Gene Gene information from NCBI Gene database.
Entrez ID 55748
Gene name Carnosine dipeptidase 2
Gene symbol CNDP2
Synonyms (NCBI Gene)
CN2CPGLHEL-S-13HsT2298PEPA
Chromosome 18
Chromosome location 18q22.3
Summary CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
398
miRTarBase ID miRNA Experiments Reference
MIRT020528 hsa-miR-155-5p Proteomics 18668040
MIRT028391 hsa-miR-30a-5p Proteomics 18668040
MIRT030380 hsa-miR-24-3p qRT-PCR;Microarray 19748357
MIRT032223 hsa-let-7b-5p Proteomics 18668040
MIRT449071 hsa-miR-493-3p PAR-CLIP 22100165
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0004180 Function Carboxypeptidase activity IEA
GO:0005515 Function Protein binding IPI 33961781
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
169800 24437 ENSG00000133313
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96KP4
Protein name Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (Peptidase A) (Threonyl dipeptidase)
Protein function Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity). Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity). Has high dipeptidase activity t
PDB 4RUH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01546 Peptidase_M20 95 469 Peptidase family M20/M25/M40 Family
PF07687 M20_dimer 208 369 Peptidase dimerisation domain Domain
Tissue specificity TISSUE SPECIFICITY: [Isoform 1]: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues
Sequence
MAALTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVE
LVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVE
RDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRFCLEGMEESGSEGLDELIFAR
KDTFFKDVDYVCISDNYWLGKKKPCIT
YGLRGICYFFIEVECSNKDLHSGVYGGSVHEAM
TDLILLMGSLVDKRGNILIPGINEAVAAVTEEEHKLYDDIDFDIEEFAKDVGAQILLHSH
KKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPNMTPEVVGEQVTSY
LTKKFAELR
SPNEFKVYMGHGGKPWVSDFSHPHYLAGRRAMKTVFGVEPDLTREGGSIPV
TLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRYNYIEGTKMLAAYLYE
VSQLKD
Sequence length 475
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Arginine and proline metabolism
Histidine metabolism
beta-Alanine metabolism
Metabolic pathways
  Glutathione synthesis and recycling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
5
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs112548120 RCV005911824
Cervical cancer Benign rs112548120 RCV005911826
Lung cancer Benign rs112548120 RCV005911827
Malignant tumor of esophagus Benign rs112548120 RCV005911825
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 26544852
Diabetic Nephropathies Associate 19373489
Kidney Failure Chronic Associate 19373489
Laryngeal Neoplasms Associate 24587265
Myotonic Dystrophy Associate 19373489
Neoplasms Associate 25225353
Pancreatic Neoplasms Associate 22128300
Protoporphyria Erythropoietic Associate 641953