Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
558
Gene name Gene Name - the full gene name approved by the HGNC.
AXL receptor tyrosine kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AXL
Synonyms (NCBI Gene) Gene synonyms aliases
ARK, AXL3, JTK11, Tyro7, UFO
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibron
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1599744167 C>G Likely-pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002758 hsa-miR-1-3p pSILAC 18668040
MIRT002758 hsa-miR-1-3p Microarray 15685193
MIRT006664 hsa-miR-34a-5p Luciferase reporter assay, qRT-PCR, Western blot 21814748
MIRT019798 hsa-miR-375 Microarray 20215506
MIRT020726 hsa-miR-155-5p Proteomics 18668040
Transcription factors
Transcription factor Regulation Reference
EZH2 Activation 23077658
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001618 Function Virus receptor activity IDA 22156524
GO:0001764 Process Neuron migration IEA
GO:0001779 Process Natural killer cell differentiation IBA 21873635
GO:0001786 Function Phosphatidylserine binding IDA 21501828
GO:0001961 Process Positive regulation of cytokine-mediated signaling pathway IDA 18840707
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
109135 905 ENSG00000167601
Protein
UniProt ID P30530
Protein name Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Protein function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and
PDB 2C5D , 4RA0 , 5U6B , 5VXZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13927 Ig_3 37 120 Domain
PF00041 fn3 226 321 Fibronectin type III domain Domain
PF00041 fn3 335 418 Fibronectin type III domain Domain
PF07714 PK_Tyr_Ser-Thr 536 803 Protein tyrosine and serine/threonine kinase Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. {ECO:0000269|PubMed:7896447}.
Sequence
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF

LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWT
HWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWS
LP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDL
ENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Sequence length 894
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  EGFR tyrosine kinase inhibitor resistance
Efferocytosis
  VEGFA-VEGFR2 Pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Gastric cancer Gastric Adenocarcinoma rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
Hypogonadotropic hypogonadism Hypogonadotropic hypogonadism, Idiopathic hypogonadotropic hypogonadism rs104894702, rs104893836, rs104893837, rs104893842, rs121909628, rs138249161, rs1601946139
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
22751098
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 23117882, 23298489, 23479507
Adenocarcinoma of Lung Associate 16354588, 22975805, 23242819, 23298489, 27100677, 30744655
Adenocarcinoma of Lung Stimulate 28468579
Adenoma Associate 33759958, 34669880
Alzheimer Disease Associate 35229272
Anemia Hemolytic Associate 23361052
Aneurysm Ruptured Stimulate 25885003
Anophthalmia with pulmonary hypoplasia Associate 37530334
Arthritis Rheumatoid Associate 10233855
Asthma Associate 29177020, 30029617