Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55770
Gene name Gene Name - the full gene name approved by the HGNC.
Exocyst complex component 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
EXOC2
Synonyms (NCBI Gene) Gene synonyms aliases
NEDFACH, SEC5, SEC5L1, Sec5p
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NEDFACH
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p25.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020620 hsa-miR-155-5p Proteomics 18668040
MIRT023654 hsa-miR-1-3p Proteomics 18668040
MIRT049928 hsa-miR-30a-5p CLASH 23622248
MIRT047777 hsa-miR-30d-5p CLASH 23622248
MIRT039714 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000145 Component Exocyst IBA 21873635
GO:0000145 Component Exocyst IDA 24056301
GO:0005515 Function Protein binding IPI 12459492, 19166349, 19885391, 20579884, 24056301, 27173435, 32296183
GO:0005829 Component Cytosol TAS
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
615329 24968 ENSG00000112685
Protein
UniProt ID Q96KP1
Protein name Exocyst complex component 2 (Exocyst complex component Sec5)
Protein function Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01833 TIG 8 92 IPT/TIG domain Domain
PF15469 Sec5 198 377 Exocyst complex component Sec5 Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in brain and placenta. {ECO:0000269|PubMed:12459492}.
Sequence
MSRSRQPPLVTGISPNEGIPWTKVTIRGENLGTGPTDLIGLTICGHNCLLTAEWMSASKI
VCRVGQAKNDKGDIIVTTKSGGRGTSTVSFKL
LKPEKIGILDQSAVWVDEMNYYDMRTDR
NKGIPPLSLRPANPLGIEIEKSKFSQKDLEMLFHGMSADFTSENFSAAWYLIENHSNTSF
EQLKMAVTNLKRQANKKSEGSLAYVKGGLSTFFEAQDALSAIHQKLEADGTEKVEGSMTQ
KLENVLNRASNTADTLFQEVLGRKDKADSTRNALNVLQRFKFLFNLPLNIERNIQKGDYD
VVINDYEKAKSLFGKTEVQVFKKYYAEVETRIEALRELLLDKLLETPSTLHDQKRYIRYL
SDLHASGDPAWQCIGAQ
HKWILQLMHSCKEGYVKDLKGNPGLHSPMLDLDNDTRPSVLGH
LSQTASLKRGSSFQSGRDDTWRYKTPHRVAFVEKLTKLVLSQLPNFWKLWISYVNGSLFS
ETAEKSGQIERSKNVRQRQNDFKKMIQEVMHSLVKLTRGALLPLSIRDGEAKQYGGWEVK
CELSGQWLAHAIQTVRLTHESLTALEIPNDLLQTIQDLILDLRVRCVMATLQHTAEEIKR
LAEKEDWIVDNEGLTSLPCQFEQCIVCSLQSLKGVLECKPGEASVFQQPKTQEEVCQLSI
NIMQVFIYCLEQLSTKPDADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCY
LERHTFLNIAEHFEKHNFQGIEKITQVSMASLKELDQRLFENYIELKADPIVGSLEPGIY
AGYFDWKDCLPPTGVRNYLKEALVNIIAVHAEVFTISKELVPRVLSKVIEAVSEELSRLM
QCVSSFSKNGALQARLEICALRDTVAVYLTPESKSSFKQALEALPQLSSGADKKLLEELL
NKFKSSMHLQLTCFQAASSTMMKT
Sequence length 924
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ras signaling pathway
Salmonella infection
  Insulin processing
VxPx cargo-targeting to cilium
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glaucoma Glaucoma, Glaucoma, Open-Angle rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328
View all (29 more)
30054594, 29891935
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 23143594, 25574825
Unknown
Disease term Disease name Evidence References Source
Cerebellar Hypoplasia neurodevelopmental disorder with dysmorphic facies and cerebellar hypoplasia GenCC
Neurodevelopmental Disorders complex neurodevelopmental disorder GenCC
Alopecia Areata Alopecia Areata GWAS
Rheumatoid arthritis Rheumatoid arthritis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 26949549, 36776048
Body Dysmorphic Disorders Associate 32639540
Brain Diseases Associate 32639540
Carcinogenesis Associate 20145037
Carcinoma Basal Cell Associate 21700618
Color Vision Defects Associate 18483556
Colorectal Neoplasms Associate 31502714
Developmental Disabilities Associate 32639540
Epilepsy Associate 32639540
Gastrointestinal Stromal Tumors Associate 32736695