Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55763
Gene name Gene Name - the full gene name approved by the HGNC.	Exocyst complex component 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EXOC1
Synonyms (NCBI Gene) Gene synonyms aliases	BM-102, SEC3, SEC3L1, SEC3P
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q12
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and f

Show/Hide all(87)

miRTarBase ID	miRNA	Experiments
MIRT972511	hsa-miR-101	CLIP-seq
MIRT972512	hsa-miR-1244	CLIP-seq
MIRT972513	hsa-miR-144	CLIP-seq
MIRT972514	hsa-miR-3591-5p	CLIP-seq
MIRT972515	hsa-miR-3613-3p	CLIP-seq
MIRT972516	hsa-miR-371b-5p	CLIP-seq
MIRT972517	hsa-miR-4643	CLIP-seq
MIRT972518	hsa-miR-466	CLIP-seq
MIRT972519	hsa-miR-4666-5p	CLIP-seq
MIRT972520	hsa-miR-4719	CLIP-seq
MIRT972521	hsa-miR-4789-3p	CLIP-seq
MIRT972522	hsa-miR-4789-5p	CLIP-seq
MIRT972523	hsa-miR-513b	CLIP-seq
MIRT972524	hsa-miR-548c-3p	CLIP-seq
MIRT972525	hsa-miR-648	CLIP-seq
MIRT972526	hsa-miR-1225-3p	CLIP-seq
MIRT972527	hsa-miR-1233	CLIP-seq
MIRT972528	hsa-miR-1273e	CLIP-seq
MIRT972529	hsa-miR-1323	CLIP-seq
MIRT972530	hsa-miR-136	CLIP-seq
MIRT972531	hsa-miR-371-5p	CLIP-seq
MIRT972516	hsa-miR-371b-5p	CLIP-seq
MIRT972517	hsa-miR-4643	CLIP-seq
MIRT972518	hsa-miR-466	CLIP-seq
MIRT972532	hsa-miR-4687-5p	CLIP-seq
MIRT972521	hsa-miR-4789-3p	CLIP-seq
MIRT972522	hsa-miR-4789-5p	CLIP-seq
MIRT972533	hsa-miR-513c	CLIP-seq
MIRT972534	hsa-miR-514b-5p	CLIP-seq
MIRT972535	hsa-miR-515-5p	CLIP-seq
MIRT972536	hsa-miR-548o	CLIP-seq
MIRT972537	hsa-miR-942	CLIP-seq
MIRT2526165	hsa-miR-3143	CLIP-seq
MIRT2526166	hsa-miR-33a	CLIP-seq
MIRT2526167	hsa-miR-33b	CLIP-seq
MIRT2526168	hsa-miR-3674	CLIP-seq
MIRT2526169	hsa-miR-369-3p	CLIP-seq
MIRT2526170	hsa-miR-374c	CLIP-seq
MIRT2526171	hsa-miR-3910	CLIP-seq
MIRT2526172	hsa-miR-4436b-3p	CLIP-seq
MIRT2526173	hsa-miR-4484	CLIP-seq
MIRT2526174	hsa-miR-4509	CLIP-seq
MIRT2526175	hsa-miR-450b-5p	CLIP-seq
MIRT2526176	hsa-miR-4714-3p	CLIP-seq
MIRT2526177	hsa-miR-4720-3p	CLIP-seq
MIRT2526178	hsa-miR-4729	CLIP-seq
MIRT2526179	hsa-miR-4761-3p	CLIP-seq
MIRT2526180	hsa-miR-4775	CLIP-seq
MIRT2526181	hsa-miR-4804-3p	CLIP-seq
MIRT2526182	hsa-miR-507	CLIP-seq
MIRT2526183	hsa-miR-539	CLIP-seq
MIRT2526184	hsa-miR-543	CLIP-seq
MIRT2526185	hsa-miR-548a-3p	CLIP-seq
MIRT2526186	hsa-miR-548an	CLIP-seq
MIRT2526187	hsa-miR-548e	CLIP-seq
MIRT2526188	hsa-miR-548f	CLIP-seq
MIRT2526189	hsa-miR-557	CLIP-seq
MIRT2526190	hsa-miR-584	CLIP-seq
MIRT2526191	hsa-miR-590-3p	CLIP-seq
MIRT2526192	hsa-miR-655	CLIP-seq
MIRT2526193	hsa-miR-660	CLIP-seq
MIRT2526165	hsa-miR-3143	CLIP-seq
MIRT2526166	hsa-miR-33a	CLIP-seq
MIRT2526167	hsa-miR-33b	CLIP-seq
MIRT2526168	hsa-miR-3674	CLIP-seq
MIRT2526171	hsa-miR-3910	CLIP-seq
MIRT2526172	hsa-miR-4436b-3p	CLIP-seq
MIRT2526173	hsa-miR-4484	CLIP-seq
MIRT2526174	hsa-miR-4509	CLIP-seq
MIRT2526175	hsa-miR-450b-5p	CLIP-seq
MIRT2526176	hsa-miR-4714-3p	CLIP-seq
MIRT2526177	hsa-miR-4720-3p	CLIP-seq
MIRT2526178	hsa-miR-4729	CLIP-seq
MIRT2526179	hsa-miR-4761-3p	CLIP-seq
MIRT2526180	hsa-miR-4775	CLIP-seq
MIRT2526181	hsa-miR-4804-3p	CLIP-seq
MIRT2526182	hsa-miR-507	CLIP-seq
MIRT2526183	hsa-miR-539	CLIP-seq
MIRT2526184	hsa-miR-543	CLIP-seq
MIRT2526185	hsa-miR-548a-3p	CLIP-seq
MIRT2526186	hsa-miR-548an	CLIP-seq
MIRT2526187	hsa-miR-548e	CLIP-seq
MIRT2526188	hsa-miR-548f	CLIP-seq
MIRT2526189	hsa-miR-557	CLIP-seq
MIRT2526190	hsa-miR-584	CLIP-seq
MIRT2526191	hsa-miR-590-3p	CLIP-seq
MIRT2526193	hsa-miR-660	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000145	Component	Exocyst	IBA	21873635
GO:0000145	Component	Exocyst	NAS	11406615
GO:0005515	Function	Protein binding	IPI	17043677, 19885391, 24344185, 25591774, 27173435, 31413325, 32296183
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	25591774
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006887	Process	Exocytosis	IBA	21873635
GO:0006887	Process	Exocytosis	NAS	11406615
GO:0006893	Process	Golgi to plasma membrane transport	IBA	21873635
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016032	Process	Viral process	IEA
GO:0016241	Process	Regulation of macroautophagy	TAS	21241894
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IDA	25591774
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050714	Process	Positive regulation of protein secretion	IMP	25591774
GO:0051607	Process	Defense response to virus	IEA
GO:0090543	Component	Flemming body	IEA
GO:0098592	Component	Cytoplasmic side of apical plasma membrane	IDA	25591774

MIM	HGNC	e!Ensembl
607879	30380	ENSG00000090989

Protein

UniProt ID

Q9NV70

Protein name

Exocyst complex component 1 (Exocyst complex component Sec3)

Protein function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and transl

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15277	Sec3-PIP2_bind	32 → 121	Exocyst complex component SEC3 N-terminal PIP2 binding PH	Domain
PF09763	Sec3_C	183 → 871	Exocyst complex component Sec3	Family

Sequence

MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK
GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ
RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY
AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE
MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG
IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH
DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER
EIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQ
SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ
QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL
GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE
VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES
QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH
FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE
NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH

Sequence length

894

Interactions

View interactions

	Reactome
			Insulin processing VxPx cargo-targeting to cilium

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Cervical cancer	cervical cancer	rs28934571, rs121913482, rs121913483	23817570

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Cervical Cancer	Cervical Cancer	Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2).		GWAS, CBGDA

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	39408874
Neoplasms	Associate	35655316
Uterine Cervical Neoplasms	Associate	30333560

EXOC1 (exocyst complex component 1)