Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	55763
Gene name	Exocyst complex component 1
Gene symbol	EXOC1
Synonyms (NCBI Gene)	BM-102SEC3SEC3L1SEC3P
Chromosome	4
Chromosome location	4q12
Summary	The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and f

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miRTarBase ID	miRNA	Experiments
MIRT972511	hsa-miR-101	CLIP-seq
MIRT972512	hsa-miR-1244	CLIP-seq
MIRT972513	hsa-miR-144	CLIP-seq
MIRT972514	hsa-miR-3591-5p	CLIP-seq
MIRT972515	hsa-miR-3613-3p	CLIP-seq
MIRT972516	hsa-miR-371b-5p	CLIP-seq
MIRT972517	hsa-miR-4643	CLIP-seq
MIRT972518	hsa-miR-466	CLIP-seq
MIRT972519	hsa-miR-4666-5p	CLIP-seq
MIRT972520	hsa-miR-4719	CLIP-seq
MIRT972521	hsa-miR-4789-3p	CLIP-seq
MIRT972522	hsa-miR-4789-5p	CLIP-seq
MIRT972523	hsa-miR-513b	CLIP-seq
MIRT972524	hsa-miR-548c-3p	CLIP-seq
MIRT972525	hsa-miR-648	CLIP-seq
MIRT972526	hsa-miR-1225-3p	CLIP-seq
MIRT972527	hsa-miR-1233	CLIP-seq
MIRT972528	hsa-miR-1273e	CLIP-seq
MIRT972529	hsa-miR-1323	CLIP-seq
MIRT972530	hsa-miR-136	CLIP-seq
MIRT972531	hsa-miR-371-5p	CLIP-seq
MIRT972516	hsa-miR-371b-5p	CLIP-seq
MIRT972517	hsa-miR-4643	CLIP-seq
MIRT972518	hsa-miR-466	CLIP-seq
MIRT972532	hsa-miR-4687-5p	CLIP-seq
MIRT972521	hsa-miR-4789-3p	CLIP-seq
MIRT972522	hsa-miR-4789-5p	CLIP-seq
MIRT972533	hsa-miR-513c	CLIP-seq
MIRT972534	hsa-miR-514b-5p	CLIP-seq
MIRT972535	hsa-miR-515-5p	CLIP-seq
MIRT972536	hsa-miR-548o	CLIP-seq
MIRT972537	hsa-miR-942	CLIP-seq
MIRT2526165	hsa-miR-3143	CLIP-seq
MIRT2526166	hsa-miR-33a	CLIP-seq
MIRT2526167	hsa-miR-33b	CLIP-seq
MIRT2526168	hsa-miR-3674	CLIP-seq
MIRT2526169	hsa-miR-369-3p	CLIP-seq
MIRT2526170	hsa-miR-374c	CLIP-seq
MIRT2526171	hsa-miR-3910	CLIP-seq
MIRT2526172	hsa-miR-4436b-3p	CLIP-seq
MIRT2526173	hsa-miR-4484	CLIP-seq
MIRT2526174	hsa-miR-4509	CLIP-seq
MIRT2526175	hsa-miR-450b-5p	CLIP-seq
MIRT2526176	hsa-miR-4714-3p	CLIP-seq
MIRT2526177	hsa-miR-4720-3p	CLIP-seq
MIRT2526178	hsa-miR-4729	CLIP-seq
MIRT2526179	hsa-miR-4761-3p	CLIP-seq
MIRT2526180	hsa-miR-4775	CLIP-seq
MIRT2526181	hsa-miR-4804-3p	CLIP-seq
MIRT2526182	hsa-miR-507	CLIP-seq
MIRT2526183	hsa-miR-539	CLIP-seq
MIRT2526184	hsa-miR-543	CLIP-seq
MIRT2526185	hsa-miR-548a-3p	CLIP-seq
MIRT2526186	hsa-miR-548an	CLIP-seq
MIRT2526187	hsa-miR-548e	CLIP-seq
MIRT2526188	hsa-miR-548f	CLIP-seq
MIRT2526189	hsa-miR-557	CLIP-seq
MIRT2526190	hsa-miR-584	CLIP-seq
MIRT2526191	hsa-miR-590-3p	CLIP-seq
MIRT2526192	hsa-miR-655	CLIP-seq
MIRT2526193	hsa-miR-660	CLIP-seq
MIRT2526165	hsa-miR-3143	CLIP-seq
MIRT2526166	hsa-miR-33a	CLIP-seq
MIRT2526167	hsa-miR-33b	CLIP-seq
MIRT2526168	hsa-miR-3674	CLIP-seq
MIRT2526171	hsa-miR-3910	CLIP-seq
MIRT2526172	hsa-miR-4436b-3p	CLIP-seq
MIRT2526173	hsa-miR-4484	CLIP-seq
MIRT2526174	hsa-miR-4509	CLIP-seq
MIRT2526175	hsa-miR-450b-5p	CLIP-seq
MIRT2526176	hsa-miR-4714-3p	CLIP-seq
MIRT2526177	hsa-miR-4720-3p	CLIP-seq
MIRT2526178	hsa-miR-4729	CLIP-seq
MIRT2526179	hsa-miR-4761-3p	CLIP-seq
MIRT2526180	hsa-miR-4775	CLIP-seq
MIRT2526181	hsa-miR-4804-3p	CLIP-seq
MIRT2526182	hsa-miR-507	CLIP-seq
MIRT2526183	hsa-miR-539	CLIP-seq
MIRT2526184	hsa-miR-543	CLIP-seq
MIRT2526185	hsa-miR-548a-3p	CLIP-seq
MIRT2526186	hsa-miR-548an	CLIP-seq
MIRT2526187	hsa-miR-548e	CLIP-seq
MIRT2526188	hsa-miR-548f	CLIP-seq
MIRT2526189	hsa-miR-557	CLIP-seq
MIRT2526190	hsa-miR-584	CLIP-seq
MIRT2526191	hsa-miR-590-3p	CLIP-seq
MIRT2526193	hsa-miR-660	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000145	Component	Exocyst	IBA
GO:0000145	Component	Exocyst	IEA
GO:0000145	Component	Exocyst	NAS	11406615, 22420621
GO:0000281	Process	Mitotic cytokinesis	NAS	22420621
GO:0005515	Function	Protein binding	IPI	16181645, 17043677, 19885391, 23414517, 24344185, 27173435, 31413325, 32296183, 33961781
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IBA
GO:0005737	Component	Cytoplasm	IDA	16181645
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	16181645
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006887	Process	Exocytosis	IBA
GO:0006887	Process	Exocytosis	IEA
GO:0006887	Process	Exocytosis	NAS	11406615
GO:0006893	Process	Golgi to plasma membrane transport	IBA
GO:0006904	Process	Vesicle docking involved in exocytosis	NAS	22420621
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016241	Process	Regulation of macroautophagy	TAS	21241894
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051607	Process	Defense response to virus	IEA
GO:0090148	Process	Membrane fission	NAS	22420621
GO:0090522	Process	Vesicle tethering involved in exocytosis	NAS	22420621
GO:0090543	Component	Flemming body	IEA

MIM	HGNC	e!Ensembl
607879	30380	ENSG00000090989

Q9NV70

Protein name

Exocyst complex component 1 (Exocyst complex component Sec3)

Protein function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and transl

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15277	Sec3-PIP2_bind	32 → 121	Exocyst complex component SEC3 N-terminal PIP2 binding PH	Domain
PF09763	Sec3_C	183 → 871	Exocyst complex component Sec3	Family

Sequence

MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK
GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ
RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY
AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE
MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG
IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH
DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER
EIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQ
SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ
QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL
GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE
VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES
QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH
FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE
NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH

Sequence length

894

Interactions

View interactions

	Reactome
			Insulin processing VxPx cargo-targeting to cilium

EXOC1 (exocyst complex component 1)