	hsa-miR-3614-5p	CLIP-seq
MIRT2518705	hsa-miR-3666	CLIP-seq
MIRT2518706	hsa-miR-3919	CLIP-seq
MIRT2518707	hsa-miR-3973	CLIP-seq
MIRT2518708	hsa-miR-4295	CLIP-seq
MIRT2214456	hsa-miR-4457	CLIP-seq
MIRT2518709	hsa-miR-4475	CLIP-seq
MIRT2214459	hsa-miR-4533	CLIP-seq
MIRT2518710	hsa-miR-454	CLIP-seq
MIRT2448488	hsa-miR-4701-3p	CLIP-seq
MIRT2518711	hsa-miR-4708-3p	CLIP-seq
MIRT2518712	hsa-miR-4756-3p	CLIP-seq
MIRT2214460	hsa-miR-494	CLIP-seq
MIRT2214461	hsa-miR-499-3p	CLIP-seq
MIRT2214462	hsa-miR-499a-3p	CLIP-seq
MIRT2214463	hsa-miR-513b	CLIP-seq
MIRT2518713	hsa-miR-519a	CLIP-seq
MIRT2518714	hsa-miR-519b-3p	CLIP-seq
MIRT2518715	hsa-miR-519c-3p	CLIP-seq
MIRT2518716	hsa-miR-548l	CLIP-seq
MIRT2214464	hsa-miR-595	CLIP-seq
MIRT2214465	hsa-miR-642b	CLIP-seq
MIRT2214466	hsa-miR-890	CLIP-seq
MIRT2518698	hsa-miR-1252	CLIP-seq
MIRT2448485	hsa-miR-1262	CLIP-seq
MIRT2518699	hsa-miR-1283	CLIP-seq
MIRT2518700	hsa-miR-130a	CLIP-seq
MIRT2518701	hsa-miR-130b	CLIP-seq
MIRT2518702	hsa-miR-301a	CLIP-seq
MIRT2518703	hsa-miR-301b	CLIP-seq
MIRT2448486	hsa-miR-3115	CLIP-seq
MIRT2214447	hsa-miR-3152-3p	CLIP-seq
MIRT2448487	hsa-miR-3185	CLIP-seq
MIRT2214448	hsa-miR-3202	CLIP-seq
MIRT2214451	hsa-miR-3614-5p	CLIP-seq
MIRT2518705	hsa-miR-3666	CLIP-seq
MIRT2518706	hsa-miR-3919	CLIP-seq
MIRT2518707	hsa-miR-3973	CLIP-seq
MIRT2518708	hsa-miR-4295	CLIP-seq
MIRT2214456	hsa-miR-4457	CLIP-seq
MIRT2518709	hsa-miR-4475	CLIP-seq
MIRT2214459	hsa-miR-4533	CLIP-seq
MIRT2518710	hsa-miR-454	CLIP-seq
MIRT2448488	hsa-miR-4701-3p	CLIP-seq
MIRT2518711	hsa-miR-4708-3p	CLIP-seq
MIRT2518712	hsa-miR-4756-3p	CLIP-seq
MIRT2214460	hsa-miR-494	CLIP-seq
MIRT2214461	hsa-miR-499-3p	CLIP-seq
MIRT2214462	hsa-miR-499a-3p	CLIP-seq
MIRT2214463	hsa-miR-513b	CLIP-seq
MIRT2518713	hsa-miR-519a	CLIP-seq
MIRT2518714	hsa-miR-519b-3p	CLIP-seq
MIRT2518715	hsa-miR-519c-3p	CLIP-seq
MIRT2518716	hsa-miR-548l	CLIP-seq
MIRT2214464	hsa-miR-595	CLIP-seq
MIRT2214465	hsa-miR-642b	CLIP-seq
MIRT2214466	hsa-miR-890	CLIP-seq

Show/Hide all(5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005829	Component	Cytosol	TAS
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IEA
GO:0007411	Process	Axon guidance	TAS
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0051386	Process	Regulation of neurotrophin TRK receptor signaling pathway	IMP	23954828

MIM	HGNC	e!Ensembl
608334	16173	ENSG00000101134

Protein

UniProt ID

Q9P104

Protein name

Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)

Protein function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activatio

PDB

1J0W

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02174	IRS	135 → 232	PTB domain (IRS-1 type)	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. {ECO:0000269|PubMed:12595900, ECO:0000269|PubMed:12730241}.

Sequence

MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVT
ELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDIS
LGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWP
LSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQS
VKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFP
AYRSEH

Sequence length

306

Interactions

View interactions

	Reactome
			RET signaling

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Celiac disease	Celiac disease	GWAS
Diabetes	Diabetes	GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Bipolar Disorder	Associate	20215924
Carcinoma Hepatocellular	Associate	32148377
Colorectal Neoplasms	Associate	28540987
Diabetes Mellitus Type 2	Associate	20187968, 22152676
Myopathies Structural Congenital	Associate	35036444
Neoplasms	Associate	28540987, 35036444
Obesity	Associate	20187968
Pheochromocytoma	Associate	20534969
Stomach Neoplasms	Associate	35036444

DOK5 (docking protein 5)