Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55748
Gene name Gene Name - the full gene name approved by the HGNC.
Carnosine dipeptidase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CNDP2
Synonyms (NCBI Gene) Gene synonyms aliases
CN2, CPGL, HEL-S-13, HsT2298, PEPA
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020528 hsa-miR-155-5p Proteomics 18668040
MIRT028391 hsa-miR-30a-5p Proteomics 18668040
MIRT030380 hsa-miR-24-3p qRT-PCR;Microarray 19748357
MIRT032223 hsa-let-7b-5p Proteomics 18668040
MIRT449071 hsa-miR-493-3p PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004180 Function Carboxypeptidase activity IEA
GO:0005515 Function Protein binding IPI 33961781
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
169800 24437 ENSG00000133313
Protein
UniProt ID Q96KP4
Protein name Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (Peptidase A) (Threonyl dipeptidase)
Protein function Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity). Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity). Has high dipeptidase activity t
PDB 4RUH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01546 Peptidase_M20 95 469 Peptidase family M20/M25/M40 Family
PF07687 M20_dimer 208 369 Peptidase dimerisation domain Domain
Tissue specificity TISSUE SPECIFICITY: [Isoform 1]: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues
Sequence
MAALTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVE
LVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVE
RDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRFCLEGMEESGSEGLDELIFAR
KDTFFKDVDYVCISDNYWLGKKKPCIT
YGLRGICYFFIEVECSNKDLHSGVYGGSVHEAM
TDLILLMGSLVDKRGNILIPGINEAVAAVTEEEHKLYDDIDFDIEEFAKDVGAQILLHSH
KKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPNMTPEVVGEQVTSY
LTKKFAELR
SPNEFKVYMGHGGKPWVSDFSHPHYLAGRRAMKTVFGVEPDLTREGGSIPV
TLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRYNYIEGTKMLAAYLYE
VSQLKD
Sequence length 475
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Arginine and proline metabolism
Histidine metabolism
beta-Alanine metabolism
Metabolic pathways
  Glutathione synthesis and recycling
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